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Article ; Online: Phase-Adapted Rehabilitation for Acute Coronavirus Disease-19 Patients and Patient With Long-term Sequelae of Coronavirus Disease-19.

Gutenbrunner, Christoph / Nugraha, Boya / Martin, Lidia Teixido

American journal of physical medicine & rehabilitation

2021 Volume 100, Issue 6, Page(s) 533–538

Abstract: Abstract: Since the beginning of the COVID-19 pandemic in early 2020, many papers have highlighted the need for the rehabilitation of patients with SARS-CoV-2 infection. Most papers refer to the need for respiratory rehabilitation in the acute phase; ... ...

Abstract	Abstract: Since the beginning of the COVID-19 pandemic in early 2020, many papers have highlighted the need for the rehabilitation of patients with SARS-CoV-2 infection. Most papers refer to the need for respiratory rehabilitation in the acute phase; however, the fact that the infection also affects other organ systems has to be considered in rehabilitation interventions. Long-term symptoms in many cases severely limit activity and participation and alter quality of life, leading to rehabilitation needs. This article proposes a phase-adapted model of linking the acute, postacute, and long-term symptoms of COVID-19 with the well-established matrix of acute, postacute, and long-term rehabilitation services. A review of currently available recommendations for phase-adapted rehabilitation strategies, including the relevance of prehabilitation within this context, is provided.
MeSH term(s)	Acute Disease ; COVID-19/complications ; COVID-19/rehabilitation ; Chronic Disease ; Humans ; Models, Theoretical ; SARS-CoV-2 ; Subacute Care/methods ; Post-Acute COVID-19 Syndrome
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000001762
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Article: Positive influence of parental education on growth of children - statistical analysis of correlation between social and nutritional factors on children's height using the St. Nicolas House Analysis.

Martin, Lidia / Dorjee, Binu / Groth, Detlef / Scheffler, Christiane

Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur

2020 Volume 77, Issue 5, Page(s) 375–387

Abstract: In nature, dominance is often shown by body size; even in humans many studies report that social status is associated with body height. In today's society, educational status is an important factor for social classification. Since growing children do not ...

Abstract	In nature, dominance is often shown by body size; even in humans many studies report that social status is associated with body height. In today's society, educational status is an important factor for social classification. Since growing children do not have their own educational or social status, they are often affected by the status of their parents. Therefore, the question appears, whether parental educational status measurably affects the growth of a child. If so, is this explainable by the nutritional factors? To test this hypothesis, seven different Indian data sets where reexamined using the St. Nicolas House Analysis. The results show a direct association between parental education and body height (hSDS) of the child, but there was no influence of parental education on the nutritional status. We conclude that education has a direct effect on height that is not mediated via nutrition.
MeSH term(s)	Body Height ; Child ; Educational Status ; Humans ; Nutritional Status ; Parents
Language	English
Publishing date	2020-05-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	396-7
ISSN	0003-5548
ISSN	0003-5548
DOI	10.1127/anthranz/2020/1177
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Article ; Online: Ultrasound-Based Recovery of Anti-Inflammatory and Antimicrobial Extracts of the Acidophilic Microalga

Ruiz-Domínguez, Mari Carmen / Robles, María / Martín, Lidia / Beltrán, Álvaro / Gava, Riccardo / Cuaresma, María / Navarro, Francisco / Vílchez, Carlos

Marine drugs

2023 Volume 21, Issue 9

Abstract: In the present study, the recovery of valuable molecules of proven anti-inflammatory and antimicrobial activity of the acidophilic ... ...

Abstract	In the present study, the recovery of valuable molecules of proven anti-inflammatory and antimicrobial activity of the acidophilic microalga
MeSH term(s)	Lutein ; Microalgae ; Anti-Infective Agents/pharmacology ; Chlorophyta ; Anti-Bacterial Agents/pharmacology ; Plant Extracts/pharmacology
Chemical Substances	Lutein (X72A60C9MT) ; Anti-Infective Agents ; Anti-Bacterial Agents ; Plant Extracts
Language	English
Publishing date	2023-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21090471
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Article: Cabozantinib for the treatment of solid tumors: a systematic review.

