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  1. Article: Leptospirose, le défi diagnostique d’un cas autochtone.

    Martelli, Federica / Gay Des Combes Gliven, Pauline / De Vallière, Serge / Favrat, Bernard / Greub, Gilbert / Kokkinakis, Ioannis

    Revue medicale suisse

    2023  Volume 19, Issue 826, Page(s) 916–919

    Abstract: Leptospirosis is a global widespread zoonosis caused by a Gram-negative bacterium of the genus Leptospira, belonging to the Spirochaetes phylum, favored by unhealthy living conditions and some professional and recreational aquatic activities. Its ... ...

    Title translation Leptospirosis, the diagnostic challenge of an indigenous case.
    Abstract Leptospirosis is a global widespread zoonosis caused by a Gram-negative bacterium of the genus Leptospira, belonging to the Spirochaetes phylum, favored by unhealthy living conditions and some professional and recreational aquatic activities. Its diagnosis could be very difficult due to the presence of non-specific clinical presentation and biological anomalies common to other infectious diseases. To detect it, the choice of the right diagnostic method is fundamental. We hereby introduce the case of a patient with no classic risk factors for leptospirosis, showing febrile headaches and rapid deterioration of her general conditions with evolution towards septicemia.
    MeSH term(s) Humans ; Animals ; Female ; Leptospirosis/diagnosis ; Leptospirosis/microbiology ; Leptospira ; Zoonoses ; Risk Factors ; Sepsis
    Language French
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2023.19.826.916
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    Zs.A 5998: Show issues Location:
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  2. Article ; Online: Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study.

    Furneri, Giovanna / Varrasi, Simone / Guerrera, Claudia Savia / Platania, Giuseppe Alessio / Torre, Vittoria / Boccaccio, Francesco Maria / Testa, Maria Federica / Martelli, Federica / Privitera, Alessandra / Razza, Grazia / Santagati, Mario / Di Nuovo, Santo / Pirrone, Concetta / Castellano, Sabrina / Caraci, Filippo / Monastero, Roberto

    Aging clinical and experimental research

    2024  Volume 36, Issue 1, Page(s) 95

    Abstract: Current drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this ... ...

    Abstract Current drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Frontal Assessment Battery (FAB), while depressive symptoms were measured with the Hamilton Depression Rating Scale (HDRS). After 6 months (Group 1), a significant decrease in MoCA performance was detected. After 9 months (Group 2), a significant decrease in MMSE, MoCA, and FAB performance was observed. ChEIs did not modify depressive symptoms. Overall, our data suggest MoCA is a potentially useful tool for evaluating the effectiveness of ChEIs.
    MeSH term(s) Humans ; Cholinesterase Inhibitors/therapeutic use ; Pilot Projects ; Alzheimer Disease/drug therapy ; Mental Status and Dementia Tests ; Treatment Outcome
    Chemical Substances Cholinesterase Inhibitors
    Language English
    Publishing date 2024-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-024-02744-4
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  3. Article ; Online: Myotomy of sternocleidomastoid muscle as a secondary procedure in laryngectomized patients.

    Santoro, Giovanni Paolo / Luparello, Paolo / Lazio, Maria Silvia / Comini, Lara Valentina / Martelli, Federica / Cannavicci, Angelo

    Head & neck

    2019  Volume 41, Issue 10, Page(s) 3743–3746

    Abstract: Background: The application of specific devices to seal the tracheal stoma in laryngectomized patients is critical for optimal pulmonary and phonatory rehabilitation. Indeed, an excessive stomal depth is one of the main causes of rehabilitation failure. ...

    Abstract Background: The application of specific devices to seal the tracheal stoma in laryngectomized patients is critical for optimal pulmonary and phonatory rehabilitation. Indeed, an excessive stomal depth is one of the main causes of rehabilitation failure. In this context, division of the sternal heads of the sternocleidomastoid muscle (SCM) is a common technique, usually performed during the laryngectomy.
    Methods: We perform a myotomy of the sternal head of the SCM in deep and narrow tracheal stoma as a secondary procedure under local anesthesia, and here we describe the surgical steps of this procedure.
    Results: The medium depth of the stoma is reduced, and no procedure-specific complications have been observed. Postoperative morphological features show a flattening of the peristomal area, and all patients have begun regular use of appropriate patches and filters.
    Conclusions: Secondary section of SCM is a safe, simple, and effective procedure in total laryngectomies with deep and narrow stoma.
    MeSH term(s) Adult ; Female ; Follow-Up Studies ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Laryngectomy/adverse effects ; Laryngectomy/methods ; Male ; Middle Aged ; Myotomy/methods ; Neck Muscles/surgery ; Patient Safety ; Quality of Life ; Reoperation/methods ; Surgical Stomas ; Treatment Outcome
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.25852
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  4. Article ; Online: Uterine and placental blood flow indexes and antinuclear autoantibodies in unexplained recurrent pregnancy loss: should they be investigated in pregnancy as correlated potential factors? A retrospective study.

