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  1. Article ; Online: Application of reflectance confocal microscopy in the diagnosis of pemphigus vulgaris and pemphigus foliaceus

    Marta Kurzeja

    Przegląd Dermatologiczny, Vol 109, Iss 2, Pp 122-

    2022  Volume 129

    Abstract: Reflectance confocal microscopy is a non-invasive diagnostic method that enables real-time visualization of tissues in near-histological resolution. Pemphigus is a chronic autoimmune skin disease in which intra-epidermal blisters are formed as a result ... ...

    Abstract Reflectance confocal microscopy is a non-invasive diagnostic method that enables real-time visualization of tissues in near-histological resolution. Pemphigus is a chronic autoimmune skin disease in which intra-epidermal blisters are formed as a result of acantholysis, i.e., loss of connection between epidermal cells. A systematic review of the literature on the use of reflectance confocal microscopy in the diagnosis of pemphigus has been carried out in this paper. Reflectance confocal microscopy enables identification of intra-epidermal acantholytic blisters in patients with pemphigus vulgaris and pemphigus foliaceus. The method also enables to identify the localization of blisters – the spinous layer in pemphigus vulgaris, and in the granular layer in pemphigus foliaceus. Thus, reflectance confocal microscopy may allow establishing non-invasively an initial diagnosis of pemphigus and differentiating pemphigus vulgaris from pemphigus foliaceus.
    Keywords pemphigus foliaceus ; pemphigus vulgaris ; reflectance confocal microscopy ; Medicine ; R ; Dermatology ; RL1-803
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Quiz dermatologiczny

    Adriana Rakowska / Marta Kurzeja / Magdalena Jasińska / Olga Warszawik-Hendzel / Lidia Rudnicka

    Przegląd Dermatologiczny, Vol 108, Iss 6, Pp 570-

    2022  Volume 571

    Keywords Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Zastosowanie refleksyjnej mikroskopii konfokalnej in vivo w dermatologii

    Małgorzata Olszewska / Lidia Rudnicka / Irena Walecka / Marta Kurzeja

    Przegląd Dermatologiczny, Vol 97, Iss 4, Pp 281-

    2010  Volume 289

    Abstract: Refleksyjna mikroskopia konfokalna in vivo jest nowoczesną, nieinwazyjnąmetodą diagnostyczną umożliwiającą obrazowanie naskórka orazgórnych warstw skóry właściwej z prawie histologiczną rozdzielczościąi dobrym kontrastem w czasie rzeczywistym. Obecnie ... ...

    Abstract Refleksyjna mikroskopia konfokalna in vivo jest nowoczesną, nieinwazyjnąmetodą diagnostyczną umożliwiającą obrazowanie naskórka orazgórnych warstw skóry właściwej z prawie histologiczną rozdzielczościąi dobrym kontrastem w czasie rzeczywistym. Obecnie metoda ta znajdujenajszersze zastosowanie w diagnostyce różnicowej łagodnychi złośliwych nowotworów skóry, szczególnie nietypowych i bardzowczesnych czerniaków, oraz innych nowotworów. W piśmiennictwiepodkreśla się możliwość rozszerzenia zakresu wskazań do diagnostycznegowykorzystania refleksyjnej mikroskopii konfokalnej in vivo,w tym do choroby Dariera, łuszczycy, kontaktowego zapalenia skóry,pęcherzycy, skórnego tocznia rumieniowatego i niektórych genodermatozprzebiegających z łysieniem. Dotychczas nie ma jednak jeszczebadań oceniających czułość i swoistość refleksyjnej mikroskopii konfokalnejin vivo w nienowotworowych chorobach skóry.
    Keywords czerniak ; diagnostyka ; mikroskopia konfokalna ; nowotwory skóry ; pęcherzyca ; Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2010-09-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Monoterapia rytuksymabem w pęcherzycy liściastej

    Małgorzata Olszewska / Lidia Rudnicka / Marta Kurzeja / Justyna Sicińska / Agnieszka Kardynał

    Przegląd Dermatologiczny, Vol 98, Iss 3, Pp 255-

    2011  Volume 265

    Abstract: Introduction. Rituximab is a chimeric human-mouse monoclonal antibody,which binds to the CD20 antigen on B and pre-B lymphocytesand causes depletion of CD20+ cells in the mechanism of complement-dependent and independent cytolysis, antibody-dependent ... ...

    Abstract Introduction. Rituximab is a chimeric human-mouse monoclonal antibody,which binds to the CD20 antigen on B and pre-B lymphocytesand causes depletion of CD20+ cells in the mechanism of complement-dependent and independent cytolysis, antibody-dependent cell cytotoxicityand the mechanism of apoptosis. Rituximab is currently registeredfor the treatment of non-Hodgkin's lymphoma, chronic lymphocyticleukaemia and rheumatoid arthritis. Rituximab has alsodemonstrated efficacy in a number of other autoimmune diseases, includingsystemic lupus erythematosus and Sjögren’s syndrome. In severeor recalcitrant cases of pemphigus vulgaris and pemphigus foliaceus,rituximab was applied as an adjuvant drug.Objective. To present the efficacy of rituximab monotherapy inpatients with pemphigus foliaceus, who had contraindications to classicimmunosuppression, and a review of the literature.Case reports. We present 2 patients with pemphigus foliaceus, a 66-year old male and a 61-year old female, treated with rituximab inmonotherapy as a first-line treatment. In the first patient serologicalnegativisation and improvement were observed 4 months after therapyinitiation. After 8 months further, significant clinical improvement,with sparse residual lesions, was observed. In the second case similarresults were achieved.Conclusions. In patients with pemphigus foliaceus significant improvementwas observed after rituximab monotherapy. Serological negativisationwas achieved prior to clinical remission. This unusual phenomenonmay be explained by rapid depletion of CD20+ cells andinhibition of antibody production, while in vivo bound pathogenicpemphigus antibodies remained active.
    Keywords biological therapy ; CD20+ cells ; pemphigus vulgaris ; Medicine ; R ; Dermatology ; RL1-803
    Subject code 610
    Language English
    Publishing date 2011-07-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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