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Article: Association between genetic variants of membrane transporters and the risk of high-grade hematologic adverse events in a cohort of Mexican children with B-cell acute lymphoblastic leukemia.

Escalante-Bautista, Deyanira / Cerecedo, Doris / Jiménez-Hernández, Elva / González-Torres, Carolina / Gaytán-Cervantes, Javier / Núñez-Enríquez, Juan Carlos / Sepúlveda-Robles, Omar Alejandro / De Ita, Marlon / Jiménez-Morales, Silvia / Sánchez-López, José Manuel / Mata-Rocha, Minerva / Torres-Nava, José Refugio / Martín-Trejo, Jorge Alfonso / Flores-Villegas, Luz Victoria / Gutiérrez-Rivera, María de Lourdes / Merino-Pasaye, Laura Elizabeth / Solís-Labastida, Karina Anastacia / Miranda-Madrazo, María Raquel / Hernández-Echáurregui, Gabriela Alicia /

Orozco-Ruíz, Darío / Flores-Lujano, Janet / Pérez-Saldívar, María Luisa / Mejía-Aranguré, Juan Manuel / Rosas-Vargas, Haydeé

Frontiers in oncology

2024 Volume 13, Page(s) 1276352

Abstract: Background: Advances in the understanding of the pathobiology of childhood B-cell acute lymphoblastic leukemia (B-ALL) have led towards risk-oriented treatment regimens and markedly improved survival rates. However, treatment-related toxicities remain a ...

Abstract	Background: Advances in the understanding of the pathobiology of childhood B-cell acute lymphoblastic leukemia (B-ALL) have led towards risk-oriented treatment regimens and markedly improved survival rates. However, treatment-related toxicities remain a major cause of mortality in developing countries. One of the most common adverse effects of chemotherapy in B-ALL is the hematologic toxicity, which may be related to genetic variants in membrane transporters that are critical for drug absorption, distribution, and elimination. In this study we detected genetic variants present in a selected group genes of the Methods: Next generation sequencing (NGS) was used to screen six genes of the ABC and seven genes of the SLC transporter families, in a cohort of 96 children with B-ALL. The grade of hematologic toxicity was classified according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, Subsequently, two groups of patients were formed: the null/low-grade (grades 1 and 2) and the high-grade (grades 3 to 5) adverse events groups. To determine whether there is an association between the genetic variants and high-grade hematologic adverse events, logistic regression analyses were performed using co-dominant, dominant, recessive, overdominant and log-additive inheritance models. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated. Results: We found two types of associations among the genetic variants identified as possible predictor factors of hematologic toxicity. One group of variants associated with high-grade toxicity risk: Conclusion: There are genetic variants in the
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1276352
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Article: Effect of long-chain omega-3 polyunsaturated fatty acids on cardiometabolic factors in children with acute lymphoblastic leukemia undergoing treatment: a secondary analysis of a randomized controlled trial.

Barbosa-Cortes, Lourdes / Atilano-Miguel, Salvador / Martin-Trejo, Jorge Alfonso / Jiménez-Aguayo, Emmanuel / Martínez-Becerril, Fabian Ismael / López-Alarcón, Mardia / Mejía Aranguré, Juan Manuel / Maldonado-Hernández, Jorge / Delgadillo-Portillo, Suyly / Guzmán-Castro, Brenda / Delgadillo-Portillo, Jazmín / Añoveros-Barrera, Ana / Solis-Labastida, Karina Anastacia / Bautista-Martinez, Benito Alejandro / Juárez-Moya, Azalia / Hernández-Piñón, Zaira / Espinoza Hernández, Laura Eugenia / Núñez-Villegas, Nora N / Jiménez-Hernández, Elva /

Pérez-Casillas, Ruy X

Frontiers in endocrinology

2023 Volume 14, Page(s) 1120364

Abstract: Introduction: Increased triglycerides (TGs) are a major risk factor for cardiovascular disease. Furthermore, hypertriglyceridemia is commonly associated with a reduction of high-density lipoprotein cholesterol (HDL-C) and an increase in atherogenic ... ...

