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  1. Article ; Online: The Barancik lecture: Comorbidity in multiple sclerosis-Looking backward, looking forward.

    Marrie, Ruth Ann

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 9, Page(s) 1049–1056

    Abstract: Comorbidity is highly prevalent in people with multiple sclerosis (MS) throughout their disease course. In the last 15 years, our understanding of the association between comorbidity and outcomes such as relapses, disability progressive, health-related ... ...

    Abstract Comorbidity is highly prevalent in people with multiple sclerosis (MS) throughout their disease course. In the last 15 years, our understanding of the association between comorbidity and outcomes such as relapses, disability progressive, health-related quality of life, health care use, and mortality has grown substantially. The broad adverse impacts of comorbidity on these outcomes point to the need to prevent and treat comorbidity effectively in people with MS. This requires having the necessary tools to evaluate comorbidity, an understanding of how MS affects management of comorbidity now, testing of interventions tailored to people with MS, and determining the best models of care to optimize comorbidity management.
    MeSH term(s) Humans ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/therapy ; Quality of Life ; Comorbidity ; Disease Progression
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231167740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
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  2. Article ; Online: Off-Road Testing: Outcome Reporting Bias in Multiple Sclerosis Trials.

    Marrie, Ruth Ann / Salter, Amber

    Neurology

    2024  Volume 102, Issue 6, Page(s) e208099

    MeSH term(s) Humans ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/therapy ; Automobile Driving ; Bias
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deciphering a Prodrome: Looking for a Disease in a Haystack

    Marrie, Ruth Ann / Palladino, Raffaele

    Neurology

    2023  Volume 101, Issue 24, Page(s) 1083–1084

    Abstract: In many chronic diseases, the underlying biological processes begin long before the condition is clinically recognized and diagnosed. After biologic onset of the disease an early, often nonspecific, set of symptoms, or prodrome, may develop before more ... ...

    Abstract In many chronic diseases, the underlying biological processes begin long before the condition is clinically recognized and diagnosed. After biologic onset of the disease an early, often nonspecific, set of symptoms, or prodrome, may develop before more characteristic symptoms of the disease present. For instance, in Parkinson disease (PD), some of the earliest manifestations, such as smell or taste dysfunction, may occur 2 decades before typical symptoms, such as tremor, appear.
    MeSH term(s) Humans ; Prodromal Symptoms ; Nervous System Diseases/diagnosis
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Subclinical atherosclerosis in multiple sclerosis.

    Marrie, Ruth Ann / Patel, Ronak / Schaffer, Stephen Allan

    Multiple sclerosis journal - experimental, translational and clinical

    2024  Volume 10, Issue 2, Page(s) 20552173241238627

    Abstract: Background: People with multiple sclerosis (MS) have an increased risk of ischemic heart disease as compared to people without MS after accounting for traditional vascular risk factors.: Objective: We assessed whether subclinical atherosclerosis, an ... ...

    Abstract Background: People with multiple sclerosis (MS) have an increased risk of ischemic heart disease as compared to people without MS after accounting for traditional vascular risk factors.
    Objective: We assessed whether subclinical atherosclerosis, an inflammatory disease of arteries, occurs in persons with MS who do not have traditional vascular risk factors, and whether the Framingham Score (FRS) predicted carotid intima media thickness (CIMT) similarly in people with and without MS.
    Methods: We recruited participants with and without MS who did not have vascular disease. Participants completed questionnaires, physical assessments, underwent an ultrasound (CIMT), and provided samples for HbA1c and lipid measurements. We defined subclinical atherosclerosis as an average CIMT ≥75
    Results: We recruited 106 participants with MS 101 without MS. The average (SD) CIMT did not differ between the MS (0.60 [0.11]) and non-MS (0.61 [0.12]) cohorts (p = 0.69), nor did the proportion with atherosclerosis (MS: 11.3% vs. non-MS 13.4%, p = 0.58). On regression analysis a 1-point increase in the FRS was associated with 11% increased odds of having atherosclerosis (95%CI: 1.04, 1.19) but MS was not.
    Conclusion: MS was not associated with subclinical atherosclerosis.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173241238627
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  5. Article ; Online: Mounting evidence for a multiple sclerosis prodrome.

