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  1. Article ; Online: Cerebral venous sinus thrombosis secondary to acute cytomegalovirus infection.

    Martin, Andrew J

    BMJ neurology open

    2023  Volume 5, Issue 2, Page(s) e000460

    Abstract: Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening disorder with a number of causes, including viral infections.: Case presentation: A 25-year-old female patient presented with a non-specific febrile illness, ... ...

    Abstract Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening disorder with a number of causes, including viral infections.
    Case presentation: A 25-year-old female patient presented with a non-specific febrile illness, headache and hepatitis. She was found to have right transverse sinus and cortical venous thrombosis in addition to acute systemic Cytomegalovirus (CMV) infection. She responded well to anticoagulation with warfarin for 6 months. CMV infection was treated conservatively.
    Conclusion: CVST is an increasingly prevalent condition often presenting with headache, focal neurological deficits and seizures. Despite extensive investigations, often no specific cause is found. CMV is a ubiquitous virus that can present with a non-specific febrile illness or a variety of organ dysfunction. CMV has been shown to be associated with predominantly venous thrombosis, most commonly lower limb deep venous thrombosis, pulmonary embolism and splanchnic vein thrombosis. The risk is highest in immunocompromised patients, though most patients are immunocompetent. There have been few reports of CVST related to CMV and all of these with a more tenuous link to acute CMV infection. Clinicians should be aware of this link, particularly in those who have CVST in the context of a febrile illness, or immunocompromised patients.
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2023-000460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: University Students' Motivation and Engagement During the COVID-19 Pandemic: The Roles of Lockdown, Isolation, and Remote and Hybrid Learning.

    Martin, Andrew J

    Australian journal of education

    2023  Volume 67, Issue 2, Page(s) 163–180

    Abstract: This investigation comprised two studies that sought to identify the role of COVID-related disruptions in Australian university students' academic motivation and engagement. Study 1 involved a dataset of 500 university students and examined the links ... ...

    Abstract This investigation comprised two studies that sought to identify the role of COVID-related disruptions in Australian university students' academic motivation and engagement. Study 1 involved a dataset of 500 university students and examined the links between COVID-19 pandemic disruptions (remote and hybrid learning modes, lockdown, isolation) and students' adaptive (e.g., planning and monitoring) and maladaptive (e.g., disengagement) dimensions of the Motivation and Engagement Scale (MES). Study 2 compared the mean motivation and engagement of Study 1 participants with mean levels from four published pre-COVID-19 Australian studies (
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2420054-2
    ISSN 2050-5884 ; 0004-9441
    ISSN (online) 2050-5884
    ISSN 0004-9441
    DOI 10.1177/00049441231179791
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  3. Article ; Online: Marin-Amat Syndrome: More Than Meets the Eye.

    Martin, Andrew J

    Neurology

    2022  Volume 100, Issue 3, Page(s) 143

    MeSH term(s) Humans ; Syndrome ; Blepharoptosis
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201484
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  4. Article ; Online: Nicotinamide for Skin-Cancer Chemoprevention in Transplantation. Reply.

    Allen, Nicholas C / Martin, Andrew J / Damian, Diona L

    The New England journal of medicine

    2023  Volume 388, Issue 26, Page(s) 2494–2495

    MeSH term(s) Humans ; Niacinamide/therapeutic use ; Transplant Recipients ; Skin Neoplasms/prevention & control ; Carcinoma, Basal Cell/prevention & control ; Chemoprevention
    Chemical Substances Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2303841
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  5. Article ; Online: The role of health demands, health resources, and adaptability in psychological strain and life satisfaction.

    Martin, Andrew J / Collie, Rebecca J / Holliman, Andrew J

    Stress and health : journal of the International Society for the Investigation of Stress

    2023  

    Abstract: The present study harnessed job demands-resources theory to identify key predictors of psychological strain (feeling overwhelmed by one's problems) and life satisfaction among a sample of 1060 adults randomly selected from the Australian electoral roll. ... ...

