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  1. Article ; Online: Odile Bain (April 28, 1939-October 16, 2012): a life dedicated to systematics and biology of filariae.

    Martin, Coralie

    PLoS neglected tropical diseases

    2014  Volume 8, Issue 2, Page(s) e2565

    MeSH term(s) Animals ; Biomedical Research/history ; Disease Models, Animal ; Female ; Filariasis ; Filarioidea ; France ; History, 20th Century ; History, 21st Century ; Humans ; Mice ; Parasitology/history ; Vietnam
    Language English
    Publishing date 2014-02-13
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0002565
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  2. Article ; Online: Obituary: Odile Bain (28/04/1939-16/10/2012).

    Martin, Coralie

    Parasite (Paris, France)

    2013  Volume 20, Page(s) 22

    MeSH term(s) France ; History, 20th Century ; History, 21st Century ; Parasitology/history ; Research/history
    Language English
    Publishing date 2013-06-19
    Publishing country France
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1187629-3
    ISSN 1776-1042 ; 1252-607X
    ISSN (online) 1776-1042
    ISSN 1252-607X
    DOI 10.1051/parasite/2013022
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  3. Article: Wolbachia

    Rodrigues, Jules / Lefoulon, Emilie / Gavotte, Laurent / Perillat-Sanguinet, Marco / Makepeace, Benjamin / Martin, Coralie / D'Haese, Cyrille A

    Royal Society open science

    2023  Volume 10, Issue 5, Page(s) 230288

    Abstract: ... ...

    Abstract Wolbachia
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.230288
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  4. Article ; Online: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.

    Lenz, Benjamin / Ehrens, Alexandra / Ajendra, Jesuthas / Risch, Frederic / Gal, Joséphine / Neumann, Anna-Lena / Reichwald, Julia J / Strutz, Wiebke / McSorley, Henry J / Martin, Coralie / Hoerauf, Achim / Hübner, Marc P

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012071

    Abstract: Background: Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune ... ...

    Abstract Background: Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune disease-driven pathology is still not sufficiently understood. In this study, we established a mouse model for microfilariae-induced eosinophilic lung disease (ELD), a manifestation caused by eosinophil hyper-responsiveness within the lung.
    Methods: Wild-type (WT) BALB/c mice were sensitized with dead microfilariae (MF) of the rodent filarial nematode Litomosoides sigmodontis three times at weekly intervals and subsequently challenged with viable MF to induce ELD. The resulting immune response was compared to non-sensitized WT mice as well as sensitized eosinophil-deficient dblGATA mice using flow cytometry, lung histology and ELISA. Additionally, the impact of IL-33 signaling on ELD development was investigated using the IL-33 antagonist HpARI2.
    Results: ELD-induced WT mice displayed an increased type 2 immune response in the lung with increased frequencies of eosinophils, alternatively activated macrophages and group 2 innate lymphoid cells, as well as higher peripheral blood IgE, IL-5 and IL-33 levels in comparison to mice challenged only with viable MF or PBS. ELD mice had an increased MF retention in lung tissue, which was in line with an enhanced MF clearance from peripheral blood. Using eosinophil-deficient dblGATA mice, we demonstrate that eosinophils are essentially involved in driving the type 2 immune response and retention of MF in the lung of ELD mice. Furthermore, we demonstrate that IL-33 drives eosinophil activation in vitro and inhibition of IL-33 signaling during ELD induction reduces pulmonary type 2 immune responses, eosinophil activation and alleviates lung lacunarity. In conclusion, we demonstrate that IL-33 signaling is essentially involved in MF-induced ELD development.
    Summary: Our study demonstrates that repeated sensitization of BALB/c mice with L. sigmodontis MF induces pulmonary eosinophilia in an IL-33-dependent manner. The newly established model recapitulates the characteristic features known to occur during eosinophilic lung diseases (ELD) such as human tropical pulmonary eosinophilia (TPE), which includes the retention of microfilariae in the lung tissue and induction of pulmonary eosinophilia and type 2 immune responses. Our study provides compelling evidence that IL-33 drives eosinophil activation during ELD and that blocking IL-33 signaling using HpARI2 reduces eosinophil activation, eosinophil accumulation in the lung tissue, suppresses type 2 immune responses and mitigates the development of structural damage to the lung. Consequently, IL-33 is a potential therapeutic target to reduce eosinophil-mediated pulmonary pathology.
    MeSH term(s) Humans ; Animals ; Mice ; Microfilariae ; Pulmonary Eosinophilia ; Immunity, Innate ; Filariasis/parasitology ; Interleukin-33 ; Lymphocytes/pathology ; Filarioidea/physiology ; Asthma ; Eosinophils ; Mice, Inbred BALB C
    Chemical Substances Interleukin-33
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012071
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  5. Article: The efficacy of the benzimidazoles oxfendazole and flubendazole against

    Risch, Frederic / Scheunemann, Johanna F / Reichwald, Julia J / Lenz, Benjamin / Ehrens, Alexandra / Gal, Joséphine / Fercoq, Frédéric / Koschel, Marianne / Fendler, Martina / Hoerauf, Achim / Martin, Coralie / Hübner, Marc P

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1213143

    Abstract: Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently under ... ...