Maroto, Pablo / Porta, Camillo / Capdevila, Jaume / Apolo, Andrea B / Viteri, Santiago / Rodriguez-Antona, Cristina / Martin, Lidia / Castellano, Daniel

Therapeutic advances in medical oncology

2022 Volume 14, Page(s) 17588359221107112

Abstract: Background: Cabozantinib is approved, in various settings, for the treatment of renal cell carcinoma, medullary thyroid cancer, and hepatocellular carcinoma, and it has been investigated for the treatment of other cancers. With the available evidence ... ...

Abstract	Background: Cabozantinib is approved, in various settings, for the treatment of renal cell carcinoma, medullary thyroid cancer, and hepatocellular carcinoma, and it has been investigated for the treatment of other cancers. With the available evidence and the real-world performance of cabozantinib compared with clinical trial data, we performed a systematic review of cabozantinib monotherapy as treatment for solid tumors in adults. Methods: This study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and registered with PROSPERO (CRD42020144680). We searched for clinical and observational studies of cabozantinib monotherapy for solid tumors using Embase, MEDLINE, and Cochrane databases (October 2020), and screened relevant congress abstracts. Eligible studies reported clinical or safety outcomes, or biomarker data. Small studies ( Results: Of 2888 citations, 114 were included (52 randomized studies, 29 observational studies, 32 nonrandomized phase I or II studies or pilot trials, and 1 analysis of data from a randomized study and a nonrandomized study). Beyond approved indications, other tumors studied were castration-resistant prostate cancer, urothelial carcinoma, Ewing sarcoma, osteosarcoma, uveal melanoma, non-small-cell lung cancer, Merkel cell carcinoma, glioblastoma, pheochromocytomas and paragangliomas, cholangiocarcinoma, gastrointestinal stromal tumor, colorectal cancer, salivary gland cancer, carcinoid and pancreatic neuroendocrine tumors, and breast, endometrial and ovarian cancers. The most common adverse events were hypertension, diarrhea, and fatigue. Conclusion: The identified evidence demonstrates the positive efficacy/effectiveness of cabozantinib monotherapy in various solid tumor types, with safety findings being consistent with those observed with other VEGFR-targeting tyrosine kinase inhibitors. When available, real-world findings were consistent with the data reported from clinical trials. A limitation of this review is the high proportion of abstracts; however, this allowed us to capture the most up-to-date findings.
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359221107112
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Article: Cabozantinib combination therapy for the treatment of solid tumors: a systematic review.

Castellano, Daniel / Apolo, Andrea B / Porta, Camillo / Capdevila, Jaume / Viteri, Santiago / Rodriguez-Antona, Cristina / Martin, Lidia / Maroto, Pablo

Therapeutic advances in medical oncology

2022 Volume 14, Page(s) 17588359221108691

Abstract: Background: Cabozantinib monotherapy is approved for the treatment of several types of solid tumors. Investigation into the use of cabozantinib combined with other therapies is increasing. To understand the evidence in this area, we performed a ... ...

Abstract	Background: Cabozantinib monotherapy is approved for the treatment of several types of solid tumors. Investigation into the use of cabozantinib combined with other therapies is increasing. To understand the evidence in this area, we performed a systematic review of cabozantinib combination therapy for the treatment of solid tumors in adults. Methods: This study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses, and the protocol was registered with PROSPERO (CRD42020144680). On 9 October 2020, we searched for clinical trials and observational studies of cabozantinib as part of a combination therapy for solid tumors using Embase, MEDLINE, and Cochrane databases, and by screening relevant congress abstracts. Eligible studies reported clinical or safety outcomes, or biomarker data. Randomized and observational studies with a sample size of fewer than 25 and studies of cabozantinib monotherapy were excluded. For each study, quality was assessed using National Institute for Health and Care Excellence methodology, and the study characteristics were described qualitatively. This study was funded by Ipsen. Results: Of 2421 citations identified, 32 articles were included (6 with results from randomized studies, 24 with results from non-randomized phase I or II studies, and 2 with results from both). The most commonly studied tumor types were metastatic urothelial carcinoma/genitourinary tumors and castration-resistant prostate cancer (CRPC). Findings from randomized studies suggested that cabozantinib combined with other therapies may lead to better progression-free survival than some current standards of care in renal cell carcinoma, CRPC, and non-small-cell lung cancer. The most common adverse events were hypertension, diarrhea, and fatigue. Conclusion: This review demonstrates the promising efficacy outcomes of cabozantinib combined with other therapies, and a safety profile similar to cabozantinib alone. However, the findings are limited by the fact that most of the identified studies were reported as congress abstracts only. More evidence from randomized trials is needed to explore cabozantinib as a combination therapy further.
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359221108691
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2022

Abstract: In this study, a characterisation is undertaken of the humid dune slacks water table situated in the arid transgressive coastal dune field of the Maspalomas Special Area of Conservation, ES701007 (Gran Canaria, Canary Islands, Spain). Humid dune slacks ... ...