    Abstract The present study harnessed job demands-resources theory to identify key predictors of psychological strain (feeling overwhelmed by one's problems) and life satisfaction among a sample of 1060 adults randomly selected from the Australian electoral roll. The investigation sought to ascertain: (a) the relative contribution of health demands (e.g., inadequate health treatment) and health resources (e.g., access to helpful health-related information) in predicting psychological strain and life satisfaction, (b) the extent to which a recently proposed personal resource-adaptability-explained variance in wellbeing beyond individuals' health demands and resources, and (c) the role of psychological strain in predicting life satisfaction in the context of these demands and resources. Applying structural equation modelling we found that contextual health demands predicted greater psychological strain, individual health resources and adaptability both predicted lower psychological strain and greater life satisfaction, and psychological strain predicted lower life satisfaction. Notably, the adverse effects of health demands reduced significantly when health resources and adaptability were entered into the modelling. Taken together, the findings offer support for a health demands-resources framework that may be applied to better support individuals to respond to the stressors in their lives and in turn boost their sense of subjective wellbeing.
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2042041-9
    ISSN 1532-2998 ; 1532-3005
    ISSN (online) 1532-2998
    ISSN 1532-3005
    DOI 10.1002/smi.3341
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  6. Article ; Online: Saturday Night Myelopathy: Flexion Myelopathy Related to Drug Intoxication.

    Martin, Andrew J / Garcia, Maria C

    The neurologist

    2021  Volume 27, Issue 1, Page(s) 27–29

    Abstract: Introduction: Myelopathy is a common condition with a variety of causes, often eluding diagnosis for some time. Prolonged flexion after surgical procedures has been described.: Case report: A 20-year-old female presented with acute paraparesis after ... ...

    Abstract Introduction: Myelopathy is a common condition with a variety of causes, often eluding diagnosis for some time. Prolonged flexion after surgical procedures has been described.
    Case report: A 20-year-old female presented with acute paraparesis after polysubstance drug intoxication and a period of prolonged neck flexion while unconscious. Imaging demonstrated extensive cervicothoracic central cord signal change, in addition to posterior neck musculature hyperintensity. Additional workup directed to other causes was negative. The patient was diagnosed with flexion myelopathy and was treated with a course of steroids, with marked improvement.
    Conclusions: The clinician should consider the possibility of flexion-related myelopathy particularly in cases of drug intoxication or prolonged unconsciousness. Signal change within cervical musculature may provide additional clues and allow diagnosis in a timely manner.
    MeSH term(s) Adult ; Cervical Vertebrae ; Female ; Humans ; Magnetic Resonance Imaging ; Pharmaceutical Preparations ; Range of Motion, Articular ; Spinal Cord Diseases/chemically induced ; Spinal Cord Diseases/diagnostic imaging ; Young Adult
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000349
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    Zs.A 4641: Show issues Location:
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  7. Article ; Online: Adaptability-what it is and what it is not: Comment on Chandra and Leong (2016).

    Martin, Andrew J

    The American psychologist

    2017  Volume 72, Issue 7, Page(s) 696–698

    Abstract: Chandra and Leong (2016) propose a new model of adaptability: the diversified portfolio model (DPM) of adaptability. Further thought and research on adaptability is a welcome addition to the limited body of work conducted on this topic to date. However, ... ...

    Abstract Chandra and Leong (2016) propose a new model of adaptability: the diversified portfolio model (DPM) of adaptability. Further thought and research on adaptability is a welcome addition to the limited body of work conducted on this topic to date. However, in their discussion there is a lack of definitional clarity, and there is frequent conflation of adaptability and resilience. It is also the case that the hypothesized adaptability model is general and could apply to many psychological constructs and processes (not just adaptability). In addition, there are gaps in research suggested by the authors that have been addressed by other researchers and there is a good deal of contemporary adaptability research that is not cited. Addressing these limitations in future work is vital to the further development of theory, research, and practice in the area of adaptability. (PsycINFO Database Record
    Language English
    Publishing date 2017-10-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209464-2
    ISSN 1935-990X ; 0003-066X
    ISSN (online) 1935-990X
    ISSN 0003-066X
    DOI 10.1037/amp0000163
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    Zs.A 997: Show issues Location:
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  8. Article ; Online: Coexistent anti-GFAP and anti-MOG antibodies presenting with isolated meningitis and papillitis: more support for overlapping pathophysiology.

    Martin, Andrew J / Strathdee, James / Wolfe, Nigel

    BMJ neurology open

    2022  Volume 4, Issue 1, Page(s) e000236

    Abstract: Background: Anti-myelin oligodendrocyte glycoprotein (MOG)-associated disorders are heterogeneous and associated predominantly with central nervous system demyelination. Anti-glial fibrillar acidic protein (GFAP) conditions are much rarer and involve ... ...