Abstract	Introduction: Increased triglycerides (TGs) are a major risk factor for cardiovascular disease. Furthermore, hypertriglyceridemia is commonly associated with a reduction of high-density lipoprotein cholesterol (HDL-C) and an increase in atherogenic small-dense low-density lipoprotein (LDL-C) levels. Studies provide support that polyunsaturated omega-3 fatty acids (ω3-LCPUFAs) are cardioprotective and have antithrombotic and anti-inflammatory effects. The potential effects of ω3-LCPUFAs on cardiometabolic factors and anti-inflammatory actions in children with acute lymphoblastic leukemia (ALL) are limited. This is a secondary analysis of a previous clinical trial registered at clinical trials.gov (# NCT01051154) that was conducted to analyze the effect of ω3-LCPUFAs in pediatric patients with ALL who were receiving treatment.Objective: To examine the effect of supplementation with ω3-LCPUFAs on cardiometabolic factors in children with ALL undergoing treatment. Methods: Thirty-four children (placebo group: 20 patients; ω3-LCPUFAs group: 14 patients) aged 6.7 ± 2.7 years who were newly diagnosed with ALL were evaluated. Children were randomized to receive either ω3-LCPUFAs or placebo capsules (sunflower oil). ω3-LCPUFAs were administered in the form of 500-mg soft capsules. The ω3-LCPUFA capsules contained 225 mg of DHA, 45 mg of EPA, and 20 mg of another ω3-LCPUFAs. The omega-3 dose was administered at a rate of 0.100 g/kg of body weight/day for three months. Main outcomes: Fasting cholesterol, HDL-C, very-low-density lipoprotein (VLDL-C), TGs, atherogenic index of plasma (AIP), android/gynoid ratio (A/GR), IL-6, TNF-α, and percentage of fat mass (DXA) were measured in all patients. Fatty acid analyses in red blood cells were performed with gas chromatography. Results: We found significantly lower levels of TGs (p=0.043), VLDL-C (p=0.039), IL-6 (p=0.025), and AIP (p=0.042) in the ω3-LCPUFAs group than in the placebo group at three months. In contrast, the total cholesterol concentration was higher at 3 months in the ω3-LCPUFAs group than in the placebo group (155 mg/dl vs. 129 mg/dl, p=0.009). The number of children with hypertriglyceridemia (85% vs. 50%; p=0.054) tended to be lower between the time of diagnosis and after 3 months of supplementation with ω3-LCPUFAs. Conclusion: These findings support the use of ω3-LCPUFAs to reduce some adverse cardiometabolic and inflammatory risk factors in children with ALL. Clinical trial registration: ClinicalTrials.gov, identifier NCT01051154.
MeSH term(s)	Humans ; Male ; Female ; Child ; Child, Preschool ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-3/therapeutic use ; Hypertriglyceridemia/drug therapy ; Hypertriglyceridemia/epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Treatment Outcome
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1120364
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Article: Maternal diet in pregnancy and acute leukemia in infants: a case-control study in Mexico City.

Pérez-Saldivar, María Luisa / Flores-García, M Karen / Núñez-Villegas, Nancy / Fajardo-Gutiérrez, Arturo / Medina-Sanson, Aurora / Jiménez-Hernández, Elva / Martín-Trejo, Jorge Alfonso / López-Santiago, Norma / Peñaloza-González, José Gabriel / Cortés-Herrera, Beatriz / Merino-Pasaye, Laura Elizabeth / Amador-Sánchez, Raquel / García-López, Luis Ramiro / Pérez-Lorenzana, Héctor / Román-Zepeda, Pedro Francisco / Castañeda-Echevarría, Alejandro / López-Caballero, María Guadalupe / Martínez-Silva, Sofía Irene / Rivera-González, Juan /

