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  1. Article ; Online: The Effect of Priority Given to Donor Card Holders on the Allocation of Livers for Transplant-Evidence From 7 Years of the Israeli Priority Program.

    Martin, Dominique E

    Transplantation

    2021  Volume 106, Issue 2, Page(s) 243–244

    MeSH term(s) Humans ; Israel ; Liver ; Tissue and Organ Procurement ; Waiting Lists
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003731
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
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  2. Article ; Online: Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults.

    Martin, Dominique E / Cadar, Andreia N / Bartley, Jenna M

    Frontiers in aging

    2023  Volume 4, Page(s) 1272336

    Abstract: In the face of global pathogens such as influenza (flu) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strategies beyond standard vaccines and virus-specific treatments are critically needed for older populations who are more ... ...

    Abstract In the face of global pathogens such as influenza (flu) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strategies beyond standard vaccines and virus-specific treatments are critically needed for older populations who are more susceptible to severe disease and death from these infections due to age-related immune dysregulation. Thus, complimentary therapeutics are needed to address the increased risk of complications and death in older adults. Metformin, an FDA approved diabetes drug, is an attractive therapeutic candidate to improve immune defenses and resilience in older adults facing viral challenge. Metformin is already a candidate anti-aging drug, but its benefits have potential to span beyond this and improve specific immune responses. Metformin can target multiple aging hallmarks as well as directly impact innate and adaptive immune cell subsets. Both retrospective and prospective studies have demonstrated metformin's efficacy in improving outcomes after SARS-CoV-2 or flu infections. Moreover, evidence from clinical trials has also suggested that metformin treatment can improve vaccination responses. In totality, these findings suggest that metformin can improve age-related declines in immunological resilience. Strategies to improve outcomes after infection or improve vaccine-induced protection are invaluable for older adults. Moreover, the ability to repurpose an already FDA approved drug has significant advantages in terms of necessary time and resources. Thus, metformin has great potential as a therapeutic to improve age-related immune dysregulation during flu and SARS-CoV-2 infections and should be further explored to confirm its ability to improve overall immunological resilience in older adults.
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2023.1272336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Certainty, Science, and the Brain-Based Definition of Death.

    Martin, Dominique E / Forlini, Cynthia / Tumilty, Emma

    AJOB neuroscience

    2023  Volume 14, Issue 3, Page(s) 279–282

    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2576262-X
    ISSN 2150-7759 ; 2150-7740
    ISSN (online) 2150-7759
    ISSN 2150-7740
    DOI 10.1080/21507740.2023.2237475
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    Zs.A 6886: Show issues Location:
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  4. Article: Targeting the hallmarks of aging to improve influenza vaccine responses in older adults.

    Cadar, Andreia N / Martin, Dominique E / Bartley, Jenna M

    Immunity & ageing : I & A

    2023  Volume 20, Issue 1, Page(s) 23

    Abstract: Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection remains a significant burden on older populations and often results in catastrophic disability in those who survive infection. Despite ...

    Abstract Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection remains a significant burden on older populations and often results in catastrophic disability in those who survive infection. Despite having vaccines designed specifically for older adults, the burden of flu remains high and overall flu vaccine efficacy remains inadequate in this population. Recent geroscience research has highlighted the utility in targeting biological aging to improve multiple age-related declines. Indeed, the response to vaccination is highly coordinated, and diminished responses in older adults are likely not due to a singular deficit, but rather a multitude of age-related declines. In this review we highlight deficits in the aged vaccine responses and potential geroscience guided approaches to overcome these deficits. More specifically, we propose that alternative vaccine platforms and interventions that target the hallmarks of aging, including inflammation, cellular senescence, microbiome disturbances, and mitochondrial dysfunction, may improve vaccine responses and overall immunological resilience in older adults. Elucidating novel interventions and approaches that enhance immunological protection from vaccination is crucial to minimize the disproportionate effect of flu and other infectious diseases on older adults.
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2168941-6
    ISSN 1742-4933
    ISSN 1742-4933
    DOI 10.1186/s12979-023-00348-6
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  5. Article ; Online: An equitable approach to enhancing the privacy of consumer information on

    Hollo, Zachary / Martin, Dominique E

    Health information management : journal of the Health Information Management Association of Australia

    2021  , Page(s) 18333583211019764

    Abstract: Australia's national electronic health record (EHR), ...

    Abstract Australia's national electronic health record (EHR),
    Language English
    Publishing date 2021-06-16
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2390067-2
    ISSN 1833-3575 ; 1833-3583
    ISSN (online) 1833-3575
    ISSN 1833-3583
    DOI 10.1177/18333583211019764
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  6. Article ; Online: In Defense of Patient Autonomy in Kidney Failure Care When Treatment Choices Are Limited.

    Martin, Dominique E / Muller, Elmi

    Seminars in nephrology

    2021  Volume 41, Issue 3, Page(s) 242–252

    Abstract: Respect for patient autonomy is a primary ethical obligation of health care providers. In kidney health care, clinical practice recommendations commonly include strategies to promote shared decision making with patients and their families about treatment ...

