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  1. Article ; Online: Global leadership in paediatric and congenital cardiac care: education and empowerment to improve outcomes in low- and middle-income countries - an interview with Krishna Kumar, MD, DM FAHA.

    Marshall, Mayme E / Jacobs, Jeffrey P / Tretter, Justin T

    Cardiology in the young

    2023  Volume 33, Issue 7, Page(s) 1071–1078

    Abstract: Dr Krishna Kumar is the focus of our sixth in a series of interviews ... ...

    Abstract Dr Krishna Kumar is the focus of our sixth in a series of interviews in
    MeSH term(s) Humans ; Child ; Developing Countries ; Leadership ; Cardiology ; India ; Boston
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Interview
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951123001695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Occlusion of left main coronary artery presenting with ventricular fibrillation in teenagers: an unrecognised cause of sudden death?

    Marshall, Mayme / Balaji, Seshadri

    Cardiology in the young

    2020  Volume 30, Issue 8, Page(s) 1212–1214

    Abstract: In young patients with unexplained ventricular fibrillation, coronary occlusion may be missed by echocardiogram and misinterpreted by CT. We report two patients presenting with ventricular fibrillation and initially negative workup, later identified to ... ...

    Abstract In young patients with unexplained ventricular fibrillation, coronary occlusion may be missed by echocardiogram and misinterpreted by CT. We report two patients presenting with ventricular fibrillation and initially negative workup, later identified to have occlusion of left main coronary artery. We demonstrate the importance of angiography to rule out coronary occlusion in patients with unexplained ventricular fibrillation.
    MeSH term(s) Adolescent ; Coronary Angiography ; Coronary Occlusion/complications ; Coronary Occlusion/diagnosis ; Coronary Vessels/diagnostic imaging ; Death, Sudden ; Humans ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/etiology
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S104795112000181X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Structured Framework for Multidisciplinary Parent Counseling and Medical Interventions for Fetuses and Infants with Trisomy 13 or Trisomy 18.

    Kim, Amanda J H / Marshall, Mayme / Gievers, Ladawna / Tate, Tyler / Taub, Sara / Dukhovny, Stephanie / Ronai, Christina / Madriago, Erin J

    American journal of perinatology

    2023  

    Abstract: Objective:  Trisomy 13 (T13) and 18 (T18) are aneuploidies associated with multiple structural congenital anomalies and high rates of fetal demise and neonatal mortality. Historically, patients with either one of these diagnoses have been treated ... ...

    Abstract Objective:  Trisomy 13 (T13) and 18 (T18) are aneuploidies associated with multiple structural congenital anomalies and high rates of fetal demise and neonatal mortality. Historically, patients with either one of these diagnoses have been treated similarly with exclusive comfort care rather than invasive interventions or intensive care, despite a wide phenotypic variation and substantial variations in survival length. However, surgical interventions have been on the rise in this population in recent years without clearly elucidated selection criterion. Our objective was to create a standardized approach to counseling expectant persons and parents of newborns with T13/T18 in order to provide collaborative and consistent counseling and thoughtful approach to interventions such as surgery.
    Study design:  This article describes our process and presents our resulting clinical care guideline.
    Results:  We formed a multi- and interdisciplinary committee. We used published literature when available and otherwise expert opinion to develop an approach to care featuring individualized assessment of the patient to estimate qualitative mortality risk and potential to benefit from intensive care and/or surgeries centered within an ethical framework.
    Conclusion:  Through multidisciplinary collaboration, we successfully created a patient-centered approach for counseling families facing a diagnosis of T13/T18. Other institutions may use our approach as a model for developing their own standardized approach.
    Key points: · Trisomy 13 and trisomy 18 are associated with high but variable morbidity and mortality.. · Research on which patients are most likely to benefit from surgery is lacking.. · We present our institution's framework to counsel families with fetal/neonatal T13/T18..
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1772748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aortic valve leaflets are asymmetric and correlated with the origin of coronary arteries.

    Koerner, Taylor S / Cunningham, Thomas / Marshall, Mayme E / Talley, Lauren S / Childress, Megan / Kharouf, Rami M / Li, Wen / Salazar, Jorge D / Corno, Antonio F

    Translational pediatrics

    2023  Volume 12, Issue 12, Page(s) 2164–2178

    Abstract: Background: Asymmetry of the aortic valve leaflets has been known since Leonardo Da Vinci, but the relationship between size and shape and origin of the coronary arteries has never been examined. Our aim was to evaluate this anatomy in a population of ... ...

