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Article ; Online: Improving Specialty Care Access via Telemedicine.

Burke, Guenevere V / Osman, Kareem A / Lew, Susie Q / Ehrhardt, Nicole / Robie, Andrew C / Amdur, Richard L / Martin, Lisa W / Sikka, Neal

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2022 Volume 29, Issue 1, Page(s) 109–115

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Hypertension/epidemiology ; Hypertension/therapy ; Pandemics ; Prospective Studies ; Telemedicine
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2021.0597
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Zs.A 4576: Show issues

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Article ; Online: The lower the achieved blood pressure goal the better.

Valdiviezo, Carolina / Martin, Lisa W / Panjrath, Gurusher S

Current opinion in cardiology

2015 Volume 30, Issue 4, Page(s) 378–382

Abstract: Purpose of review: Hypertension is the eminent risk factor for renal and cardiovascular disease (CVD). Its management is a topic of public health priority. As either too high or too low blood pressure (BP) levels can have detrimental effects on health, ... ...

Abstract	Purpose of review: Hypertension is the eminent risk factor for renal and cardiovascular disease (CVD). Its management is a topic of public health priority. As either too high or too low blood pressure (BP) levels can have detrimental effects on health, optimal targets for BP continue to be controversial. The current manuscript will review relevant data published over the last year that add to this topic of controversy. Recent findings: Recent studies confirm increased CVD-related risk with increasing SBP levels more than 140 mmHg among patients with hypertension and CVD as well as those over the age of 60 years. A SBP target less than 140 mmHg conveyed lessened risk of CVD-related events. There is some evidence suggesting that the ideal BP target lies between 120 and 140 mmHg. Summary: Recent data support a target SBP of less than 140 mmHg among patients with hypertension or CVD, and achievement of this target might benefit those older than 60 years of age as well. Treating to SBPs below 120 mmHg may not result in further benefit. Data from randomized controlled trials specifically addressing the question whether lower BPs are associated with better outcomes are needed to further define ideal BP-target goals.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Goals ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0000000000000187
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Zs.A 2556: Show issues

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Article: A Case-control Study to Evaluate the Prevalence of Nonalcoholic Fatty Liver Disease Among Patients with Moderate-to-severe Psoriasis.

Awosika, Olabola / Eleryan, Misty G / Rengifo-Pardo, Monica / Doherty, Lindsay / Martin, Lisa W / Ehrlich, Alison

The Journal of clinical and aesthetic dermatology

2018 Volume 11, Issue 6, Page(s) 33–37

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2018-06-01
Publishing country	United States
Document type	Journal Article
ISSN	1941-2789
ISSN	1941-2789
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Article ; Online: Serial 7-Day Electrocardiogram Patch Screening for AF in High-Risk Older Women by the CHARGE-AF Score.

Lin, Jeffrey Y / Larson, Joseph / Schoenberg, Jenny / Sepulveda, Alejandra / Tinker, Lesley / Wheeler, Matthew / Albert, Christine / Manson, JoAnn E / Wells, Gretchen / Martin, Lisa W / Froelicher, Victor / LaMonte, Mike / Kooperberg, Charles / Hlatky, Mark A / Greenland, Philip / Stefanick, Marcia L / Perez, Marco V

JACC. Clinical electrophysiology

2022 Volume 8, Issue 12, Page(s) 1523–1534

Abstract: Background: Asymptomatic atrial fibrillation (AF) is associated with an increased risk of stroke. The yield of serial electrocardiographic (ECG) screening for AF is unknown.: Objectives: The aim of this study was to determine the frequency of AF ... ...

Abstract	Background: Asymptomatic atrial fibrillation (AF) is associated with an increased risk of stroke. The yield of serial electrocardiographic (ECG) screening for AF is unknown. Objectives: The aim of this study was to determine the frequency of AF detected by serial, 7-day ECG patch screenings in older women identified as having an elevated risk of AF according to the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology)-AF clinical prediction score. Methods: Postmenopausal women with a 5-year predicted risk of new-onset AF ≥5% according to CHARGE-AF were recruited from the ongoing WHISH (Women's Health Initiative Strong and Healthy) randomized trial of a physical activity intervention. Participants with AF at baseline by self-report or medical records review were excluded. Screening with 7-day ECG patch monitors was performed at baseline, 6 months, and 12 months from study enrollment. Results: On baseline monitoring, 2.5% of the cohort had AF detected, increasing to 3.7% by 6 months and 4.9% cumulatively by 12 months. Yield of patch screening was higher among participants with a higher (≥10%) CHARGE-AF score: 4.2% had AF detected at baseline, 5.9% at 6 months, and 7.2% at 12 months. Most participants with patch-identified AF never had a clinical diagnosis of AF (36 of 46 [78%]). Conclusions: Older women with an elevated CHARGE-AF score had a high prevalence of AF on 7-day ECG patch screening. Serial screening over 12 months substantially increased the detection of AF. These data can be useful in helping identify high-risk participants for enrollment in future studies of the management of asymptomatic AF.(Women's Health Initiative Silent Atrial Fibrillation Recording Study [WHISH STAR]; NCT05366803.).
MeSH term(s)	Humans ; Female ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/complications ; Electrocardiography ; Stroke ; Heart ; Mass Screening
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2022.08.024
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Article ; Online: The association of walking pace and incident heart failure and subtypes among postmenopausal women.

