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Article ; Online: Antidepressant effect r TMS during pregnancy in a case of Major Depression Resistant to Pharmacological Treatment.

Martínez-Gras, Isabel / Jurado-Barba, Rosa / Sánchez-Pastor, Luis / Rubio, Gabriel / Prieto-Montalvo, Julio

2021 Volume 49, Issue 6, Page(s) 282–285

Abstract: Major depressive disorder (MDD) is a common complication of pregnancy and the postpartum period. Approximately 5% of women who have MDD during pregnancy or the postpartum period meet criteria for resistant depression, associated with increased morbidity ... ...

Abstract	Major depressive disorder (MDD) is a common complication of pregnancy and the postpartum period. Approximately 5% of women who have MDD during pregnancy or the postpartum period meet criteria for resistant depression, associated with increased morbidity in both the newborn and the pregnant woman. Currently we have different therapeutic options for the treatment of MDD during pregnancy, although in cases of resistance during that period the treatment criteria are not that well established.
MeSH term(s)	Antidepressive Agents/therapeutic use ; Depression ; Depression, Postpartum ; Depressive Disorder, Major/drug therapy ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications/drug therapy
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2021-11-01
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1480971-0
ISSN	1578-2735 ; 1575-071X ; 1139-9287
ISSN (online)	1578-2735
ISSN	1575-071X ; 1139-9287
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Article: Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia.

García-Fernández, Lorena / Romero-Ferreiro, Verónica / Sánchez-Pastor, Luis / Dompablo, Mónica / Martínez-Gras, Isabel / Espejo-Saavedra, Juan Manuel / Rentero, David / Aparicio, Ana Isabel / Alvarez-Mon, Miguel Angel / Lahera, Guillermo / Lee, Jimmy / Santos, Jose Luis / Rodriguez-Jimenez, Roberto

Journal of clinical medicine

2022 Volume 11, Issue 4

Abstract: Negative symptoms are not considered a unitary construct encompassing two different domains, diminished expression, and avolition-apathy. The aim of this study was to explore the relationships between each domain and psychosocial functioning and quality ... ...

Abstract	Negative symptoms are not considered a unitary construct encompassing two different domains, diminished expression, and avolition-apathy. The aim of this study was to explore the relationships between each domain and psychosocial functioning and quality of life in people with a first psychotic episode of schizophrenia. In total, 61 outpatients were assessed with the Clinical Assessment Interview for Negative Symptoms (CAINS), The Functioning Assesment Short Test (FAST) and The Quality of Life Scale (QLS). The mean global score for CAINS was 21.5 (SD: 15.6), with a CAINS Avolition-Apathy (MAP) score of 17.0 (SD: 11.8), and CAINS Diminished Expression (EXP) score of 4.5 (SD: 5.0). The mean FAST score was 31.9 (SD: 18.9), and 41.1 (SD: 17.9) for QLS. Linear regression analysis revealed a significant (F(4,53) = 15.65,
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11040983
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Article: Emotional Processing Profile in Patients with First Episode Schizophrenia: The Influence of Neurocognition.

Romero-Ferreiro, Verónica / García-Fernández, Lorena / Aparicio, Ana Isabel / Martínez-Gras, Isabel / Dompablo, Mónica / Sánchez-Pastor, Luis / Rentero, David / Alvarez-Mon, Miguel Ángel / Espejo-Saavedra, Juan Manuel / Lahera, Guillermo / Marí-Beffa, Paloma / Santos, José Luis / Rodriguez-Jimenez, Roberto

Journal of clinical medicine

2022 Volume 11, Issue 7

Abstract: This study sought to investigate the influence of neurocognition on the emotional processing profiles of patients with first-episode schizophrenia, using the 4-branch Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) (Perceiving Emotions; ... ...