Granados-Kraulles, Jorge / Flores-Botello, Jesús / Medrano-López, Francisco / Rodríguez-Vázquez, María Adriana / Torres-Valle, Delfino / Mora-Rico, Karina / Mora-Ríos, Félix G / R García-Cortés, Luis / Salcedo-Lozada, Perla / Flores-Lujano, Janet / Núñez-Enríquez, Juan Carlos / Bekker-Méndez, Vilma Carolina / Mata-Rocha, Minerva / Rosas-Vargas, Haydeé / Duarte-Rodríguez, David Aldebarán / Jiménez-Morales, Silvia / Hidalgo-Miranda, Alfredo / López-Carrillo, Lizbeth / Mejía-Aranguré, Juan Manuel

Frontiers in oncology

2024 Volume 13, Page(s) 1165323

Abstract: Introduction: Epidemiological studies around the world on acute leukemia (AL) and risk factors in infants are scarce. Infant AL has been proposed to originate : Methods: We conducted a hospital-based case-control study from 2010 to 2019 on maternal ... ...

Abstract	Introduction: Epidemiological studies around the world on acute leukemia (AL) and risk factors in infants are scarce. Infant AL has been proposed to originate Methods: We conducted a hospital-based case-control study from 2010 to 2019 on maternal diet during pregnancy in nine high-specialty public hospitals of different health institutions that diagnose and offer treatment to children with AL in Mexico City. Cases (n=109) were children ≤24 months of age with Results: Cases were slightly predominantly female (52.3%). The years of education of the mother in cases and controls was 0-9 on average, and those who reported smoking cigarettes and consuming alcohol during pregnancy did so at a low frequency. Regarding the mother's diet, the main findings were that the consumption of allium vegetables during pregnancy was inversely associated with AL for medium and high consumption (OR=0.26, 95% CI 0.14-0.46; Conclusion: The results suggest that maternal intake during pregnancy of allium vegetables, specifically garlic, is inversely associated with the development of AL in children ≤24 months old. On the other hand, consumption of high-fat dairy products is positively associated with AL in children ≤24 months old.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1165323
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Article: IKZF1

Garcia-Solorio, Joaquin / Núñez-Enriquez, Juan Carlos / Jiménez-Olivares, Marco / Flores-Lujano, Janet / Flores-Espino, Fernanda / Molina-Garay, Carolina / Cervera, Alejandra / Casique-Aguirre, Diana / Peñaloza-Gonzalez, José Gabriel / Baños-Lara, Ma Del Rocío / García-Soto, Ángel / Galván-Díaz, César Alejandro / Olaya-Vargas, Alberto / Aguilar, Hilario Flores / Mata-Rocha, Minerva / Garrido-Hernández, Miguel Ángel / Solís-Poblano, Juan Carlos / Luna-Silva, Nuria Citlalli / Cano-Cuapio, Lena Sarahi /

Aristil-Chery, Pierre Mitchel / Herrera-Quezada, Fernando / Carrillo-Sanchez, Karol / Muñoz-Rivas, Anallely / Flores-Lagunes, Luis Leonardo / Mendoza-Caamal, Elvia Cristina / Villegas-Torres, Beatriz Eugenia / González-Osnaya, Vincent / Jiménez-Hernández, Elva / Torres-Nava, José Refugio / Martín-Trejo, Jorge Alfonso / Gutiérrez-Rivera, María de Lourdes / Espinosa-Elizondo, Rosa Martha / Merino-Pasaye, Laura Elizabeth / Pérez-Saldívar, María Luisa / Jiménez-Morales, Silvia / Curiel-Quesada, Everardo / Rosas-Vargas, Haydeé / Mejía-Arangure, Juan Manuel / Alaez-Verson, Carmen

Frontiers in oncology

2024 Volume 14, Page(s) 1337954

Abstract: Background: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. : Methods: A ... ...

