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  1. Article ; Online: Infant feeding for people living with HIV in high resource settings: a multi-disciplinary approach with best practices to maximise risk reduction.

    Powell, Anna M / Knott-Grasso, Mary Ann / Anderson, Jean / Livingston, Alison / Rosenblum, Nadine / Sturdivant, Heather / Byrnes, Kristen C / Martel, Krista / Sheffield, Jeanne S / Golden, W Christopher / Agwu, Allison L

    Lancet regional health. Americas

    2023  Volume 22, Page(s) 100509

    Abstract: Shared decision making for infant feeding in the context of HIV in high-resourced settings is necessary to acknowledge patient autonomy, meet increasing patient requests and address the changing reality of perinatal HIV care. In low-to middle-income ... ...

    Abstract Shared decision making for infant feeding in the context of HIV in high-resourced settings is necessary to acknowledge patient autonomy, meet increasing patient requests and address the changing reality of perinatal HIV care. In low-to middle-income countries (LMIC), where the majority of individuals living with HIV reside, persons with HIV are recommended to breastfeed their infants. In the setting of maternal anti-retroviral therapy (ART) use throughout pregnancy, viral suppression and appropriate neonatal post-exposure prophylaxis (PEP) use, updated information indicates that the risk of HIV transmission through breastmilk may be between 0.3 and 1%. While not endorsing or recommending breastfeeding, the United States' DHHS perinatal guidelines are similarly pivoting, stating that individuals should "receive patient-centred, evidence-based counselling on infant feeding options." Similar statements appear in the British, Canadian, Swiss, European, and Australasian perinatal guidelines. We assembled a multi-disciplinary group at our institution to develop a structured shared decision-making process and protocol for successful implementation of breastfeeding. We recommend early and frequent counselling about infant feeding options, which should include well known benefits of breastfeeding even in the context of HIV and the individual's medical and psychosocial circumstances, with respect and support for patient's autonomy in choosing their infant feeding option.
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2023.100509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increasing the meaningful involvement of women in HIV cure-related research: a qualitative interview study in the United States.

    Dubé, Karine / Barr, Elizabeth / Philbin, Morgan / Perez-Brumer, Amaya / Minalga, Brian / Peterson, Beth / Averitt, Dawn / Picou, Bridgette / Martel, Krista / Chung, Cecilia / Mejía, María / Cameron, Martha / Graham, Gail / Dee, Lynda / Dixon Diallo, Dázon / Gordon, Ebony / Korolkova, Anastasia / Dyer, Typhanye / Auerbach, Judith D /
    Scully, Eileen / Dong, Krista L / Gianella, Sara

    HIV research & clinical practice

    2024  Volume 24, Issue 1, Page(s) 2246717

    Abstract: Background: Cisgender women represent over half of people living with HIV globally. However, current research efforts toward a cure for HIV focus predominantly on cisgender men. The under-representation of women in HIV cure clinical studies is ... ...

