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  1. AU="Martínez-Cortés, Ismael"
  2. AU="Suresh, K."
  3. AU=Kishi Takuya
  4. AU="Moreira, Helena"
  5. AU="Malta, C-E"
  6. AU="Karaji, Niloofar"
  7. AU="Tjempakasari, Artaria"
  8. AU=Sepulveda-Crespo Daniel

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  1. Artikel: Los exosomas de las células presentadoras de antígeno y su papel en la regulación de las respuestas inmunológicas.

    Maravillas-Montero, José Luis / Martínez-Cortés, Ismael

    Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

    2017  Band 64, Heft 4, Seite(n) 463–476

    Abstract: Cells release several biomolecules to the extracellular environment using them as a communication alternative with neighbor cells. Besides these molecules, cells also release more complex elements, like vesicles; structures composed of a lipidic bilayer ... ...

    Titelübersetzung Regulation of immune responses by exosomes derived from antigen presenting cells.
    Abstract Cells release several biomolecules to the extracellular environment using them as a communication alternative with neighbor cells. Besides these molecules, cells also release more complex elements, like vesicles; structures composed of a lipidic bilayer with transmembrane proteins that protect a hydrophilic content. Exosomes are a small subtype of vesicles (30-150 nm), produced by many cell types, such as tumor cells, neurons, epithelial cells and immune cells. Included in this last group, antigen presenting cells produce exosomes that contain different types of molecules depending on their activation and/or maturation state. In recent years there has been an exponential interest in exosomes due to the recent evidences that show the immunomodulatory properties of these vesicles and therefore, their great potential in diagnostic approaches and development of therapies for different inflammation-associated pathologies.
    Mesh-Begriff(e) Adaptive Immunity ; Antigen-Presenting Cells/cytology ; Antigen-Presenting Cells/immunology ; Exosome Multienzyme Ribonuclease Complex/immunology ; Exosomes/immunology ; Humans
    Chemische Substanzen Exosome Multienzyme Ribonuclease Complex (EC 3.1.-)
    Sprache Spanisch
    Erscheinungsdatum 2017-12-14
    Erscheinungsland Mexico
    Dokumenttyp Journal Article
    ZDB-ID 639125-4
    ISSN 0002-5151
    ISSN 0002-5151
    DOI 10.29262/ram.v64i4.285
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A polyherbal phytogenic additive improved growth performance, health, and immune response in dairy calves

    Sánchez, Nallely / Lee-Rangel, Hector A. / Martínez-Cortés, Ismael / Mendoza, German D. / Hernández, Pedro A. / Espinoza, Enrique / Vazque Valladolid, Anayeli / Flores Ramírez, Rogelio / Roque-Jimenez, Alejandro / Campillo-Navarro, Marcia / Relling, Alejandro E.

    Food and agricultural immunology. 2021 Jan. 01, v. 32, no. 1

    2021  

    Abstract: The objective was to characterize the effects of a supplemental Herbal Antibiotics Source (HAnS) on performance, blood chemistry, blood cells, and antibody counts of Holstein calves. Forty calves (initial BW 45.8 ± 7.2 kg) were randomly assigned to ... ...

    Abstract The objective was to characterize the effects of a supplemental Herbal Antibiotics Source (HAnS) on performance, blood chemistry, blood cells, and antibody counts of Holstein calves. Forty calves (initial BW 45.8 ± 7.2 kg) were randomly assigned to treatments: 0, 3, 4, and 5 g d⁻¹ HAnS. The additive improved hip height and thoracic girth. The reduction of starter diet intake among individuals varied greatly, while milk replacer intake increased. HAnS at intermediate doses reduced the cases of pneumonia. It also linearly reduced the blood serum glucose and B-OH butyrate. Urea and monocytes showed a quadratic response, and basophils decreased. HAnS improves calf development at intermediate doses and reduces the incidence of diseases.
    Schlagwörter Holstein ; antibodies ; blood glucose ; blood serum ; butyrates ; growth performance ; immune response ; milk replacer ; monocytes ; pneumonia ; starter diets ; urea
    Sprache Englisch
    Erscheinungsverlauf 2021-0101
    Umfang p. 482-498.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 1015019-5
    ISSN 1465-3443 ; 0954-0105
    ISSN (online) 1465-3443
    ISSN 0954-0105
    DOI 10.1080/09540105.2021.1967296
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: Influence of a Polyherbal Choline Source in Dogs: Body Weight Changes, Blood Metabolites, and Gene Expression.