    Abstract Background: Anti-myelin oligodendrocyte glycoprotein (MOG)-associated disorders are heterogeneous and associated predominantly with central nervous system demyelination. Anti-glial fibrillar acidic protein (GFAP) conditions are much rarer and involve meningoencephalomyelitis with papillitis in addition to characteristic imaging findings and are generally a severe condition. Multiple autoantibodies can exist in patients and may support overlapping pathophysiological mechanisms. The co-occurrence of MOG and GFAP antibodies, however, is rare, with only two cases previously reported.
    Case: A 53-year-old man presented with headache and fevers, with quick resolution, though with the later development of asymptomatic papillitis. He had a full recovery without the need for immunotherapy. He underwent extensive investigations and was found to have both anti-GFAP and anti-MOG antibodies in the cerebrospinal fluid. Extensive other immunological and infectious investigations were negative. Imaging was largely unremarkable.
    Conclusions: This is the third case of overlapping anti-GFAP and anti-MOG antibody-associated syndrome of self-limited lymphocytic meningitis, serving to expand the phenotype. Clinicians should consider testing for GFAP and MOG antibodies in otherwise unexplained meningitis, particularly with associated papillitis. This case may also help provide future insights into the pathophysiology of each condition.
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2021-000236
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  9. Article ; Online: Estimation of the treatment effect following a clinical trial that stopped early for benefit.

    Marschner, Ian C / Schou, Manjula / Martin, Andrew J

    Statistical methods in medical research

    2022  Volume 31, Issue 12, Page(s) 2456–2469

    Abstract: When a clinical trial stops early for benefit, the maximum likelihood estimate (MLE) of the treatment effect may be subject to overestimation bias. Several authors have proposed adjusting for this bias using the conditional MLE, which is obtained by ... ...

    Abstract When a clinical trial stops early for benefit, the maximum likelihood estimate (MLE) of the treatment effect may be subject to overestimation bias. Several authors have proposed adjusting for this bias using the conditional MLE, which is obtained by conditioning on early stopping. However, this approach has a fundamental problem in that the adjusted estimate may not be in the direction of benefit, even though the study has stopped early due to benefit. In this paper, we address this problem by embedding both the MLE and the conditional MLE within a broader class of penalised likelihood estimates, and choosing a member of the class that is a favourable compromise between the two. This penalised MLE, and its associated confidence interval, always lie in the direction of benefit when the study stops early for benefit. We study its properties using both simulations and analyses of the ENZAMET trial in metastatic prostate cancer. Conditional on stopping early for benefit, the method is found to have good unbiasedness and coverage properties, along with very favourable efficiency at earlier interim analyses. We recommend the penalised MLE as a supplementary analysis to a conventional primary analysis when a clinical trial stops early for benefit.
    MeSH term(s) Bias ; Likelihood Functions ; Research Design ; Clinical Trials as Topic
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1136948-6
    ISSN 1477-0334 ; 0962-2802
    ISSN (online) 1477-0334
    ISSN 0962-2802
    DOI 10.1177/09622802221122445
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  10. Article: University students in COVID-19 lockdown: The role of adaptability and fluid reasoning in supporting their academic motivation and engagement.

    Martin, Andrew J / Ginns, Paul / Collie, Rebecca J

    Learning and instruction

    2022  Volume 83, Page(s) 101712

    Abstract: This study drew on Job Demands-Resources theory and data from 500 Australian university students to investigate the role of COVID-related lockdown, perceived adaptability, and fluid reasoning in students' self-efficacy-and the role of these factors in ... ...

    Abstract This study drew on Job Demands-Resources theory and data from 500 Australian university students to investigate the role of COVID-related lockdown, perceived adaptability, and fluid reasoning in students' self-efficacy-and the role of these factors in students' engagement and disengagement. Lockdown was associated with higher disengagement; perceived adaptability was associated with higher self-efficacy; and both perceived adaptability and fluid reasoning were significantly and positively associated with engagement. Self-efficacy significantly mediated the relationship between perceived adaptability and engagement and disengagement, while moderation tests revealed that fluid reasoning yielded a significant positive role for the self-efficacy of students in lockdown. These findings shed light on factors during COVID-19 that are implicated in students' academic development and provide direction for psycho-educational interventions.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2011980-X
    ISSN 1873-3263 ; 0959-4752
    ISSN (online) 1873-3263
    ISSN 0959-4752
    DOI 10.1016/j.learninstruc.2022.101712
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