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  1. Book ; Online: Metodología de la investigación

    Hadi, Mohamed / Martel, Christian / Huayta, Freddy / Rojas, Rómulo / Arias, José

    Guía para el proyecto de tesis

    2023  

    Keywords Encyclopaedias & reference works ; metodología de la investigación ; método científico ; proyecto de tesis
    Language Spanish
    Size 1 electronic resource (85 pages)
    Publisher Instituto Universitario de Innovación Ciencia y Tecnología Inudi Perú
    Publishing place Puno
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030377212
    ISBN 9786125069634 ; 612506963X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Pequeños pasos en investigación

    Nathalie, Torero Solano de Martel / Suarez, Edith / Martel, Christian

    un manual para iniciarse en el campo de la investigación científica

    2023  

    Keywords Research & information: general ; metodología de la investigación ; investigación científica ; manual académico
    Language Spanish
    Size 1 electronic resource (75 pages)
    Publisher Instituto Universitario de Innovación Ciencia y Tecnología Inudi Perú
    Publishing place Puno
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030375097
    ISBN 9786125069757 ; 6125069753
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Metodología de la investigación

    Medina, Miguel / Rojas, Rómulo / Bustamante, Wilder / Loaiza, Raquel / Martel, Christian / Castillo, Roxana

    Técnicas e instrumentos de investigación

    2023  

    Keywords Library & information sciences ; investigación científica ; metodología de la investigación ; instrumentos
    Language Spanish
    Size 1 electronic resource (60 pages)
    Publisher Instituto Universitario de Innovación Ciencia y Tecnología Inudi Perú
    Publishing place Puno
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030374860
    ISBN 9786125069702 ; 6125069702
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: In vitro

    Sierra-Sánchez, Álvaro / Magne, Brice / Savard, Etienne / Martel, Christian / Ferland, Karel / Barbier, Martin A / Demers, Anabelle / Larouche, Danielle / Arias-Santiago, Salvador / Germain, Lucie

    Burns & trauma

    2023  Volume 11, Page(s) tkad043

    Abstract: Background: The aim of this : Methods: Fibroblasts and keratinocytes from three humans were extracted from skin biopsies (N = 3) and cells from the same donor were used to produce both hbTESS models. For SASS manufacture, keratinocytes were seeded ... ...

    Abstract Background: The aim of this
    Methods: Fibroblasts and keratinocytes from three humans were extracted from skin biopsies (N = 3) and cells from the same donor were used to produce both hbTESS models. For SASS manufacture, keratinocytes were seeded over three self-assembled dermal sheets comprising fibroblasts and the extracellular matrix they produced (n = 12), while for HPSS production, keratinocytes were cultured over hydrogels composed of fibroblasts embedded in either plasma as unique biomaterial (Fibrin), plasma combined with hyaluronic acid (Fibrin-HA) or plasma combined with collagen (Fibrin-Col) (n/biomaterial = 9). The production time was 46-55 days for SASSs and 32-39 days for HPSSs. Substitutes were characterized by histology, mechanical testing, PrestoBlue™-assay, immunofluorescence (Ki67, Keratin (K) 10, K15, K19, Loricrin, type IV collagen) and Western blot (type I and IV collagens).
    Results: The SASSs were more resistant to tensile forces (
    Conclusions: This study demonstrates, for the first time, that both hbTESS models present similar
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775996-9
    ISSN 2321-3876 ; 2321-3868
    ISSN (online) 2321-3876
    ISSN 2321-3868
    DOI 10.1093/burnst/tkad043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnosis of idiopathic amyotrophic lateral sclerosis using Fourier-transform infrared spectroscopic analysis of patient-derived skin.