Miremad, Moafi-Madani / Lin, Xiaochen / Rasla, Somwail / El Meligy, Amr / Roberts, Mary B / Laddu, Deepika / Allison, Matthew / Martin, Lisa W / Shadyab, Aladdin H / Manson, Jo Ann E / Chlebowski, Rowan / Panjrath, Gurusher / LaMonte, Michael J / Liu, Simin / Eaton, Charles B

Journal of the American Geriatrics Society

2022 Volume 70, Issue 5, Page(s) 1405–1417

Abstract: Background: To investigate the association between walking pace and the risk of heart failure (HF) and HF sub-types.: Methods: We examined associations of self-reported walking pace with risk of incident HF and HF subtypes of preserved (HFpEF) and ... ...

Abstract	Background: To investigate the association between walking pace and the risk of heart failure (HF) and HF sub-types. Methods: We examined associations of self-reported walking pace with risk of incident HF and HF subtypes of preserved (HFpEF) and reduced (HFrEF) ejection fractions, among 25,183 postmenopausal women, ages 50-79 years. At enrollment into the Women's Health Initiative cohort in 1993-1998, this subset of women was free of HF, cancer, or the inability to walk one block, with self-reported information on walking pace and walking duration. Multivariable Cox regression was used to examine associations of walking pace (casual <2 mph [referent], average 2-3 mph, and fast >3 mph) with incident HF. We also examined the joint association of walking pace and duration with incident HF. Results: There were 1455 incident adjudicated acute decompensated HF hospitalization cases during a median of 16.9 years of follow-up. There was a strong inverse association between walking pace and overall risk of HF (HR = 0.73, 95% CI [0.65, 0.83] for average vs. casual walking; HR = 0.66, 95%CI [0.56, 0.78] for fast vs. casual walking). There were similar associations of walking pace with HFpEF (HR = 0.73, 95%CI [0.62, 0.86] average vs. casual; HR = 0.63, 95%CI [0.50, 0.80] for fast vs. casual) and with HFrEF (HR = 0.72, 95%CI [0.57, 0.91] for average vs. casual; HR = 0.74, 95%CI [0.54, 0.99] for fast vs. casual). The risk of HF associated with fast walking with less than 1 h/week walking duration was comparable with the risk of HF among casual and average walkers with more than 2 h/week walking duration. Conclusion: Walking pace was inversely associated with risks of overall HF, HFpEF, and HFrEF in postmenopausal women. Whether interventions to increase the walking pace in older adults will reduce HF risk and whether fast pace will compensate for the short duration of walking warrants further study.
MeSH term(s)	Aged ; Female ; Heart Failure/epidemiology ; Humans ; Postmenopause ; Prognosis ; Risk Factors ; Stroke Volume ; Ventricular Function, Left ; Walking Speed
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.17657
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Article ; Online: Relationship Between Dietary Magnesium Intake and Incident Heart Failure Among Older Women: The WHI.

Wu, Wen-Chih / Huang, Mengna / Taveira, Tracey H / Roberts, Mary B / Martin, Lisa W / Wellenius, Gregory A / Johnson, Karen C / Manson, JoAnn E / Liu, Simin / Eaton, Charles B

Journal of the American Heart Association

2020 Volume 9, Issue 7, Page(s) e013570

Abstract: Background Women represent a large proportion of the growing heart failure (HF) epidemic, yet data are lacking regarding optimal dietary and lifestyle prevention strategies for them. Specifically, the association between magnesium intake and HF in a ... ...

