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Article: L’architecture comme expérience, habiter autrement avec la philosophie de John Dewey.

Martin, Hugo

2023 Volume 68, Issue 880, Page(s) 60–63

Abstract: If architecture can be considered an art form, it is at the cost of reconfiguring what we consider to be an aesthetic experience. Thus conceived as processes, not finished objects, refuting the separation between the active creator and the passive ... ...

Title translation	Architecture as experience, living differently with the philosophy of John Dewey.
Abstract	If architecture can be considered an art form, it is at the cost of reconfiguring what we consider to be an aesthetic experience. Thus conceived as processes, not finished objects, refuting the separation between the active creator and the passive spectator and between ideas, actions and affects, the architectural projects accompanied and documented by the urban and architectural experiments laboratory la Preuve par 7 engage a collective, experimental, sensitive and political understanding of their discipline.
Language	French
Publishing date	2023-10-23
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/j.soin.2023.09.016
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Book ; Online: Measure framework for the pure selection equation

Martin, Hugo

global well posedness and numerical investigations

2023

Abstract: We study the classic pure selection integrodifferential equation, stemming from adaptative dynamics, in a measure framework by mean of duality approach. After providing a well posedness result under fairly general assumptions, we focus on the asymptotic ... ...

Abstract	We study the classic pure selection integrodifferential equation, stemming from adaptative dynamics, in a measure framework by mean of duality approach. After providing a well posedness result under fairly general assumptions, we focus on the asymptotic behavior of various cases, illustrated by some numerical simulations.
Keywords	Mathematics - Analysis of PDEs ; Quantitative Biology - Populations and Evolution
Publishing date	2023-04-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A New Paradigm to Investigate the Neuroscience of Irritability in Youth.

Martin, Hugo / Eshel, Neir

Biological psychiatry global open science

2024 Volume 4, Issue 2, Page(s) 100288

Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2667-1743
ISSN (online)	2667-1743
DOI	10.1016/j.bpsgos.2024.100288
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Article ; Online: Differences in Growth and Water Use Efficiency in Four Almond Varieties Grafted onto Rootpac-20

Álvarez, Sara / Núñez, Lidia / Martin, Hugo / Barajas, Enrique / Mirás-Avalos, José Manuel

Horticulturae. 2023 Feb. 22, v. 9, no. 3

2023

Abstract: Almond cultivation in the Mediterranean area has undergone important changes leading to the current trend of intensification. In this scenario, low-vigor rootstocks have recently been developed, such as the ‘Rootpac®’ series, but knowledge about the ... ...

Abstract	Almond cultivation in the Mediterranean area has undergone important changes leading to the current trend of intensification. In this scenario, low-vigor rootstocks have recently been developed, such as the ‘Rootpac®’ series, but knowledge about the rootstock’s influence on adaptation to high-density planting systems is very scarce. The objective of this work was to assess the morphological and physiological response of four almond cultivars grafted on ‘Rootpac-20’. To this end, one-year-old almond plants (Prunus dulcis (Mill) D. A. Webb.) cv ‘Penta’ (P), ‘Guara’ (G), ‘Vialfas’ (V) and ‘Soleta’ (S) were grown in pots, irrigated at field capacity (from June to September). Plant height and trunk diameter were measured periodically, and the water use efficiency of production was determined at the end of the trial. Evapotranspiration was measured throughout the experiment. The trunk diameter was greater in S and G at the end of the trial. Similarly, the tallest plants were G while the shortest ones were P. In general, G and S had a higher water use efficiency than V and P. ‘Soleta’ grafted on ‘Rootpac-20’ had higher evapotranspiration values (+25%), which is an important issue when selecting plant material, especially in the case of limited water availability for irrigation.
Keywords	Prunus dulcis ; almonds ; cultivars ; evapotranspiration ; field capacity ; irrigation ; physiological response ; plant height ; rootstocks ; water use efficiency ; Mediterranean region
Language	English
Dates of publication	2023-0222
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae9030295
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Social dimensions of learning – the experience of young adult students with Asperger syndrome at a supported IT education

Joel Hedegaard / Martin Hugo

Scandinavian Journal of Disability Research, Vol 19, Iss 3, Pp 256-

2017 Volume 268

Abstract: The purpose of this paper is to describe how young adults with Asperger syndrome experience an educational project called ‘the IT-track’. The methods used included participant observation and research interviews. The results were interpreted within the ... ...

