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  1. Article ; Online: Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children.

    Córdova, Samir / Tena-Garitaonaindia, Mireia / Álvarez-Mercado, Ana Isabel / Gámez-Belmonte, Reyes / Gómez-Llorente, Mª Amelia / Sánchez de Medina, Fermín / Martínez-Cañavate, Ana / Martínez-Augustin, Olga / Gómez-Llorente, Carolina

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with ...

    Abstract Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (
    MeSH term(s) Child ; Animals ; Mice ; Humans ; Pediatric Obesity ; Asthma ; Feces ; Claudin-1 ; Cytochromes b ; NF-kappa B
    Chemical Substances Claudin-1 ; Cytochromes b (9035-37-4) ; NF-kappa B
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020866
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  2. Article ; Online: Preliminary pilot study results of the EAACI allergy educational needs in primary care pediatricians Task Force in managing allergic disorders.

    Cabrera, Martha / Ryan, Dermot / Erlewyn-Lajeunesse, Michel / Levin, Michael Eliad / Martínez-Cañavate, Ana / Villaizán Pérez, Carmen / Angier, Elizabeth / Trujillo, Juan / Cárdenas-Rebollo, José Miguel / Losappio, Laura / Reali, Laura

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 1, Page(s) e13907

    MeSH term(s) Humans ; Pilot Projects ; Anaphylaxis ; Advisory Committees ; Pediatricians ; Primary Health Care
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13907
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  3. Article: Alergia a metilprednisolona.

    Pérez-Aragón, Ana Josefa / Díaz-Molina, Manuel / Romero-Paniagua, María Teresa / Martínez-Cañavate, Ana

    Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

    2019  Volume 66, Issue 3, Page(s) 386–387

    Title translation Allergy to methylprednisolone.
    MeSH term(s) Child ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Glucocorticoids/adverse effects ; Humans ; Male ; Methylprednisolone/adverse effects
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Language Spanish
    Publishing date 2019-09-18
    Publishing country Mexico
    Document type Case Reports ; Letter
    ZDB-ID 639125-4
    ISSN 0002-5151
    ISSN 0002-5151
    DOI 10.29262/ram.v66i3.639
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  4. Article ; Online: Obesity and Asthma: A Missing Link.

    Gomez-Llorente, Mª Amelia / Romero, Raquel / Chueca, Natalia / Martinez-Cañavate, Ana / Gomez-Llorente, Carolina

    International journal of molecular sciences

    2017  Volume 18, Issue 7

    Abstract: Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of ... ...

    Abstract Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women. Systemic inflammation and mechanical effect, both due to the expansion of the adipose tissue, have been proposed as the main reasons for the association between obesity and asthma. However, the mechanisms involved are not yet fully understood. Moreover, it has also been suggested that insulin resistance syndrome can have a role in the association between these conditions. The intestinal microbiota is an important factor in the development of the immune system, and can be considered a link between obesity and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels as a consequence of a microbiota dysbiosis have been found. In addition, changes in microbiota composition result in a modification of carbohydrate fermentation capacity, therefore modifying short chain fatty acid (SCFA) levels. The main objective of this review is to summarize the principal findings that link obesity and asthma.
    Language English
    Publishing date 2017-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18071490
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  5. Article ; Online: Decision-making for pediatric allergy immunotherapy for aeroallergens: a narrative review.

    Tortajada-Girbés, Miguel / Mesa Del Castillo, María / Larramona, Helena / Lucas, José Manuel / Álvaro Lozano, Montserrat / Tabar, Ana Isabel / Soler López, Begoña / Martínez-Cañavate, Ana

    European journal of pediatrics

    2019  Volume 178, Issue 12, Page(s) 1801–1812

    Abstract: There has been exciting progress in diagnosis and in the treatment of allergic patients. The objective of this review is to summarize the most relevant contributions in the past 10 years with a special focus on the pediatric population allergic to ... ...