Abstract	In this study, a characterisation is undertaken of the humid dune slacks water table situated in the arid transgressive coastal dune field of the Maspalomas Special Area of Conservation, ES701007 (Gran Canaria, Canary Islands, Spain). Humid dune slacks are listed as a European Union Habitat (EU Habitat 2190 humid dune slacks) in Annex I of the EU Habitats Directive. This water table is relatively stable throughout the year, with a 41 cm maximum oscillation. The annual dynamics of the flow pattern and water table level depend on the climate conditions. At the end of the hydrological dry season the mean water table drops (ca. 11 cm) and water flows to the lagoon. After rains, the mean water table level rises (ca. 4 cm) and flows towards the Maspalomas beach. The distribution of plant communities (associated to EU Habitat 2190) in the Maspalomas humid dune slacks depends on water table depth, pH and salinity. The knowledge acquired in this study of the water table dynamics has enabled a better understanding of the spatial distribution patterns of the vegetation of these slacks, in particular with respect to the relationship between the water table flux toward the coast during the dry season and the distribution of plant communities in the slacks closest to the coast. The study of the dynamics of the water table of the slacks and the associated vegetation has allowed us to better understand the characteristics of the Maspalomas humid dune slacks and potentially improve their management as EU Habitat. This is especially significant considering that the only European arid climate dune field where this habitat can be found is in Maspalomas.
Keywords	European Union ; arid zones ; coasts ; dry season ; habitats ; pH ; salinity ; vegetation ; water table ; Canary Islands ; Spain
Language	English
Dates of publication	2022-12
Size	p. 73.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	2053395-0
ISSN	1874-7841 ; 1400-0350
ISSN (online)	1874-7841
ISSN	1400-0350
DOI	10.1007/s11852-022-00919-7
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Article ; Online: Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.

Luan, Wei / Wright, Amanda L / Brown-Wright, Heledd / Le, Sheng / San Gil, Rebecca / Madrid San Martin, Lidia / Ling, Karen / Jafar-Nejad, Paymaan / Rigo, Frank / Walker, Adam K

Molecular psychiatry

2023 Volume 28, Issue 6, Page(s) 2445–2461

Abstract: TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms of TDP-43 dysfunction are poorly understood, however, ... ...

Abstract	TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms of TDP-43 dysfunction are poorly understood, however, activation of cell stress pathways may contribute to pathogenesis. We, therefore, sought to identify which cell stress components are critical for driving disease onset and neurodegeneration in ALS and FTD. We studied the rNLS8 transgenic mouse model, which expresses human TDP-43 with a genetically-ablated nuclear localisation sequence within neurons of the brain and spinal cord resulting in cytoplasmic TDP-43 pathology and progressive motor dysfunction. Amongst numerous cell stress-related biological pathways profiled using qPCR arrays, several critical integrated stress response (ISR) effectors, including CCAAT/enhancer-binding homologous protein (Chop/Ddit3) and activating transcription factor 4 (Atf4), were upregulated in the cortex of rNLS8 mice prior to disease onset. This was accompanied by early up-regulation of anti-apoptotic gene Bcl2 and diverse pro-apoptotic genes including BH3-interacting domain death agonist (Bid). However, pro-apoptotic signalling predominated after onset of motor phenotypes. Notably, pro-apoptotic cleaved caspase-3 protein was elevated in the cortex of rNLS8 mice at later disease stages, suggesting that downstream activation of apoptosis drives neurodegeneration following failure of early protective responses. Unexpectedly, suppression of Chop in the brain and spinal cord using antisense oligonucleotide-mediated silencing had no effect on overall TDP-43 pathology or disease phenotypes in rNLS8 mice. Cytoplasmic TDP-43 accumulation therefore causes very early activation of ISR and both anti- and pro-apoptotic signalling that switches to predominant pro-apoptotic activation later in disease. These findings suggest that precise temporal modulation of cell stress and death pathways may be beneficial to protect against neurodegeneration in ALS and FTD.
MeSH term(s)	Humans ; Mice ; Animals ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Mice, Transgenic
Chemical Substances	DNA-Binding Proteins ; TDP-43 protein, mouse
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02036-9
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Article ; Online: Comparative Efficacy of Cabozantinib and Ramucirumab After Sorafenib for Patients with Hepatocellular Carcinoma and Alpha-fetoprotein ≥ 400 ng/mL: A Matching-Adjusted Indirect Comparison.