Abstract	The purpose of this paper is to describe how young adults with Asperger syndrome experience an educational project called ‘the IT-track’. The methods used included participant observation and research interviews. The results were interpreted within the theoretical framework described by ‘Supported Education’ (SED). The most prominent experience among the students was social learning. Students describe that they gradually began to function better socially with others and developed various abilities, such as asking for help, and talking to groups.The teachers emerged in the interviews as the single most important source of support as they formed the basis of two key points of SED. Overall, studying at the IT-track resulted in the students extending their horizons of possibility by breaking away from their previous sense of isolation which was marked by idleness and loneliness. By participating at the IT-track, the students’ sense of participation and meaningfulness increased.
Keywords	Education ; Asperger syndrome ; social learning ; Social sciences (General) ; H1-99
Subject code	370
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Stockholm University Press
Document type	Article ; Online
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Article: Régimes hyperlipidiques et dépression

Bullich, Sébastien / Martin, Hugo / Fioramonti, Xavier / Guiard, Bruno P.

Société française de nutrition Cahiers de nutrition et de diététique. 2022 July 10,

2022

Abstract: Major depression is a psychiatric pathology based on different neurobiological mechanisms. Among these mechanisms, there is a hypersensitivity of the hypothalamic-pituitary-adrenal axis and modifications of various processes such as inflammation and ... ...

Abstract	Major depression is a psychiatric pathology based on different neurobiological mechanisms. Among these mechanisms, there is a hypersensitivity of the hypothalamic-pituitary-adrenal axis and modifications of various processes such as inflammation and oxidative stress. Various arguments suggest that these mechanisms lead to a deficit in monoaminergic neurotransmission. In particular, major depression is thought to result from an attenuation of serotonin (5-HT) levels in the brain. There is increasing evidence that patients with type 1 and type 2 diabetes are more likely to develop mood disorders than patients without diabetes. These epidemiological data are supported by studies conducted in different animal models displaying deficit in insulin signaling (exposure to cytotoxic compounds to the insulin-producing beta cell or hyperlipidic diets) leads to depressive-like states. This article summarizes the evidence linking metabolic and psychiatric disorders. It then presents the different mechanistic hypotheses that may explain this comorbidity. Finally, it opens the way to new therapeutic avenues that would consist in using oral antidiabetic drugs alone or in combination with antidepressants for an optimal management of DM.
Keywords	animals ; brain ; comorbidity ; cytotoxicity ; emotions ; hypersensitivity ; inflammation ; insulin ; noninsulin-dependent diabetes mellitus ; oxidative stress ; serotonin ; synaptic transmission ; therapeutics
Language	English
Dates of publication	2022-0710
Publishing place	Elsevier Masson SAS
Document type	Article
Note	Pre-press version
ZDB-ID	840946-8
ISSN	0007-9960
ISSN	0007-9960
DOI	10.1016/j.cnd.2022.07.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae.

Martin, Hugo / Doumic, Marie / Teixeira, Maria Teresa / Xu, Zhou

Cell & bioscience

2021 Volume 11, Issue 1, Page(s) 180

Abstract: Background: Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. This process called replicative senescence is associated with ... ...