    Abstract Background: Asymmetry of the aortic valve leaflets has been known since Leonardo Da Vinci, but the relationship between size and shape and origin of the coronary arteries has never been examined. Our aim was to evaluate this anatomy in a population of pediatric patients using a cross-sectional study design.
    Methods: Consecutive pediatric patients with trans-esophageal echocardiography (TEE), with or without trans-thoracic echocardiography (TTE), were included in our study. Exclusion criteria: (I) bicuspid aortic valve; (II) aortic valve stenosis; (III) hypoplasia of aortic valve annulus, or aortic root; (IV) truncal valve; (V) coronary artery atresia; (VI) previous surgery on aortic valve and/or coronary arteries. In pre-operative TTE and intra-operative TEE inter-commissural distance and length of aortic valve leaflets were measured in short axis view in the isovolumic phase of systole. Echocardiography investigations, anonymized and randomly coded, were independently reviewed by at least two readers. Echocardiography, angiography, cardiac computed tomography (CT) scan and magnetic resonance imaging (MRI), and operative notes were reviewed to identify origin of coronary arteries.
    Results: Two hundred sixty-one pediatric patients were identified, 93 excluded per our criteria, leaving 168 patients, age 2.6±4.3 years, weight 12.87±17.34 kg, 128 (76%) with normal and 40 (24%) with abnormal coronary arteries. In TTE and TEE measurements the non-coronary leaflet had larger area (P<0.001), while the right and left had equal areas, but different shape, with the left leaflet longer (P<0.001) and narrower (P=0.005) than the right. With the major source of blood flow from the right coronary sinus, the non-coronary leaflet was still the longest. However, there was no statically significant difference between the size and shape previously observed between the right and left leaflets.
    Conclusions: Our study showed asymmetry of size and shape among aortic valve leaflets, and a relationship with coronary artery origin. The complex aortic root anatomy must be approximated to optimize function of any surgical repair. These findings also may prove useful in the pre-operative definition of coronary artery anatomy and in the recognition of coronary artery anomalies.
    Language English
    Publishing date 2023-12-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Structured Framework for Multidisciplinary Parent Counseling and Medical Interventions for Fetuses and Infants with Trisomy 13 or Trisomy 18

    Kim, Amanda J.H. / Marshall, Mayme / Gievers, Ladawna / Tate, Tyler / Taub, Sara / Dukhovny, Stephanie / Ronai, Christina / Madriago, Erin J.

    American Journal of Perinatology

    2023  

    Abstract: Objective: Trisomy 13 (T13) and 18 (T18) are aneuploidies associated with multiple structural congenital anomalies and high rates of fetal demise and neonatal mortality. Historically, patients with either one of these diagnoses have been treated ... ...

    Abstract Objective: Trisomy 13 (T13) and 18 (T18) are aneuploidies associated with multiple structural congenital anomalies and high rates of fetal demise and neonatal mortality. Historically, patients with either one of these diagnoses have been treated similarly with exclusive comfort care rather than invasive interventions or intensive care, despite a wide phenotypic variation and substantial variations in survival length. However, surgical interventions have been on the rise in this population in recent years without clearly elucidated selection criterion. Our objective was to create a standardized approach to counseling expectant persons and parents of newborns with T13/T18 in order to provide collaborative and consistent counseling and thoughtful approach to interventions such as surgery.
    Study Design: This article describes our process and presents our resulting clinical care guideline.
    Results: We formed a multi- and interdisciplinary committee. We used published literature when available and otherwise expert opinion to develop an approach to care featuring individualized assessment of the patient to estimate qualitative mortality risk and potential to benefit from intensive care and/or surgeries centered within an ethical framework.
    Conclusion: Through multidisciplinary collaboration, we successfully created a patient-centered approach for counseling families facing a diagnosis of T13/T18. Other institutions may use our approach as a model for developing their own standardized approach.
    Key Points: Trisomy 13 and trisomy 18 are associated with high but variable morbidity and mortality. Research on which patients are most likely to benefit from surgery is lacking. We present our institution's framework to counsel families with fetal/neonatal T13/T18.
    Keywords trisomy 13 ; trisomy 18 ; antenatal counseling ; shared decision-making
    Language English
    Publishing date 2023-08-24
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1772748
    Database Thieme publisher's database

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  6. Article ; Online: Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy.

    Marshall, Mayme / Malik, Aneeq / Shah, Maully / Fish, Frank A / Etheridge, Susan P / Aziz, Peter F / Russell, Mark W / Tisma, Svjetlana / Pflaumer, Andreas / Sreeram, Narayanswami / Kubus, Peter / Law, Ian H / Kantoch, Michal J / Kertesz, Naomi J / Strieper, Margaret / Erickson, Christopher C / Moore, Jeremy P / Nakano, Stephanie J / Singh, Harinder R /
    Chang, Philip / Cohen, Mitchell / Fournier, Anne / Ilina, Maria V / Zimmermann, Frank / Horndasch, Michaela / Li, Walter / Batra, Anjan S / Liberman, Leonardo / Hamilton, Robert / Janson, Christopher M / Sanatani, Shubhayan / Zeltser, Ilana / McDaniel, George / Blaufox, Andrew D / Garnreiter, Jason M / Balaji, Seshadri

    Pediatric cardiology

    2023  

    Abstract: Hypertrophic cardiomyopathy (HCM), a common cardiomyopathy in children, is an important cause of morbidity and mortality. Early recognition and appropriate management are important. An electrocardiogram (ECG) is often used as a screening tool in children ...