    Bruno, Valentina / Ticconi, Carlo / Martelli, Federica / Nuccetelli, Marzia / Capogna, Maria Vittoria / Sorge, Roberto / Piccione, Emilio / Pietropolli, Adalgisa

    BMC pregnancy and childbirth

    2020  Volume 20, Issue 1, Page(s) 44

    Abstract: Background: The potential role of antinuclear antibodies (ANA) in recurrent pregnancy loss (RPL) pathogenesis is still debated, although some evidences suggest that they could affect pregnancy outcome, leading to a higher miscarriage rate in these ... ...

    Abstract Background: The potential role of antinuclear antibodies (ANA) in recurrent pregnancy loss (RPL) pathogenesis is still debated, although some evidences suggest that they could affect pregnancy outcome, leading to a higher miscarriage rate in these patients. A hypothesized mechanism is through changes in uterine flow in pre-conceptional stage, by modifying endometrial receptivity in RPL. However, scant data are available, in pregnancy, about their role in RPL placental perfusion, also in relation to its potential treatments, such as low molecular weight heparin (LMWH). The aim of this study is to retrospectively further investigate the correlation between two-dimensional (2D) and three-dimensional (3D) uterine and placental flow indexes and the presence or the absence of ANA in women with unexplained RPL (uRPL), treated or not treated with LMWH.
    Methods: 2D Doppler measurement of pulsatility index (PI) of the uterine arteries and 3D ultrasonography determination of vascularization index (VI), flow index (FI) and vascularization flow index (VFI) was carried out with the aid of the virtual organ computer-aided analysis (VOCAL) technique in LMWH treated (n 24) and not treated-uRPL patients (n 20) and in the relative control group (n 27), each group divided in ANA+ and ANA- subgroups. Serum assay for the presence of ANA was performed in all women.
    Results: No differences were found in PI, VFI and VI values, by comparing the different groups. A difference in VI values was found for ANA- patients between RPL women not treated with LMWH and the treated ones (p = 0,01), which have lower VI values and similar to controls. By considering only ANA- treated and not treated RPL patients, the ROC curve shows an area of 0,80 and at the VI cut-off of 11,08 a sensitivity of 85% and a specificity of 67%.
    Conclusions: LMWH could exert a potential beneficial effect in restoring the physiological blood flow supply in terms of VI in uRPL ANA- status, suggesting to include ANA and VI investigations in the RPL diagnostic algorithm in a research context, since further studies are needed to clarify this challenging hypothesis in order to try to ameliorate ANA and abnormal placental vascularization negative influence on RPL pregnancy outcome .
    MeSH term(s) Abortion, Habitual/diagnostic imaging ; Abortion, Habitual/immunology ; Abortion, Habitual/prevention & control ; Adult ; Antibodies, Antinuclear/immunology ; Anticoagulants/therapeutic use ; Blood Flow Velocity ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Imaging, Three-Dimensional ; Pilot Projects ; Placenta/blood supply ; Placenta/diagnostic imaging ; Placental Circulation ; Pregnancy ; Pulsatile Flow ; Ultrasonography, Doppler ; Ultrasonography, Prenatal ; Uterine Artery/diagnostic imaging ; Uterus/blood supply ; Uterus/diagnostic imaging
    Chemical Substances Antibodies, Antinuclear ; Anticoagulants ; Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-020-2724-6
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  5. Article ; Online: Cancer population may be paradoxically protected from severe manifestations of COVID-19.

    Gallo, Oreste / Locatello, Luca Giovanni / Orlando, Pietro / Martelli, Federica / Piccica, Matteo / Lagi, Filippo / Trotta, Michele

    The Journal of infection

    2020  Volume 81, Issue 2, Page(s) e156–e158

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Neoplasms ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.011
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  6. Article ; Online: Amniotic fluid antiphospholipid antibodies: potential role in antiphospholipid syndrome-independent aberrant implantation process.