Abstract	Background: Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. This process called replicative senescence is associated with genomic instability and participates in tissue and organismal ageing. Experimental data using single-cell approaches in the budding yeast model organism show that telomerase-negative cells often experience abnormally long cell cycles, which can be followed by cell cycles of normal duration, before reaching the terminal senescent state. These series of non-terminal cell cycle arrests contribute to the heterogeneity of senescence and likely magnify its genomic instability. Due to their apparent stochastic nature, investigating the dynamics and the molecular origins of these arrests has been difficult. In particular, whether the non-terminal arrests series stem from a mechanism similar to the one that triggers terminal senescence is not known. Results: Here, we provide a mathematical description of sequences of non-terminal arrests to understand how they appear. We take advantage of an experimental data set of cell cycle duration measurements performed in individual telomerase-negative yeast cells that keep track of the number of generations since telomerase inactivation. Using numerical simulations, we show that the occurrence of non-terminal arrests is a generation-dependent process that can be explained by the shortest telomere reaching a probabilistic threshold length. While the onset of senescence is also triggered by telomere shortening, we highlight differences in the laws that describe the number of consecutive arrests in non-terminal arrests compared to senescence arrests, suggesting distinct underlying mechanisms and cellular states. Conclusions: Replicative senescence is a complex process that affects cell divisions earlier than anticipated, as exemplified by the frequent occurrence of non-terminal arrests early after telomerase inactivation. The present work unravels two kinetically and mechanistically distinct generation-dependent processes underlying non-terminal and terminal senescence arrests. We suggest that these two processes are responsible for two consequences of senescence at the population level, the increase of genome instability on the one hand, and the limitation of proliferation capacity on the other hand.
Language	English
Publishing date	2021-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-021-00693-3
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Article ; Online: Efficacy of non-invasive intelligent volume assured pressure support (iVAPS) and pressure support ventilation (PSV) in clinical practice.

Horvath, Christian Michael / Brill, Anne-Kathrin / Baty, Florent / Brutsche, Martin Hugo

Swiss medical weekly

2021 Volume 151, Page(s) w20506

Abstract: Aims of the study: Noninvasive ventilation (NIV) is a well-established treatment option for hypercapnic respiratory failure; however, the best mode of ventilation remains unknown. The aim of this retrospective study was to compare patients’ adherence to ...

Abstract	Aims of the study: Noninvasive ventilation (NIV) is a well-established treatment option for hypercapnic respiratory failure; however, the best mode of ventilation remains unknown. The aim of this retrospective study was to compare patients’ adherence to NIV using either pressure support ventilation (PSV) or intelligent volume-assured pressure support (iVAPS). Patients and methods: In this retrospective cohort study, we assessed in- and outpatients suffering from hypercapnic respiratory failure of various aetiologies (chronic obstructive pulmonary disease [COPD], obese COPD [body mass index >30 kg/m2], obesity hypoventilation syndrome and other diseases such as amyotrophic lateral sclerosis or interstitial lung disease) after NIV initiation with PSV or iVAPS. Adherence to treatment was compared between these modes using the Wilcoxon test. Within-group differences were tested using linear regression models. Mortality and emergency hospital readmission rates were modelled using Kaplan-Meier estimates and Cox proportional hazards models. Results: Adherence to treatment was similar in both groups throughout the observation period – after 6 weeks: PSV 363 min/night (interquartile range [IQR] 200–448), iVAPS 369 min/night (IQR 310–468) (p = 0.619); after 1 year: PSV 423 (323–500), iVAPS 429 (298–475) (p = 0.901); at the last follow up: PSV 481 (395–586), iVAPS 426 (391–565) (p = 0.284). NIV reduced PaCO2 significantly compared with baseline at all follow-ups: PSV −1.29/−1.49/−1.49 kPa, iVAPS −1.47/−1.23/−1.24 kPa, p <0.001 each, PSV vs iVAPS: p = 0.250, 0.756 and 0.352, respectively. Median survival time (PSV 5.06 years, iVAPS median not reached; p = 0.800) and time to first readmission (PSV 3.6 years, iVAPS 7.33 years, p = 0.200) did not differ between groups. Obese COPD patients had a longer time to hospital readmission than lean COPD patients (3.8 vs 1.5 years, hazard ratio (HR) 0.39, 95% confidence interval [CI] 0.16–0. 74; p = 0.007). Good adherence (>4 h/night and >80% nightly usage) was associated with a lower mortality rate (HR 0.34, 95% CI 0.15–0.77; p = 0.010). Conclusion: In a real-world setting of a mixed population with hypercapnic respiratory failure, iVAPS and PSV seem to be similarly effective in improving gas exchange and demonstrate excellent adherence to treatment. A longer survival was noted in NIV-adherent patients. Randomised controlled studies are necessary to identify patients who might benefit more from hybrid ventilation modes.
MeSH term(s)	Humans ; Lung ; Noninvasive Ventilation ; Positive-Pressure Respiration ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration ; Respiratory Insufficiency/therapy ; Retrospective Studies
Language	English
Publishing date	2021-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2021.20506
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Article ; Online: The impact of insulin on the serotonergic system and consequences on diabetes-associated mood disorders.