Abstract	Background: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. Methods: A total of 206 pediatric patients with Results: We identified the Discussion: Our findings demonstrated that Mexican patients with B-ALL have a higher prevalence of genetic markers associated with poor outcomes. Incorporating genomic methodologies into the diagnostic process, a significant unmet need in low- and mid-income countries, will allow a comprehensive identification of relevant alterations, improving disease classification, treatment selection, and the general outcome.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1337954
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Article ; Online: Global expression profiling of CD10 + /CD19 + pre-B lymphoblasts from Hispanic B-ALL patients correlates with comparative TARGET database analysis.

Castañeda-Partida, Laura / Ocadiz-Delgado, Rodolfo / Sánchez-López, José Manuel / García-Villa, Enrique / Peñaloza-González, José Gabriel / Velázquez-Aviña, Martha Margarita / Torres-Nava, José Refugio / Martín-Trejo, Jorge Alfonso / Solís-Labastida, Karina / Guerra-Castillo, Francisco Xavier / Bekker-Méndez, Vilma Carolina / Rosales-García, Víctor Hugo / Romero-Rodríguez, Dámaris / Mojica-Espinoza, Raúl / Mendez-Tenorio, Alfonso / Ramírez-Calzada, Crystel A / Álvarez-Ríos, Elízabeth / Mejía-Aranguré, Juan Manuel / Gariglio, Patricio

Discover. Oncology

2022 Volume 13, Issue 1, Page(s) 28

Abstract: Mexico City has one of the highest incidences of acute lymphoblastic leukemia (ALL) globally, with patients showing low survival, and high relapse rates. To gain more insight into the molecular features of B-ALL in Mexican children, we isolated CD10 + / ... ...

Abstract	Mexico City has one of the highest incidences of acute lymphoblastic leukemia (ALL) globally, with patients showing low survival, and high relapse rates. To gain more insight into the molecular features of B-ALL in Mexican children, we isolated CD10 + /CD19 + precursor B lymphoblasts from four bone marrow and nine peripheral blood samples of B-ALL patients using a fluorescence-activated cell sorting protocol. The global gene expression profile (BM vs PB) revealed 136 differentially expressed genes; 62 were upregulated (45.6%) and 74 were downregulated (54.4%). Pearson's correlation coefficient was calculated to determine the similarity between pre-B lymphoblast populations. We selected 26 highly significant genes and validated 21 by RT-qPCR (CNN3, STON2, CALN1, RUNX2, GADD45A, CDC45, CDC20, PLK1, AIDA, HCK, LY86, GPR65, PIK3CG, LILRB2, IL7R, TCL1A, DOCK1, HIST1H3G, PTPN14, CD72, and NT5E). The gene set enrichment analysis of the total expression matrix and the ingenuity pathway analysis of the 136 differentially expressed genes showed that the cell cycle was altered in the bone marrow with four overexpressed genes (PLK1, CDC20, CDC45, and GADD45A) and a low expression of IL7R and PIK3CG, which are involved in B cell differentiation. A comparative bioinformatics analysis of 15 bone marrow and 10 peripheral blood samples from Hispanic B-ALL patients collected by the TARGET program, corroborated the genes observed, except for PIK3CG. We conclude the Mexican and the Hispanic B-ALL patients studied present common driver alterations and histotype-specific mutations that could facilitate risk stratification and diagnostic accuracy and serve as potential therapeutic targets.
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-022-00480-7
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Article: Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.