    Abstract Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently under preparation for phase 2 clinical trials in filariasis patients. This study aimed to investigate the immune system's role during treatment with OXF and FBZ and explore the potential to boost the treatment efficacy via stimulation of the immune system. Wild type (WT) BALB/c, eosinophil-deficient
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1213143
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  6. Article ; Online: Machine learning approach to support taxonomic species discrimination based on helminth collections data.

    Borba, Victor Hugo / Martin, Coralie / Machado-Silva, José Roberto / Xavier, Samanta C C / de Mello, Flávio L / Iñiguez, Alena Mayo

    Parasites & vectors

    2021  Volume 14, Issue 1, Page(s) 230

    Abstract: Background: There are more than 300 species of capillariids that parasitize various vertebrate groups worldwide. Species identification is hindered because of the few taxonomically informative structures available, making the task laborious and genus ... ...

    Abstract Background: There are more than 300 species of capillariids that parasitize various vertebrate groups worldwide. Species identification is hindered because of the few taxonomically informative structures available, making the task laborious and genus definition controversial. Thus, its taxonomy is one of the most complex among Nematoda. Eggs are the parasitic structures most viewed in coprological analysis in both modern and ancient samples; consequently, their presence is indicative of positive diagnosis for infection. The structure of the egg could play a role in genera or species discrimination. Institutional biological collections are taxonomic repositories of specimens described and strictly identified by systematics specialists.
    Methods: The present work aims to characterize eggs of capillariid species deposited in institutional helminth collections and to process the morphological, morphometric and ecological data using machine learning (ML) as a new approach for taxonomic identification. Specimens of 28 species and 8 genera deposited at Coleção Helmintológica do Instituto Oswaldo Cruz (CHIOC, IOC/FIOCRUZ/Brazil) and Collection de Nématodes Zooparasites du Muséum National d'Histoire Naturelle de Paris (MNHN/France) were examined under light microscopy. In the morphological and morphometric analyses (MM), the total length and width of eggs as well as plugs and shell thickness were considered. In addition, eggshell ornamentations and ecological parameters of the geographical location (GL) and host (H) were included.
    Results: The performance of the logistic model tree (LMT) algorithm showed the highest values in all metrics compared with the other algorithms. Algorithm J48 produced the most reliable decision tree for species identification alongside REPTree. The Majority Voting algorithm showed high metric values, but the combined classifiers did not attenuate the errors revealed in each algorithm alone. The statistical evaluation of the dataset indicated a significant difference between trees, with GL + H + MM and MM only with the best scores.
    Conclusions: The present research proposed a novel procedure for taxonomic species identification, integrating data from centenary biological collections and the logic of artificial intelligence techniques. This study will support future research on taxonomic identification and diagnosis of both modern and archaeological capillariids.
    MeSH term(s) Animals ; Classification ; Collections as Topic ; Helminths/classification ; Machine Learning/trends ; Nematoda/classification
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-021-04721-6
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  7. Article: Machine learning approach to support taxonomic species discrimination based on helminth collections data

    Borba, Victor Hugo / Martin, Coralie / Machado-Silva, José Roberto / Xavier, Samanta C. C / de Mello, Flávio L / Iñiguez, Alena Mayo

    Parasites & vectors. 2021 Dec., v. 14, no. 1

    2021  

    Abstract: BACKGROUND: There are more than 300 species of capillariids that parasitize various vertebrate groups worldwide. Species identification is hindered because of the few taxonomically informative structures available, making the task laborious and genus ... ...

    Abstract BACKGROUND: There are more than 300 species of capillariids that parasitize various vertebrate groups worldwide. Species identification is hindered because of the few taxonomically informative structures available, making the task laborious and genus definition controversial. Thus, its taxonomy is one of the most complex among Nematoda. Eggs are the parasitic structures most viewed in coprological analysis in both modern and ancient samples; consequently, their presence is indicative of positive diagnosis for infection. The structure of the egg could play a role in genera or species discrimination. Institutional biological collections are taxonomic repositories of specimens described and strictly identified by systematics specialists. METHODS: The present work aims to characterize eggs of capillariid species deposited in institutional helminth collections and to process the morphological, morphometric and ecological data using machine learning (ML) as a new approach for taxonomic identification. Specimens of 28 species and 8 genera deposited at Coleção Helmintológica do Instituto Oswaldo Cruz (CHIOC, IOC/FIOCRUZ/Brazil) and Collection de Nématodes Zooparasites du Muséum National d’Histoire Naturelle de Paris (MNHN/France) were examined under light microscopy. In the morphological and morphometric analyses (MM), the total length and width of eggs as well as plugs and shell thickness were considered. In addition, eggshell ornamentations and ecological parameters of the geographical location (GL) and host (H) were included. RESULTS: The performance of the logistic model tree (LMT) algorithm showed the highest values in all metrics compared with the other algorithms. Algorithm J48 produced the most reliable decision tree for species identification alongside REPTree. The Majority Voting algorithm showed high metric values, but the combined classifiers did not attenuate the errors revealed in each algorithm alone. The statistical evaluation of the dataset indicated a significant difference between trees, with GL + H + MM and MM only with the best scores. CONCLUSIONS: The present research proposed a novel procedure for taxonomic species identification, integrating data from centenary biological collections and the logic of artificial intelligence techniques. This study will support future research on taxonomic identification and diagnosis of both modern and archaeological capillariids.
    Keywords Nematoda ; algorithms ; archaeology ; artificial intelligence ; data collection ; decision support systems ; egg shell ; eggs ; helminths ; light microscopy ; logit analysis ; morphometry ; species identification ; vertebrates ; Brazil ; France
    Language English
    Dates of publication 2021-12
    Size p. 230.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2409480-8
    ISSN 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-021-04721-6
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  8. Article ; Online: Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels.