Martin, Hugo / Bullich, Sébastien / Guiard, Bruno P / Fioramonti, Xavier

Journal of neuroendocrinology

2021 Volume 33, Issue 4, Page(s) e12928

Abstract: The idea that insulin could influence emotional behaviours has long been suggested. However, the underlying mechanisms have yet to be solved and there is no direct and clear-cut evidence demonstrating that such action involves brain serotonergic neurones. ...

Abstract	The idea that insulin could influence emotional behaviours has long been suggested. However, the underlying mechanisms have yet to be solved and there is no direct and clear-cut evidence demonstrating that such action involves brain serotonergic neurones. Indeed, initial arguments in favour of the association between insulin, serotonin and mood arise from clinical or animal studies showing that impaired insulin action in type 1 or type 2 diabetes causes anxiety- and depressive symptoms along with blunted plasma and brain serotonin levels. The present review synthesises the main mechanistic hypotheses that might explain the comorbidity between diabetes and depression. It also provides a state of knowledge of the direct and indirect experimental evidence that insulin modulates brain serotonergic neurones. Finally, it highlights the literature suggesting that antidiabetic drugs present antidepressant-like effects and, conversely, that serotonergic antidepressants impact glucose homeostasis. Overall, this review provides mechanistic insights into how insulin signalling alters serotonergic neurotransmission and related behaviours bringing new targets for therapeutic options.
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.12928
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Article ; Online: Diagnostic precision and identification of rare diseases is dependent on distance of residence relative to tertiary medical facilities

Anna-Lena Walter / Florent Baty / Frank Rassouli / Stefan Bilz / Martin Hugo Brutsche

Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background Diagnostic precision and the identification of rare diseases is a daily challenge, which needs specialized expertise. We hypothesized, that there is a correlation between the distance of residence to the next tertiary medical facility ...

Abstract	Abstract Background Diagnostic precision and the identification of rare diseases is a daily challenge, which needs specialized expertise. We hypothesized, that there is a correlation between the distance of residence to the next tertiary medical facility with highly specialized care and the diagnostic precision, especially for rare diseases. Results Using a nation-wide hospitalization database, we found a negative association between diagnostic diversity and travel time to the next tertiary referral hospital when including all cases throughout the overall International Classification of Diseases version 10 German Modification (ICD-10-GM) diagnosis codes. This was paralleled with a negative association of standardized incidence rates in all groups of rare diseases defined by the Orphanet rare disease nomenclature, except for rare teratologic and rare allergic diseases. Conclusion Our findings indicate a higher risk of being mis-, under- or late diagnosed especially in rare diseases when living more distant to a tertiary medical facility. Greater distance to the next tertiary medical facility basically increases the chance for hospitalization in a non-comprehensive regional hospital with less diagnostic capacity, and, thus, impacts on adapted health care access. Therefore, solutions for overcoming the distance to specialized care as an indicator of health care access are a major goal in the future.
Keywords	Rare diseases ; Diagnostic diversity ; Distance to center ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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