Trojan, Jörg / Mollon, Patrick / Daniele, Bruno / Marteau, Florence / Martín, Lidia / Li, Yuxin / Xu, Qing / Piscaglia, Fabio / Zaucha, Renata / Sarker, Debashis / Lim, Ho Yeong / Venerito, Marino

Advances in therapy

2021 Volume 38, Issue 5, Page(s) 2472–2490

Abstract: Introduction: Cabozantinib and ramucirumab are approved for the treatment of adults with hepatocellular carcinoma (HCC) following prior sorafenib treatment; ramucirumab is restricted to use in patients with serum alpha-fetoprotein (AFP) ≥ 400 ng/mL. ... ...

Abstract	Introduction: Cabozantinib and ramucirumab are approved for the treatment of adults with hepatocellular carcinoma (HCC) following prior sorafenib treatment; ramucirumab is restricted to use in patients with serum alpha-fetoprotein (AFP) ≥ 400 ng/mL. This matching-adjusted indirect comparison evaluated the efficacy and safety of both drugs after sorafenib in patients with HCC and AFP ≥ 400 ng/mL. Methods: Individual patient data (IPD) from the CELESTIAL trial (cabozantinib) and population-level data from the REACH-2 trial (ramucirumab) were used. To align with REACH-2, the CELESTIAL population was limited to patients who received first-line sorafenib only and had baseline serum AFP ≥ 400 ng/mL. The IPD from CELESTIAL were weighted to balance the distribution of 11 effect-modifying baseline characteristics with those of REACH-2. Overall survival (OS; primary endpoint) and progression-free survival (PFS) were compared for the CELESTIAL (matching-adjusted) and REACH-2 populations using weighted Kaplan-Meier (KM) curves and parametric (OS, Weibull; PFS, log-logistic) modeling. Rates of treatment-related adverse events (TRAEs) and TRAE-related discontinuations were also compared. Results: After matching and weighting, baseline characteristics were balanced between populations (REACH-2, N = 292; CELESTIAL, effective sample size = 105). Weighted KM estimates for OS (median [95% CI]) were not significantly different between cabozantinib and ramucirumab (10.6 [9.5-17.3] months versus 8.7 [7.3-10.8] months; p = 0.104), but PFS was significantly longer for cabozantinib than for ramucirumab (5.5 [4.6-7.4] months versus 2.8 [2.7-4.1] months; p = 0.016). Parametric modeling results were consistent with the weighted KM analysis. Rates of some grade 3 or 4 TRAEs were lower with ramucirumab than with cabozantinib; however, TRAE-related discontinuation rates were similar (p = 0.271). Conclusion: In this MAIC, cabozantinib significantly prolonged median PFS compared with ramucirumab after prior sorafenib treatment in patients with HCC and AFP ≥ 400 ng/mL; rates of some grade 3 or 4 TRAEs were lower with ramucirumab than cabozantinib but related discontinuation rates were not significantly different between treatments. Trial registration: Clinical trials.gov identifiers: CELESTIAL trial (NCT01908426) and REACH-2 trial (NCT02435433). These slides can be retrieved under Electronic Supplementary Material.
MeSH term(s)	Adult ; Anilides ; Antibodies, Monoclonal, Humanized ; Carcinoma, Hepatocellular/drug therapy ; Humans ; Liver Neoplasms/drug therapy ; Pyridines ; Sorafenib ; alpha-Fetoproteins ; Ramucirumab
Chemical Substances	Anilides ; Antibodies, Monoclonal, Humanized ; Pyridines ; alpha-Fetoproteins ; cabozantinib (1C39JW444G) ; Sorafenib (9ZOQ3TZI87)
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-021-01700-2
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Article ; Online: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

San Gil, Rebecca / Pascovici, Dana / Venturato, Juliana / Brown-Wright, Heledd / Mehta, Prachi / Madrid San Martin, Lidia / Wu, Jemma / Luan, Wei / Chui, Yi Kit / Bademosi, Adekunle T / Swaminathan, Shilpa / Naidoo, Serey / Berning, Britt A / Wright, Amanda L / Keating, Sean S / Curtis, Maurice A / Faull, Richard L M / Lee, John D / Ngo, Shyuan T /

Lee, Albert / Morsch, Marco / Chung, Roger S / Scotter, Emma / Lisowski, Leszek / Mirzaei, Mehdi / Walker, Adam K

Nature communications

2024 Volume 15, Issue 1, Page(s) 1508

Abstract: Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic ... ...

