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  1. Article ; Online: Responsive Supramolecular Polymers for Diagnosis and Treatment.

    Martínez-Orts, Mónica / Pujals, Silvia

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Stimuli-responsive supramolecular polymers are ordered nanosized materials that are held together by non-covalent interactions (hydrogen-bonding, metal-ligand coordination, π-stacking and, host-guest interactions) and can reversibly undergo self-assembly. ...

    Abstract Stimuli-responsive supramolecular polymers are ordered nanosized materials that are held together by non-covalent interactions (hydrogen-bonding, metal-ligand coordination, π-stacking and, host-guest interactions) and can reversibly undergo self-assembly. Their non-covalent nature endows supramolecular polymers with the ability to respond to external stimuli (temperature, light, ultrasound, electric/magnetic field) or environmental changes (temperature, pH, redox potential, enzyme activity), making them attractive candidates for a variety of biomedical applications. To date, supramolecular research has largely evolved in the development of smart water-soluble self-assemblies with the aim of mimicking the biological function of natural supramolecular systems. Indeed, there is a wide variety of synthetic biomaterials formulated with responsiveness to control and trigger, or not to trigger, aqueous self-assembly. The design of responsive supramolecular polymers ranges from the use of hydrophobic cores (i.e., benzene-1,3,5-tricarboxamide) to the introduction of macrocyclic hosts (i.e., cyclodextrins). In this review, we summarize the most relevant advances achieved in the design of stimuli-responsive supramolecular systems used to control transport and release of both diagnosis agents and therapeutic drugs in order to prevent, diagnose, and treat human diseases.
    MeSH term(s) Humans ; Benzene ; Biocompatible Materials ; Cyclodextrins ; Electricity ; Stimuli Responsive Polymers ; Water
    Chemical Substances Benzene (J64922108F) ; Biocompatible Materials ; Cyclodextrins ; Stimuli Responsive Polymers ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks.

    Sarabia-Vallejo, Álvaro / Molina, Ana / Martínez-Orts, Mónica / D'Onofrio, Alice / Staderini, Matteo / Bolognesi, Maria Laura / Martín, M Antonia / Olives, Ana I / Menéndez, J Carlos

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 6

    Abstract: A group of functionalized fluorene derivatives that are structurally similar to the cellular prion protein ... ...

    Abstract A group of functionalized fluorene derivatives that are structurally similar to the cellular prion protein ligand
    MeSH term(s) Insulin ; Amyloid/chemistry ; Amyloidogenic Proteins ; Fluorometry ; Fluorenes/chemistry
    Chemical Substances Insulin ; Amyloid ; Amyloidogenic Proteins ; Fluorenes
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  3. Article ; Online: Conformational and Structural Characterization of Carbohydrates and their Interactions Studied by NMR.

    Cañada, Francisco Javier / Canales, Ángeles / Valverde, Pablo / de Toro, Beatriz Fernández / Martínez-Orts, Mónica / Phillips, Paola Oquist / Pereda, Amaia

    Current medicinal chemistry

    2021  Volume 29, Issue 7, Page(s) 1147–1172

    Abstract: Carbohydrates, either free or as glycans conjugated with other biomolecules, participate in a plethora of essential biological processes. Their apparent simplicity in terms of chemical functionality hides an extraordinary diversity and structural ... ...

    Abstract Carbohydrates, either free or as glycans conjugated with other biomolecules, participate in a plethora of essential biological processes. Their apparent simplicity in terms of chemical functionality hides an extraordinary diversity and structural complexity. Deeply deciphering at the atomic level their structures is essential to understand their biological function and activities, but it is still a challenging task in need of complementary approaches and no generalized procedures are available to address the study of such complex, natural glycans. The versatility of Nuclear Magnetic Resonance spectroscopy (NMR) often makes it the preferred choice to study glycans and carbohydrates in solution media. The most basic NMR parameters, namely chemical shifts, coupling constants, and nuclear Overhauser effects, allow defining short or repetitive chain sequences and characterize their structures and local geometries either in the free state or when interacting with other biomolecules, rendering additional information on the molecular recognition processes. The increased accessibility to carbohydrate molecules extensively or selectively labeled with
    MeSH term(s) Carbohydrates/chemistry ; Humans ; Magnetic Resonance Spectroscopy/methods ; Models, Molecular ; Molecular Conformation ; Polysaccharides/chemistry
    Chemical Substances Carbohydrates ; Polysaccharides
    Language English
    Publishing date 2021-07-05
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666210705154046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Competitive upconversion-linked immunoassay using peptide mimetics for the detection of the mycotoxin zearalenone.

    Peltomaa, Riikka / Farka, Zdeněk / Mickert, Matthias J / Brandmeier, Julian C / Pastucha, Matěj / Hlaváček, Antonín / Martínez-Orts, Mónica / Canales, Ángeles / Skládal, Petr / Benito-Peña, Elena / Moreno-Bondi, María C / Gorris, Hans H

    Biosensors & bioelectronics

    2020  Volume 170, Page(s) 112683

    Abstract: Due to increasing food safety standards, the analysis of mycotoxins has become essential in the food industry. In this work, we have developed a competitive upconversion-linked immunosorbent assay (ULISA) for the analysis of zearalenone (ZEA), one of the ...

