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Article ; Online: Author Correction: Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets.

Kim, In-Jeong / Lanthier, Paula A / Clark, Madeline J / De La Barrera, Rafael A / Tighe, Michael P / Szaba, Frank M / Travis, Kelsey L / Low-Beer, Timothy C / Cookenham, Tres S / Lanzer, Kathleen G / Bernacki, Derek T / Johnson, Lawrence L / Schneck, Amanda A / Ross, Corinna N / Tardif, Suzette D / Layne-Colon, Donna / Mdaki, Stephanie D / Dick, Edward J / Chuba, Colin /

Gonzalez, Olga / Brasky, Kathleen M / Dutton, John / Rutherford, Julienne N / Coffey, Lark L / Singapuri, Anil / Martin, Claudia Sanchez San / Chiu, Charles Y / Thomas, Stephen J / Modjarrad, Kayvon / Patterson, Jean L / Blackman, Marcia A

NPJ vaccines

2022 Volume 7, Issue 1, Page(s) 99

Language	English
Publishing date	2022-08-20
Publishing country	England
Document type	Published Erratum
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-022-00520-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets.

NPJ vaccines

2022 Volume 7, Issue 1, Page(s) 9

Abstract: Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was ... ...

Abstract	Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was previously shown to be protective in non-pregnant mice and rhesus macaques. In this study, we further examined the efficacy of ZPIV against ZIKV infection during pregnancy in immunocompetent C57BL6 mice and common marmoset monkeys (Callithrix jacchus). We showed that, in C57BL/6 mice, ZPIV significantly reduced ZIKV-induced fetal malformations. Protection of fetuses was positively correlated with virus-neutralizing antibody levels. In marmosets, the vaccine prevented vertical transmission of ZIKV and elicited neutralizing antibodies that remained above a previously determined threshold of protection for up to 18 months. These proof-of-concept studies demonstrate ZPIV's protective efficacy is both potent and durable and has the potential to prevent the harmful consequence of ZIKV infection during pregnancy.
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00426-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood.

Ng, Dianna L / Granados, Andrea C / Santos, Yale A / Servellita, Venice / Goldgof, Gregory M / Meydan, Cem / Sotomayor-Gonzalez, Alicia / Levine, Andrew G / Balcerek, Joanna / Han, Lucy M / Akagi, Naomi / Truong, Kent / Neumann, Neil M / Nguyen, David N / Bapat, Sagar P / Cheng, Jing / Martin, Claudia Sanchez-San / Federman, Scot / Foox, Jonathan /

Gopez, Allan / Li, Tony / Chan, Ray / Chu, Cynthia S / Wabl, Chiara A / Gliwa, Amelia S / Reyes, Kevin / Pan, Chao-Yang / Guevara, Hugo / Wadford, Debra / Miller, Steve / Mason, Christopher E / Chiu, Charles Y

Science advances

2021 Volume 7, Issue 6

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA sequencing to analyze 286 nasopharyngeal (NP) swab and 53 whole-blood (WB) samples ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA sequencing to analyze 286 nasopharyngeal (NP) swab and 53 whole-blood (WB) samples from 333 patients with COVID-19 and controls. Overall, a muted immune response was observed in COVID-19 relative to other infections (influenza, other seasonal coronaviruses, and bacterial sepsis), with paradoxical down-regulation of several key differentially expressed genes. Hospitalized patients and outpatients exhibited up-regulation of interferon-associated pathways, although heightened and more robust inflammatory responses were observed in hospitalized patients with more clinically severe illness. Two-layer machine learning-based host classifiers consisting of complete (>1000 genes), medium (<100), and small (<20) gene biomarker panels identified COVID-19 disease with 85.1-86.5% accuracy when benchmarked using an independent test set. SARS-CoV-2 infection has a distinct biosignature that differs between NP swabs and WB and can be leveraged for COVID-19 diagnosis.
MeSH term(s)	Area Under Curve ; COVID-19/diagnosis ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Gene Library ; Humans ; Machine Learning ; Nasopharynx/virology ; RNA, Viral/blood ; RNA, Viral/metabolism ; ROC Curve ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; Transcriptome
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abe5984
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.