    Mendoza-Martínez, Germán David / Hernández-García, Pedro Abel / Plata-Pérez, Fernando Xicoténcatl / Martínez-García, José Antonio / Lizarazo-Chaparro, Augusto Cesar / Martínez-Cortes, Ismael / Campillo-Navarro, Marcia / Lee-Rangel, Héctor Aarón / De la Torre-Hernández, María Eugenia / Gloria-Trujillo, Adrian

    Animals : an open access journal from MDPI

    2022  Band 12, Heft 10

    Abstract: Choline chloride is used to provide choline in dog foods; however, in other domestic species, it has been replaced with a polyherbal containing phosphatidylcholine. A polyherbal ... ...

    Abstract Choline chloride is used to provide choline in dog foods; however, in other domestic species, it has been replaced with a polyherbal containing phosphatidylcholine. A polyherbal containing
    Sprache Englisch
    Erscheinungsdatum 2022-05-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12101313
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Concentrations of tilmicosin in mammary gland secretions of dairy cows following subcutaneous administration of one or two doses of an experimental preparation of tilmicosin and its efficacy against intramammary infections caused by Staphylococcus aureus.

    Mendoza, Jesus / Martínez-Cortés, Ismael / López-Ordaz, Reyes / Gutiérrez, Lilia / Sumano, Hector

    American journal of veterinary research

    2016  Band 77, Heft 9, Seite(n) 922–930

    Abstract: OBJECTIVE To determine the concentration of tilmicosin in mammary gland secretions of dairy cows following administration of an experimental preparation once or twice during the dry period (45-day period immediately prior to calving during which cows are ...

    Abstract OBJECTIVE To determine the concentration of tilmicosin in mammary gland secretions of dairy cows following administration of an experimental preparation once or twice during the dry period (45-day period immediately prior to calving during which cows are not milked) and to evaluate its efficacy for the treatment of cows with intramammary infections (IMIs) caused by Staphylococcus aureus at dry off (cessation of milking; first day of dry period), compared with that of an intramammary infusion of ceftiofur. ANIMALS 172 cows. PROCEDURES Milk samples were collected for microbiological culture 5 days before dry off and at calving and 15 and 30 days after calving. Cows with Staphylococcus IMIs were randomly assigned to receive an experimental preparation of tilmicosin (20 mg/kg, SC) once at dry off (n = 58) or at dry off and again 20 days later (56) or receive a long-acting intramammary preparation of ceftiofur (500 mg/mammary gland; 56) at dry off. Mammary gland secretions were collected from 5 cows in the tilmicosin-treated groups every 5 days after dry off until calving for determination of tilmicosin concentration. RESULTS Mean maximum concentration of tilmicosin in mammary gland secretions ranged from 14.4 to 20.9 μg/mL after the first dose and was 17.1 μg/mL after the second dose. The bacteriologic cure rate was 100% for all 3 treatments. Tilmicosin was detectable for 0 and 18 days after calving in the milk of cows treated with 1 and 2 doses of tilmicosin, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Administration of an experimental preparation of tilmicosin (20 mg/kg, SC) once to dairy cows at dry off might be useful for the treatment of S aureus IMIs.
    Mesh-Begriff(e) Animals ; Cattle ; Cephalosporins/administration & dosage ; Female ; Humans ; Lactation ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/microbiology ; Mastitis, Bovine/drug therapy ; Mastitis, Bovine/metabolism ; Mastitis, Bovine/microbiology ; Milk/microbiology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/metabolism ; Staphylococcal Infections/veterinary ; Staphylococcus aureus ; Tylosin/analogs & derivatives ; Tylosin/metabolism
    Chemische Substanzen Cephalosporins ; ceftiofur (83JL932I1C) ; tilmicosin (XL4103X2E3) ; Tylosin (YEF4JXN031)
    Sprache Englisch
    Erscheinungsdatum 2016-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    DOI 10.2460/ajvr.77.9.922
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 422: Hefte anzeigen Standort:
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  5. Artikel ; Online: Tilmicosin modulates the innate immune response and preserves casein production in bovine mammary alveolar cells during Staphylococcus aureus infection.