Abstract	Background Women represent a large proportion of the growing heart failure (HF) epidemic, yet data are lacking regarding optimal dietary and lifestyle prevention strategies for them. Specifically, the association between magnesium intake and HF in a multiracial cohort of women is uncertain. Methods and Results We included 97 725 postmenopausal women from the WHI (Women's Health Initiative) observational studies and placebo arms of the hormone trial. Magnesium intake was measured at baseline by a 122-item validated food-frequency questionnaire and stratified into quartiles based on diet only, total intake (diet with supplements), and residual intake (calibration by total energy). Incident hospitalized HF (2153 events, median follow-up 8.1 years) was adjudicated by medical record abstraction. In Cox proportional hazards models, we evaluated the association between magnesium intake and HF adjusting for potential confounders. Analyses were repeated on a subcohort (n=18 745; median-follow-up, 13.2 years) for whom HF cases were subclassified into preserved ejection fraction (526 events), reduced ejection fraction (291 events) or unknown (168 events). Most women were white (85%) with a mean age of 63. Compared with the highest quartile of magnesium intake, women in the lowest quartile had an increased risk of incident HF, with adjusted hazard ratios of 1.32 (95% CI, 1.02-1.71) for diet only (
MeSH term(s)	Age Factors ; Aged ; Diet/adverse effects ; Dietary Supplements ; Female ; Heart Disease Risk Factors ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Humans ; Incidence ; Magnesium/administration & dosage ; Magnesium Deficiency/diagnosis ; Magnesium Deficiency/epidemiology ; Middle Aged ; Postmenopause ; Prospective Studies ; Recommended Dietary Allowances ; Risk Assessment ; Sex Factors ; Time Factors ; United States/epidemiology ; Ventricular Function, Left
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2020-03-20
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.119.013570
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Article ; Online: When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African American and Hispanic Women.

Breathett, Khadijah / Kohler, Lindsay N / Eaton, Charles B / Franceschini, Nora / Garcia, Lorena / Klein, Liviu / Martin, Lisa W / Ochs-Balcom, Heather M / Shadyab, Aladdin H / Cené, Crystal W

Journal of cardiac failure

2020 Volume 27, Issue 2, Page(s) 217–223

Abstract: Background: African American and Hispanic postmenopausal women have the highest risk for heart failure compared with other races, but heart failure prevalence is lower than expected in some national cohorts. It is unknown whether psychosocial factors ... ...

Abstract	Background: African American and Hispanic postmenopausal women have the highest risk for heart failure compared with other races, but heart failure prevalence is lower than expected in some national cohorts. It is unknown whether psychosocial factors are associated with lower risk of incident heart failure hospitalization among high-risk postmenopausal minority women. Methods and results: Using the Women's Health Initiative Study, African American and US Hispanic women were classified as high-risk for incident heart failure hospitalization with 1 or more traditional heart failure risk factors and the highest tertile heart failure genetic risk scores. Positive psychosocial factors (optimism, social support, religion) and negative psychosocial factors (living alone, social strain, depressive symptoms) were measured using validated survey instruments at baseline. Adjusted subdistribution hazard ratios of developing heart failure hospitalization were determined with death as a competing risk. Positive deviance indicated not developing incident heart failure hospitalization with 1 or more risk factors and the highest tertile for genetic risk. Among 7986 African American women (mean follow-up of 16 years), 27.0% demonstrated positive deviance. Among high-risk African American women, optimism was associated with modestly reduced risk of heart failure hospitalization (subdistribution hazard ratio 0.94, 95% confidence interval 0.91-0.99), and social strain was associated with modestly increased risk of heart failure hospitalization (subdistribution hazard ratio 1.07, 95% confidence interval 1.02-1.12) in the initial models; however, no psychosocial factors were associated with heart failure hospitalization in fully adjusted analyses. Among 3341 Hispanic women, 25.1% demonstrated positive deviance. Among high-risk Hispanic women, living alone was associated with increased risk of heart failure hospitalization (subdistribution hazard ratio 1.97, 95% confidence interval 1.06-3.63) in unadjusted analyses; however, no psychosocial factors were associated with heart failure hospitalization in fully adjusted analyses. Conclusions: Among postmenopausal African American and Hispanic women, a significant proportion remained free from heart failure hospitalization despite having the highest genetic risk profile and 1 or more traditional risk factors. No observed psychosocial factors were associated with incident heart failure hospitalization in high-risk African Americans and Hispanics. Additional investigation is needed to understand protective factors among high-risk African American and Hispanic women.
MeSH term(s)	Black or African American ; Ethnicity ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Hispanic or Latino ; Humans ; Postmenopause ; Risk Factors
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2020.11.009
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Zs.A 4340: Show issues

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Article ; Online: Changes in physical and mental health are associated with cardiovascular disease incidence in postmenopausal women.

Saquib, Nazmus / Brunner, Robert / Desai, Manisha / Kroenke, Candyce / Martin, Lisa W / Daviglus, Martha / Allen, Norrina B / Robinson, Jennifer / Tindle, Hilary / Stefanick, Marcia L

Age and ageing

2019 Volume 48, Issue 3, Page(s) 448–453

Abstract: Background: physical and mental health are important risk factors for cardiovascular disease (CVD) incidence and death among postmenopausal women. The objective of this study was to assess whether changes in physical and mental health were associated ... ...