    Abstract There has been exciting progress in diagnosis and in the treatment of allergic patients. The objective of this review is to summarize the most relevant contributions in the past 10 years with a special focus on the pediatric population allergic to aeroallergens and provide the most relevant references and practical issues for the decision-making. Current guidelines on allergy diagnosis recommend a thorough clinical history as the first step, followed by allergen extract testing using an in vivo prick test and/or an in vitro specific IgE test. Molecular diagnosis is recommended when previous tests are inconclusive. In practice, the most important factors to decide the AIT treatment are the actual intensity and duration of the patient's symptoms and the availability of appropriate AIT products for the patient's sensitization profile at high allergen concentrations and with confirmed efficacy and safety from clinical trials. This document summarizes outstanding references for allergic immunotherapy decision-making and provides summary tables and figures analyzing the most important factors related to the decision for allergen immunotherapy and the safety risks related. The experts concluded that AIT is efficacious and safe for the treatment of allergic patients that is available for the most frequent aeroallergens.What is Known:• The prevalence of allergic asthma and rhinitis in children has increased in recent decades.• The efficacy and safety of allergen immunotherapy has been shown in multiple studies and systematic reviews.What is New:• This document summarizes outstanding references for allergic immunotherapy decision-making and provides summary tables and figures analyzing the most important factors related to the decision for allergen immunotherapy and the safety risks related. Recommendations of expert authors for the decision of the patients more suitable for allergen immunotherapy are included.
    MeSH term(s) Allergens/immunology ; Child ; Decision Making ; Desensitization, Immunologic ; Humans ; Inhalation Exposure
    Chemical Substances Allergens
    Language English
    Publishing date 2019-08-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-019-03444-2
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  6. Article: A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children.

    Gomez-Llorente, Mª Amelia / Martínez-Cañavate, Ana / Chueca, Natalia / Rico, Mª de la Cruz / Romero, Raquel / Anguita-Ruiz, Augusto / Aguilera, Concepción Mª / Gil-Campos, Mercedes / Mesa, Maria D / Khakimov, Bekzod / Morillo, Jose Antonio / Gil, Ángel / Camacho, José / Gomez-Llorente, Carolina

    Biomedicines

    2020  Volume 8, Issue 9

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines8090359
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  7. Article ; Online: A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy.

    Martínez-Cañavate, Ana / Sierra, Saleta / Lara-Villoslada, Federico / Romero, Julio / Maldonado, José / Boza, Julio / Xaus, Jordi / Olivares, Mónica

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2009  Volume 20, Issue 6, Page(s) 592–600

    Abstract: The increase in the prevalence of allergic diseases in children has been attributed to an unbalanced immune response probably due to environmental factors. The immunoregulatory properties of probiotic bacteria could balance the disequilibrium in the ... ...

    Abstract The increase in the prevalence of allergic diseases in children has been attributed to an unbalanced immune response probably due to environmental factors. The immunoregulatory properties of probiotic bacteria could balance the disequilibrium in the immune response causing the allergic response. The aim of this study was to evaluate the immunological effects of the consumption of a dairy product containing two probiotic strains in children suffering from allergy. A double-blinded, randomized, control comparative study was performed with 44 allergic children. Children were randomly distributed in two groups, a control Yogurt and a Probiotic group. Both groups daily consumed 200 ml of a dairy fermented product for 3 months. The Yogurt group consumed a conventional yogurt, whereas the Probiotic group consumed a similar dairy product where Lactobacillus bulgaricus was substituted by a mixture of Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711 (at least 10(6) cfu/g each strain). Intestinal and immunological parameters were measured in fecal and blood samples. The consumption of the probiotic product induced a significant decrease in the level of IgE in plasma (p = 0.03) and an increase in CD4(+)/CD25(+) T regulatory cells (p = 0.01). The decrease in IgE was accompanied by a significant increase in mucosal IgA (p = 0.01). However, changes in other effector cells potentially involved in allergic reactions such as eosinophiles, basophiles or other IgE+ cells were not detected. The consumption of the probiotic product also induced significant changes in innate response as a significant increase in natural killer cells was detected (p = 0.03). The daily consumption of a probiotic product containing L. gasseri CECT5714 and L. coryniformis CECT5711 for 3 months induces, in allergic children, beneficial effects on immune parameters involved in the allergic response such as a reduction of IgE in plasma and an increase in regulatory T cells. The probiotic product also enhanced innate and specific immune parameters that may improve the general health status of children.
    MeSH term(s) Blood/immunology ; Blood/microbiology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Child ; Child, Preschool ; Double-Blind Method ; Feces/microbiology ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/microbiology ; Immunity, Innate ; Immunoglobulin E/blood ; Interleukin-2 Receptor alpha Subunit/metabolism ; Lactobacillus/classification ; Lactobacillus/immunology ; Probiotics/administration & dosage ; T-Lymphocytes, Regulatory/immunology ; Yogurt/microbiology
    Chemical Substances Interleukin-2 Receptor alpha Subunit ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2009-09
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/j.1399-3038.2008.00833.x
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  8. Article ; Online: Pediatric allergy and immunology in Spain.

