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  1. Article: Hydrogen-Bonded Matched Ion Pair Gold(I) Catalysis.

    Martí, Àlex / Ogalla, Gala / Echavarren, Antonio M

    ACS catalysis

    2023  Volume 13, Issue 15, Page(s) 10217–10223

    Abstract: The enantioselective reaction of 1,6-enynes ... ...

    Abstract The enantioselective reaction of 1,6-enynes with
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2155-5435
    ISSN 2155-5435
    DOI 10.1021/acscatal.3c02638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis

    Franchino, Allegra / Martí, Àlex / Echavarren, Antonio M.

    Journal of the American Chemical Society. 2022 Feb. 09, v. 144, no. 8

    2022  

    Abstract: A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asymmetric induction. The successful ... ...

    Abstract A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asymmetric induction. The successful implementation of this paradigm is demonstrated in 5-exo-dig and 6-endo-dig cyclizations of 1,6-enynes, combining an achiral phosphinourea Au(I) chloride complex with a BINOL-derived phosphoramidate Ag(I) salt and thus allowing the first general use of chiral anions in Au(I)-catalyzed reactions of challenging alkyne substrates. Experiments with modified complexes and anions, ¹H NMR titrations, kinetic data, and studies of solvent and nonlinear effects substantiate the key H-bonding interaction at the heart of the catalytic system. This conceptually novel approach, which lies at the intersection of metal catalysis, H-bond organocatalysis, and asymmetric counterion-directed catalysis, provides a blueprint for the development of supramolecularly assembled chiral ligands for metal complexes.
    Keywords alkynes ; catalytic activity ; chlorides ; enantioselectivity ; hydrogen bonding ; ligands ; solvents
    Language English
    Dates of publication 2022-0209
    Size p. 3497-3509.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c11978
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis.

    Franchino, Allegra / Martí, Àlex / Echavarren, Antonio M

    Journal of the American Chemical Society

    2022  Volume 144, Issue 8, Page(s) 3497–3509

    Abstract: A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asymmetric induction. The successful ... ...

    Abstract A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asymmetric induction. The successful implementation of this paradigm is demonstrated in 5-
    MeSH term(s) Anions ; Catalysis ; Cyclization ; Ligands ; Molecular Structure ; Stereoisomerism
    Chemical Substances Anions ; Ligands
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c11978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Silver-Free Au(I) Catalysis Enabled by Bifunctional Urea- and Squaramide-Phosphine Ligands via H-Bonding.

    Franchino, Allegra / Martí, Àlex / Nejrotti, Stefano / Echavarren, Antonio M

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 46, Page(s) 11989–11996

    Abstract: A library of gold(I) chloride complexes with phosphine ligands incorporating pendant (thio)urea and squaramide H-bond donors was prepared with the aim of promoting chloride abstraction from Au(I) via H-bonding. In the absence of silver additives, ... ...

    Abstract A library of gold(I) chloride complexes with phosphine ligands incorporating pendant (thio)urea and squaramide H-bond donors was prepared with the aim of promoting chloride abstraction from Au(I) via H-bonding. In the absence of silver additives, complexes bearing squaramides and trifluoromethylated aromatic ureas displayed good catalytic activity in the cyclization of N-propargyl benzamides, as well as in a 1,6-enyne cycloisomerization, a tandem cyclization-indole addition reaction and the hydrohydrazination of phenylacetylene. Kinetic studies and DFT calculations indicate that the energetic span of the reaction is accounted by both the chloride abstraction step, facilitated by the bidentate H-bond donor via an associative mechanism, and the subsequent cyclization step.
    MeSH term(s) Catalysis ; Kinetics ; Ligands ; Phosphines ; Quinine/analogs & derivatives ; Silver ; Urea
    Chemical Substances Ligands ; Phosphines ; squaramide ; Silver (3M4G523W1G) ; Urea (8W8T17847W) ; Quinine (A7V27PHC7A) ; phosphine (FW6947296I)
    Language English
    Publishing date 2021-06-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202101751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.

    Bjorkman, Sarah H / Marti, Alex / Jena, Jayashree / García-Peña, Luis Miguel / Weatherford, Eric T / Kato, Kevin / Koneru, Jivan / Chen, Jason / Sood, Ayushi / Potthoff, Matthew J / Adams, Christopher M / Abel, E Dale / Pereira, Renata O

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1563

    Abstract: In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for ... ...

    Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for thermoregulation, partially by increasing FGF21 expression. In the present study, we tested the hypothesis that Atf4 and Fgf21 induction in BAT are both required for BAT thermogenesis under physiological stress by generating mice selectively lacking either Atf4 (ATF4 BKO) or Fgf21 (FGF21 BKO) in UCP1-expressing adipocytes. After 3 days of cold exposure, core body temperature was significantly reduced in ad-libitum-fed ATF4 BKO mice, which correlated with Fgf21 downregulation in brown and beige adipocytes, and impaired browning of white adipose tissue. Conversely, despite having reduced browning, FGF21 BKO mice had preserved core body temperature after cold exposure. Mechanistically, ATF4, but not FGF21, regulates amino acid import and metabolism in response to cold, likely contributing to BAT thermogenic capacity under ad libitum-fed conditions. Importantly, under fasting conditions, both ATF4 and FGF21 were required for thermogenesis in cold-exposed mice. Thus, ATF4 regulates BAT thermogenesis under fed conditions likely in a FGF21-independent manner, in part via increased amino acid uptake and metabolism.
    MeSH term(s) Animals ; Mice ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Adipocytes/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Amino Acids/metabolism ; Cold Temperature ; Fibroblast Growth Factors ; Mice, Inbred C57BL ; Thermogenesis/genetics ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
    Chemical Substances Activating Transcription Factor 4 (145891-90-3) ; Amino Acids ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; Uncoupling Protein 1 ; Atf4 protein, mouse
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52004-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidermal growth factor receptor first generation tyrosine-kinase inhibitors.

    Martinez-Marti, Alex / Navarro, Alejandro / Felip, Enriqueta

    Translational lung cancer research

    2019  Volume 8, Issue Suppl 3, Page(s) S235–S246

    Abstract: The epidermal growth factor receptor ( ...

    Abstract The epidermal growth factor receptor (
    Language English
    Publishing date 2019-12-06
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr.2019.04.20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HIV-Positive Patients with Lung Cancer: Is Immunotherapy a Safe and Active Option for Them?

    Navarro, Alejandro / Martinez-Marti, Alex / Felip, Enriqueta

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2018  Volume 13, Issue 7, Page(s) 874–876

    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; HIV ; Humans ; Immunotherapy ; Lung Neoplasms ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2018.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 652: Show issues

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  8. Article ; Online: H

    Elliott, Daniel C / Marti, Alex / Mauleón, Pablo / Pfaltz, Andreas

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2019  Volume 25, Issue 8, Page(s) 1918–1922

    Abstract: In recent years, ... ...

    Abstract In recent years, H
    Language English
    Publishing date 2019-01-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201805549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Current State-of-the-Art Therapy for Malignant Pleural Mesothelioma and Future Options Centered on Immunotherapy.

    Cedres, Susana / Valdivia, Augusto / Iranzo, Patricia / Callejo, Ana / Pardo, Nuria / Navarro, Alejandro / Martinez-Marti, Alex / Assaf-Pastrana, Juan David / Felip, Enriqueta / Garrido, Pilar

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Malignant pleural mesothelioma (MPM) is a locally aggressive disease related to asbestos exposure with a median survival for untreated patients of 4-8 months. The combination of chemotherapy based on platinum and antifolate is the standard treatment, and ...

    Abstract Malignant pleural mesothelioma (MPM) is a locally aggressive disease related to asbestos exposure with a median survival for untreated patients of 4-8 months. The combination of chemotherapy based on platinum and antifolate is the standard treatment, and the addition of bevacizumab adds two months to median survival. Recently, in first-line treatment, immunotherapy combining nivolumab with ipilimumab has been shown to be superior to chemotherapy in the CheckMate-743 study in terms of overall survival (18.1 months), leading to its approval by the FDA and EMA. The positive results of this study represent a new standard of treatment for patients with MPM; however, not all patients will benefit from immunotherapy treatment. In an effort to improve the selection of patient candidates for immunotherapy for different tumors, biomarkers that have been associated with a greater possibility of response to treatment have been described. MPM is a type of tumor with low mutational load and neo-antigens, making it a relatively non-immunogenic tumor for T cells and possibly less susceptible to responding to immunotherapy. Different retrospective studies have shown that PD-L1 expression occurs in 20-40% of patients and is associated with a poor prognosis; however, the predictive value of PD-L1 in response to immunotherapy has not been confirmed. The purpose of this work is to review the state of the art of MPM treatment in the year 2023, focusing on the efficacy results of first-line or subsequent immunotherapy studies on patients with MPM and possible chemo-immunotherapy combination strategies. Additionally, potential biomarkers of response to immunotherapy will be reviewed, such as histology, PD-L1, lymphocyte populations, and TMB.
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms.

    Bjorkman, Sarah H / Marti, Alex / Jena, Jayashree / Garcia Pena, Luis M / Weatherford, Eric T / Kato, Kevin / Koneru, Jivan / Chen, Jason / Sood, Ayushi / Potthoff, Matthew J / Adams, Christopher M / Abel, E Dale / Pereira, Renata O

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for ... ...

    Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for thermoregulation, partially via upregulation of FGF21. In the present study, we tested the hypothesis that
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.09.531964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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