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  1. Article ; Online: Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.

    Thomas, Nicole / Dreval, Kostiantyn / Gerhard, Daniela S / Hilton, Laura K / Abramson, Jeremy S / Ambinder, Richard F / Barta, Stefan / Bartlett, Nancy L / Bethony, Jeffrey / Bhatia, Kishor / Bowen, Jay / Bryan, Anthony C / Cesarman, Ethel / Casper, Corey / Chadburn, Amy / Cruz, Manuela / Dittmer, Dirk P / Dyer, Maureen A / Farinha, Pedro /
    Gastier-Foster, Julie M / Gerrie, Alina S / Grande, Bruno M / Greiner, Timothy / Griner, Nicholas B / Gross, Thomas G / Harris, Nancy L / Irvin, John D / Jaffe, Elaine S / Henry, David / Huppi, Rebecca / Leal, Fabio E / Lee, Michael S / Martin, Jean Paul / Martin, Marie-Reine / Mbulaiteye, Sam M / Mitsuyasu, Ronald / Morris, Vivian / Mullighan, Charles G / Mungall, Andrew J / Mungall, Karen / Mutyaba, Innocent / Nokta, Mostafa / Namirembe, Constance / Noy, Ariela / Ogwang, Martin D / Omoding, Abraham / Orem, Jackson / Ott, German / Petrello, Hilary / Pittaluga, Stefania / Phelan, James D / Ramos, Juan Carlos / Ratner, Lee / Reynolds, Steven J / Rubinstein, Paul G / Sissolak, Gerhard / Slack, Graham / Soudi, Shaghayegh / Swerdlow, Steven H / Traverse-Glehen, Alexandra / Wilson, Wyndham H / Wong, Jasper / Yarchoan, Robert / ZenKlusen, Jean C / Marra, Marco A / Staudt, Louis M / Scott, David W / Morin, Ryan D

    Blood

    2023  Volume 141, Issue 8, Page(s) 904–916

    Abstract: Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), ... ...

    Abstract Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), leaving its relationship to adult BL (aBL) and other adult lymphomas not fully explored. We sought to more thoroughly identify the somatic changes that underlie lymphomagenesis in aBL and any molecular features that associate with clinical disparities within and between pBL and aBL. Through comprehensive whole-genome sequencing of 230 BL and 295 diffuse large B-cell lymphoma (DLBCL) tumors, we identified additional significantly mutated genes, including more genetic features that associate with tumor Epstein-Barr virus status, and unraveled new distinct subgroupings within BL and DLBCL with 3 predominantly comprising BLs: DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3 and CCND3), and Q53-BL (quiet TP53). Each BL subgroup is characterized by combinations of common driver and noncoding mutations caused by aberrant somatic hypermutation. The largest subgroups of BL cases, IC-BL and DGG-BL, are further characterized by distinct biological and gene expression differences. IC-BL and DGG-BL and their prototypical genetic features (ID3 and TP53) had significant associations with patient outcomes that were different among aBL and pBL cohorts. These findings highlight shared pathogenesis between aBL and pBL, and establish genetic subtypes within BL that serve to delineate tumors with distinct molecular features, providing a new framework for epidemiologic, diagnostic, and therapeutic strategies.
    MeSH term(s) Child ; Humans ; Adult ; Burkitt Lymphoma/pathology ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mutation
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  2. Article ; Online: Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma.

    Grande, Bruno M / Gerhard, Daniela S / Jiang, Aixiang / Griner, Nicholas B / Abramson, Jeremy S / Alexander, Thomas B / Allen, Hilary / Ayers, Leona W / Bethony, Jeffrey M / Bhatia, Kishor / Bowen, Jay / Casper, Corey / Choi, John Kim / Culibrk, Luka / Davidsen, Tanja M / Dyer, Maureen A / Gastier-Foster, Julie M / Gesuwan, Patee / Greiner, Timothy C /
    Gross, Thomas G / Hanf, Benjamin / Harris, Nancy Lee / He, Yiwen / Irvin, John D / Jaffe, Elaine S / Jones, Steven J M / Kerchan, Patrick / Knoetze, Nicole / Leal, Fabio E / Lichtenberg, Tara M / Ma, Yussanne / Martin, Jean Paul / Martin, Marie-Reine / Mbulaiteye, Sam M / Mullighan, Charles G / Mungall, Andrew J / Namirembe, Constance / Novik, Karen / Noy, Ariela / Ogwang, Martin D / Omoding, Abraham / Orem, Jackson / Reynolds, Steven J / Rushton, Christopher K / Sandlund, John T / Schmitz, Roland / Taylor, Cynthia / Wilson, Wyndham H / Wright, George W / Zhao, Eric Y / Marra, Marco A / Morin, Ryan D / Staudt, Louis M

    Blood

    2019  Volume 133, Issue 12, Page(s) 1313–1324

    Abstract: Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in more than 90% of cases in ... ...

    Abstract Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in more than 90% of cases in malaria-endemic regions, and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Through an integrative analysis of whole-genome and transcriptome data, we show a striking genome-wide increase in aberrant somatic hypermutation in EBV-positive tumors, supporting a link between EBV and activation-induced cytidine deaminase (AICDA) activity. In addition to identifying novel candidate BL genes such as
    MeSH term(s) Adolescent ; Adult ; Biomarkers, Tumor/genetics ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/pathology ; Burkitt Lymphoma/virology ; Child ; Child, Preschool ; Cohort Studies ; Cytidine Deaminase/genetics ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/virology ; Female ; Follow-Up Studies ; Genes, Immunoglobulin ; Genome, Human ; Herpesvirus 4, Human/isolation & purification ; Humans ; Infant ; Infant, Newborn ; Male ; Mutation ; Phenotype ; Prognosis ; Transcriptome ; Young Adult
    Chemical Substances Biomarkers, Tumor ; AICDA (activation-induced cytidine deaminase) (EC 3.5.4.-) ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-09-871418
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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