    Abstract Hypertrophic cardiomyopathy (HCM), a common cardiomyopathy in children, is an important cause of morbidity and mortality. Early recognition and appropriate management are important. An electrocardiogram (ECG) is often used as a screening tool in children to detect heart disease. The ECG patterns in children with HCM are not well described.ECGs collected from an international cohort of children, and adolescents (≤ 21 years) with HCM were reviewed. 482 ECGs met inclusion criteria. Age ranged from 1 day to 21 years, median 13 years. Of the 482 ECGs, 57 (12%) were normal. The most common abnormalities noted were left ventricular hypertrophy (LVH) in 108/482 (22%) and biventricular hypertrophy (BVH) in 116/482 (24%) Of the patients with LVH/BVH (n = 224), 135 (60%) also had a strain pattern (LVH in 83, BVH in 52). Isolated strain pattern (in the absence of criteria for hypertrophy) was seen in 43/482 (9%). Isolated pathologic Q waves were seen in 71/482 (15%). Pediatric HCM, 88% have an abnormal ECG. The most common ECG abnormalities were LVH or BVH with or without strain. Strain pattern without hypertrophy and a pathologic Q wave were present in a significant proportion (24%) of patients. Thus, a significant number of children with HCM have ECG abnormalities that are not typical for "hypertrophy". The presence of the ECG abnormalities described above in a child should prompt further examination with an echocardiogram to rule out HCM.
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-023-03252-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination.

    Marshall, Mayme / Ferguson, Ian D / Lewis, Paul / Jaggi, Preeti / Gagliardo, Christina / Collins, James Stewart / Shaughnessy, Robin / Caron, Rachel / Fuss, Cristina / Corbin, Kathleen Jo E / Emuren, Leonard / Faherty, Erin / Hall, E Kevin / Di Pentima, Cecilia / Oster, Matthew E / Paintsil, Elijah / Siddiqui, Saira / Timchak, Donna M / Guzman-Cottrill, Judith A

    Pediatrics

    2021  Volume 148, Issue 3

    Abstract: Trials of coronavirus disease 2019 (COVID-19) vaccination included limited numbers of children, so they may not have detected rare but important adverse events in this population. We report 7 cases of acute myocarditis or myopericarditis in healthy male ... ...

    Abstract Trials of coronavirus disease 2019 (COVID-19) vaccination included limited numbers of children, so they may not have detected rare but important adverse events in this population. We report 7 cases of acute myocarditis or myopericarditis in healthy male adolescents who presented with chest pain all within 4 days after the second dose of Pfizer-BioNTech COVID-19 vaccination. Five patients had fever around the time of presentation. Acute COVID-19 was ruled out in all 7 cases on the basis of negative severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction test results of specimens obtained by using nasopharyngeal swabs. None of the patients met criteria for multisystem inflammatory syndrome in children. Six of the 7 patients had negative severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody assay results, suggesting no previous infection. All patients had an elevated troponin. Cardiac MRI revealed late gadolinium enhancement characteristic of myocarditis. All 7 patients resolved their symptoms rapidly. Three patients were treated with nonsteroidal antiinflammatory drugs only, and 4 received intravenous immunoglobulin and corticosteroids. In this report, we provide a summary of each adolescent's clinical course and evaluation. No causal relationship between vaccine administration and myocarditis has been established. Continued monitoring and reporting to the US Food and Drug Administration Vaccine Adverse Event Reporting System is strongly recommended.
    MeSH term(s) Acute Disease ; Adolescent ; COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Nucleic Acid Testing ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Coronavirus Nucleocapsid Proteins/immunology ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Male ; Myocarditis/diagnostic imaging ; Myocarditis/etiology ; Phosphoproteins/immunology ; Systemic Inflammatory Response Syndrome/diagnosis ; Time Factors ; Troponin/blood ; Young Adult
    Chemical Substances COVID-19 Vaccines ; Coronavirus Nucleocapsid Proteins ; Phosphoproteins ; Troponin ; nucleocapsid phosphoprotein, SARS-CoV-2 ; Gadolinium (AU0V1LM3JT) ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-052478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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