    Martel, Christian / Tsutsumi, Tamao / Cément, Vincent / Khuong, Hélène T / Dupré, Nicolas / Ismail, Ashraf A / Gros-Louis, François

    The Analyst

    2020  Volume 145, Issue 10, Page(s) 3678–3685

    Abstract: One of the great challenges in identifying effective therapy in many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), is the lack of reliable biomarkers. In this study, we applied infrared imaging microspectroscopy, a valuable ... ...

    Abstract One of the great challenges in identifying effective therapy in many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), is the lack of reliable biomarkers. In this study, we applied infrared imaging microspectroscopy, a valuable technique to investigate biomolecule fingerprints and secondary structure of proteins within biological tissue. We hypothesized that, since skin and CNS have the same embryonic origin, spectral differences associated with ALS-specific pathological events will be readily detectable through skin testing using this technique. Cells from healthy individuals and ALS patients were isolated from skin biopsies in order to generate tissue-engineered in vitro skin (TES). Infrared spectra of the generated TES were recorded using a focal-plane-array Fourier transform infrared (FPA-FTIR) spectrometer, and hierarchical cluster analysis of the spectral data was performed in order to establish clear differences between the tested TES specimens. Interestingly, our analyses showed that it was readily possible to discriminate ALS- and control-TES solely based on differences in associated FTIR spectra, mainly located between 1149 and 1473 cm
    MeSH term(s) Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/metabolism ; Case-Control Studies ; Humans ; Skin/metabolism ; Spectroscopy, Fourier Transform Infrared
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/c9an02282a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Pinocchio testing in the forensic analysis of waiting lists: using public waiting list data from Finland and Spain for testing Newcomb-Benford's Law.

    Pinilla, Jaime / López-Valcárcel, Beatriz G / González-Martel, Christian / Peiro, Salvador

    BMJ open

    2018  Volume 8, Issue 5, Page(s) e022079

    Abstract: Objective: Newcomb-Benford's Law (NBL) proposes a regular distribution for first digits, second digits and digit combinations applicable to many different naturally occurring sources of data. Testing deviations from NBL is used in many datasets as a ... ...

    Abstract Objective: Newcomb-Benford's Law (NBL) proposes a regular distribution for first digits, second digits and digit combinations applicable to many different naturally occurring sources of data. Testing deviations from NBL is used in many datasets as a screening tool for identifying data trustworthiness problems. This study aims to compare public available waiting lists (WL) data from Finland and Spain for testing NBL as an instrument to flag up potential manipulation in WLs.
    Design: Analysis of the frequency of Finnish and Spanish WLs first digits to determine if their distribution is similar to the pattern documented by NBL. Deviations from the expected first digit frequency were analysed using Pearson's χ
    Setting/participants: Publicly available WL data from Finland and Spain, two countries with universal health insurance and National Health Systems but characterised by different levels of transparency and good governance standards.
    Main outcome measures: Adjustment of the observed distribution of the numbers reported in Finnish and Spanish WL data to the expected distribution according to NBL.
    Results: WL data reported by the Finnish health system fits first digit NBL according to all statistical tests used (p=0.6519 in χ
    Conclusions: Testing deviations from NBL distribution can be a useful tool to identify problems with WL data trustworthiness and signalling the need for further testing.
    MeSH term(s) Finland ; Humans ; National Health Programs ; Probability ; Research Design ; Spain ; Statistics as Topic/methods ; Universal Health Insurance ; Waiting Lists
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2018-022079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Characterization of the phenotype with cognitive impairment and protein mislocalization in SCA34.

    Beaudin, Marie / Sellami, Leila / Martel, Christian / Touzel-Deschênes, Lydia / Houle, Gabrielle / Martineau, Laurence / Lacroix, Kevin / Lavallée, Andréane / Chrestian, Nicolas / Rouleau, Guy A / Gros-Louis, François / Laforce, Robert / Dupré, Nicolas

    Neurology. Genetics

    2020  Volume 6, Issue 2, Page(s) e403

    Abstract: Objective: To better characterize the neurologic and cognitive profile of patients with spinocerebellar ataxia 34 (SCA34) caused by : Methods: We investigated a 5-generation French-Canadian kindred presenting with a late-onset cerebellar ataxia and ... ...