Abstract	This study sought to investigate the influence of neurocognition on the emotional processing profiles of patients with first-episode schizophrenia, using the 4-branch Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) (Perceiving Emotions; Facilitating Emotions; Understanding Emotions and Managing Emotions). A sample of 78 patients with first-episode schizophrenia and a group of 90 non-psychiatric control subjects were included in this work. The initial results showed that patients had lower scores than controls for the "Understanding Emotions" and "Managing Emotions" MSCEIT branches. However, after controlling for neurocognition, the only deficits were found on the "Managing Emotions" branch of the MSCEIT. This branch can be considered as measuring a more sophisticated level of emotional processing, which may constitute a deficit in itself. In conclusion, patients with first-episode schizophrenia present deficits in social cognition at the highest level that seem to be independent from neurocognition. These findings support the inclusion of the "Managing Emotions" branch of the MSCEIT as part of the MCCB.
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11072044
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Article ; Online: Digital Technology for Internet Access by Patients With Early-Stage Schizophrenia in Spain: Multicenter Research Study.

Fernández-Sotos, Patricia / Fernández-Caballero, Antonio / González, Pascual / Aparicio, Ana Isabel / Martínez-Gras, Isabel / Torio, Iosune / Dompablo, Mónica / García-Fernández, Lorena / Santos, José Luis / Rodriguez-Jimenez, Roberto

Journal of medical Internet research

2019 Volume 21, Issue 4, Page(s) e11824

Abstract: Background: Digital technology and social networks are part of everyday life in the current internet age, especially among young people. To date, few studies have been published worldwide on the pattern of use of digital technology devices and ... ...

Abstract	Background: Digital technology and social networks are part of everyday life in the current internet age, especially among young people. To date, few studies have been published worldwide on the pattern of use of digital technology devices and applications in patients with early-stage schizophrenia and even fewer comparing them with healthy participants (not using data from general population surveys) from the same demographic areas. In Spain, no such study has been carried out. Objective: The aim of this study was to analyze how patients with early-stage schizophrenia use internet and social networks compared with healthy participants matched by age and gender and also to examine which devices are utilized to access internet resources. Methods: A cross-sectional, multicentric study was carried out through a semistructured interview asking about the use of digital technology devices and internet. The sample comprised 90 patients and 90 healthy participants. The semistructured interview was conducted on 30 outpatients and 30 healthy subjects in each of the 3 different cities (Madrid, Alicante, and Cuenca). Student t test was used for continuous variables and chi-square test for categorical variables. In the case of ordinal variables, nonparametric Mann-Whitney U and Kruskal-Wallis H tests for independent samples were performed to compare groups. Results: The results indicated that a large proportion of patients with early-stage schizophrenia have access to different digital devices and use them frequently. In addition, both groups coincide in the order of preference and the purpose for which they use the devices. However, a lower frequency of use of most digital technology devices was detected in patients compared with healthy participants. In the case of some devices, this was due to the impossibility of access and not a lack of interest. Conclusions: To our knowledge, this is the first study to analyze patterns of internet access and use of digital technology devices and applications in Spanish patients with early-stage schizophrenia compared with healthy participants from the same demographic areas. The results on significant access and use of digital technology and internet shown in this cross-sectional study will allow enhanced and more efficient treatment strategies to be planned, utilizing digital technology devices, for patients with early-stage schizophrenia.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Data Collection/methods ; Female ; Humans ; Internet ; Internet Access/trends ; Male ; Neoplasm Staging ; Schizophrenia/therapy ; Social Networking ; Spain ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-03-14
Publishing country	Canada
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/11824
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Article ; Online: Modulation of impulsivity by topiramate: implications for the treatment of alcohol dependence.

Rubio, Gabriel / Martínez-Gras, Isabel / Manzanares, Jorge

Journal of clinical psychopharmacology

2009 Volume 29, Issue 6, Page(s) 584–589

Abstract: Topiramate (TP), an anticonvulsant drug, has been widely used in the treatment of disorders characterized by impulsivity symptoms, so it goes to reason that it might be useful in addictive disorders. Recently, TP has been used to treat alcohol dependence, ...

