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  1. AU="Martin, S J"
  2. AU="Szendrői, Miklós"
  3. AU="Moncel, Marie-Hélène"
  4. AU=Otu Akaninyene AU=Otu Akaninyene
  5. AU="Chiba, Kentaro"
  6. AU="Zhou, Jihua"
  7. AU="Ronald Bartels"
  8. AU="Liñares, J"
  9. AU="Valle, Valentina"
  10. AU="Tóth, András"
  11. AU="Pawar, Atul Darasing"
  12. AU="Semper, Chelsea"
  13. AU="Kraus, Joanne F"

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  1. Artikel: The structure and composition of morbillivirus: a brief review.

    Martin, S J

    Revue scientifique et technique (International Office of Epizootics)

    2020  Band 5, Heft 2, Seite(n) 389–393

    Sprache Englisch
    Erscheinungsdatum 2020-09-09
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 792125-1
    ISSN 1608-0637 ; 0253-1933
    ISSN (online) 1608-0637
    ISSN 0253-1933
    DOI 10.20506/rst.5.2.252
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch: Apoptosis and cancer

    Martin, Seamus J.

    5 tab

    (Oncology)

    1997  

    Verfasserangabe ed. Seamus J. Martin
    Serientitel Oncology
    Schlagwörter Neoplasms / physiopathology ; Apoptosis / physiology ; Apoptosis ; Krebs ; Krebszelle
    Schlagwörter Apoptose ; Programmierter Zelltod ; Krebs ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Sprache Englisch
    Umfang XI, 265 S. : Ill., graph. Darst.
    Verlag Karger Landes Systems
    Erscheinungsort Basel u.a.
    Erscheinungsland Schweiz
    Dokumenttyp Buch
    Anmerkung Includes index
    HBZ-ID HT008954411
    ISBN 3-8055-6579-8 ; 978-3-8055-6579-0
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    1998 A 5926 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: Formation of a morphine-conditioned place preference does not change the size of evoked potentials in the ventral hippocampus-nucleus accumbens projection.

    Sakae, D Y / Martin, S J

    Scientific reports

    2019  Band 9, Heft 1, Seite(n) 5206

    Abstract: In opioid addiction, cues and contexts associated with drug reward can be powerful triggers for drug craving and relapse. The synapses linking ventral hippocampal outputs to medium spiny neurons of the accumbens may be key sites for the formation and ... ...

    Abstract In opioid addiction, cues and contexts associated with drug reward can be powerful triggers for drug craving and relapse. The synapses linking ventral hippocampal outputs to medium spiny neurons of the accumbens may be key sites for the formation and storage of associations between place or context and reward, both drug-related and natural. To assess this, we implanted rats with electrodes in the accumbens shell to record synaptic potentials evoked by electrical stimulation of the ventral hippocampus, as well as continuous local-field-potential activity. Rats then underwent morphine-induced (10 mg/kg) conditioned-place-preference training, followed by extinction. Morphine caused an acute increase in the slope and amplitude of accumbens evoked responses, but no long-term changes were evident after conditioning or extinction of the place preference, suggesting that the formation of this type of memory does not lead to a net change in synaptic strength in the ventral hippocampal output to the accumbens. However, analysis of the local field potential revealed a marked sensitization of theta- and high-gamma-frequency activity with repeated morphine administration. This phenomenon may be linked to the behavioral changes-such as psychomotor sensitization and the development of drug craving-that are associated with chronic use of addictive drugs.
    Mesh-Begriff(e) Animals ; Conditioning, Psychological ; Evoked Potentials/drug effects ; Hippocampus/physiopathology ; Male ; Morphine/adverse effects ; Morphine/pharmacology ; Morphine Dependence/physiopathology ; Nucleus Accumbens/physiopathology ; Rats
    Chemische Substanzen Morphine (76I7G6D29C)
    Sprache Englisch
    Erscheinungsdatum 2019-03-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-41568-5
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  4. Artikel ; Online: GM-CSF is a marker of compartmentalised intrathecal inflammation in multiple sclerosis.

    Martin, S-J / Brand-Arzamendi, K / Saab, G / Muccilli, A / Oh, J / Schneider, R

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Band 29, Heft 11-12, Seite(n) 1373–1382

    Abstract: Background: Granulocyte-macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine secreted by various immune cells. Several studies have demonstrated an expansion of GM-CSF producing T cells in the blood or CSF of people with MS (pwMS) ...