    Bruno, Valentina / Nuccetelli, Marzia / Ticconi, Carlo / Bruno, Antonella / Martelli, Federica / Capogna, Maria Vittoria / Bernardini, Sergio / Piccione, Emilio / Pietropolli, Adalgisa

    Reproductive biology and endocrinology : RB&E

    2019  Volume 17, Issue 1, Page(s) 79

    Abstract: Background: The direct role of antiphospholipid antibodies (aPL) at maternal-fetal interface has not been fully investigated, especially whether they are involved in physiological and pathological implantation conditions, in an antiphospholipid syndrome ...

    Abstract Background: The direct role of antiphospholipid antibodies (aPL) at maternal-fetal interface has not been fully investigated, especially whether they are involved in physiological and pathological implantation conditions, in an antiphospholipid syndrome (APS)-independent manner. In fact, trophoblast cells and placental endothelial cells at the implantation site express potential aPL targeted-phospholipid antigens (PL Ags); thus, the local production and presence of their specific antibodies, not related to APS (characterized by aPL presence in the peripheral blood), could be a potential marker of aberrant invasion, implantation and fetal-maternal immune tolerance processes.
    Methods: Anti-Beta
    Results: aCL and anti-β
    Conclusions: The presence of aPL in the AF (not related to APS) could reveal a potential clinical significance at maternal-fetal interface in selected pregnancy complications, in which an aberrant implantation process, and in turn an impaired fetal-maternal immune tolerance cross-talk, could occur.
    MeSH term(s) Adult ; Amniotic Fluid/immunology ; Amniotic Fluid/metabolism ; Antibodies, Anticardiolipin/immunology ; Antibodies, Antiphospholipid/immunology ; Antibodies, Antiphospholipid/metabolism ; Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/metabolism ; Embryo Implantation/immunology ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Female ; Humans ; Immune Tolerance/immunology ; Maternal-Fetal Relations ; Placenta/cytology ; Placenta/immunology ; Placenta/metabolism ; Pregnancy ; Trophoblasts/immunology ; Trophoblasts/metabolism ; beta 2-Glycoprotein I/immunology
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Antiphospholipid ; beta 2-Glycoprotein I
    Language English
    Publishing date 2019-10-15
    Publishing country England
    Document type Journal Article
    ISSN 1477-7827
    ISSN (online) 1477-7827
    DOI 10.1186/s12958-019-0527-2
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  7. Article ; Online: The Apathy Evaluation Scale (AES-C): Psychometric Properties and Invariance of Italian Version in Mild Cognitive Impairment and Alzheimer's Disease.

    Furneri, Giovanna / Platania, Silvia / Privitera, Alessandra / Martelli, Federica / Smeriglio, Rossana / Razza, Grazia / Maci, Tiziana / Castellano, Sabrina / Drago, Filippo / Santagati, Mario / Caponnetto, Pasquale / Caraci, Filippo / Di Nuovo, Santo

    International journal of environmental research and public health

    2021  Volume 18, Issue 18

    Abstract: Apathy is a neuropsychiatric symptom observed in different neurological and psychiatric disorders. Although apathy is considered a symptom, it has been recently reconsidered as a syndrome characterised by three dimensions: cognitive symptoms, affective ... ...

    Abstract Apathy is a neuropsychiatric symptom observed in different neurological and psychiatric disorders. Although apathy is considered a symptom, it has been recently reconsidered as a syndrome characterised by three dimensions: cognitive symptoms, affective symptoms and behavioural symptoms. Recent studies have shown that apathy can be considered as a prodromal symptom of Alzheimer's disease (AD), but also an indicator of the transition from mild cognitive impairment to AD. According to this scenario, an early detection of apathy in subjects with Mild Cognitive Impairment (MCI) and Mild AD can be a valid psychometric strategy to improve an early diagnosis and promote a prompt intervention. The Apathy Evaluation Scale is a validated tool composed of 18 items that assess and quantify emotional, behavioural and cognitive aspects of apathy. The aim of this study is to assess the specific reliability and validity of the Italian version of the Apathy Evaluation Scale-Clinician Version (AES-C) to detect apathy both in amnestic MCI and mild AD patients. In the present paper, we therefore examined the psychometric properties and the invariance of the Italian Version of the AES-C conducted on a sample composed of an experimental group of amnestic MCI and AD patients (N = 107) and a control group (N = 107) constituted by Age- and Sex-matched healthy controls. Results confirm the goodness of the scale. Confirmatory factory analysis confirmed that the AES-C Italian Version presents the same stability of one second-order factor and three first-order factors identified in the original version, and all items are predicted by a single general factor. Moreover, the scale was found to be invariant across both populations. Moreover, reliability and discriminant analysis showed good values. We found in the experimental group a negative correlation between the AES-C and Frontal Assessment Battery (FAB) (rs = -0.21,
    MeSH term(s) Alzheimer Disease/diagnosis ; Apathy ; Cognitive Dysfunction/diagnosis ; Humans ; Italy/epidemiology ; Neuropsychological Tests ; Psychometrics ; Reproducibility of Results
    Language English
    Publishing date 2021-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18189597
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  8. Article ; Online: A new, easy, and swift technique for minor salivary gland biopsy in Sjogren's syndrome.