Duarte-Rodríguez, David Aldebarán / Flores-Lujano, Janet / McNally, Richard J Q / Pérez-Saldivar, María Luisa / Jiménez-Hernández, Elva / Martín-Trejo, Jorge Alfonso / Espinoza-Hernández, Laura Eugenia / Medina-Sanson, Aurora / Paredes-Aguilera, Rogelio / Merino-Pasaye, Laura Elizabeth / Velázquez-Aviña, Martha Margarita / Torres-Nava, José Refugio / Espinosa-Elizondo, Rosa Martha / Amador-Sánchez, Raquel / Dosta-Herrera, Juan José / Mondragón-García, Javier Anastacio / González-Ulibarri, Juana Esther / Martínez-Silva, Sofía Irene / Espinoza-Anrubio, Gilberto /

Paz-Bribiesca, María Minerva / Salcedo-Lozada, Perla / Landa-García, Rodolfo Ángel / Ramírez-Colorado, Rosario / Hernández-Mora, Luis / Santamaría-Ascencio, Marlene / López-Loyola, Anselmo / Godoy-Esquivel, Arturo Hermilo / García-López, Luis Ramiro / Anguiano-Ávalos, Alison Ireri / Mora-Rico, Karina / Castañeda-Echevarría, Alejandro / Rodríguez-Jiménez, Roberto / Cibrian-Cruz, José Alberto / Solís-Labastida, Karina Anastacia / Cárdenas-Cardos, Rocío / López-Santiago, Norma / Flores-Villegas, Luz Victoria / Peñaloza-González, José Gabriel / González-Ávila, Ana Itamar / Sánchez-Ruiz, Martin / Rivera-Luna, Roberto / Rodríguez-Villalobos, Luis Rodolfo / Hernández-Pérez, Francisco / Olvera-Durán, Jaime Ángel / García-Cortés, Luis Rey / Mata-Rocha, Minerva / Sepúlveda-Robles, Omar Alejandro / Bekker-Méndez, Vilma Carolina / Jiménez-Morales, Silvia / Meléndez-Zajgla, Jorge / Rosas-Vargas, Haydée / Vega, Elizabeth / Núñez-Enríquez, Juan Carlos / Mejía-Aranguré, Juan Manuel

Frontiers in oncology

2024 Volume 14, Page(s) 1304633

Abstract: Background: A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the ... ...

Abstract	Background: A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC). Methods: A population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff's spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained. Results: A total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed. Conclusions: The identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1304633
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Article: Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry.

Flores-Lujano, Janet / Allende-López, Aldo / Duarte-Rodríguez, David Aldebarán / Alarcón-Ruiz, Erika / López-Carrillo, Lizbeth / Shamah-Levy, Teresa / Cebrián, Mariano E / Baños-Lara, Ma Del Rocío / Casique-Aguirre, Diana / Elizarrarás-Rivas, Jesús / López-Aquino, Javier Antonio / Garrido-Hernández, Miguel Ángel / Olvera-Caraza, Daniela / Terán-Cerqueda, Vanessa / Martínez-José, Karina Beatriz / Aristil-Chery, Pierre Mitchel / Alvarez-Rodríguez, Enoch / Herrera-Olivares, Wilfrido / Ruíz-Arguelles, Guillermo J /

Chavez-Aguilar, Lénica Anahí / Márquez-Toledo, Aquilino / Cano-Cuapio, Lena Sarahi / Luna-Silva, Nuria Citlalli / Martínez-Martell, Maria Angélica / Ramirez-Ramirez, Anabel Beatriz / Merino-Pasaye, Laura Elizabeth / Galván-Díaz, César Alejandro / Medina-Sanson, Aurora / Gutiérrez-Rivera, Maria de Lourdes / Martín-Trejo, Jorge Alfonso / Rodriguez-Cedeño, Emmanuel / Bekker-Méndez, Vilma Carolina / Romero-Tlalolini, María de Los Ángeles / Cruz-Maza, Astin / Juárez-Avendaño, Gerardo / Pérez-Tapia, Sonia Mayra / Rodríguez-Espinosa, Juan Carlos / Suárez-Aguirre, Miriam Carmina / Herrera-Quezada, Fernando / Hernández-Díaz, Anahí / Galván-González, Lizbeth Alondra / Mata-Rocha, Minerva / Olivares-Sosa, Amanda Idaric / Rosas-Vargas, Haydeé / Jiménez-Morales, Silvia / Cárdenas-González, Mariana / Álvarez-Buylla Roces, María Elena / Duque-Molina, Célida / Pelayo, Rosana / Mejía-Aranguré, Juan Manuel / Núñez-Enriquez, Juan Carlos

Frontiers in oncology

2024 Volume 14, Page(s) 1304263

Abstract: Introduction: Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed ... ...

