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  1. Article ; Online: Medical algorithm: Diagnosis and treatment of hypersensitivity reactions to cancer chemotherapy.

    Madrigal-Burgaleta, Ricardo / Vazquez-Revuelta, Paula / Marti-Garrido, Jaume / Lleonart-Bellfill, Ramon / Ali, Fawzia Runa / Alvarez-Cuesta, Emilio

    Allergy

    2021  Volume 76, Issue 8, Page(s) 2636–2640

    MeSH term(s) Algorithms ; Anaphylaxis ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy ; Humans ; Hypersensitivity ; Neoplasms/drug therapy
    Language English
    Publishing date 2021-05-20
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Delabeling patients from chemotherapy and biologics allergy: Implementing drug provocation testing.

    Vázquez-Revuelta, Paula / Martí-Garrido, Jaume / Molina-Mata, Kevin / Lleonart-Bellfill, Ramon / Rey-Salido, Montserrat / Madrigal-Burgaleta, Ricardo

    The journal of allergy and clinical immunology. In practice

    2020  Volume 9, Issue 4, Page(s) 1742–1745.e1

    MeSH term(s) Biological Products ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/therapy ; Humans ; Penicillins ; Pharmaceutical Preparations ; Skin Tests
    Chemical Substances Biological Products ; Penicillins ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.11.021
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  3. Article ; Online: Anaphylaxis after anal intercourse with tolerance by vaginal route.

    Martí-Garrido, Jaume / López-Salgueiro, Ramón / Bartolomé-Zavala, Borja / Perales-Chordá, Carolina / de Rojas, Dolores Hernández-Fernández

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2018  Volume 122, Issue 3, Page(s) 346–347

    MeSH term(s) Anal Canal ; Anaphylaxis/etiology ; Anaphylaxis/immunology ; Female ; Humans ; Immunologic Tests ; Middle Aged ; Semen/immunology ; Sexual Behavior ; Vagina
    Language English
    Publishing date 2018-10-09
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2018.10.006
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  4. Article ; Online: Clinical Characterization and Diagnostic Approaches for Patients Reporting Hypersensitivity Reactions to Quinolones.

    Doña, Inmaculada / Pérez-Sánchez, Natalia / Salas, María / Barrionuevo, Esther / Ruiz-San Francisco, Arturo / Hernández Fernández de Rojas, Dolores / Martí-Garrido, Jaume / Andreu-Ros, Inmaculada / López-Salgueiro, Ramón / Moreno, Esther / Torres, María José

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 8, Page(s) 2707–2714.e2

    Abstract: Background: Quinolones are the second most frequent cause of hypersensitivity reactions (HSRs) to antibiotics. A marked increase in the number of patients with HSRs to quinolones has been detected.: Objective: To describe the clinical characteristics ...

    Abstract Background: Quinolones are the second most frequent cause of hypersensitivity reactions (HSRs) to antibiotics. A marked increase in the number of patients with HSRs to quinolones has been detected.
    Objective: To describe the clinical characteristics of patients with HSRs to quinolones and present methods for their diagnosis.
    Methods: Patients attending the allergy unit due to reactions suggestive of HSRs to quinolones were prospectively evaluated between 2005 and 2018. Diagnosis was achieved using clinical history, skin tests (STs), basophil activation tests (BATs), and drug provocation tests (DPTs) if ST and BAT results were negative.
    Results: We included 128 subjects confirmed as having HSRs to quinolones and 42 found to be tolerant. Anaphylaxis was the most frequent entity in immediate HSRs and was most commonly induced by moxifloxacin. Patients were evaluated a median of 150 days (interquartile range, 60-365 days) after the reaction. Of patients who underwent ST and BAT, 40.7% and 70%, respectively, were positive. DPT with a quinolone was performed in 48 cases, giving results depending on the culprit drug: when moxifloxacin was involved, 62.5% of patients gave a positive DPT result to ciprofloxacin, whereas none reacted to levofloxacin. The risk of HSR was 96 times higher in subjects who reported moxifloxacin-induced anaphylaxis and 18 times higher in those reporting immediate reactions compared with clinical entities induced by quinolones other than moxifloxacin and nonimmediate reactions.
    Conclusions: The diagnosis of HSR to quinolones is complex. The use of clinical history is essential as a first step. BAT shows higher sensitivity than STs. DPTs can be useful for finding safe alternative quinolones.
    MeSH term(s) Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Humans ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/epidemiology ; Levofloxacin ; Quinolones ; Skin Tests
    Chemical Substances Quinolones ; Levofloxacin (6GNT3Y5LMF)
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.04.051
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  5. Article ; Online: Characterization of anaphylaxis reveals different metabolic changes depending on severity and triggers.

