Article ; Online: Reversing the Psychiatric Effects of Neurodevelopmental Cannabinoid Exposure
International Journal of Molecular Sciences, Vol 22, Iss 7861, p
Exploring Pharmacotherapeutic Interventions for Symptom Improvement
2021 Volume 7861
Abstract: Neurodevelopmental exposure to psychoactive compounds in cannabis, specifically THC, is associated with a variety of long-term psychopathological outcomes. This increased risk includes a higher prevalence of schizophrenia, mood and anxiety disorders, and ...
| Abstract | Neurodevelopmental exposure to psychoactive compounds in cannabis, specifically THC, is associated with a variety of long-term psychopathological outcomes. This increased risk includes a higher prevalence of schizophrenia, mood and anxiety disorders, and cognitive impairments. Clinical and pre-clinical research continues to identify a wide array of underlying neuropathophysiological sequelae and mechanisms that may underlie THC-related psychiatric risk vulnerability, particularly following adolescent cannabis exposure. A common theme among these studies is the ability of developmental THC exposure to induce long-term adaptations in the mesocorticolimbic system which resemble pathological endophenotypes associated with these disorders. This narrative review will summarize recent clinical and pre-clinical evidence that has elucidated these THC-induced developmental risk factors and examine how specific pharmacotherapeutic interventions may serve to reverse or perhaps prevent these cannabis-related risk outcomes. |
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| Keywords | cannabis ; marijuana ; THC ; endocannabinoid system ; adolescence ; neurodevelopment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999 |
| Language | English |
| Publishing date | 2021-07-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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