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  1. AU="Martha Funabashi"
  2. AU="Vasina, Svetlana"
  3. AU=Reber Stephan A.
  4. AU="Kenan Onel"
  5. AU="Lawrence, Marc R"
  6. AU="Zeiler, Frederick A"
  7. AU="de la Cueva, Pablo"
  8. AU="Fuh, Jerry Ying Hsi"
  9. AU="Park, Adrian J"
  10. AU="Joshi, K D"

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  1. Artikel ; Online: Expert consensus on a standardised definition and severity classification for adverse events associated with spinal and peripheral joint manipulation and mobilisation

    Katherine A Pohlman / Martha Funabashi / Lindsay M Gorrell / Stacie A Salsbury / Andrea Bergna

    BMJ Open, Vol 11, Iss

    protocol for an international e-Delphi study

    2021  Band 11

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: NTG-101

    Ajay Matta / Muhammad Zia Karim / Hoda Gerami / Peter Jun / Martha Funabashi / Greg Kawchuk / Alyssa Goldstein / Warren Foltz / Marshall Sussman / Bjorn C. Eek / W. Mark Erwin

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    A Novel Molecular Therapy that Halts the Progression of Degenerative Disc Disease

    2018  Band 13

    Abstract: Abstract The tremendous cost, pain and disability associated with degenerative disc disease (DDD) makes the development of a biological agent that can mitigate the course of DDD, a critical unmet need. We have identified and reported that a single ... ...

    Abstract Abstract The tremendous cost, pain and disability associated with degenerative disc disease (DDD) makes the development of a biological agent that can mitigate the course of DDD, a critical unmet need. We have identified and reported that a single injection of a combination of recombinant human (rh) Transforming growth factor beta 1 (TGF-β1) and Connective tissue growth factor (CTGF) proteins into the injured intervertebral disc (IVD) nucleus pulposus (NP) can mediate DDD in a pre-clinical rodent model. In this study, we developed and evaluated the efficacy of a novel molecular therapy (NTG-101) containing rhTGF-β1 and rhCTGF proteins suspended in an excipient solution using in vivo models of DDD including rat-tail and chondrodystrophic (CD) canines. Needle puncture injury in CD-canine NPs resulted in loss of hydration, disc height and showed radiographic evidence of DDD like humans. However, NTG-101-injected IVDs maintained disc height and demonstrated retention of viscoelastic properties as compared to IVDs injected with phosphate buffer saline (PBS, 1X, pH = 7.2). In addition, a single intra-discal injection of NTG-101 into the injured IVD-NPs resulted in sustained expression of healthy extra-cellular matrix (ECM) proteins (aggrecan, collagen 2A1) and reduced expression of inflammation associated proteins and molecules (IL-1β, IL-6, IL-8, MMP-13, Cox-2 and PGE2) as compared to vehicle controls. In conclusion, we demonstrated that a single intra-discal injection of the novel formulation, NTG-101 confers a robust anti-inflammatory, anti-catabolic and pro-anabolic effects in pre-clinical models of DDD thereby restoring homeostasis. These findings suggest the therapeutic potential of NTG-101 for clinical use.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-11-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A newmethod to analyze the subjective visual vertical in patients with bilateral vestibular dysfunction

    Martha Funabashi / Taiza Elaine Grespan Santos-Pontelli / José Fernando Colafêmina / Theo Zeferino Pavan / Antonio Adilton Oliveira Carneiro / Osvaldo Massaiti Takayanagui

    Clinics, Vol 67, Iss 10, Pp 1127-

    2012  Band 1131

    Abstract: OBJECTIVE: The aim of this study was to assess the subjective visual vertical in patients with bilateral vestibular dysfunction and to propose a new method to analyze subjective visual vertical data in these patients. METHODS: Static subjective visual ... ...