    Abstract Objective: To better characterize the neurologic and cognitive profile of patients with spinocerebellar ataxia 34 (SCA34) caused by
    Methods: We investigated a 5-generation French-Canadian kindred presenting with a late-onset cerebellar ataxia and recruited age- and education-matched controls to evaluate the presence of neurocognitive impairment. Immunohistochemistry of dermal fibroblasts derived from a patient's skin biopsy was performed.
    Results: Patients had a late-onset slowly progressive cerebellar syndrome (mean age at onset 47 years; range 32-60 years) characterized by truncal and limb ataxia, dysarthria, hypometric saccades, and saccadic pursuits. No patient had past or current signs of erythrokeratodermia variabilis, which had previously been reported. MRI revealed cerebellar atrophy, with pontine atrophy (4 of 6 patients), and cruciform hypersignal in the pons (2 of 6 patients). Fluorodeoxyglucose-PET showed diffuse cerebellar hypometabolism in all 5 tested patients with subtle parietal hypometabolism in 3. Significant cognitive deficits were found in executive functioning, along with apparent visuospatial, attention, and psychiatric involvement. Immunohistochemistry of dermal fibroblasts showed mislocalization of the ELOVL4 protein, which appeared punctate and aggregated, supporting a dominant negative effect of the mutation on protein localization.
    Conclusions: Our findings support the pathogenicity of
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2818607-2
    ISSN 2376-7839
    ISSN 2376-7839
    DOI 10.1212/NXG.0000000000000403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Conference proceedings: State rainy day funds and the state budget crisis of 2002-?

    González-Martel, Christian / Levinson, Arik

    Prepared for the Conference on State Fiscal Crises

    (Working papers / Georgetown University, Economics Department ; 03,05)

    2003  

    Institution Georgetown University / Economics Department
    Author's details Christian Gonzalez
    Series title Working papers / Georgetown University, Economics Department ; 03,05
    Keywords Länderfinanzen ; Haushaltskonsolidierung ; Konjunktur ; USA
    Language English
    Size Online-Ressource, 15, [9] p., text, ill
    Edition [Elektronische Ressource]
    Publisher Georgetown Univ., Georgetown College, School of Foreign Service
    Publishing place Washington, DC
    Document type Book ; Online ; Conference proceedings
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  9. Article: Technical rules based on nearest-neighbour predictions optimised by genetic algorithms

    González-Martel, Christian / Fernández Rodríguez, Fernando / Sosvilla-Rivero, Simon

    Progress in financial markets research , p. 137-165

    evidence from the Madrid stock market

    2012  , Page(s) 137–165

    Author's details Christian González-Martel, Fernando Fernández-Rodríguez and Simon Sosvilla-Rivero
    Keywords Finanzanalyse ; Wertpapierhandel ; Aktienmarkt ; Spanien
    Language English
    Size graph. Darst.
    Publisher Nova Science Publ.
    Publishing place New York, NY
    Document type Article
    ISBN 978-1-611-22864-9 ; 1-611-22864-6
    Database ECONomics Information System

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  10. Article: Optimization of technical rules by genetic algorithms

    Fernández Rodríguez, Fernando / González-Martel, Christian / Sosvilla-Rivero, Simón

    Applied financial economics Vol. 15, No. 11 , p. 773-775

    evidence from the Madrid stock market

    2005  Volume 15, Issue 11, Page(s) 773–775

    Author's details Fernando Fernández-Rodríguez, Christian González-Martel and Simón Sosvilla-Rivero
    Keywords Wertpapierhandel ; Finanzanalyse ; Aktienindex ; Spanien ; 49
    Language English
    Publisher Routledge
    Publishing place London
    Document type Article
    ZDB-ID 1077973-5
    Database ECONomics Information System

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