    Perales-Chorda, Carolina / Obeso, David / Twomey, Laura / Rojas-Benedicto, Ayelén / Puchades-Carrasco, Leonor / Roca, Marta / Pineda-Lucena, Antonio / Laguna, José Julio / Barbas, Coral / Esteban, Vanesa / Martí-Garrido, Jaume / Ibañez-Echevarria, Ethel / López-Salgueiro, Ramón / Barber, Domingo / Villaseñor, Alma / Hernández Fernández de Rojas, Dolores

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2021  Volume 51, Issue 10, Page(s) 1295–1309

    Abstract: Background: Despite the increasing incidence of anaphylaxis, its underlying molecular mechanisms and biomarkers for appropriate diagnosis remain undetermined. The rapid onset and potentially fatal outcome in the absence of managed treatment prevent its ... ...

    Abstract Background: Despite the increasing incidence of anaphylaxis, its underlying molecular mechanisms and biomarkers for appropriate diagnosis remain undetermined. The rapid onset and potentially fatal outcome in the absence of managed treatment prevent its study. Up today, there are still no known biomarkers that allow an unequivocal diagnosis. Therefore, the aim of this study was to explore metabolic changes in patients suffering anaphylactic reactions depending on the trigger (food and/or drug) and severity (moderate and severe) in a real-life set-up.
    Methods: Eighteen episodes of anaphylaxis, one per patient, were analysed. Sera were collected during the acute phase (T1), the recovery phase (T2) and around 2-3 months after the anaphylactic reaction (T0: basal state). Reactions were classified following an exhaustive allergological evaluation for severity and trigger. Sera samples were analysed using untargeted metabolomics combining liquid chromatography coupled to mass spectrometry (LC-MS) and proton nuclear magnetic resonance spectroscopy (
    Results: 'Food T1 vs T2' and 'moderate T1 vs T2' anaphylaxis comparisons showed clear metabolic patterns during the onset of an anaphylactic reaction, which differed from those induced by drugs, food + drug or severe anaphylaxis. Moreover, the model of food anaphylaxis was able to distinguish the well-characterized IgE (antibiotics) from non-IgE-mediated anaphylaxis (nonsteroidal anti-inflammatory drugs), suggesting a differential metabolic pathway associated with the mechanism of action. Metabolic differences between 'moderate vs severe' at the acute phase T1 and at basal state T0 were studied. Among the altered metabolites, glucose, lipids, cortisol, betaine and oleamide were observed altered.
    Conclusions: The results of this exploratory study provide the first evidence that different anaphylactic triggers or severity induce differential metabolic changes along time or at specific time-point, respectively. Besides, the basal status T0 might identify high-risk patients, thus opening new ways to understand, diagnose and treat anaphylaxis.
    MeSH term(s) Allergens ; Anaphylaxis/chemically induced ; Anaphylaxis/etiology ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Biomarkers ; Food ; Humans
    Chemical Substances Allergens ; Anti-Inflammatory Agents, Non-Steroidal ; Biomarkers
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13991
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    Zs.A 767: Show issues Location:
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  6. Article ; Online: R-ALERGO. Rutas alergosaludables en Valencia.

    Temes Cordovez, Rafael R / Moya Fuero, Alfonso / Martí Garrido, Jaume / Perales Chordá, Carolina / Díaz Palacios, Miguel / Hernández Fernández de Rojas, Dolores

    Gaceta sanitaria

    2016  Volume 30, Issue 2, Page(s) 140–143

    Abstract: R-ALERGO is a project developed by researchers from the Universitat Politècnica de València and the Hospital Universitario La Fe (Valencia, Spain). The main objective of the project is to create a mobile application identifying, within the city of ... ...

    Title translation R-ALERGO. Allergy-healthy routes in Valencia.
    Abstract R-ALERGO is a project developed by researchers from the Universitat Politècnica de València and the Hospital Universitario La Fe (Valencia, Spain). The main objective of the project is to create a mobile application identifying, within the city of Valencia, the most favorable routes for allergic individuals. The application is developed using nine environmental variables with a potential effect on the development of clinical manifestations in allergic individuals. The application combines the use of spatial analysis based on network technology and implemented with a geographic information system software. The first 01 version is under evaluation for a Healthy app hallmark. The next step in this project is to design a clinical validation process to test its usefulness in allergic individuals.
    Language Spanish
    Publishing date 2016-03
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1038713-4
    ISSN 1578-1283 ; 0213-9111
    ISSN (online) 1578-1283
    ISSN 0213-9111
    DOI 10.1016/j.gaceta.2015.11.003
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