    Abstract OBJECTIVE: The aim of this study was to assess the subjective visual vertical in patients with bilateral vestibular dysfunction and to propose a new method to analyze subjective visual vertical data in these patients. METHODS: Static subjective visual vertical tests were performed in 40 subjects split into two groups. Group A consisted of 20 healthy volunteers, and Group B consisted of 20 patients with bilateral vestibular dysfunction. Each patient performed six measurements of the subjective visual vertical test, and the mean values were calculated and analyzed. RESULTS: Analyses of the numerical values of subjective visual vertical deviations (the conventional method of analysis) showed that the mean deviation was 0.326±1.13º in Group A and 0.301±1.87º in Group B. However, by analyzing the absolute values of the subjective visual vertical (the new method of analysis proposed), the mean deviation became 1.35±0.48º in Group A and 2.152±0.93º in Group B. The difference in subjective visual vertical deviations between groups was statistically significant (p,<0.05) only when the absolute values and the range of deviations were considered. CONCLUSION: An analysis of the absolute values of the subjective visual vertical more accurately reflected the visual vertical misperception in patients with bilateral vestibular dysfunction.
    Schlagwörter Vestibular Function Tests ; Vestibular Labyrinth ; Vestibular Diseases ; Saccule ; Utricule ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2012-10-01T00:00:00Z
    Verlag Faculdade de Medicina / USP
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Subjective Visual Vertical during Caloric Stimulation in Healthy Subjects

    Martha Funabashi / Aline I. Flores / Amanda Vicentino / Camila G. C. Barros / Octavio M. Pontes-Neto / João P. Leite / Taiza E. G. Santos-Pontelli

    Rehabilitation Research and Practice, Vol

    Implications to Research and Neurorehabilitation

    2015  Band 2015

    Abstract: Background. The subjective visual vertical (SVV) is a perception often impaired in patients with neurologic disorders and is considered a sensitive tool to detect otolithic dysfunctions. However, it remains unclear whether the semicircular canals (SCCs) ... ...

    Abstract Background. The subjective visual vertical (SVV) is a perception often impaired in patients with neurologic disorders and is considered a sensitive tool to detect otolithic dysfunctions. However, it remains unclear whether the semicircular canals (SCCs) are also involved in the visual vertical perception. Objective. The aim of this study was to analyze the influence of horizontal SCCs on SVV by caloric stimulation in healthy subjects. Methods. SVV was performed before and during the ice-cold caloric stimulation (4°C, right ear) in 30 healthy subjects. Results. The mean SVV tilts before and during the caloric stimulation were 0.31° ± 0.39 and −0.28° ± 0.40, respectively. There was no significant difference between the mean SVV tilts before and during stimulation p=0.113. Conclusion. These results suggest that horizontal SCCs do not influence SVV. Therefore, investigations and rehabilitation approaches for SVV misperceptions should be focused on otolithic and cognitive strategies.
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Software para avaliação da subjetiva vertical visual

    Theo Zeferino Pavan / Martha Funabashi / José Ailton Oliveira Carneiro / Taiza Elaine Grespan dos Santos Pontelli / Walfred Tedeschi / José Fernando Colafêmina / Antonio Adilton Olivera Carneiro

    Brazilian Journal of Otorhinolaryngology , Vol 78, Iss 5, Pp 51-

    um estudo transversal observacional Software for subjective visual vertical assessment: an observational cross-sectional study

    2012  Band 58

    Abstract: A orientação espacial em relação ao eixo gravitacional é de suma importância para a manu tenção da postura, marcha e para a maioria das atividades motoras realizadas pelo ser humano. A subjetiva vertical visual é um exame que avalia a percepção ... ...