    Marrie, Ruth Ann

    Nature reviews. Neurology

    2019  Volume 15, Issue 12, Page(s) 689–690

    MeSH term(s) Biomarkers/blood ; Dimethyl Fumarate/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Multiple Sclerosis/blood ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/drug therapy ; Neurofilament Proteins/blood ; Prodromal Symptoms
    Chemical Substances Biomarkers ; Immunosuppressive Agents ; Neurofilament Proteins ; neurofilament protein L ; Dimethyl Fumarate (FO2303MNI2)
    Language English
    Publishing date 2019-10-25
    Publishing country England
    Document type News
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-019-0283-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recognizing the diversity gap in multiple sclerosis.

    Marrie, Ruth Ann

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2019  Volume 25, Issue 11, Page(s) 1425–1426

    MeSH term(s) Humans ; Multiple Sclerosis
    Language English
    Publishing date 2019-05-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458519850070
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  7. Article ; Online: Comorbidity in multiple sclerosis: Past, present and future.

    Marrie, Ruth Ann

    Clinical and investigative medicine. Medecine clinique et experimentale

    2019  Volume 42, Issue 1, Page(s) E5–E12

    Abstract: Purpose: Multiple sclerosis (MS) is an inflammatory and degenerative condition affecting the central nervous system. Like many neurologic diseases, it is chronic and incurable, and confers a substantial burden on affected individuals, their families and ...

    Abstract Purpose: Multiple sclerosis (MS) is an inflammatory and degenerative condition affecting the central nervous system. Like many neurologic diseases, it is chronic and incurable, and confers a substantial burden on affected individuals, their families and society. Although many individuals suffering from a serious chronic disease also suffer from comorbid conditions, the important consequences of their interaction often receive little attention. This was particularly true for MS two decades ago. Broadening our perspective by better understanding the effects of comorbidity on an individual with a particular chronic disease offers us an opportunity to improve understanding of prognosis, personalize disease management, develop new therapeutic approaches and illuminate the pathophysiology of disease.
    Source: Studies examining the incidence, prevalence and outcomes related to comorbidity in MS will be discussed, along with areas requiring further investigation.
    Conclusion: Comorbidity is highly prevalent in MS throughout the disease course. Comorbid conditions, including depression, anxiety, hypertension, hyperlipidemia, diabetes and chronic lung disease, adversely affect a broad range of outcomes. Less is known about the effects of MS on outcomes related to these comorbid conditions. These findings highlight an urgent need to determine how to best prevent and treat comorbidity in MS.
    MeSH term(s) Chronic Disease/epidemiology ; Comorbidity ; Depression/epidemiology ; Depression/pathology ; Humans ; Hypertension/epidemiology ; Hypertension/pathology ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/pathology
    Language English
    Publishing date 2019-03-23
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 434004-8
    ISSN 1488-2353 ; 0147-958X
    ISSN (online) 1488-2353
    ISSN 0147-958X
    DOI 10.25011/cim.v42i1.32383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 345: Show issues

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  8. Article ; Online: Maternal and fetal risks of natalizumab exposure in utero: A fine balance.

    Marrie, Ruth Ann

    Neurology

    2018  Volume 90, Issue 10, Page(s) 443–444

    MeSH term(s) Female ; Humans ; Multiple Sclerosis ; Natalizumab ; Pregnancy
    Chemical Substances Natalizumab
    Language English
    Publishing date 2018-02-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000005075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Guest Editorial.

    Marrie, Ruth Ann / Salter, Amber

    International journal of MS care

    2021  Volume 23, Issue 6, Page(s) iva–iv

    Language English
    Publishing date 2021-12-29
    Publishing country United States
    Document type Editorial
    ISSN 1537-2073
    ISSN 1537-2073
    DOI 10.7224/1537-2073-23.6.iva
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Psychiatric comorbidity in immune-mediated inflammatory diseases.

    Marrie, Ruth Ann / Bernstein, Charles N

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2021  Volume 20, Issue 2, Page(s) 298–299

    Language English
    Publishing date 2021-05-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20873
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