Article ; Online: The m
2021 Volume 27, Issue 9, Page(s) 1102–1125
Abstract: Polyadenylated nuclear (PAN) RNA is a long noncoding transcript involved in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic reactivation and regulation of cellular and viral gene expression. We have previously shown that PAN RNA has dynamic ... ...
| Abstract | Polyadenylated nuclear (PAN) RNA is a long noncoding transcript involved in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic reactivation and regulation of cellular and viral gene expression. We have previously shown that PAN RNA has dynamic secondary structure and protein binding profiles that can be influenced by epitranscriptomic modifications. |
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| MeSH term(s) | Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Base Pairing ; Base Sequence ; Cell Line, Tumor ; Endonucleases/genetics ; Endonucleases/metabolism ; Epigenesis, Genetic ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein Group C/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group C/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Lymphocytes/metabolism ; Lymphocytes/virology ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Nucleic Acid Conformation ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Nuclear/genetics ; RNA, Nuclear/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Reverse Transcription ; Sequence Analysis, RNA ; Transcriptome |
| Chemical Substances | HNRNPC protein, human ; Heterogeneous-Nuclear Ribonucleoprotein Group C ; RBM15 protein, human ; RNA, Long Noncoding ; RNA, Messenger ; RNA, Nuclear ; RNA-Binding Proteins ; YTHDF2 protein, human ; N-methyladenosine (CLE6G00625) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Endonucleases (EC 3.1.-) ; SND1 protein, human (EC 3.1.-) ; Adenosine (K72T3FS567) |
| Language | English |
| Publishing date | 2021-06-29 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Retracted Publication |
| ZDB-ID | 1241540-6 |
| ISSN | 1469-9001 ; 1355-8382 |
| ISSN (online) | 1469-9001 |
| ISSN | 1355-8382 |
| DOI | 10.1261/rna.078777.121 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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