    Abstract A orientação espacial em relação ao eixo gravitacional é de suma importância para a manu tenção da postura, marcha e para a maioria das atividades motoras realizadas pelo ser humano. A subjetiva vertical visual é um exame que avalia a percepção individual de verticalidade. OBJETIVOS: Os objetivos deste estudo foram: (1) desenvolver um sistema virtual para avaliar a subjetiva vertical visual, (2) produzir uma ferramenta simples para a prática clínica e (3) medir os valores da subjetiva vertical visual em indivíduos saudáveis usando a nova ferramenta. Forma de estudo: estudo obser vacional transversal. MÉTODO: Trinta voluntários saudáveis realizaram a subjetiva vertical visual em ambas as condições, estática e dinâmica. O exame consistia em ajustar uma linha virtual na posição vertical usando o mouse do computador. Na condição estática, a linha virtual foi projetada em uma tela branca. Na condição dinâmica, círculos pretos giravam no sentido horário e anti-horário. Seis medidas foram feitas e o desvio médio em relação a vertical real, calculado. RESULTADOS: Os desvios médios da subjetiva vertical visual foram: estática -0,372º ± 1,21; dinâmica sentido horário 1,53º ± 1,80 e dinâmica sentido anti-horário -1,11º ± 2,46. CONCLUSÃO: Este software mostrou ser prático e preciso para ser inserido na rotina de exames clínicos. Spatial orientation in relation to the gravitational axis is significantly important for the maintenance of the posture, gait and for most of the human's motor activities. The subjective visual vertical exam evaluates the individual's perception of vertical orientation. OBJECTIVES: The aims of this study were (1) to develop a virtual system to evaluate the subjective visual vertical exam, (2) to provide a simple tool to clinical practice and (3) to assess the subjective visual vertical values of healthy subjects using the new software. Study Design: observational cross-sectional study. METHODS: Thirty healthy volunteers performed the subjective visual vertical exam in both static and dynamic conditions. The exam consisted in adjusting a virtual line in the vertical position using the computer mouse. For the static condition, the virtual line was projected in a white background. For the dynamic condition, black circles rotated in clockwise or counterclockwise directions. Six measurements were taken and the mean deviations in relation to the real vertical calculated. RESULTS: The mean values of subjective visual vertical measurements were: static -0.372º; ± 1.21; dynamic clockwise 1.53º ± 1.80 and dynamic counterclockwise -1.11º ± 2.46. CONCLUSION: This software showed to be practical and accurate to be used in clinical routines.
    Schlagwörter software ; sáculo e utrículo ; testes de função vestibular ; vestíbulo do labirinto ; saccule and utricle ; software design ; vestibular function tests ; vestibule ; labyrinth ; Otorhinolaryngology ; RF1-547 ; Medicine ; R ; DOAJ:Otorhinolaryngology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Portugiesisch
    Erscheinungsdatum 2012-10-01T00:00:00Z
    Verlag Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: The use of a neck brace does not influence visual vertical perception

    Martha Funabashi / Natya N.L. Silva / Luciana M. Watanabe / Taiza E.G Santos-Pontelli / José Fernando Colafêmina / Antonio A.O. Carneiro / Osvaldo M. Takayanagui

    Arquivos de Neuro-Psiquiatria, Vol 69, Iss 3, Pp 509-

    2011  Band 512

    Abstract: Subjective visual vertical (SVV) evaluates the individual's capacity to determine the vertical orientation. Using a neck brace (NB) allow volunteers' heads fixation to reduce cephalic tilt during the exam, preventing compensatory ocular torsion and ... ...

    Abstract Subjective visual vertical (SVV) evaluates the individual's capacity to determine the vertical orientation. Using a neck brace (NB) allow volunteers' heads fixation to reduce cephalic tilt during the exam, preventing compensatory ocular torsion and erroneous influence on SVV result. OBJECTIVE: To analyze the influence of somatosensory inputs caused by a NB on the SVV. METHOD: Thirty healthy volunteers performed static and dynamic SVV: six measures with and six without the NB. RESULTS: The mean values for static SVV were -0.075º±1.15º without NB and -0.372º±1.21º with NB. For dynamic SVV in clockwise direction were 1.73º±2.31º without NB and 1.53º±1.80º with NB. For dynamic SVV in counterclockwise direction was -1.50º±2.44º without NB and -1.11º±2.46º with NB. Differences between measurements with and without the NB were not statistically significant. CONCLUSION: Although the neck has many sensory receptors, the use of a NB does not provide sufficient afferent input to change healthy subjects' perception of visual verticality.
    Schlagwörter percepção visual ; propriocepção ; sáculo ; utrículo ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2011-06-01T00:00:00Z
    Verlag Academia Brasileira de Neurologia - ABNEURO
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: World Congress Integrative Medicine & Health 2017