Abstract	Background: physical and mental health are important risk factors for cardiovascular disease (CVD) incidence and death among postmenopausal women. The objective of this study was to assess whether changes in physical and mental health were associated with CVD incidence and death. Methods: in the Women's Health Initiative Observational Study, 48,906 women (50-79 years) had complete data at baseline on physical and mental health (assessed with Short Form-36) and key covariates. Changes in self-reported physical and mental health were calculated between baseline and year 3. Incident CVD and death between year 3 and end of the study were verified with medical records. Results: over a median 8.2-year follow-up, 2,319 women developed CVD, and 1,571 women died, including 361 CVD deaths. Women with continued poor health and those with worsened health had significantly increased risk of CVD incidence, CVD-specific death and all-cause death relative to women with continued good health. Both major and minor declines in physical health were associated with an increased risk of these outcomes relative to women with no change in physical health. Only major declines in mental health were associated with poor prognosis. Conclusions: changes in physical and mental health over 3 years were independently associated with subsequent CVD events.
MeSH term(s)	Aged ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Female ; Health Status ; Humans ; Incidence ; Mental Health ; Middle Aged ; Postmenopause/physiology ; Postmenopause/psychology ; Risk Factors ; Surveys and Questionnaires
Language	English
Publishing date	2019-01-29
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afy213
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 448: Show issues

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Article ; Online: Association of Dietary Magnesium Intake with Fatal Coronary Heart Disease and Sudden Cardiac Death.

Li, Jason / Hovey, Kathleen M / Andrews, Christopher A / Quddus, Abdullah / Allison, Matthew A / Van Horn, Linda / Martin, Lisa W / Salmoirago-Blotcher, Elena / Song, Yiqing / Manson, JoAnn E / Albert, Christine M / Lu, Bing / Eaton, Charles B

Journal of women's health (2002)

2019 Volume 29, Issue 1, Page(s) 7–12

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Aged ; Cohort Studies ; Coronary Disease/epidemiology ; Death, Sudden, Cardiac/epidemiology ; Female ; Humans ; Magnesium/administration & dosage ; Middle Aged ; Nutritional Status ; Postmenopause ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Risk Reduction Behavior ; Surveys and Questionnaires ; United States/epidemiology
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2019.7775
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Zs.A 3584: Show issues

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Article ; Online: Racial/Ethnic Differences in 25-Hydroxy Vitamin D and Parathyroid Hormone Levels and Cardiovascular Disease Risk Among Postmenopausal Women.

Zhang, Xi / Tu, Wanzhu / Manson, JoAnn E / Tinker, Lesley / Liu, Simin / Cauley, Jane A / Qi, Lihong / Mouton, Charles / Martin, Lisa W / Hou, Lifang / Song, Yiqing

Journal of the American Heart Association

2019 Volume 8, Issue 4, Page(s) e011021

Abstract: Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We ... ...

Abstract	Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We prospectively examined black-white differences in the associations of total, free, and bioavailable 25( OH )D, vitamin D-binding protein, and parathyroid hormone levels at baseline with incident CVD (including nonfatal myocardial infarction, nonfatal stroke, and CVD death) in postmenopausal women. Methods and Results We conducted a case-cohort study among 79 705 postmenopausal women, aged 50 to 79 years, who were free of CVD at baseline in the WHI-OS (Women's Health Initiative Observational Study). A subcohort of 1300 black and 1500 white participants were randomly chosen as controls; a total of 550 black and 1500 white women who developed incident CVD during a mean follow-up of 11 years were chosen as cases. We directly measured total 25( OH )D, vitamin D-binding protein, albumin, parathyroid hormone, and calculated free and bioavailable 25( OH )D. Weighted Cox proportional hazards models were used to examine their associations with CVD risk. Although vitamin D-binding protein and total, free, and bioavailable 25( OH )D were not significantly associated with CVD risk in black or white women, a significant positive association between parathyroid hormone and CVD risk persisted in white women (hazard ratio comparing the highest quartile with the lowest, 1.37; 95% CI , 1.06-1.77) but not in black women (hazard ratio comparing the highest quartile with the lowest, 1.12; 95% CI, 0.79-1.58), independent of total, free, and bioavailable 25( OH )D or vitamin D-binding protein. Conclusions Circulating levels of vitamin D biomarkers are not related to CVD risk in either white or black women. Higher parathyroid hormone levels may be an independent risk factor for CVD in white women.
MeSH term(s)	Aged ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/ethnology ; Case-Control Studies ; Continental Population Groups ; Ethnic Groups ; Female ; Follow-Up Studies ; Forecasting ; Humans ; Incidence ; Middle Aged ; Parathyroid Hormone/blood ; Postmenopause/blood ; Prospective Studies ; Risk Assessment/methods ; Risk Factors ; United States/epidemiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Biomarkers ; Parathyroid Hormone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2019-02-04
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.118.011021
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