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  1. Article: Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors.

    Martínez-Pérez, Paula / García-Rupérez, Jaime

    Beilstein journal of nanotechnology

    2019  Volume 10, Page(s) 677–683

    Abstract: Porous materials have become one of the best options for the development of optical sensors, since they maximize the interaction between the optical field and the target substances, which boosts the sensitivity. In this work, we propose the use of a ... ...

    Abstract Porous materials have become one of the best options for the development of optical sensors, since they maximize the interaction between the optical field and the target substances, which boosts the sensitivity. In this work, we propose the use of a readily available mesoporous material for the development of such sensors: commercial polycarbonate track-etched membranes. In order to demonstrate their utility for this purpose, we firstly characterized their optical response in the near-infrared range. This response is an interference fringe pattern, characteristic of a Fabry-Pérot interferometer, which is an optical device typically used for sensing purposes. Afterwards, several refractive index sensing experiments were performed by placing different concentrations of ethanol solution on the polycarbonate track-etched membranes. As a result, a sensitivity value of around 56 nm/RIU was obtained and the reusability of the substrate was demonstrated. These results pave the way for the development of optical porous sensors with such easily available mesoporous material.
    Language English
    Publishing date 2019-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.10.67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I.

    Sabek, Jad / Martínez-Pérez, Paula / García-Rupérez, Jaime

    Computational biology and chemistry

    2019  Volume 80, Page(s) 147–151

    Abstract: A computational study of the interaction of cardiac troponin I (cTnI) with its specific antibody and of that antibody with skeletal troponin I (sTnI), the principal interferon of cTnI, is carried out. Computational and simulation tools such as FTSite, ... ...

    Abstract A computational study of the interaction of cardiac troponin I (cTnI) with its specific antibody and of that antibody with skeletal troponin I (sTnI), the principal interferon of cTnI, is carried out. Computational and simulation tools such as FTSite, FTMap, FTDock and pyDock are used to determine the binding sites of these molecules and to study their interactions and molecular docking performance, allowing us to obtain relevant information related with the antigen-antibody interaction for each of the targets. In the context of the development of immunosensing platforms, this type of computational analysis allows performing a preliminary in-silico affinity study of the available bioreceptors for a better selection when moving to the experimental stage, with the subsequent saving in cost and time.
    MeSH term(s) Animals ; Binding Sites ; Chickens ; Molecular Docking Simulation ; Protein Binding ; Protein Conformation ; Single-Chain Antibodies/immunology ; Single-Chain Antibodies/metabolism ; Troponin I/classification ; Troponin I/immunology ; Troponin I/metabolism
    Chemical Substances Single-Chain Antibodies ; Troponin I
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Journal Article
    ISSN 1476-928X
    ISSN (online) 1476-928X
    DOI 10.1016/j.compbiolchem.2019.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Continuous Detection of Increasing Concentrations of Thrombin Employing a Label-Free Photonic Crystal Aptasensor.

    Martínez-Pérez, Paula / Gómez-Gómez, Maribel / Angelova, Todora / Griol, Amadeu / Hurtado, Juan / Bellieres, Laurent / García-Rupérez, Jaime

    Micromachines

    2020  Volume 11, Issue 5

    Abstract: Thrombin generation is a complex and finely regulated pathway that provokes dynamical changes of thrombin concentration in blood when a vascular injury occurs. In order to characterize the initiation phase of such process, when thrombin concentration is ... ...

    Abstract Thrombin generation is a complex and finely regulated pathway that provokes dynamical changes of thrombin concentration in blood when a vascular injury occurs. In order to characterize the initiation phase of such process, when thrombin concentration is in the nmol/L range, a label-free optical aptasensor is proposed here. This aptasensor combines a 1D photonic crystal structure consisting of a silicon corrugated waveguide with thrombin binding aptamers on its surface as bioreceptors. As a result, this aptasensor has been demonstrated to specifically detect thrombin concentrations ranging from 270 pmol/L to 27 nmol/L with an estimated detection limit of 33.5 pmol/L and a response time of ~2 min. Furthermore, it has also been demonstrated that this aptasensor is able to continuously respond to consecutive increasing concentrations of thrombin and to detect binding events as they occur. All these features make this aptasensor a good candidate to continuously study how thrombin concentration progressively increases during the initiation phase of the coagulation cascade.
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11050464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of learning styles in a laparoscopic technical skills course. Implications for surgical training.

    Martín Parra, José Ignacio / Toledo Martínez, Enrique / Martínez Pérez, Paula / Ruiz Gómez, José Luis / Fernández Santiago, Roberto / López Useros, Antonio / Manuel Palazuelos, José Carlos / Rodríguez Sanjuán, Juan Carlos

    Cirugia espanola

    2021  Volume 99, Issue 10, Page(s) 730–736

    Abstract: Introduction: Learning surgical techniques is a dynamic process. In the 1980s David Kolb described developed a learning model that enabled teaching styles to adapt for better learner outcomes. The aim of this study was to identify the Kolb learning ... ...