    Carolyn Ee / Sharmala Thuraisingam / Marie Pirotta / Simon French / Charlie Xue / Helena Teede / Agnete E. Kristoffersen / Fuschia Sirois / Trine Stub / Jennifer Engler / Stefanie Joos / Corina Güthlin / Jennifer Felenda / Christiane Beckmann / Florian Stintzing / Roni Evans / Gert Bronfort / Daniel Keefe / Anna Taberko /
    Linda Hanson / Alex Haley / Haiwei Ma / Joseph Jolton / Lana Yarosh / Francis Keefe / Jung Nam / Liwanag Ojala / Mary J. Kreitzer / Careen Fink / Karin Kraft / Andrew Flower / George Lewith / Kim Harman / Beth Stuart / Felicity L. Bishop / Jane Frawley / Lilla Füleki / Eva Kiss / Tamas Vancsik / Tibor Krenacs / Martha Funabashi / Katherine A. Pohlman / Silvano Mior / Haymo Thiel / Michael D. Hill / David J. Cassidy / Michael Westaway / Jerome Yager / Eric Hurwitz / Gregory N. Kawchuk / Maeve O’Beirne / Sunita Vohra / Isabelle Gaboury / Chantal Morin / Katharina Gaertner / Loredana Torchetti / Martin Frei-Erb / Michael Kundi / Michael Frass / Eugenia Gallo / Valentina Maggini / Mattia Comite / Francesco Sofi / Sonia Baccetti / Alfredo Vannacci / Mariella Di Stefano / Maria V. Monechi / Luigi Gori / Elio Rossi / Fabio Firenzuoli / Rocco D. Mediati / Giovanna Ballerini / Paula Gardiner / Anna S. Lestoquoy / Lily Negash / Sarah Stillman / Prachi Shah / Jane Liebschutz / Pamela Adelstein / Christine Farrell-Riley / Ivy Brackup / Brian Penti / Robert Saper / Isabel Giralt Sampedro / Gilda Carvajal / Andreas Gleiss / Marie M. Gross / Dorothea Brendlin / Jonas Röttger / Wiebke Stritter / Georg Seifert / Noelle Grzanna / Rainer Stange / Peter W. Guendling / Wen Gu / Yan Lu / Jie Wang / Chengcheng Zhang / Hua Bai / Yuxi He / Xiaoxu Zhang / Zhengju Zhang / Dali Wang / Fengxian Meng / Alexander Hagel / Heinz Albrecht / Claudia Vollbracht / Wolfgang Dauth / Wolfgang Hagel / Francesco Vitali / Ingo Ganzleben / Hans Schultis / Peter Konturek / Jürgen Stein / Markus Neurath / Martin Raithel / Bianka Krick / Heidemarie Haller / Petra Klose / Gustav Dobos / Sherko Kümmel / Holger Cramer / Felix J. Saha / Anna Kowoll / Barbara Ebner / Bettina Berger / Kyung-Eun Choi / Lisha He / Han Wang / X. He / C. Gu / Y. Zhang / Linhua Zhao / Xiaolin Tong / Xinhui He / Chengjuan Gu / Ying Zhang / Robin S. T. Ho / Vincent C. H. Chung / Xinyin Wu / Charlene H. L. Wong / Justin C. Y. Wu / Samuel Y. S. Wong / Alexander Y. L. Lau / Regina W. S. Sit / Wendy Wong / Michelle Holmes / Felicity Bishop / Lynn Calman / Dave Newell / Jonathan Field / Win L. Htut / Dongwoon Han / Da I. Choi / Soo J. Choi / Ha Y. Kim / Jung H. Hwang / Ching W. Huang / Bo H. Jang / Fang P. Chen / Seong G. Ko / Wenjing Huang / De Jin / Fengmei Lian / Soobin Jang / Kyeong