    Abstract Background: Granulocyte-macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine secreted by various immune cells. Several studies have demonstrated an expansion of GM-CSF producing T cells in the blood or CSF of people with MS (pwMS). However, whether this equates to greater concentrations of circulating cytokine remains unknown as quantification is difficult with traditional assays.
    Objective: To determine whether GM-CSF can be quantified and whether GM-CSF levels are elevated in pwMS.
    Methods: We employed Single Molecule Array (Simoa) to measure GM-CSF in both CSF and blood. We then investigated relationships between GM-CSF levels and measures of blood-CSF-barrier integrity.
    Results: GM-CSF was quantifiable in all samples and was significantly higher in the CSF of pwMS compared with controls. No association was found between CSF GM-CSF levels and Q-Albumin - a measure of blood-CSF-barrier integrity. CSF GM-CSF correlated with measures of intrathecal inflammation, and these relationships were greater in primary progressive MS compared with relapsing-remitting MS.
    Conclusion: GM-CSF levels are elevated specifically in the CSF of pwMS. Our results suggest that elevated cytokine levels may reflect (at least partial) intrathecal production, as opposed to simple diffusion across a dysfunctional blood-CSF-barrier.
    Mesh-Begriff(e) Humans ; Granulocyte-Macrophage Colony-Stimulating Factor ; Multiple Sclerosis ; Cytokines ; Inflammation ; Albumins
    Chemische Substanzen Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Cytokines ; Albumins
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231195861
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Deformed wing virus variant shift from 2010 to 2016 in managed and feral UK honey bee colonies.

    Kevill, J L / Stainton, K C / Schroeder, D C / Martin, S J

    Archives of virology

    2021  Band 166, Heft 10, Seite(n) 2693–2702

    Abstract: Deformed wing virus (DWV) has been linked to the global decline of honey bees. DWV exists as three master variants (DWV-A, DWV-B, and DWV-C), each with differing outcomes for the honey bee host. Research in the USA showed a shift from DWV-A to DWV-B ... ...

    Abstract Deformed wing virus (DWV) has been linked to the global decline of honey bees. DWV exists as three master variants (DWV-A, DWV-B, and DWV-C), each with differing outcomes for the honey bee host. Research in the USA showed a shift from DWV-A to DWV-B between 2010 to 2016 in honey bee colonies. Likewise, in the UK, a small study in 2007 found only DWV-A, whereas in 2016, DWV-B was the most prevalent variant. This suggests a shift from DWV-A to DWV-B might have occurred in the UK between 2007 and 2016. To investigate this further, data from samples collected in 2009/10 (n = 46) were compared to existing data from 2016 (n = 42). These samples also allowed a comparison of DWV variants between Varroa-untreated (feral) and Varroa-treated (managed) colonies. The results revealed that, in the UK, DWV-A was far more prevalent in 2009/10 (87%) than in 2016 (43%). In contrast, DWV-B was less prevalent in 2009/10 (76%) than in 2016 (93%). Regardless if colonies had been treated for Varroa (managed) or not (feral), the same trend from DWV-A to DWV-B occurred. Overall, the results reveal a decrease in DWV-A and an increase in DWV-B in UK colonies.
    Mesh-Begriff(e) Animals ; Bees/parasitology ; Bees/virology ; Genetic Variation ; Prevalence ; RNA Virus Infections/epidemiology ; RNA Virus Infections/veterinary ; RNA Virus Infections/virology ; RNA Viruses/genetics ; RNA Viruses/isolation & purification ; United Kingdom/epidemiology ; Varroidae ; Viral Load
    Sprache Englisch
    Erscheinungsdatum 2021-07-17
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-021-05162-3
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  6. Artikel ; Online: Microsporidia: a new taxonomic, evolutionary, and ecological synthesis.

    Bojko, Jamie / Reinke, Aaron W / Stentiford, Grant D / Williams, Bryony / Rogers, Martin S J / Bass, David

    Trends in parasitology

    2022  Band 38, Heft 8, Seite(n) 642–659

    Abstract: Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which ...

    Abstract Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which sequence data are available. Comparing these results with existing phylogenomic analyses, we suggest an updated taxonomic framework to replace the inconsistent clade numbering system, using informal taxonomic names: Glugeida (previously clades 5/3), Nosematida (4a), Enterocytozoonida (4b), Amblyosporida (3/5), Neopereziida (1), and Ovavesiculida (2). Cellular, parasitological, and ecological traits for 281 well-defined species are compared with identify clade-specific patterns across long-branch Microsporidia. We suggest that future taxonomic circumscriptions of Microsporidia should involve additional markers (SSU/ITS/LSU), and that a comprehensive suite of phenotypic and ecological traits help to predict broad microsporidian functional and lineage diversity.
    Mesh-Begriff(e) Microsporidia/genetics ; Phylogeny
    Sprache Englisch
    Erscheinungsdatum 2022-06-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.05.007
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  7. Artikel ; Online: Erratum to "Natural almond skin reduced oxidative stress and inflammation in an experimental model of inflammatory bowel disease" [Int. Immunopharmacol. 11(8) (2011) 915-924].

    Mandalari, Giuseppina / Bisignano, Carlo / Genovese, Tiziana / Mazzon, Emanuela / Wickham, Martin S J / Paterniti, Irene / Cuzzocrea, Salvatore

    International immunopharmacology

    2023  Band 127, Seite(n) 111187

    Sprache Englisch
    Erscheinungsdatum 2023-12-16
    Erscheinungsland Netherlands
    Dokumenttyp Published Erratum
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111187
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  8. Artikel ; Online: Oldest Varroa tolerant honey bee population provides insight into the origins of the global decline of honey bees.

