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  1. Book ; Thesis: Die Reproduzierbarkeit von Klassifikationssystemen der Hüftkopfnekrose

    Märtin, Ulrich

    Inter- und intrarater Reliabilität der ARCO-Klassifikation im Vergleich mit einem neu vorgeschlagenem System

    2008  

    Author's details vorgelegt von Ulrich Märtin
    Language German
    Size 94 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 2008
    HBZ-ID HT015884007
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 D 348 order for loan Magazin

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  2. Article ; Online: Unlocking the Future: Pluripotent Stem Cell-Based Lung Repair.

    Goecke, Tobias / Ius, Fabio / Ruhparwar, Arjang / Martin, Ulrich

    Cells

    2024  Volume 13, Issue 7

    Abstract: The human respiratory system is susceptible to a variety of diseases, ranging from chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis to acute respiratory distress syndrome (ARDS). Today, lung diseases represent one of the major ... ...

    Abstract The human respiratory system is susceptible to a variety of diseases, ranging from chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis to acute respiratory distress syndrome (ARDS). Today, lung diseases represent one of the major challenges to the health care sector and represent one of the leading causes of death worldwide. Current treatment options often focus on managing symptoms rather than addressing the underlying cause of the disease. The limitations of conventional therapies highlight the urgent clinical need for innovative solutions capable of repairing damaged lung tissue at a fundamental level. Pluripotent stem cell technologies have now reached clinical maturity and hold immense potential to revolutionize the landscape of lung repair and regenerative medicine. Meanwhile, human embryonic (HESCs) and human-induced pluripotent stem cells (hiPSCs) can be coaxed to differentiate into lung-specific cell types such as bronchial and alveolar epithelial cells, or pulmonary endothelial cells. This holds the promise of regenerating damaged lung tissue and restoring normal respiratory function. While methods for targeted genetic engineering of hPSCs and lung cell differentiation have substantially advanced, the required GMP-grade clinical-scale production technologies as well as the development of suitable preclinical animal models and cell application strategies are less advanced. This review provides an overview of current perspectives on PSC-based therapies for lung repair, explores key advances, and envisions future directions in this dynamic field.
    MeSH term(s) Animals ; Humans ; Endothelial Cells ; Pluripotent Stem Cells ; Induced Pluripotent Stem Cells/metabolism ; Lung ; Pulmonary Fibrosis/metabolism
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Dual-Energy-CT

    Sedlmair, Martin Ulrich

    physikalische Modelle und Anwendungen

    (Berichte aus der medizinischen Physik)

    2010  

    Author's details Martin Ulrich Sedlmair
    Series title Berichte aus der medizinischen Physik
    Keywords Dual-Source-Computertomographie
    Subject Dual-Source-Computertomografie ; Dual-Source-CT
    Subject code 616.075722
    Language German
    Size XIV, 167 S. : Ill., graph. Darst., 21 cm, 272 gr.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2009
    HBZ-ID HT016452234
    ISBN 978-3-8322-8899-0 ; 3-8322-8899-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4500 order for loan Magazin

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  4. Book: Engineering of stem cells

    Amit, Michal / Martin, Ulrich

    (Advances in biochemical engineering - biotechnology ; 114)

    2009  

    Author's details vol. ed.: Ulrich Martin. With contrib. by M. Amit
    Series title Advances in biochemical engineering - biotechnology ; 114
    Advances in biochemical engineering, biotechnology
    Collection Advances in biochemical engineering, biotechnology
    Keywords Stammzelle ; Biomedizinische Technik
    Subject Stem cell ; BMT ; Biomedical engineering ; Biomedizintechnik
    Language English
    Size XIII, 239 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016103732
    ISBN 978-3-540-88805-5 ; 9783540888062 ; 3-540-88805-5 ; 3540888063
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5301 order for loan Magazin

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  5. Book ; Thesis: Prähospitale Thrombolyse-Therapie mit rekombinantem Gewebe-Plasminogen-Aktivator (rt-PA) beim akuten Myokardinfarkt

    Martin, Ulrich

    1999  

    Author's details vorgelegt von Ulrich Martin
    Language German
    Size 73 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2000
    HBZ-ID HT012871840
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 D 2421 order for loan Magazin

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  6. Article ; Online: Genome stability of programmed stem cell products.

