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  1. Article: Identification of DNA Methylation Changes That Predict Onset of Post-traumatic Stress Disorder and Depression Following Physical Trauma.

    Martin, Carina A / Vorn, Rany / Schrieber, Martin / Lai, Chen / Yun, Sijung / Kim, Hyung-Suk / Gill, Jessica

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 738347

    Abstract: Post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly experienced after exposure to highly stressful events, including physical trauma, yet, biological predictors remain elusive. Methylation of DNA may provide key ... ...

    Abstract Post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly experienced after exposure to highly stressful events, including physical trauma, yet, biological predictors remain elusive. Methylation of DNA may provide key insights, as it likely is reflective of factors that may increase the risk in trauma patients, as DNA methylation is altered by previous stressors. Here, we compared DNA methylation patterns using bisulfite sequencing in patients with a physical trauma that required more than a 24-h hospitalization (
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.738347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population.

    Guedes, Vivian A / Lange, Rael T / Lippa, Sara M / Lai, Chen / Greer, Kisha / Mithani, Sara / Devoto, Christina / A Edwards, Katie / Wagner, Chelsea L / Martin, Carina A / Driscoll, Angela E / Wright, Megan M / Gillow, Kelly C / Baschenis, Samantha M / Brickell, Tracey A / French, Louis M / Gill, Jessica M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4002

    Abstract: Traumatic brain injury (TBI) can be associated with long-term neurobehavioral symptoms. Here, we examined levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in extracellular vesicles isolated from blood, and their ... ...

    Abstract Traumatic brain injury (TBI) can be associated with long-term neurobehavioral symptoms. Here, we examined levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in extracellular vesicles isolated from blood, and their relationship with TBI severity and neurobehavioral symptom reporting. Participants were 218 service members and veterans who sustained uncomplicated mild TBIs (mTBI, n = 107); complicated mild, moderate, or severe TBIs (smcTBI, n = 66); or Injured controls (IC, orthopedic injury without TBI, n = 45). Within one year after injury, but not after, NfL was higher in the smcTBI group than mTBI (p = 0.001, d = 0.66) and IC (p = 0.001, d = 0.35) groups, which remained after controlling for demographics and injury characteristics. NfL also discriminated the smcTBI group from IC (AUC:77.5%, p < 0.001) and mTBI (AUC:76.1%, p < 0.001) groups. No other group differences were observed for NfL or GFAP at either timepoint. NfL correlated with post-concussion symptoms (r
    MeSH term(s) Brain Injuries, Traumatic/complications ; Extracellular Vesicles ; Humans ; Intermediate Filaments ; Military Personnel ; Post-Concussion Syndrome ; Veterans
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05772-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exosomal microRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control.

    Vorn, Rany / Suarez, Maiko / White, Jacob C / Martin, Carina A / Kim, Hyung-Suk / Lai, Chen / Yun, Si-Jung / Gill, Jessica M / Lee, Hyunhwa

    Biomedicines

    2021  Volume 10, Issue 1

    Abstract: Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exomiRNAs) may be important mediators of molecular and cellular changes involved ... ...

    Abstract Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exomiRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10010036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Extracellular Vesicle Proteins and MicroRNAs Are Linked to Chronic Post-Traumatic Stress Disorder Symptoms in Service Members and Veterans With Mild Traumatic Brain Injury.

    Guedes, Vivian A / Lai, Chen / Devoto, Christina / Edwards, Katie A / Mithani, Sara / Sass, Dilorom / Vorn, Rany / Qu, Bao-Xi / Rusch, Heather L / Martin, Carina A / Walker, William C / Wilde, Elisabeth A / Diaz-Arrastia, Ramon / Gill, Jessica M / Kenney, Kimbra

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 745348

    Abstract: Symptoms of post-traumatic stress disorder (PTSD) are common in military populations, and frequently associated with a history of combat-related mild traumatic brain injury (mTBI). In this study, we examined relationships between severity of PTSD ... ...

    Abstract Symptoms of post-traumatic stress disorder (PTSD) are common in military populations, and frequently associated with a history of combat-related mild traumatic brain injury (mTBI). In this study, we examined relationships between severity of PTSD symptoms and levels of extracellular vesicle (EV) proteins and miRNAs measured in the peripheral blood in a cohort of military service members and Veterans (SMs/Vs) with chronic mTBI(s). Participants (
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.745348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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