    Brettell, L E / Martin, S J

    Scientific reports

    2017  Band 7, Seite(n) 45953

    Abstract: The ecto-parasitic mite Varroa destructor has transformed the previously inconsequential Deformed Wing Virus (DWV) into the most important honey bee viral pathogen responsible for the death of millions of colonies worldwide. Naturally, DWV persists as a ... ...

    Abstract The ecto-parasitic mite Varroa destructor has transformed the previously inconsequential Deformed Wing Virus (DWV) into the most important honey bee viral pathogen responsible for the death of millions of colonies worldwide. Naturally, DWV persists as a low level covert infection transmitted between nest-mates. It has long been speculated that Varroa via immunosuppression of the bees, activate a covert infection into an overt one. Here we show that despite Varroa feeding on a population of 20-40 colonies for over 30 years on the remote island of Fernando de Noronha, Brazil no such activation has occurred and DWV loads have remained at borderline levels of detection. This supports the alternative theory that for a new vector borne viral transmission cycle to start, an outbreak of an overt infection must first occur within the host. Therefore, we predict that this honey bee population is a ticking time-bomb, protected by its isolated position and small population size. This unique association between mite and bee persists due to the evolution of low Varroa reproduction rates. So the population is not adapted to tolerate Varroa and DWV, rather the viral quasispecies has simply not yet evolved the necessary mutations to produce a virulent variant.
    Mesh-Begriff(e) Animals ; Base Sequence ; Bees/genetics ; Bees/parasitology ; Bees/virology ; Internationality ; RNA Viruses/genetics ; RNA Viruses/physiology ; Reproduction ; Varroidae/genetics ; Varroidae/physiology
    Sprache Englisch
    Erscheinungsdatum 2017-04-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep45953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Microsporidia: a new taxonomic, evolutionary, and ecological synthesis

    Bojko, Jamie / Reinke, Aaron W. / Stentiford, Grant D. / Williams, Bryony / Rogers, Martin S.J. / Bass, David

    Trends in parasitology. 2022,

    2022  

    Abstract: Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which ...

    Abstract Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which sequence data are available. Comparing these results with existing phylogenomic analyses, we suggest an updated taxonomic framework to replace the inconsistent clade numbering system, using informal taxonomic names: Glugeida (previously clades 5/3), Nosematida (4a), Enterocytozoonida (4b), Amblyosporida (3/5), Neopereziida (1), and Ovavesiculida (2). Cellular, parasitological, and ecological traits for 281 well-defined species are compared with identify clade-specific patterns across long-branch Microsporidia. We suggest that future taxonomic circumscriptions of Microsporidia should involve additional markers (SSU/ITS/LSU), and that a comprehensive suite of phenotypic and ecological traits help to predict broad microsporidian functional and lineage diversity.
    Schlagwörter Microsporidia ; genomics ; parasitology ; phenotype ; phylogeny
    Sprache Englisch
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.05.007
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  10. Artikel: Deformed wing virus variant shift from 2010 to 2016 in managed and feral UK honey bee colonies

    Kevill, J. L. / Stainton, K. C. / Schroeder, D. C. / Martin, S. J.

    Archives of virology. 2021 Oct., v. 166, no. 10

    2021  

    Abstract: Deformed wing virus (DWV) has been linked to the global decline of honey bees. DWV exists as three master variants (DWV-A, DWV-B, and DWV-C), each with differing outcomes for the honey bee host. Research in the USA showed a shift from DWV-A to DWV-B ... ...

    Abstract Deformed wing virus (DWV) has been linked to the global decline of honey bees. DWV exists as three master variants (DWV-A, DWV-B, and DWV-C), each with differing outcomes for the honey bee host. Research in the USA showed a shift from DWV-A to DWV-B between 2010 to 2016 in honey bee colonies. Likewise, in the UK, a small study in 2007 found only DWV-A, whereas in 2016, DWV-B was the most prevalent variant. This suggests a shift from DWV-A to DWV-B might have occurred in the UK between 2007 and 2016. To investigate this further, data from samples collected in 2009/10 (n = 46) were compared to existing data from 2016 (n = 42). These samples also allowed a comparison of DWV variants between Varroa-untreated (feral) and Varroa-treated (managed) colonies. The results revealed that, in the UK, DWV-A was far more prevalent in 2009/10 (87%) than in 2016 (43%). In contrast, DWV-B was less prevalent in 2009/10 (76%) than in 2016 (93%). Regardless if colonies had been treated for Varroa (managed) or not (feral), the same trend from DWV-A to DWV-B occurred. Overall, the results reveal a decrease in DWV-A and an increase in DWV-B in UK colonies.
    Schlagwörter Deformed wing virus ; Varroa ; honey ; honey bees ; virology
    Sprache Englisch
    Erscheinungsverlauf 2021-10
    Umfang p. 2693-2702.
    Erscheinungsort Springer Vienna
    Dokumenttyp Artikel
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-021-05162-3
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