    Martin, Ulrich

    Advanced drug delivery reviews

    2017  Volume 120, Page(s) 108–117

    Abstract: Inherited and acquired genomic abnormalities are known to cause genetic diseases and contribute to cancer formation. Recent studies demonstrated a substantial mutational load in mouse and human embryonic and induced pluripotent stem cells (ESCs and iPSCs) ...

    Abstract Inherited and acquired genomic abnormalities are known to cause genetic diseases and contribute to cancer formation. Recent studies demonstrated a substantial mutational load in mouse and human embryonic and induced pluripotent stem cells (ESCs and iPSCs). Single nucleotide variants, copy number variations, and larger chromosomal abnormalities may influence the differentiation capacity of pluripotent stem cells and the functionality of their derivatives in disease modeling and drug screening, and are considered a serious risk for cellular therapies based on ESC or iPSC derivatives. This review discusses the types and origins of different genetic abnormalities in pluripotent stem cells, methods for their detection, and the mechanisms of development and enrichment during reprogramming and culture expansion.
    MeSH term(s) Animals ; Cellular Reprogramming/genetics ; Cellular Reprogramming/physiology ; Embryonic Stem Cells/physiology ; Genomic Instability/physiology ; Pluripotent Stem Cells/physiology ; Stem Cells/physiology
    Language English
    Publishing date 2017-09-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2017.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Therapeutic Application of Pluripotent Stem Cells: Challenges and Risks.

    Martin, Ulrich

    Frontiers in medicine

    2017  Volume 4, Page(s) 229

    Abstract: Stem-cell-based therapies are considered to be promising and innovative but complex approaches. Induced pluripotent stem cells (iPSCs) combine the advantages of adult stem cells with the hitherto unique characteristics of embryonic stem cells (ESCs). ... ...

    Abstract Stem-cell-based therapies are considered to be promising and innovative but complex approaches. Induced pluripotent stem cells (iPSCs) combine the advantages of adult stem cells with the hitherto unique characteristics of embryonic stem cells (ESCs). Major progress has already been achieved with regard to reprogramming technology, but also regarding targeted genome editing and scalable expansion and differentiation of iPSCs and ESCs, in some cases yielding highly enriched preparations of well-defined cell lineages at clinically required dimensions. It is noteworthy, however, that for many applications critical requirements such as the targeted specification into distinct cellular subpopulations and a proper cell maturation remain to be achieved. Moreover, current hurdles such as low survival rates and insufficient functional integration of cellular transplants remain to be overcome. Nevertheless, PSC technologies obviously have come of age and matured to a stage where various clinical applications of PSC-based cellular therapies have been initiated and are conducted.
    Language English
    Publishing date 2017-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2017.00229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ultrasound-guided initial diagnosis and follow-up of pediatric idiopathic intracranial hypertension.

    Kerscher, Susanne Regina / Zipfel, Julian / Haas-Lude, Karin / Bevot, Andrea / Schuhmann, Martin Ulrich

    Pediatric radiology

    2024  

    Abstract: Background: Idiopathic intracranial hypertension in children often presents with non-specific symptoms found in conditions such as hydrocephalus. For definite diagnosis, invasive intracranial pressure measurement is usually required. Ultrasound (US) of ... ...