    Abstract Background: Cisgender women represent over half of people living with HIV globally. However, current research efforts toward a cure for HIV focus predominantly on cisgender men. The under-representation of women in HIV cure clinical studies is particularly problematic given data suggesting that sex-dependent phenotypes limit scientific discovery.
    Objective: We aimed to generate considerations to increase the meaningful involvement of women in HIV cure-related research.
    Materials and methods: We conducted in-depth interviews with biomedical researchers and community members to better understand factors that could increase the meaningful involvement of women in HIV cure clinical trials. Participants were affiliated with academia, industry, community advisory boards, and community-based organizations, and were identified using listings from the AIDS Clinical Trials Group and the Martin Delaney Collaboratories. We used conventional content analysis to analyze the qualitative data.
    Results: We recruited 27 participants, of whom 11 were biomedical researchers and 16 were community members. Participants included 25 cisgender women, 1 transgender woman, and 1 cisgender man. Key considerations emerged, including the need to ensure that HIV cure studies reflect HIV epidemiologic trends and having accurate representation by sex and gender in HIV cure research. To increase the meaningful involvement of women, recommendations included instituting intentional enrollment goals, frequent and mandatory reporting on enrollment, and incentives for sites to enroll women. Additional themes included the need for agency and self-determination, attention to lived experiences, trauma and healing, and adequate support for women (e.g. logistical, psychosocial, mental, emotional, and physical). Participants noted that women would be willing to participate in HIV cure trials, related procedures (e.g. biopsies), and analytical treatment interruptions. They also expressed a desired for women-centered and holistic clinical trial designs that account for intersectionality.
    Conclusions: Our empirical inquiry extends recent calls to action to increase diversity of people involved in HIV cure research. Redressing the under-inclusion of women in HIV cure research is an urgent imperative. The entire field must mobilize and reform to achieve this goal. Meaningfully involving women across the gender spectrum in HIV cure research is needed to ensure that interventions are safe, effective, scalable, and acceptable for all people with HIV.
    MeSH term(s) Female ; Humans ; Male ; United States/epidemiology ; Qualitative Research ; Empirical Research ; Academies and Institutes ; Biopsy ; HIV Infections/drug therapy ; HIV Infections/epidemiology
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2578-7470
    ISSN (online) 2578-7470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Dose Response: Perceptions of People Living with HIV in the United States on Alternatives to Oral Daily Antiretroviral Therapy.

    Dubé, Karine / Eskaf, Shadi / Evans, David / Sauceda, John / Saberi, Parya / Brown, Brandon / Averitt, Dawn / Martel, Krista / Meija, Maria / Campbell, Danielle / Barr, Liz / Kanazawa, John / Perry, Kelly / Patel, Hursch / Luter, Stuart / Poteat, Tonia / Auerbach, Judith D / Wohl, David A

    AIDS research and human retroviruses

    2019  Volume 36, Issue 4, Page(s) 324–348

    Abstract: There are two concurrent and novel major research pathways toward strategies for HIV control: (1) long-acting antiretroviral therapy (ART) formulations and (2) research aimed at conferring sustained ART-free HIV remission, considered a step toward an HIV ...

    Abstract There are two concurrent and novel major research pathways toward strategies for HIV control: (1) long-acting antiretroviral therapy (ART) formulations and (2) research aimed at conferring sustained ART-free HIV remission, considered a step toward an HIV cure. The importance of perspectives from people living with HIV on the development of new modalities is high, but data are lacking. We administered an online survey in which respondents selected their likelihood of participation or nonparticipation in HIV cure/remission research based on potential risks and perceived benefits of these new modalities. We also tested the correlation between perceptions of potential risks and benefits with preferences of virologic control strategies and/or responses to scenario choices, while controlling for respondent characteristics. Of the 282 eligible respondents, 42% would be willing to switch from oral daily ART to long-acting ART injectables or implantables taken at 6-month intervals, and 24% to a hypothetical ART-free remission strategy. We found statistically significant gender differences in perceptions of risk and preferences of HIV control strategies, and possible psychosocial factors that could mediate willingness to switch to novel HIV treatment or remission options. Our study yielded data on possible desirable product characteristics for future HIV treatment and remission options. Findings also revealed differences in motivations and preferences across gender and other sociodemographic characteristics that may be actionable as part of research recruitment efforts. The diversity of participant perspectives reveals the need to provide a variety of therapeutic options to people living with HIV and to acknowledge their diverse experiential expertise when developing novel HIV therapies.
    MeSH term(s) Adult ; Aged ; Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use ; Dose-Response Relationship, Drug ; Drug Therapy/psychology ; Female ; HIV Infections/drug therapy ; HIV Infections/psychology ; Humans ; Male ; Middle Aged ; Patient Participation/psychology ; Qualitative Research ; Surveys and Questionnaires ; United States ; Young Adult
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2019-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2019.0175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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