Abstract	Introduction: Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca). Methods: A population-based study was conducted. Children aged less than 20 years, resident in these states, and newly diagnosed with AL in public/private hospitals during the period 2021-2022 were identified. Crude incidence rates (cIR), standardized incidence rates (ASIRw), and incidence rates by state subregions (ASIRsr) were calculated. Rates were calculated using the direct and indirect method and reported per million children under 20 years of age. In addition, specific rates were calculated by age group, sex, leukemia subtype, and immunophenotype. Results: A total of 388 cases with AL were registered. In the three states, the ASIRw for AL was 51.5 cases per million (0-14 years); in Puebla, it was 53.2, Tlaxcala 54.7, and Oaxaca de 47.7. In the age group between 0-19 years, the ASIRw were 44.3, 46.4, 48.2, and 49.6, in Puebla, Tlaxcala, and Oaxaca, respectively. B-cell acute lymphoblastic leukemia was the most common subtype across the three states. Conclusion: The incidence of childhood AL in the central-south region of Mexico is within the range of rates reported in other populations of Latin American origin. Two incidence peaks were identified for lymphoblastic and myeloid leukemias. In addition, differences in the incidence of the disease were observed among state subregions which could be attributed to social factors linked to the ethnic origin of the inhabitants. Nonetheless, this hypothesis requires further investigation.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1304263
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Article: Mutational Landscape of

Molina Garay, Carolina / Carrillo Sánchez, Karol / Flores Lagunes, Luis Leonardo / Jiménez Olivares, Marco / Muñoz Rivas, Anallely / Villegas Torres, Beatríz Eugenia / Flores Aguilar, Hilario / Núñez Enríquez, Juan Carlos / Jiménez Hernández, Elva / Bekker Méndez, Vilma Carolina / Torres Nava, José Refugio / Flores Lujano, Janet / Martín Trejo, Jorge Alfonso / Mata Rocha, Minerva / Medina Sansón, Aurora / Espinoza Hernández, Laura Eugenia / Peñaloza Gonzalez, José Gabriel / Espinosa Elizondo, Rosa Martha / Flores Villegas, Luz Victoria /

Amador Sanchez, Raquel / Pérez Saldívar, María Luisa / Sepúlveda Robles, Omar Alejandro / Rosas Vargas, Haydeé / Jiménez Morales, Silvia / Galindo Delgado, Patricia / Mejía Aranguré, Juan Manuel / Alaez Verson, Carmen

Frontiers in pediatrics

2022 Volume 10, Page(s) 899742

Abstract: Background: In Mexico, the incidence of acute myeloid leukemia (AML) has increased in the last few years. Mortality is higher than in developed countries, even though the same chemotherapy protocols are used. CCAAT Enhancer Binding Protein Alpha (: ... ...

