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  1. Article: Drug induced systemic lupus erythematosus due to ophthalmic timolol.

    Zamber, R W / Starkebaum, G / Rubin, R L / Martens, H F / Wener, M H

    The Journal of rheumatology

    1992  Volume 19, Issue 6, Page(s) 977–979

    Abstract: We report a case of systemic lupus erythematosus (SLE) apparently induced by topical use of ophthalmic timolol maleate, a beta adrenergic blocking agent. The patient developed fever, malaise, pleurisy and recurrent sterile pleural effusions while taking ... ...

    Abstract We report a case of systemic lupus erythematosus (SLE) apparently induced by topical use of ophthalmic timolol maleate, a beta adrenergic blocking agent. The patient developed fever, malaise, pleurisy and recurrent sterile pleural effusions while taking no medication other than timolol. Antinuclear antibodies in a homogenous pattern, and markedly elevated histone antibodies (IgG anti-(H2A-H2B)-DNA) were present while antibodies to native DNA were absent. After discontinuation of the timolol, his symptoms improved promptly and the pleural effusions resolved. To our knowledge, this is the first report of timolol induced SLE.
    MeSH term(s) Administration, Oral ; Aged ; Aged, 80 and over ; Antibodies/analysis ; Antibodies/immunology ; Antibodies, Antinuclear/analysis ; Antibodies, Antinuclear/immunology ; Enzyme-Linked Immunosorbent Assay ; Fever/complications ; Glaucoma/drug therapy ; Histones/immunology ; Humans ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/immunology ; Male ; Pleurisy/complications ; Timolol/administration & dosage ; Timolol/adverse effects ; Timolol/therapeutic use
    Chemical Substances Antibodies ; Antibodies, Antinuclear ; Histones ; Timolol (817W3C6175)
    Language English
    Publishing date 1992-06
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 135: Show issues

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  2. Article: Decreased testosterone levels in men with rheumatoid arthritis: effect of low dose prednisone therapy.

    Martens, H F / Sheets, P K / Tenover, J S / Dugowson, C E / Bremner, W J / Starkebaum, G

    The Journal of rheumatology

    1994  Volume 21, Issue 8, Page(s) 1427–1431

    Abstract: Objective: To determine whether men with rheumatoid arthritis (RA) have abnormal hypothalamic-pituitary-gonadal axis function and to measure the effects of low dose prednisone therapy in these patients.: Methods: We measured testosterone, follicle ... ...

    Abstract Objective: To determine whether men with rheumatoid arthritis (RA) have abnormal hypothalamic-pituitary-gonadal axis function and to measure the effects of low dose prednisone therapy in these patients.
    Methods: We measured testosterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) in 36 men aged 38-75 (mean age +/- 1 sd = 62 +/- 10 years) who had longstanding active RA (mean disease duration = 17 +/- 12 years) and in 70 healthy elderly male controls, aged 53-83 (mean age 68 = +/- 6 years). We divided the group with RA into those taking no prednisone (n = 12) and those taking 5 to 10 mg/day of prednisone (n = 24) and analyzed these groups separately to determine whether low doses of prednisone affected testosterone levels.
    Results: Compared to the healthy controls, patients with RA not taking prednisone had normal testosterone levels but significantly elevated levels of FSH and LH (p < 0.01 for both comparisons). In contrast, patients with RA taking prednisone had significantly lower testosterone levels (p < 0.05), but levels of FSH and LH were only slightly elevated compared to controls. Compared to patients not taking prednisone, patients taking prednisone had lower levels of testosterone, FSH, and LH.
    Conclusion: Male patients with RA who are not taking prednisone have significantly elevated levels of FSH and LH with normal testosterone levels, suggesting a state of compensated partial gonadal failure. Male patients with RA taking low doses of prednisone have lower testosterone and gonadotropin levels, suggesting that prednisone may suppress the hypothalmic-pituitary-testicular axis. Since testosterone affects immune function as well as bone and muscle metabolism, androgen deficiency in some men with RA may predispose these patients to more severe disease and to increased complications of steroid therapy such as myopathy and osteoporosis.
    MeSH term(s) Adult ; Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Follicle Stimulating Hormone/blood ; Humans ; Male ; Middle Aged ; Prednisone/therapeutic use ; Radioimmunoassay ; Testosterone/agonists ; Testosterone/blood
    Chemical Substances Testosterone (3XMK78S47O) ; Follicle Stimulating Hormone (9002-68-0) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 1994-08
    Publishing country Canada
    Document type Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 135: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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