    Nieto, Antonio / Mazon, Angel / Martin-Mateos, Maria Anunciacion / Plaza, Ana-Maria / Garde, Jesus / Alonso, Elena / Martorell, Antonio / Boquete, Manuel / Lorente, Felix / Ibero, Marcel / Bone, Javier / Pamies, Rafael / Garcia, Juan Miguel / Echeverria, Luis / Nevot, Santiago / Martinez-Cañavate, Ana / Fernandez-Benitez, Margarita / Garcia-Marcos, Luis

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2011  Volume 22, Issue 7, Page(s) 742–750

    Abstract: The data of the ISAAC project in Spain show a prevalence of childhood asthma ranging from 7.1% to 15.3%, with regional differences; a higher prevalence, 22.6% to 35.8%, is described for rhinitis, and atopic dermatitis is found in 4.1% to 7.6% of children. ...

    Abstract The data of the ISAAC project in Spain show a prevalence of childhood asthma ranging from 7.1% to 15.3%, with regional differences; a higher prevalence, 22.6% to 35.8%, is described for rhinitis, and atopic dermatitis is found in 4.1% to 7.6% of children. The prevalence of food allergy is 3%. All children in Spain have the right to be visited in the National Health System. The medical care at the primary level is provided by pediatricians, who have obtained their titles through a 4-yr medical residency training program. The education on pediatric allergy during that period is not compulsory and thus very variable. There are currently 112 certified European pediatric allergists in Spain, who have obtained the accreditation of the European Union of Medical Specialist for proven skills and experience in pediatric allergy. Future specialists in pediatric allergy should obtain their titles through a specific education program to be developed in one of the four accredited training units on pediatric allergy, after obtaining the title on pediatrics. The Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) gathers over 350 pediatric allergists and pediatricians working in this field. SEICAP has a growing activity including yearly congresses, continued education courses, elaboration of technical clinical documents and protocols, education of patients, and collaboration with other scientific societies and associations of patients. The official journal of SEICAP is Allergologia et Immunophatologia, published every 2 months since 1972. The web site of SEICAP, http://www.seicap.es, open since 2004, offers information for professionals and extensive information on pediatric allergic and immunologic disorders for the lay public; the web site is receiving 750 daily visits during 2011. The pediatric allergy units are very active in clinical work, procedures as immunotherapy or induction of oral tolerance in food allergy, contribution to scientific literature, and collaboration in international projects.
    MeSH term(s) Allergy and Immunology/education ; Allergy and Immunology/trends ; Child ; Delivery of Health Care ; Humans ; Hypersensitivity/epidemiology ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Immunotherapy ; Pediatrics/education ; Pediatrics/trends ; Societies, Medical ; Spain/epidemiology
    Language English
    Publishing date 2011-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/j.1399-3038.2011.01211.x
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