    Comini, Lara Valentina / Lazio, Maria Silvia / Taverna, Cecilia / Luparello, Paolo / Maggiore, Giandomenico / Martelli, Federica / Novelli, Luca / Santoro, Giovanni Paolo

    The Laryngoscope

    2019  Volume 130, Issue 4, Page(s) 873–875

    MeSH term(s) Biopsy/methods ; Humans ; Lip ; Needles ; Salivary Glands, Minor/pathology ; Sjogren's Syndrome/pathology
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28094
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  9. Article ; Online: The impact of the COVID-19 pandemic on the quality of life of head and neck cancer survivors.

    Gallo, Oreste / Bruno, Chiara / Locatello, Luca Giovanni / Martelli, Federica / Cilona, Maria / Orlando, Pietro / Fancello, Giuseppe / Maggiore, Giandomenico / Viberti, Francesca / Ciabatti, Pierguido / Boccuzzi, Simone / Mandalà, Marco

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2021  Volume 29, Issue 11, Page(s) 6297–6304

    Abstract: Background: Head and neck cancer (HNC) survivors are particularly vulnerable to the deleterious consequences of lockdown and social distancing. The psychosocial effects of the COVID-19 pandemic on this group are still unknown, and we want to explore how ...

    Abstract Background: Head and neck cancer (HNC) survivors are particularly vulnerable to the deleterious consequences of lockdown and social distancing. The psychosocial effects of the COVID-19 pandemic on this group are still unknown, and we want to explore how their quality of life (QoL) has changed in this unique situation.
    Materials and methods: An online survey, composed of pandemic-specific items, plus the EORTC QLQ-C30, was administered to a cohort of HNC survivors. Using previously published reference values as a control group, we have evaluated the impact of the pandemic on their QoL. We have also explored the differences between those who had received a total laryngectomy (LP, laryngectomized population) vs other HNC patients, in order to assess the role of tracheostomy in this regard.
    Results: One hundred and twenty-one HNC patients completed the survey. The scores of the physical (80.5 vs 85, p = 0.028), role (78 vs 84, p = 0.030), and emotional functioning (76 vs 81, p = 0.041) were significantly different in the two groups, with worse functioning in our patients. Comparing LP with the other HNC patients, social (76.6 vs 88.9, p = 0.008) and physical functioning (75.5 vs 86.1, p = 0.006) were significantly worse in the former group. LP also reported a greater perception that others are afraid to be close to them (1.67 vs 1.32, p = 0.020). No differences were found between LP with and without voice prosthesis.
    Conclusions: Our results show how HNC patients are at high risk for a worsening in QoL because of the ongoing COVID-19 global pandemic.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Head and Neck Neoplasms ; Humans ; Pandemics ; Quality of Life ; SARS-CoV-2 ; Surveys and Questionnaires ; Survivors
    Language English
    Publishing date 2021-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-021-06198-6
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  10. Article ; Online: Effect of chorionic villus sampling on placental volume and vascularization in the first trimester of pregnancy.

    Bruno, Valentina / Martelli, Federica / Capogna, Maria Vittoria / Youssef, Aly / Bruno, Antonella / Ticconi, Carlo / Piccione, Emilio / Pietropolli, Adalgisa

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2018  Volume 33, Issue 5, Page(s) 726–730

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Chorionic Villi Sampling/adverse effects ; Female ; Humans ; Imaging, Three-Dimensional ; Organ Size ; Placenta/blood supply ; Placental Circulation ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Ultrasonography, Doppler/methods ; Ultrasonography, Prenatal
    Language English
    Publishing date 2018-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2018.1500541
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