Abstract	Topiramate (TP), an anticonvulsant drug, has been widely used in the treatment of disorders characterized by impulsivity symptoms, so it goes to reason that it might be useful in addictive disorders. Recently, TP has been used to treat alcohol dependence, but it is still not known whether the effects of TP on alcohol consumption are related with its action on impulsivity. The aim of this preliminary study was to investigate which dimension of behavioral impulsivity is associated with the effects of TP. A 12-week, double-blind, placebo-controlled pilot study of TP for the treatment of alcohol dependence was conducted. Subjects were men recruited from alcoholism treatment units (TP = 31; placebo = 32). Diagnoses were made using the Structured Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Behavioral inhibition was assessed using the continuous performance test (CPT) and the stop-signal task. Differential reinforcement for low-rate responding (DRLR) was used to evaluate the delay-discounting dimension. Alcohol craving and alcohol consumption during the study were evaluated. Patients treated with TP presented lower rates of alcohol consumption in the number of drinks per drinking day (P < 0.05) and the number of heavy drinking days (P < 0.001). Scores on alcohol craving scales decreased significantly, and there was more improvement on the continuous performance test (total omissions and total commissions) and on the stop-signal task in the TP group than in the control group. Improved alcohol consumption behavior was associated with performance on the behavioral inhibition paradigm. The results of this study indicate that TP reduces drinking and that the mechanisms underlying this effect may involve, at least in part, modulation of the behavioral inhibition paradigm.
MeSH term(s)	Adolescent ; Adult ; Alcohol Deterrents/therapeutic use ; Alcoholism/drug therapy ; Alcoholism/psychology ; Double-Blind Method ; Fructose/analogs & derivatives ; Fructose/therapeutic use ; Humans ; Impulsive Behavior/drug therapy ; Impulsive Behavior/psychology ; Male ; Middle Aged ; Pilot Projects ; Young Adult
Chemical Substances	Alcohol Deterrents ; topiramate (0H73WJJ391) ; Fructose (30237-26-4)
Language	English
Publishing date	2009-12
Publishing country	United States
Document type	Comparative Study ; Controlled Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0b013e3181bfdb79
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Article ; Online: Increased vulnerability to ethanol consumption in adolescent maternal separated mice.

García-Gutiérrez, María S / Navarrete, Francisco / Aracil, Auxiliadora / Bartoll, Adrián / Martínez-Gras, Isabel / Lanciego, José L / Rubio, Gabriel / Manzanares, Jorge

Addiction biology

2016 Volume 21, Issue 4, Page(s) 847–858

Abstract: The purpose of this study was to evaluate the effects of early life stress on the vulnerability to ethanol consumption in adolescence. To this aim, mice were separated from their mothers for 12 hours/day on postnatal days 8 and 12. Emotional behavior ( ... ...

Abstract	The purpose of this study was to evaluate the effects of early life stress on the vulnerability to ethanol consumption in adolescence. To this aim, mice were separated from their mothers for 12 hours/day on postnatal days 8 and 12. Emotional behavior (light-dark box, elevated plus maze and tail suspension tests) and pre-attentional deficit (pre-pulse inhibition) were evaluated in adolescent maternal separated (MS) mice. Alterations of the corticotropin-releasing factor (CRF), glucocorticoid receptor (NR3C1), tyrosine hydroxylase (TH), mu-opioid receptor (MOr), brain-derived neurotrophic factor (BDNF), neuronal nuclei (NeuN), microtubule-associated protein 2 (MAP2) and neurofilament heavy (NF200)-immunoreactive fibers were studied in the paraventricular nucleus of the hypothalamus (PVN), ventral tegmental area (VTA), nucleus accumbens (NAc) or hippocampus (HIP). The effects of maternal separation (alone or in combination with additional stressful stimuli) on ethanol consumption during adolescence were evaluated using the oral ethanol self-administration paradigm. MS mice presented mood-related alterations and pre-attentional deficit. Increased CRF, MOr and TH, and reduced BDNF, NR3C1, NeuN, MAP2 and NF200-immunoreactive fibers were observed in the PVN, NAc and HIP of adolescent MS mice. In the oral ethanol self-administration test, adolescent MS mice presented higher ethanol consumption and motivation. Exposure to additional new stressful stimuli during adolescence significantly increased the vulnerability to ethanol consumption induced by maternal separation. These results clearly demonstrated that exposure to early life stress increased the vulnerability to ethanol consumption, potentiated the effects of stressful stimuli exposure during adolescence on ethanol consumption and modified the expression of key targets involved in the response to stress, ethanol reinforcing properties and cognitive processes.
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.12266
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Article ; Online: Startle-response based tasks and laboratory measures of impulsivity in abstinent alcoholic patients.

