Article ; Online: Challenges in perioperative blood transfusions in kidney transplantation and the need for Patient Blood Management.
Blood transfusion = Trasfusione del sangue
2023 Volume 22, Issue 3, Page(s) 206–212
Abstract: Background: Anemia is highly prevalent in end-stage chronic kidney disease patients, increasing their risk of receiving blood transfusions during and on the days after a kidney transplant (KTx) surgery. However, there is currently a lack of data that ... ...
| Abstract | Background: Anemia is highly prevalent in end-stage chronic kidney disease patients, increasing their risk of receiving blood transfusions during and on the days after a kidney transplant (KTx) surgery. However, there is currently a lack of data that thoroughly describes this phenomenon in this population, the associated risk factors, and how they could benefit from the application of Patient Blood Management (PBM) guidelines. Materials and methods: Observational study. All adult patients who received a KTx between January 1 Results: We found that a high amount (39%) of KTx recipients required at least one blood transfusion during the perioperative period. And that 1) most of these patients had anemia at the time of transplantation (85.4%), 2) iron status upon admission was associated with the transfusion of more blood units (3.9 vs 2.7, p=0.019), 3) surgical reintervention (OR 7.28, 2.35-22.54) and deceased donor donation (OR 1.99, 1.24-3.21) were associated with an increased risk of transfusion, and finally, 4) there was an association between a higher number of blood units transfused and impaired kidney graft function six months after hospital discharge (1.6 vs 1.9, p=0.02). Conclusions: In conclusion, PBM guidelines should be applied to patients on the KTx deceased donor waiting list and especially those scheduled to receive a transplant from a living donor. This could potentially increase the utilization efficiency of blood products and avoid transfusion-related severe adverse effects. |
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| MeSH term(s) | Humans ; Kidney Transplantation ; Male ; Female ; Middle Aged ; Blood Transfusion ; Adult ; Anemia/therapy ; Anemia/blood ; Anemia/etiology ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/blood ; Perioperative Care/methods ; Aged ; Risk Factors |
| Language | English |
| Publishing date | 2023-10-09 |
| Publishing country | Italy |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2135732-8 |
| ISSN | 2385-2070 ; 0041-1787 ; 1723-2007 |
| ISSN (online) | 2385-2070 |
| ISSN | 0041-1787 ; 1723-2007 |
| DOI | 10.2450/BloodTransfus.577 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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