Abstract	Background: In Mexico, the incidence of acute myeloid leukemia (AML) has increased in the last few years. Mortality is higher than in developed countries, even though the same chemotherapy protocols are used. CCAAT Enhancer Binding Protein Alpha ( Aim of the study: To identify the mutational landscape of the Materials and methods: DNA was extracted from bone marrow aspirates at diagnosis. Targeted massive parallel sequencing of Results: CEBPA Conclusion: CEBPA mutational profiles in Mexican pediatric AML patients and their clinical implications were evaluated for the first time. The frequency of
Language	English
Publishing date	2022-07-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.899742
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Article: Underexpression of

May-Hau, Didier Ismael / Bárcenas-López, Diego Alberto / Núñez-Enríquez, Juan Carlos / Bekker-Méndez, Vilma Carolina / Beltrán-Anaya, Fredy Omar / Jiménez-Hernández, Elva / Ortíz-Maganda, Mónica Patricia / Guerra-Castillo, Francisco Xavier / Medina-Sanson, Aurora / Flores-Lujano, Janet / Martín-Trejo, Jorge Alfonso / Peñaloza-González, José Gabriel / Velázquez-Aviña, Martha Margarita / Torres-Nava, José Refugio / Hernández-Echáurregui, Gabriela Alicia / Espinosa-Elizondo, Rosa Martha / Gutiérrez-Rivera, María de Lourdes / Sanchez-Hernandez, Rodrigo / Pérez-Saldívar, María Luisa /

Flores-Villegas, Luz Victoria / Merino-Pasaye, Laura Elizabeth / Duarte-Rodríguez, David Aldebarán / Mata-Rocha, Minerva / Sepúlveda-Robles, Omar Alejandro / Rosas-Vargas, Haydeé / Hidalgo-Miranda, Alfredo / Mejía-Aranguré, Juan Manuel / Jiménez-Morales, Silvia

Frontiers in oncology

2022 Volume 12, Page(s) 887766

Abstract: Background: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent pediatric cancer worldwide. Despite improvements in treatment regimens, approximately 20% of the cases cannot be cured, highlighting the necessity for identifying ... ...

Abstract	Background: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent pediatric cancer worldwide. Despite improvements in treatment regimens, approximately 20% of the cases cannot be cured, highlighting the necessity for identifying new biomarkers to improve the current clinical and molecular risk stratification schemes. We aimed to investigate whether Methods: A nested case-control study including Mexican children with BCP-ALL was conducted. Results: A lower expression of Conclusion: Our findings suggest that
Language	English
Publishing date	2022-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.887766
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Article: Analytical study of

Sepúlveda-Robles, Omar / Jiménez-Hernández, Elva / Domínguez-Catzín, Victoria / Gómez-Flores, Eber / Martín-Trejo, Jorge Alfonso / Flores-Lujano, Janet / Torres-Nava, José Refugio / Núñez-Enríquez, Juan Carlos / De Ita, Marlon / Medina-Sanson, Aurora / Mata-Rocha, Minerva / Morales-Castillo, Blanca Angelica / Bravata-Alcántara, Juan Carlos / Nájera-Cortés, Alan Steve / Sánchez-Escobar, Norberto / Peñaloza-Gonzalez, José Gabriel / Espinosa-Elizondo, Rosa Martha / Flores-Villegas, Luz Victoria / Amador-Sanchez, Raquel /

Orozco-Ruiz, Darío / Pérez-Saldívar, Maria Luisa / Velázquez-Aviña, Martha Margarita / Merino-Pasaye, Laura Elizabeth / Solís-Labastida, Karina Anastacia / González-Ávila, Ana Itamar / Santillán-Juárez, Jessica Denisse / Bekker-Méndez, Vilma Carolina / Jiménez-Morales, Silvia / Rangel-López, Angélica / Rosas-Vargas, Haydeé / Mejía-Aranguré, Juan Manuel

Frontiers in pediatrics

2022 Volume 10, Page(s) 946690

Abstract: Background: The distribution of : Methods: We retrospectively analyzed the presence of : Results: The overall frequency of the fusion genes was 50.7%; : Conclusion: The pediatric population of Mexico City with AML had frequencies ... ...

Abstract	Background: The distribution of Methods: We retrospectively analyzed the presence of Results: The overall frequency of the fusion genes was 50.7%; Conclusion: The pediatric population of Mexico City with AML had frequencies of
Language	English
Publishing date	2022-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.946690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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