    Abstract Background: Idiopathic intracranial hypertension in children often presents with non-specific symptoms found in conditions such as hydrocephalus. For definite diagnosis, invasive intracranial pressure measurement is usually required. Ultrasound (US) of the optic nerve sheath diameter provides a non-invasive method to assess intracranial pressure. Transtemporal US allows imaging of the third ventricle and thus assessment for hydrocephalus.
    Objective: To investigate whether the combination of US optic nerve sheath and third ventricle diameter can be used as a screening tool in pediatric idiopathic intracranial hypertension to indicate elevated intracranial pressure and exclude hydrocephalus as an underlying pathology. Further, to analyze whether both parameters can be used to monitor treatment outcome.
    Materials and methods: We prospectively included 36 children with idiopathic intracranial hypertension and 32 controls. Using a 12-Mhz linear transducer and a 1-4-Mhz phased-array transducer, respectively, optic nerve sheath and third ventricle diameters were determined initially and during the course of treatment.
    Results: In patients, the mean optic nerve sheath diameter was significantly larger (6.45±0.65 mm, controls: 4.96±0.32 mm) and the mean third ventricle diameter (1.69±0.65 mm, controls: 2.99±1.31 mm) was significantly smaller compared to the control group, P<0.001. Optimal cut-off values were 5.55 mm for the optic nerve sheath and 1.83 mm for the third ventricle diameter.
    Conclusions: The combined use of US optic nerve sheath and third ventricle diameter is an ideal non-invasive screening tool in pediatric idiopathic intracranial hypertension to indicate elevated intracranial pressure while ruling out hydrocephalus. Treatment can effectively be monitored by repeated US, which also reliably indicates relapse.
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-024-05905-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 927: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article: Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?

    Martin, Ulrich

    Molecular and cellular pediatrics

    2015  Volume 2, Issue 1, Page(s) 15

    Abstract: Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), associated lung and liver pathologies ... ...

    Abstract Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), associated lung and liver pathologies remain largely untreatable and no real breakthrough is visible for the majority of patients suffering from cystic fibrosis (CF).Novel compounds have to be identified and tailored in combination to specific CFTR mutations, to different tissues, or even to the individual patient. Immortalized cell lines overexpressing mutant CFTR are typically used to screen candidate molecules but have proven to be poor predictors of clinical efficacy. The complexity of CFTR maturation and turnover requires the use of cellular models that closely recapitulate the specific properties of the clinically most affected organs. Importantly, current screening efforts based on primary airway cells or intestinal organoids cannot specifically target single rare CFTR mutations or mimic multiple cell types.In the near future, genetically engineered induced pluripotent stem cells will provide an excellent basis for personalized organotypic models of CF disease and biological screens for identification of CFTR potentiators and correctors.
    Language English
    Publishing date 2015-12-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2785551-X
    ISSN 2194-7791
    ISSN 2194-7791
    DOI 10.1186/s40348-015-0023-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New muscle for old hearts: engineering tissue from pluripotent stem cells.

    Martin, Ulrich

    Human gene therapy

    2015  Volume 26, Issue 5, Page(s) 305–311

    Abstract: Stem cell-based therapies are considered to be promising and innovative therapeutic strategies for heart repair. Patient-derived induced pluripotent stem cells (iPSCs) are now available, which combine the advantages of autologous adult stem cells with ... ...

    Abstract Stem cell-based therapies are considered to be promising and innovative therapeutic strategies for heart repair. Patient-derived induced pluripotent stem cells (iPSCs) are now available, which combine the advantages of autologous adult stem cells with the unlimited potential of embryonic stem cells for proliferation and differentiation. Intense research has driven dramatic progress in various areas of iPSC technology relevant for clinically applicable iPSC-based cellular therapies. At this point, it is already possible to generate transgene-free autologous iPSCs from small blood samples or hair, to scale up the expansion and differentiation of iPSCs to clinically required dimensions, and to obtain highly enriched cardiomyocyte preparations. On the other hand, critical hurdles such as the targeted specification of distinct cardiomyocyte subpopulations, survival and proper functional integration of cellular transplants after myocardial infarction, and in vitro engineering of prevascularized muscle patches have yet to be overcome. Nevertheless, concepts of cellular cardiomyoplasty seem to have come of age and the first clinical applications of iPSC-based heart repair can be expected within the coming years.
    MeSH term(s) Animals ; Cell Differentiation ; Cell- and Tissue-Based Therapy/methods ; Guided Tissue Regeneration/methods ; Humans ; Induced Pluripotent Stem Cells/cytology ; Myocardium/cytology ; Myocytes, Cardiac/cytology ; Pluripotent Stem Cells/cytology ; Stem Cell Transplantation ; Tissue Engineering
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2015.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2988: Show issues Location:
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