Deng, Xianding / Garcia-Knight, Miguel A / Khalid, Mir M / Servellita, Venice / Wang, Candace / Morris, Mary Kate / Sotomayor-González, Alicia / Glasner, Dustin R / Reyes, Kevin R / Gliwa, Amelia S / Reddy, Nikitha P / Martin, Claudia Sanchez San / Federman, Scot / Cheng, Jing / Balcerek, Joanna / Taylor, Jordan / Streithorst, Jessica A / Miller, Steve / Kumar, G Renuka /

Sreekumar, Bharath / Chen, Pei-Yi / Schulze-Gahmen, Ursula / Taha, Taha Y / Hayashi, Jennifer / Simoneau, Camille R / McMahon, Sarah / Lidsky, Peter V / Xiao, Yinghong / Hemarajata, Peera / Green, Nicole M / Espinosa, Alex / Kath, Chantha / Haw, Monica / Bell, John / Hacker, Jill K / Hanson, Carl / Wadford, Debra A / Anaya, Carlos / Ferguson, Donna / Lareau, Liana F / Frankino, Phillip A / Shivram, Haridha / Wyman, Stacia K / Ott, Melanie / Andino, Raul / Chiu, Charles Y

medRxiv : the preprint server for health sciences

2021

Abstract: We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California. Named B.1.427/B.1.429 to denote its 2 lineages, the variant emerged around May 2020 and increased from 0% ...

Abstract	We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California. Named B.1.427/B.1.429 to denote its 2 lineages, the variant emerged around May 2020 and increased from 0% to >50% of sequenced cases from September 1, 2020 to January 29, 2021, exhibiting an 18.6-24% increase in transmissibility relative to wild-type circulating strains. The variant carries 3 mutations in the spike protein, including an L452R substitution. Our analyses revealed 2-fold increased B.1.427/B.1.429 viral shedding in vivo and increased L452R pseudovirus infection of cell cultures and lung organoids, albeit decreased relative to pseudoviruses carrying the N501Y mutation found in the B.1.1.7, B.1.351, and P.1 variants. Antibody neutralization assays showed 4.0 to 6.7-fold and 2.0-fold decreases in neutralizing titers from convalescent patients and vaccine recipients, respectively. The increased prevalence of a more transmissible variant in California associated with decreased antibody neutralization warrants further investigation.
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.03.07.21252647
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood.

Ng, Dianna L / Goldgof, Gregory M / Shy, Brian R / Levine, Andrew G / Balcerek, Joanna / Bapat, Sagar P / Prostko, John / Rodgers, Mary / Coller, Kelly / Pearce, Sandra / Franz, Sergej / Du, Li / Stone, Mars / Pillai, Satish K / Sotomayor-Gonzalez, Alicia / Servellita, Venice / Martin, Claudia Sanchez San / Granados, Andrea / Glasner, Dustin R /

Han, Lucy M / Truong, Kent / Akagi, Naomi / Nguyen, David N / Neumann, Neil M / Qazi, Daniel / Hsu, Elaine / Gu, Wei / Santos, Yale A / Custer, Brian / Green, Valerie / Williamson, Phillip / Hills, Nancy K / Lu, Chuanyi M / Whitman, Jeffrey D / Stramer, Susan L / Wang, Candace / Reyes, Kevin / Hakim, Jill M C / Sujishi, Kirk / Alazzeh, Fariba / Pham, Lori / Thornborrow, Edward / Oon, Ching-Ying / Miller, Steve / Kurtz, Theodore / Simmons, Graham / Hackett, John / Busch, Michael P / Chiu, Charles Y

Nature communications

2020 Volume 11, Issue 1, Page(s) 4698

Abstract: Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area ... ...

Abstract	Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors in early April 2020. We additionally describe the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizing antibody titers in COVID-19 patients. The median time to seroconversion ranged from 10.3-11.0 days for these 3 assays. Neutralizing antibodies rose in tandem with immunoglobulin titers following symptom onset, and positive percent agreement between detection of IgG and neutralizing titers was >93%. These findings emphasize the importance of using highly accurate tests for surveillance studies in low-prevalence populations, and provide evidence that seroreactivity using SARS-CoV-2 anti-nucleocapsid protein IgG and anti-spike IgM assays are generally predictive of in vitro neutralizing capacity.
MeSH term(s)	Antibodies, Neutralizing/blood ; Antibodies, Viral/immunology ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; San Francisco/epidemiology ; Sensitivity and Specificity ; Seroepidemiologic Studies ; Serologic Tests/methods
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Keywords	covid19
Language	English
Publishing date	2020-09-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18468-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.

Ng, Dianna L / Goldgof, Gregory M / Shy, Brian R / Levine, Andrew G / Balcerek, Joanna / Bapat, Sagar P / Prostko, John / Rodgers, Mary / Coller, Kelly / Pearce, Sandy / Franz, Sergej / Du, Li / Stone, Mars / Pillai, Satish K / Sotomayor-Gonzalez, Alicia / Servellita, Venice / Martin, Claudia Sanchez San / Granados, Andrea / Glasner, Dustin R /

Han, Lucy M / Truong, Kent / Akagi, Naomi / Nguyen, David N / Neumann, Neil M / Qazi, Daniel / Hsu, Elaine / Gu, Wei / Santos, Yale A / Custer, Brian / Green, Valerie / Williamson, Phillip / Hills, Nancy K / Lu, Chuanyi M / Whitman, Jeffrey D / Stramer, Susan / Wang, Candace / Reyes, Kevin / Hakim, Jill M C / Sujishi, Kirk / Alazzeh, Fariba / Pham, Lori / Oon, Ching-Ying / Miller, Steve / Kurtz, Theodore / Hackett, John / Simmons, Graham / Busch, Michael P / Chiu, Charles Y

medRxiv : the preprint server for health sciences

2020

Abstract: We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the ... ...