Marin, Marta / Jurado, Rosa / Ponce, Guillermo / Koeneke, Alejandra / Martinez-Gras, Isabel / Jiménez-Arriero, Miguel Ángel / Rubio, Gabriel

Alcohol and alcoholism (Oxford, Oxfordshire)

2015 Volume 50, Issue 3, Page(s) 286–295

MeSH term(s)	Adult ; Alcohol Abstinence/psychology ; Alcoholism/physiopathology ; Alcoholism/psychology ; Anxiety/psychology ; Case-Control Studies ; Cohort Studies ; Humans ; Impulsive Behavior ; Inhibition (Psychology) ; Male ; Middle Aged ; Neuropsychological Tests ; Reflex, Startle
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604956-4
ISSN	1464-3502 ; 0309-1635 ; 0735-0414
ISSN (online)	1464-3502
ISSN	0309-1635 ; 0735-0414
DOI	10.1093/alcalc/agv006
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Article: Clinical and Demographic Characteristics of Binge Drinkers Associated with Lack of Efficacy of Brief Intervention and Medical Advice.

Rubio, Gabriel / López-Rodríguez, Juan A / Zuluaga, Pilar / Ponce, Guillermo / Martínez-Gras, Isabel / Jiménez-Arriero, Miguel Ángel

Adicciones

2015 Volume 27, Issue 2, Page(s) 90–98

Abstract: Unlabelled: Brief Counseling Intervention (BCI) and Medical advice (MA) are psychotherapeutic approaches used for the treatment of binge drinkers in Primary Care. Although binge drinking is a common pattern of alcohol misuse in Europe and in the US, no ... ...

Abstract	Unlabelled: Brief Counseling Intervention (BCI) and Medical advice (MA) are psychotherapeutic approaches used for the treatment of binge drinkers in Primary Care. Although binge drinking is a common pattern of alcohol misuse in Europe and in the US, no studies have evaluated those subjects who do not respond to Brief Counseling Interventions or Medical Advice. Objective: To determine the clinical and demographic characteristics of binge drinkers in whom BCI or MA are not effective in reducing harmful alcohol use. Methods: This is a secondary analysis of data from a randomized alcohol brief intervention trial with a 12-month follow-up period. A total of 674 subjects (89%) participated right through to the end of the study. The primary outcome measure was change in harmful alcohol use from baseline to 12 months. Results: The strongest baseline predictors of harmful alcohol use during follow-up were educational status, young adults, and high number of cigarettes smoked, present family history of alcoholism, treatment condition and number of drinks per episode of binge drinking. Conclusions: Binge drinkers are a heterogeneous group that responds to brief intervention or MA but in a subgroup of them these interventions fail to prevent harmful alcohol use. Other interventions should be implemented for these subjects.
MeSH term(s)	Adult ; Binge Drinking/diagnosis ; Binge Drinking/epidemiology ; Binge Drinking/therapy ; Directive Counseling ; Female ; Humans ; Male ; Psychotherapy ; Socioeconomic Factors ; Treatment Failure
Language	English
Publishing date	2015-06-17
Publishing country	Spain
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2018873-0
ISSN	0214-4840
ISSN	0214-4840
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Article ; Online: Inhibición prepulso del reflejo de la respuesta de sobresalto en los trastornos neuropsiquiátricos.

García-Sánchez, Fernando / Martínez-Gras, Isabel / Rodríguez-Jiménez, Roberto / Rubio, Gabriel

Revista de neurologia

2011 Volume 53, Issue 7, Page(s) 422–432

Abstract: Introduction: Prepulse inhibition (PPI) of startle is an operational measure of the pre-attentive filtering process known as sensorimotor gating. PPI occurs when a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong ... ...