    Abstract Introduction: Learning surgical techniques is a dynamic process. In the 1980s David Kolb described developed a learning model that enabled teaching styles to adapt for better learner outcomes. The aim of this study was to identify the Kolb learning styles of the participants in a laparoscopic technical skills course and to check see if there was any relationship with performance.
    Methods: An observational descriptive study was conducted with 64 participants in an intensive course in which they performed laparoscopic manual intestinal anastomoses. All completed Kolb's inventory of learning styles. For each anastomosis, join quality was assessed and the performing time recorded. After that, they were analyzed through statistical studies.
    Results: The most frequent learning style was assimilating type (39.1%). No significant differences were observed between different learning styles and gender, professional category, the time taken or the quality of the anastomoses.
    Conclusions: Assimilating type was the most frequent Kolb learning style, with no differences observed between categories, age or gender. There is no relationship between the learning style of the participants and the results obtained in the course.
    MeSH term(s) Cognition ; Humans ; Laparoscopy ; Learning
    Language English
    Publishing date 2021-11-09
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2021.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stabilization of Polymeric Nanofibers Layers for Use as Real-Time and In-Flow Photonic Sensors.

    Ponce-Alcántara, Salvador / Martínez-Pérez, Paula / Pérez-Márquez, Ana / Maudes, Jon / Murillo, Nieves / García-Rupérez, Jaime

    Sensors (Basel, Switzerland)

    2019  Volume 19, Issue 18

    Abstract: In order to increase the sensitivity of a sensor, the relationship between its volume and the surface available to be functionalized is of great importance. Accordingly, porous materials are becoming very relevant, because they have a notable surface-to- ... ...

    Abstract In order to increase the sensitivity of a sensor, the relationship between its volume and the surface available to be functionalized is of great importance. Accordingly, porous materials are becoming very relevant, because they have a notable surface-to-volume ratio. Moreover, they offer the possibility to infiltrate the target substances on them. Among other porous structures, polymeric nanofibers (NFs) layers fabricated by electrospinning have emerged as a very promising alternative to low-cost and easy-to-produce high-performance photonic sensors. However, experimental results show a spectrum drift when performing sensing measurements in real-time. That drift is responsible for a significant error when trying to determine the refractive index variation for a target solution, and, because of that, for the detection of the presence of certain analytes. In order to avoid that problem, different chemical and thermal treatments were studied. The best results were obtained for thermal steps at 190 °C during times between 3 and 5 h. As a result, spectrum drifts lower than 5 pm/min and sensitivities of 518 nm/refractive index unit (RIU) in the visible range of the spectrum were achieved in different electrospun NFs sensors.
    Language English
    Publishing date 2019-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s19183847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analysis of learning styles in a laparoscopic technical skills course. Implications for surgical training.

    Martín Parra, José Ignacio / Toledo Martínez, Enrique / Martínez Pérez, Paula / Ruiz Gómez, José Luis / Fernández Santiago, Roberto / López Useros, Antonio / Manuel Palazuelos, José Carlos / Rodríguez Sanjuán, Juan Carlos

    Cirugia espanola

    2020  

    Abstract: Introduction: Learning surgical techniques is a dynamic process. In the 1980s David Kolb described developed a learning model that enabled teaching styles to adapt for better learner outcomes. The aim of this study was to identify the Kolb learning ... ...

    Title translation Análisis de los estilos de aprendizaje en un curso de habilidades técnicas laparoscópicas. Implicaciones para el entrenamiento quirúrgico.
    Abstract Introduction: Learning surgical techniques is a dynamic process. In the 1980s David Kolb described developed a learning model that enabled teaching styles to adapt for better learner outcomes. The aim of this study was to identify the Kolb learning styles of the participants in a laparoscopic technical skills course and to check see if there was any relationship with performance.
    Methods: An observational descriptive study was conducted with 64 participants in an intensive course in which they performed laparoscopic manual intestinal anastomoses. All completed Kolb's inventory of learning styles. For each anastomosis, join quality was assessed and the performing time recorded. After that, they were analyzed through statistical studies.
    Results: The most frequent learning style was assimilating type (39.1%). No significant differences were observed between different learning styles and gender, professional category, the time taken or the quality of the anastomoses.
    Conclusions: Assimilating type was the most frequent Kolb learning style, with no differences observed between categories, age or gender. There is no relationship between the learning style of the participants and the results obtained in the course.
    Language Spanish
    Publishing date 2020-12-23
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2020.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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