Article ; Online: Surgical management of acute appendicitis during the European COVID-19 second wave: safe and effective.
2023 Volume 49, Issue 1, Page(s) 57–67
Abstract: Introduction: The COVID-19 (SARS-CoV-2) pandemic drove acute care surgeons to pivot from long established practice patterns. Early safety concerns regarding increased postoperative complication risk in those with active COVID infection promoted ... ...
Abstract | Introduction: The COVID-19 (SARS-CoV-2) pandemic drove acute care surgeons to pivot from long established practice patterns. Early safety concerns regarding increased postoperative complication risk in those with active COVID infection promoted antibiotic-driven non-operative therapy for select conditions ahead of an evidence-base. Our study assesses whether active or recent SARS-CoV-2 positivity increases hospital length of stay (LOS) or postoperative complications following appendectomy. Methods: Data were derived from the prospective multi-institutional observational SnapAppy cohort study. This preplanned data analysis assessed consecutive patients aged ≥ 15 years who underwent appendectomy for appendicitis (November 2020-May 2021). Patients were categorized based on SARS-CoV-2 seropositivity: no infection, active infection, and prior infection. Appendectomy method, LOS, and complications were abstracted. The association between SARS-CoV-2 seropositivity and complications was determined using Poisson regression, while the association with LOS was calculated using a quantile regression model. Results: Appendectomy for acute appendicitis was performed in 4047 patients during the second and third European COVID waves. The majority were SARS-CoV-2 uninfected (3861, 95.4%), while 70 (1.7%) were acutely SARS-CoV-2 positive, and 116 (2.8%) reported prior SARS-CoV-2 infection. After confounder adjustment, there was no statistically significant association between SARS-CoV-2 seropositivity and LOS, any complication, or severe complications. Conclusion: During sequential SARS-CoV-2 infection waves, neither active nor prior SARS-CoV-2 infection was associated with prolonged hospital LOS or postoperative complication. Despite early concerns regarding postoperative safety and outcome during active SARS-CoV-2 infection, no such association was noted for those with appendicitis who underwent operative management. |
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MeSH term(s) | Humans ; Acute Disease ; Appendectomy/methods ; Appendicitis/surgery ; Appendicitis/complications ; Cohort Studies ; COVID-19/epidemiology ; COVID-19/complications ; Length of Stay ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; SARS-CoV-2 |
Language | English |
Publishing date | 2023-01-19 |
Publishing country | Germany |
Document type | Journal Article ; Observational Study |
ZDB-ID | 2275480-5 |
ISSN | 1863-9941 ; 1863-9933 |
ISSN (online) | 1863-9941 |
ISSN | 1863-9933 |
DOI | 10.1007/s00068-022-02149-w |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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