    Martínez-Cortés, Ismael / Acevedo-Domínguez, Naray A / Olguin-Alor, Roxana / Cortés-Hernández, Arimelek / Álvarez-Jiménez, Violeta / Campillo-Navarro, Marcia / Sumano-López, Héctor S / Gutiérrez-Olvera, Lilia / Martínez-Gómez, Daniel / Maravillas-Montero, José L / Loor, Juan J / García-Zepeda, Eduardo A / Soldevila, Gloria

    Journal of animal science

    2018  Band 97, Heft 2, Seite(n) 644–656

    Abstract: Tilmicosin is an antimicrobial agent used to treat intramammary infections against Staphylococcus aureus and has clinical anti-inflammatory effects. However, the mechanism by which it modulates the inflammatory process in the mammary gland is unknown. We ...

    Abstract Tilmicosin is an antimicrobial agent used to treat intramammary infections against Staphylococcus aureus and has clinical anti-inflammatory effects. However, the mechanism by which it modulates the inflammatory process in the mammary gland is unknown. We evaluated the effect of tilmicosin treatment on the modulation of the mammary innate immune response after S. aureus infection and its effect on casein production in mammary epithelial cells. To achieve this goal, we used immortalized mammary epithelial cells (MAC-T), pretreated for 12 h or treated with tilmicosin after infection with S. aureus (ATCC 27543). Our data showed that tilmicosin decreases intracellular infection (P < 0.01) and had a protective effect on MAC-T reducing apoptosis after infection by 80% (P < 0.01). Furthermore, tilmicosin reduced reactive oxygen species (ROS) (P < 0.01), IL-1β (P < 0.01), IL-6 (P < 0.01), and TNF-α (P < 0.05) production. In an attempt to investigate the signaling pathways involved in the immunomodulatory effect of tilmicosin, mitogen-activated protein kinase (MAPK) phosphorylation was measured by fluorescent-activated cell sorting. Pretreatment with tilmicosin increased ERK1/2 (P < 0.05) but decreased P38 phosphorylation (P < 0.01). In addition, the anti-inflammatory effect of tilmicosin helped to preserve casein synthesis in mammary epithelial cells (P < 0.01). This result indicates that tilmicosin could be an effective modulator inflammation in the mammary gland. Through regulation of MAPK phosphorylation, ROS production and pro-inflammatory cytokine secretion tilmicosin can provide protection from cellular damage due to S. aureus infection and help to maintain normal physiological functions of the bovine mammary epithelial cell.
    Mesh-Begriff(e) Alveolar Epithelial Cells/metabolism ; Animals ; Anti-Bacterial Agents/pharmacology ; Caseins/metabolism ; Cattle ; Cytokines/metabolism ; Female ; Immunity, Innate/drug effects ; Mammary Glands, Animal/metabolism ; Mastitis, Bovine/drug therapy ; Mastitis, Bovine/microbiology ; Mitogen-Activated Protein Kinases/metabolism ; Signal Transduction/drug effects ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/veterinary ; Staphylococcus aureus/drug effects ; Tylosin/analogs & derivatives ; Tylosin/pharmacology
    Chemische Substanzen Anti-Bacterial Agents ; Caseins ; Cytokines ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; tilmicosin (XL4103X2E3) ; Tylosin (YEF4JXN031)
    Sprache Englisch
    Erscheinungsdatum 2018-12-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/sky463
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1312: Hefte anzeigen Standort:
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