Abstract	Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD, and developed a complementary open-access webtool, TDP-map ( https://shiny.rcc.uq.edu.au/TDP-map/ ). We identified distinct protein subsets enriched for diverse biological pathways with temporal alterations in protein abundance, including increases in protein folding factors prior to disease onset. This included increased levels of DnaJ homolog subfamily B member 5, DNAJB5, which also co-localized with TDP-43 pathology in diseased human motor cortex. DNAJB5 over-expression decreased TDP-43 aggregation in cell and cortical neuron cultures, and knockout of Dnajb5 exacerbated motor impairments caused by AAV-mediated cytoplasmic TDP-43 expression in mice. Together, these findings reveal molecular mechanisms at distinct stages of ALS and FTLD progression and suggest that protein folding factors could be protective in neurodegenerative diseases.
MeSH term(s)	Animals ; Humans ; Mice ; Amyotrophic Lateral Sclerosis/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Frontotemporal Dementia/metabolism ; Frontotemporal Lobar Degeneration/metabolism ; Neurons/metabolism ; Proteomics ; TDP-43 Proteinopathies/metabolism ; Protein Aggregates
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human ; Tardbp protein, mouse ; Protein Aggregates
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45646-9
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Article ; Online: Circulating Neutrophil Extracellular Traps Are Elevated in Patients With Deep Infiltrating Endometriosis.

Munrós, Jordina / Tàssies, Dolors / Reverter, Joan Carles / Martin, Lidia / Pérez, Amelia / Carmona, Francisco / Martínez-Zamora, María Ángeles

Reproductive sciences (Thousand Oaks, Calif.)

2018 Volume 26, Issue 1, Page(s) 70–76

Abstract: Neutrophil extracellular traps (NETs) have been described to be related to the pathogenesis of inflammatory and autoimmune conditions. Endometriosis is currently considered a chronic inflammatory condition. Therefore, we performed a preliminary case- ... ...

Abstract	Neutrophil extracellular traps (NETs) have been described to be related to the pathogenesis of inflammatory and autoimmune conditions. Endometriosis is currently considered a chronic inflammatory condition. Therefore, we performed a preliminary case-control study to compare the circulating plasma NET levels in patients with surgically confirmed endometriosis (E group, n = 82) and those of patients without surgical findings of endometriosis (C group, n = 35). Venous blood samples were obtained at the time of surgery. Circulating plasma NET levels were assessed as histone-DNA complexes (ie, nucleosomes) by a quantitative sandwich enzyme-linked immunosorbent assay. The results were expressed in arbitrary units. Circulating plasma NET levels were significantly higher in the E group compared with the C group (median [25th; 75th percentiles]): E group: 0.734 [0.484; 1.363]; C group: 0.541 [0.411; 0.653]; P = .005). The subanalysis of E group patients with deep infiltrating endometriosis (DIE group) or without DIE (non-DIE group) showed that plasma NET levels were higher in the DIE group ( P = .02). No differences were observed in NET levels among patients with and without severe pelvic pain or in patients with and without infertility, regardless of the presence of endometriotic lesions. Therefore, our study shows significantly higher NET levels in patients with endometriosis, which seem to be attributed to increased levels in the subgroup of patients with DIE, suggesting that the presence of elevated circulating plasma NET levels may reflect an inflammatory status in this gynecological condition. Further research is warranted to confirm our findings and to assess the exact role of NETs in the pathophysiological mechanisms of endometriosis.
MeSH term(s)	Adult ; Case-Control Studies ; Endometriosis/blood ; Endometriosis/complications ; Extracellular Traps/metabolism ; Female ; Humans ; Inflammation/blood ; Inflammation/complications ; Nucleosomes/metabolism
Chemical Substances	Nucleosomes
Language	English
Publishing date	2018-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1177/1933719118757682
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