Title translation	Prepulse inhibition of the startle response/reflex in neuropsychiatric disorders.
Abstract	Introduction: Prepulse inhibition (PPI) of startle is an operational measure of the pre-attentive filtering process known as sensorimotor gating. PPI occurs when a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong startle inducing stimulus, and reduces the magnitude of the startle response. This experimental paradigm has been studied in laboratory animal as well as in patients with schizophrenia. Recently, PPI deficits have been observed in other psychiatric disorders that shared some deficit in cognitive and sensorimotor gating. Development: We have reviewed studies examining prepulse inhibition in humans across some neuropsychiatric disorders for asses the clinical and neurobiological implications of this paradigm. Conclusions: PPI deficits have been observed in multiple psychiatric disorders many of which present a common correlate anatomic-functional and a dysfunction in several neurotransmission systems, mainly dopamine system. These dysfunctions are independent of categorical diagnostic and they have proposed as a biological marker of vulnerability for some psychiatric disorders.
MeSH term(s)	Animals ; Biomarkers ; Humans ; Mental Disorders/physiopathology ; Nervous System Diseases/physiopathology ; Neural Inhibition/physiology ; Reflex, Startle/physiology ; Schizophrenia/physiopathology ; Sensory Gating/physiology
Chemical Substances	Biomarkers
Language	Spanish
Publishing date	2011-10-01
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Psychological symptomatology and impaired prepulse inhibition of the startle reflex are associated with cannabis-induced psychosis.

Morales-Muñoz, Isabel / Martínez-Gras, Isabel / Ponce, Guillermo / de la Cruz, Javier / Lora, David / Rodríguez-Jiménez, Roberto / Jurado-Barba, Rosa / Navarrete, Francisco / García-Gutiérrez, María Salud / Manzanares, Jorge / Rubio, Gabriel

Journal of psychopharmacology (Oxford, England)

2017 Volume 31, Issue 8, Page(s) 1035–1045

Abstract: Background: Cannabis-induced psychotic disorder (CIPD) is a psychiatric disorder induced by cannabis consumption. The psychological and psychophysiological features of this disorder are still unknown. We aimed to examine the psychological, personality ... ...

Abstract	Background: Cannabis-induced psychotic disorder (CIPD) is a psychiatric disorder induced by cannabis consumption. The psychological and psychophysiological features of this disorder are still unknown. We aimed to examine the psychological, personality and psychophysiological features of patients with CIPD. This study is an analytical extension of our previously published data, which previously found prepulse inhibition (PPI) deficits in the CIPD group used in this current paper. Methods: We used a sample of 45 patients with CIPD. After 9 months of follow up, these patients were assessed with a Symptom Checklist-90-R (SCL-90-R) questionnaire of psychopathology, with the Eysenck Personality Questionnaire, and with a psychophysiological paradigm of inhibition of the startle reflex (PPI). These results were compared with a group of patients with schizophrenia and cannabis abuse (SCHZ) ( n = 54); patients with cannabis dependence (CD) ( n = 21); and healthy controls ( n = 50). Results: CIPD patients obtained significant higher scores in the SCL-90-R subscale of neuroticism. These patients showed PPI percentages similar to SCHZ patients within early attentional levels (30 ms). The variables with greater correlation, and that appeared in the CIPD group were interpersonal sensitivity, depression and phobia. Conclusions: Neurotic symptomatology and difficulties in inhibition of the startle reflex might be risk factors for developing CIPD.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Humans ; Male ; Marijuana Abuse/complications ; Marijuana Abuse/physiopathology ; Marijuana Abuse/psychology ; Neuroticism/drug effects ; Neuroticism/physiology ; Personality Inventory ; Prepulse Inhibition/physiology ; Psychoses, Substance-Induced/complications ; Psychoses, Substance-Induced/physiopathology ; Psychoses, Substance-Induced/psychology ; Reflex, Startle/physiology ; Schizophrenia/physiopathology ; Young Adult
Language	English
Publishing date	2017-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639313-5
ISSN	1461-7285 ; 0269-8811
ISSN (online)	1461-7285
ISSN	0269-8811
DOI	10.1177/0269881117711920
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