    Abstract Due to increasing food safety standards, the analysis of mycotoxins has become essential in the food industry. In this work, we have developed a competitive upconversion-linked immunosorbent assay (ULISA) for the analysis of zearalenone (ZEA), one of the most frequently encountered mycotoxins in food worldwide. Instead of a toxin-conjugate conventionally used in competitive immunoassays, we designed a ZEA mimicking peptide extended by a biotin-linker and confirmed its excellent suitability to mimic ZEA by nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR) analysis. Upconversion nanoparticles (UCNP, type NaYF
    MeSH term(s) Biosensing Techniques ; Chromatography, Liquid ; Food Contamination/analysis ; Immunoassay ; Mycotoxins/analysis ; Peptides ; Tandem Mass Spectrometry ; Zea mays ; Zearalenone/analysis
    Chemical Substances Mycotoxins ; Peptides ; Zearalenone (5W827M159J)
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2020.112683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Efficient Chemoenzymatic Synthesis of N-Glycans with a β1,4-Galactosylated Bisecting GlcNAc Motif.

    Weiss, Michael / Ott, Dimitri / Karagiannis, Theodoros / Weishaupt, Markus / Niemietz, Mathäus / Eller, Steffen / Lott, Marie / Martínez-Orts, Mónica / Canales, Ángeles / Razi, Nahid / Paulson, James C / Unverzagt, Carlo

    Chembiochem : a European journal of chemical biology

    2020  Volume 21, Issue 22, Page(s) 3212–3215

    Abstract: In human serum immunoglobulin G (IgG), a rare modification of biantennary complex N-glycans lead to a β1,4-galactosylated bisecting GlcNAc branch. We found that the bisecting GlcNAc on a biantennary core-fucosylated N-glycan was enzymatically ... ...

    Abstract In human serum immunoglobulin G (IgG), a rare modification of biantennary complex N-glycans lead to a β1,4-galactosylated bisecting GlcNAc branch. We found that the bisecting GlcNAc on a biantennary core-fucosylated N-glycan was enzymatically galactosylated under stringent reaction conditions. Further optimizations led to an efficient enzymatic approach to this particular modification for biantennary substrates. Notably, tri- and tetra-antennary complex N-glycans were not converted by bovine galactosyltransferase. An N-glycan with a galactosylated bisecting GlcNAc was linked to a lanthanide binding tag. The pseudo-contact shifts (PCS) obtained from the corresponding Dy-complex were used to calculate the conformational preferences of the rare N-glycan. Besides two extended conformations only a single folded conformation was found.
    MeSH term(s) Acetylglucosamine/chemistry ; Acetylglucosamine/metabolism ; Carbohydrate Conformation ; Galactose/chemistry ; Galactose/metabolism ; Glycosylation ; Humans ; Polysaccharides/biosynthesis ; Polysaccharides/chemistry
    Chemical Substances Polysaccharides ; Acetylglucosamine (V956696549) ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2020-08-19
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202000268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Competitive upconversion-linked immunoassay using peptide mimetics for the detection of the mycotoxin zearalenone

    Peltomaa, Riikka / Farka, Zdeněk / Mickert, Matthias J / Brandmeier, Julian C / Pastucha, Matěj / Hlaváček, Antonín / Martínez-Orts, Mónica / Canales, Ángeles / Skládal, Petr / Benito-Peña, Elena / Moreno-Bondi, María C / Gorris, Hans H

    Biosensors & bioelectronics. 2020 Dec. 15, v. 170

    2020  

    Abstract: Due to increasing food safety standards, the analysis of mycotoxins has become essential in the food industry. In this work, we have developed a competitive upconversion-linked immunosorbent assay (ULISA) for the analysis of zearalenone (ZEA), one of the ...

    Abstract Due to increasing food safety standards, the analysis of mycotoxins has become essential in the food industry. In this work, we have developed a competitive upconversion-linked immunosorbent assay (ULISA) for the analysis of zearalenone (ZEA), one of the most frequently encountered mycotoxins in food worldwide. Instead of a toxin-conjugate conventionally used in competitive immunoassays, we designed a ZEA mimicking peptide extended by a biotin-linker and confirmed its excellent suitability to mimic ZEA by nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR) analysis. Upconversion nanoparticles (UCNP, type NaYF₄:Yb,Tm) served as background-free optical label for the detection of the peptide mimetic in the competitive ULISA. Streptavidin-conjugated UCNPs were prepared by click reaction using an alkyne-PEG-neridronate linker. The UCNP conjugate clearly outperformed conventional labels such as enzymes or fluorescent dyes. With a limit of detection of 20 pg mL⁻¹ (63 pM), the competitive ULISA is well applicable to the detection of ZEA at the levels set by the European legislation. Moreover, the ULISA is specific for ZEA and its metabolites (α- and β-zearalenol) without significant cross-reactivity with other related mycotoxins. We detected ZEA in spiked and naturally contaminated maize samples using liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) as a reference method to demonstrate food analysis in real samples.
    Keywords biosensors ; corn ; cross reaction ; detection limit ; fluorescence ; food analysis ; food industry ; food safety ; immunoassays ; metabolites ; nuclear magnetic resonance spectroscopy ; peptides ; surface plasmon resonance ; tandem mass spectrometry ; zearalenone
    Language English
    Dates of publication 2020-1215
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2020.112683
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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