Abstract	We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.
Keywords	covid19
Language	English
Publishing date	2020-05-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.05.19.20107482
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley, Dawn M / Van Rompay, Koen K / Coffey, Lark L / Ardeshir, Amir / Keesler, Rebekah I / Bliss-Moreau, Eliza / Grigsby, Peta L / Steinbach, Rosemary J / Hirsch, Alec J / MacAllister, Rhonda P / Pecoraro, Heidi L / Colgin, Lois M / Hodge, Travis / Streblow, Daniel N / Tardif, Suzette / Patterson, Jean L / Tamhankar, Manasi / Seferovic, Maxim / Aagaard, Kjersti M /

Martín, Claudia Sánchez-San / Chiu, Charles Y / Panganiban, Antonito T / Veazey, Ronald S / Wang, Xiaolei / Maness, Nicholas J / Gilbert, Margaret H / Bohm, Rudolf P / Adams Waldorf, Kristina M / Gale, Michael / Rajagopal, Lakshmi / Hotchkiss, Charlotte E / Mohr, Emma L / Capuano, Saverio V / Simmons, Heather A / Mejia, Andres / Friedrich, Thomas C / Golos, Thaddeus G / O'Connor, David H

Nature medicine

2018 Volume 24, Issue 8, Page(s) 1104–1107

Abstract: Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few ... ...

Abstract	Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
MeSH term(s)	Abortion, Spontaneous/virology ; Animals ; Female ; Kaplan-Meier Estimate ; Male ; Pregnancy ; Primates ; Stillbirth/veterinary ; Zika Virus/physiology ; Zika Virus Infection/veterinary
Language	English
Publishing date	2018-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-018-0088-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood

Nat Commun

Abstract	Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors in early April 2020. We additionally describe the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizing antibody titers in COVID-19 patients. The median time to seroconversion ranged from 10.3-11.0 days for these 3 assays. Neutralizing antibodies rose in tandem with immunoglobulin titers following symptom onset, and positive percent agreement between detection of IgG and neutralizing titers was >93%. These findings emphasize the importance of using highly accurate tests for surveillance studies in low-prevalence populations, and provide evidence that seroreactivity using SARS-CoV-2 anti-nucleocapsid protein IgG and anti-spike IgM assays are generally predictive of in vitro neutralizing capacity.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #780000
Database	COVID19

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Article ; Online: SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood

Ng, Dianna L. / Goldgof, Gregory M. / Shy, Brian R. / Levine, Andrew G. / Balcerek, Joanna / Bapat, Sagar P. / Prostko, John / Rodgers, Mary / Coller, Kelly / Pearce, Sandra / Franz, Sergej / Du, Li / Stone, Mars / Pillai, Satish K. / Sotomayor-Gonzalez, Alicia / Servellita, Venice / Martin, Claudia Sanchez San / Granados, Andrea / Glasner, Dustin R. /

Han, Lucy M. / Truong, Kent / Akagi, Naomi / Nguyen, David N. / Neumann, Neil M. / Qazi, Daniel / Hsu, Elaine / Gu, Wei / Santos, Yale A. / Custer, Brian / Green, Valerie / Williamson, Phillip / Hills, Nancy K. / Lu, Chuanyi M. / Whitman, Jeffrey D. / Stramer, Susan L. / Wang, Candace / Reyes, Kevin / Hakim, Jill M. C. / Sujishi, Kirk / Alazzeh, Fariba / Pham, Lori / Thornborrow, Edward / Oon, Ching-Ying / Miller, Steve / Kurtz, Theodore / Simmons, Graham / Hackett, John / Busch, Michael P. / Chiu, Charles Y.

Nature Communications

2020 Volume 11, Issue 1

Abstract: Abstract Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area ... ...

Abstract	Abstract Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors in early April 2020. We additionally describe the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizing antibody titers in COVID-19 patients. The median time to seroconversion ranged from 10.3–11.0 days for these 3 assays. Neutralizing antibodies rose in tandem with immunoglobulin titers following symptom onset, and positive percent agreement between detection of IgG and neutralizing titers was >93%. These findings emphasize the importance of using highly accurate tests for surveillance studies in low-prevalence populations, and provide evidence that seroreactivity using SARS-CoV-2 anti-nucleocapsid protein IgG and anti-spike IgM assays are generally predictive of in vitro neutralizing capacity.
Keywords	General Biochemistry, Genetics and Molecular Biology ; General Physics and Astronomy ; General Chemistry ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2553671-0
ISSN	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18468-8
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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