    Kilarski, Witold W / Martin, Coralie / Pisano, Marco / Bain, Odile / Babayan, Simon A / Swartz, Melody A

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 2895

    Abstract: Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine ... ...

    Abstract Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors assisting in filariae dissemination, we image Litomosoides sigmodontis infective larvae during their escape from the skin. Burrowing through the dermis filariae exclusively enter pre-collecting lymphatics by mechanical disruption of their wall. Once inside collectors, their rapid and unidirectional movement towards the lymph node is supported by the morphology of lymphatic valves. In a microfluidic maze mimicking lymphatic vessels, filariae follow the direction of the flow, the first biomechanical factor capable of helminth guidance within the host. Finally, non-infective nematodes that rely on universal morpho-physiological cues alone also migrate through the dermis, and break in lymphatics, indicating that the ability to spread by the lymphatic route is an ancestral trait rather than acquired parasitic adaptation.
    MeSH term(s) Animals ; Female ; Filariasis/parasitology ; Filarioidea/physiology ; Humans ; Lymphatic System/blood supply ; Lymphatic System/parasitology ; Lymphatic Vessels/parasitology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Skin/parasitology
    Language English
    Publishing date 2019-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-10675-2
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  9. Article: Zoonotic infection caused by Onchocerca japonica (Nematoda: Filarioidea) in a 69-year-old woman in Kanto Region, Eastern Honshu, Japan

    Okazaki, Daijiro / Fukuda, Masako / Hebisawa, Akira / Uni, Shigehiko / Junker, Kerstin / Suzuki, Yoshio / Nakano, Michiyo / Agatsuma, Takeshi / Hasegawa, Hideo / Yamada, Minoru / Nakatani, Jun / Hara, Tatsuru / Martin, Coralie / Kimura, Daisuke / Takaoka, Hiroyuki

    Parasitology international. 2022 Dec., v. 91

    2022  

    Abstract: Reports of zoonotic infections caused by the filarial nematode Onchocerca japonica have recently increased in Japan. A 69-year-old woman living in Sosa City, Chiba Prefecture, Kanto Region, Honshu, developed a painful nodule at the metacarpophalangeal ... ...

    Abstract Reports of zoonotic infections caused by the filarial nematode Onchocerca japonica have recently increased in Japan. A 69-year-old woman living in Sosa City, Chiba Prefecture, Kanto Region, Honshu, developed a painful nodule at the metacarpophalangeal joint of the index finger of her right hand. The causative agent was identified as a female O. japonica based on the histopathological characteristics (i.e., cuticle with transverse triangular ridges but without inner striae) of the biopsy specimens of the nodule. The species identification was corroborated by cox1 gene sequencing of the worm tissues isolated from paraffin-embedded sections of the specimens. Subsequent to the excision of the nodule, followed by anthelmintic treatment, the patient remained asymptomatic. Human infection with O. japonica has not previously been reported in Kanto Region, Eastern Honshu. The present case is likely linked to the recent expansion of the geographic range of the Japanese wild boar into this area.
    Keywords Japan ; Onchocerca ; anthelmintics ; biopsy ; etiological agents ; excision ; females ; genes ; geographical distribution ; histopathology ; parasitology ; patients ; species identification ; wild boars ; women ; zoonoses
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1363151-2
    ISSN 1383-5769
    ISSN 1383-5769
    DOI 10.1016/j.parint.2022.102643
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  10. Article ; Online: Redescription, molecular characterisation and

    Mat Udin, Ahmad Syihan / Uni, Shigehiko / Rodrigues, Jules / Martin, Coralie / Junker, Kerstin / Agatsuma, Takeshi / Low, Van Lun / Saijuntha, Weerachai / Omar, Hasmahzaiti / Zainuri, Nur Afiqah / Fukuda, Masako / Matsubayashi, Makoto / Kimura, Daisuke / Takaoka, Hiroyuki / Ramli, Rosli

    Current research in parasitology & vector-borne diseases

    2023  Volume 5, Page(s) 100154

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2023-11-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-114X
    ISSN (online) 2667-114X
    DOI 10.1016/j.crpvbd.2023.100154
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