H. Kim / Eun K. Lee / Seung H. Sun / Ho Y. Go / Youme Ko / Sunju Park / Yong C. Shin / Hubert Janik / Natalie Greiffenhagen / Jürgen Bolte / Mariusz Jaworski / Miroslawa Adamus / Aleksandra Dobrzynska / Michael Jeitler / Jessica Jaspers / Christel von Scheidt / Barbara Koch / Andreas Michalsen / Nico Steckhan / Christian Kessler / Wen-jing Huang / Bing Pang / Feng-Mei Lian / Miek Jong / Erik Baars / Anja Glockmann / Harald Hamre / Mosaburo Kainuma / Aya Murakami / Toshio Kubota / Daisuke Kobayashi / Yasuhiro Sumoto / Norihiro Furusyo / Shin-Ichi Ando / Takao Shimazoe / Olaf Kelber / S. Verjee / Eva Gorgus / Dieter Schrenk / Kathi Kemper / Ellie Hill / Nisha Rao / Gregg Gascon / John Mahan / Gunver Kienle / Jörg Dietrich / Claudia Schmoor / Roman Huber / Weon H. Kim / Mansoor Ahmed / Luzhu He / Jung Hye Hwang / Nora Meggyeshazi / Csaba Kovago / Anne K. Klaus / Roland Zerm / Danilo Pranga / Thomas Ostermann / Marcus Reif / Hans Broder von Laue / Benno Brinkhaus / Matthias Kröz / Daniela Rodrigues Recchia / Hans B. von Laue / Christien T. 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Gómez / Mónica Valero Sabater / Rosaria Ferreri / Simonetta Bernardini / Roberto Pulcri / Franco Cracolici / Massimo Rinaldi / Claudio Porciani / Peter Fisher / John Hughes / Ariadna Mendoza / Hugh MacPherson / Jacqueline Filshie / Antonia Di Francesco / Alberto Bernardini / Monica Messe / Vincenzo Primitivo / Piera A. Iasella / Monica Taminato / Jaqueline Do Carmo Alcantara / Katia R. De Oliveira / Debora C. De Azevedo Rodrigues / Juliana R. Campana Mumme / Olga K. Matsumoto Sunakozawa / Vicente Odone Filho / Joshua Goldenberg / Andrew Day / Masa Sasagawa / Lesley Ward / Kieran Cooley / Thora Gunnarsdottir / Ingibjorg Hjaltadottir / Mahdie Hajimonfarednejad / Nicole Hannan / Rut Hellsing / Susanne Andermo / Maria Arman / Iris von Hörsten / Patricia Vásquez Torrielo / Carmen L. Andrade Vilaró / Francisco Cerda Cabrera / Henny Hui / Eric Ziea / Dora Tsui / Joyce Hsieh / Christine Lam / Edith Chan / Mark P. Jensen / Samuel L. Battalio / Joy Chan / Karlyn A. Edwards / Kevin J. Gertz / Melissa A. Day / Leslie H. Sherlin / Dawn M. Ehde / Bo-Hyoung Jang / Anja Börner / Jihong Lee / Boram Lee / Gyu T. Chang / Alejandra Menassa / Yoshiharu Motoo / Jürgen Müller / Sabine Rabini / Bettina Vinson / Martin Storr / Martin Niemeijer / Joop Hoekman / Wied Ruijssenaaars / Faith C. Njoku / Arne J. Norheim / Filiz Okumus / Halime Oncu-Celik

    BMC Complementary and Alternative Medicine, Vol 17, Iss S1, Pp 1-

    part two

    2017  Band 65

    Schlagwörter Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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