    Abstract Respect for patient autonomy is a primary ethical obligation of health care providers. In kidney health care, clinical practice recommendations commonly include strategies to promote shared decision making with patients and their families about treatment options to promote patient autonomy and improve patient outcomes. However, for many people with kidney failure, treatment options may be unavailable or inaccessible. In these circumstances some clinicians may act paternalistically and withhold information from patients because of a fear of causing harm or because clinicians believe that patient autonomy is not a relevant consideration. In this article, we reflect on the concept of autonomy in the context of clinical decision making in kidney failure care, with particular attention to resource-constrained settings and the disclosure of information to patients for whom treatment may be inaccessible. We examine and address key concerns that patient autonomy may be impossible, irrelevant, or harmful in the context of limited treatment choices, and discuss factors that may influence paternalistic practices in such settings. We conclude that respect for autonomy is intrinsically and instrumentally valuable, and argue that in neglecting patient autonomy in resource-constrained settings, clinicians may exacerbate and entrench the structural inequalities and health inequities they are committed to addressing.
    MeSH term(s) Decision Making ; Health Inequities ; Humans ; Personal Autonomy ; Renal Insufficiency
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2021.05.005
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    Se 784: Show issues Location:
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  7. Article ; Online: Ethical Aspects of Kidney Donation and Transplantation for Migrants.

    Martin, Dominique E / Fadhil, Riadh A S / Więcek, Andrzej

    Seminars in nephrology

    2022  Volume 42, Issue 4, Page(s) 151271

    Abstract: Migrants represent a large and diverse population globally that includes international refugees, stateless persons, expatriate workers, and more. Many migrants face significant barriers in accessing health care, especially scarce and costly resources ... ...

    Abstract Migrants represent a large and diverse population globally that includes international refugees, stateless persons, expatriate workers, and more. Many migrants face significant barriers in accessing health care, especially scarce and costly resources such as dialysis and kidney transplantation. Improving equity of access to these kidney replacement therapies for migrant populations may present a range of complex ethical dilemmas, particularly in the setting of crises and when considering the use of residency status and citizenship as eligibility criteria for access to treatment. In this article, we discuss ethical obligations to provide kidney care for migrants, the implications of the self-sufficiency concept with regard to access to deceased donation and transplantation, factors that may influence evaluation of the risks and benefits of transplantation for migrants with insecure access to care, and the vulnerability of migrants to organ trafficking. We also present a set of general recommendations to assist in preventing and managing ethical dilemmas when making decisions about policy or practice regarding kidney care for migrants.
    MeSH term(s) Humans ; Transients and Migrants ; Health Services Accessibility ; Renal Dialysis ; Kidney Transplantation ; Kidney
    Language English
    Publishing date 2022-12-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2022.07.005
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  8. Article ; Online: Transitions in decision-making authority at the end of life: a problem of law, ethics and practice in deceased donation.

    Then, Shih-Ning / Martin, Dominique E

    Journal of medical ethics

    2020  Volume 48, Issue 2, Page(s) 112–117

    Abstract: Where a person is unable to make medical decisions for themselves, law and practice allows others to make decisions on their behalf. This is common at the end of a person's life where decision-making capacity is often lost. A further, and separate, ... ...

    Abstract Where a person is unable to make medical decisions for themselves, law and practice allows others to make decisions on their behalf. This is common at the end of a person's life where decision-making capacity is often lost. A further, and separate, decision that is often considered at the time of death (and often preceding death) is whether the person wanted to act as an organ or tissue donor. However, in some jurisdictions, the lawful decision-maker for the donation decision (the 'donation decision-maker') is different from the person who was granted decision-making authority for medical decisions during the person's life. To date, little attention has been given in the literature to the ethical concerns and practical problems that arise where this shift in legal authority occurs. Such a change in decision-making authority is particularly problematic where premortem measures are suggested to maximise the chances of a successful organ donation. This paper examines this shift in decision-making authority and discusses the legal, ethical and practical implications of such frameworks.
    MeSH term(s) Death ; Decision Making ; Humans ; Morals ; Organ Transplantation ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2020-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2020-106572
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  9. Article ; Online: A Call for Dialysis-Specific Resource Allocation Guidelines During COVID-19.

    Parsons, Jordan A / Martin, Dominique E

    The American journal of bioethics : AJOB

    2020  Volume 20, Issue 7, Page(s) 199–201

    MeSH term(s) Betacoronavirus ; Bioethics ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Renal Dialysis ; Resource Allocation ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2020.1777346
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  10. Article ; Online: Trade in kidneys is ethically intolerable.

    Martin, Dominique E

    Indian journal of medical ethics

    2016  Volume 1, Issue 3, Page(s) 180–183

    Abstract: In India, as in most countries where trade in human organs is legally prohibited, policies governing transplantation from living donors are designed to identify and exclude prospective donors who have a commercial interest in donation. The effective ... ...

    Abstract In India, as in most countries where trade in human organs is legally prohibited, policies governing transplantation from living donors are designed to identify and exclude prospective donors who have a commercial interest in donation. The effective implementation of such policies requires resources, training and motivation on the part of health professionals responsible for organ procurement and transplantation. If professionals are unconvinced by or unfamiliar with the ethical justification of the relevant laws and policies, they may fail to perform a robust evaluation of prospective donors and transplant candidates, and to act on suspicions or evidence of illicit activities. I comment here on a recent paper by Aggarwal and Adhikary (2016), in which the authors imply that tolerance of illicit commercialism in living kidney donation programmes is not unreasonable, given the insufficiency of kidneys available for transplantation. I argue that such tolerance is unethical not only because of the harmful consequences of kidney trafficking, but because professional tolerance of commercialism undermines public trust in organ procurement programmes and impairs the development of sustainable donation and transplant systems.
    MeSH term(s) Humans ; India ; Kidney Transplantation/ethics ; Living Donors/ethics ; Prospective Studies ; Tissue Donors/ethics ; Tissue and Organ Procurement
    Language English
    Publishing date 2016-07
    Publishing country India
    Document type Journal Article ; Comment
    ISSN 0975-5691
    ISSN (online) 0975-5691
    DOI 10.20529/IJME.2016.049
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