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  1. AU="Martin Bucher"
  2. AU="Kirschvink N"
  3. AU="Sánchez, Isabel"
  4. AU="Kapphahn, Rebecca J"
  5. AU="Bertuccio, Claudia A"
  6. AU="Jennifer A Gaddy"
  7. AU="Tuccar, Eray"
  8. AU="Koch, Karen E"
  9. AU="Kelly, Allicia P"
  10. AU=Kakinuma Takashi
  11. AU="Nachira, Lorenza"
  12. AU="Wei, Xiang"
  13. AU="Daniell, Esther"
  14. AU="Chou, Chau-Wen"
  15. AU=Kaur Supreet
  16. AU="Yun, Joho"
  17. AU="Tran, Bao G"
  18. AU="Ou Li"
  19. AU="Ting Chen" AU="Ting Chen"
  20. AU="Wilson, Jaymi"
  21. AU="Vane, Christopher H"
  22. AU="Mabbott, Donald"
  23. AU="Martín-Trejo, Jorge Alfonso"
  24. AU=Rieder Hans L

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  1. Artikel ; Online: The Potential of Omics in Biological Dosimetry

    Daniela Hladik / Martin Bucher / David Endesfelder / Ursula Oestreicher

    Radiation, Vol 2, Iss 6, Pp 78-

    2022  Band 90

    Abstract: Biological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe radiation accidents where a large number of people are ... ...

    Abstract Biological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe radiation accidents where a large number of people are potentially affected, it is possible to distinguish irradiated from non-irradiated people in order to initiate appropriate medical care if necessary. In addition to severe incidents caused by technical failure, environmental disasters, military actions, or criminal abuse, there are also radiation accidents in which only one or a few individuals are affected in the frame of occupational or medical exposure. The requirements for biological dosimetry are fundamentally different for these two scenarios. In particular, for large-scale radiation accidents, pre-screening methods are necessary to increase the throughput of samples for a rough first-dose categorization. The rapid development and increasing use of omics methods in research as well as in individual applications provides new opportunities for biological dosimetry. In addition to the discovery and search for new biomarkers, dosimetry assays based on omics technologies are becoming increasingly interesting and hold great potential, especially for large-scale dosimetry. In the following review, the different areas of biological dosimetry, the problems in finding suitable biomarkers, the current status of biomarker research based on omics, the potential applications of assays using omics technologies, and also the limitations for the different areas of biological dosimetry are discussed.
    Schlagwörter biological dosimetry ; omics ; transcriptomics ; proteomics ; metabolomics ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The German Uranium Miners’ Biobank—A Biobank for OMICs Radiation Research

    Maria Gomolka / Martin Bucher / Lukas Duchrow / Beate Hochstrat / Dirk Taeger / Georg Johnen / Simone Moertl

    Radiation, Vol 2, Iss 5, Pp 62-

    2022  Band 77

    Abstract: Systematic bio- and databanks are key prerequisites for modern radiation research to investigate radiation response mechanisms in the context of genetic, environmental and lifestyle-associated factors. This report presents the current status of the ... ...

    Abstract Systematic bio- and databanks are key prerequisites for modern radiation research to investigate radiation response mechanisms in the context of genetic, environmental and lifestyle-associated factors. This report presents the current status of the German Uranium Miners’ Biobank. In 2008, the bio- and databank was established at the Federal Office for Radiation Protection, and the sampling of biological materials from former uranium miners with and without lung cancer was initiated. For this purpose, various biological specimens, such as DNA and RNA, were isolated from blood samples as well as from formalin-fixed paraffin-embedded lung tissue. High-quality biomaterials suitable for OMICs research and the associated data on occupational radiation and dust exposure, and medical and lifestyle data from over 1000 individuals have been stored so far. Various experimental data, e.g., genome-wide SNPs, whole genome transcriptomic and miRNA data, as well as individual chromosomal aberration data from subgroups of biobank samples, are already available upon request for in-depth research on radiation-induced long-term effects, individual radiation susceptibility to lung cancer and radon-induced fingerprints in lung cancer. This biobank is the first systematic uranium miners´ biobank worldwide that is suitable for OMICs research on radiation-exposed workers. It offers the opportunity to link radiation-induced perturbations of biological pathways or processes and putative adverse outcome(s) by OMICs profiling at different biological organization levels.
    Schlagwörter biobank ; radon ; uranium ; mining ; occupational ; exposure ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Dose Variations Using an X-Ray Cabinet to Establish in vitro Dose-Response Curves for Biological Dosimetry Assays

    Martin Bucher / Tina Weiss / David Endesfelder / Francois Trompier / Yoann Ristic / Patrizia Kunert / Helmut Schlattl / Augusto Giussani / Ursula Oestreicher

    Frontiers in Public Health, Vol

    2022  Band 10

    Abstract: In biological dosimetry, dose-response curves are essential for reliable retrospective dose estimation of individual exposure in case of a radiation accident. Therefore, blood samples are irradiated in vitro and evaluated based on the applied assay. ... ...

    Abstract In biological dosimetry, dose-response curves are essential for reliable retrospective dose estimation of individual exposure in case of a radiation accident. Therefore, blood samples are irradiated in vitro and evaluated based on the applied assay. Accurate physical dosimetry of the irradiation performance is a critical part of the experimental procedure and is influenced by the experimental setup, especially when X-ray cabinets are used. The aim of this study was to investigate variations and pitfalls associated with the experimental setups used to establish calibration curves in biological dosimetry with X-ray cabinets. In this study, irradiation was performed with an X-ray source (195 kV, 10 mA, 0.5 mm Cu filter, dose rate 0.52 Gy/min, 1st and 2nd half-value layer = 1.01 and 1.76 mm Cu, respectively, average energy 86.9 keV). Blood collection tubes were irradiated with a dose of 1 Gy in vertical or horizontal orientation in the center of the beam area with or without usage of an additional fan heater. To evaluate the influence of the setups, physical dose measurements using thermoluminescence dosimeters, electron paramagnetic resonance dosimetry and ionization chamber as well as biological effects, quantified by dicentric chromosomes and micronuclei, were compared. This study revealed that the orientation of the sample tubes (vertical vs. horizontal) had a significant effect on the radiation dose with a variation of −41% up to +49% and contributed to a dose gradient of up to 870 mGy inside the vertical tubes due to the size of the sample tubes and the associated differences in the distance to the focal point of the tube. The number of dicentric chromosomes and micronuclei differed by ~30% between both orientations. An additional fan heater had no consistent impact. Therefore, dosimetric monitoring of experimental irradiation setups is mandatory prior to the establishment of calibration curves in biological dosimetry. Careful consideration of the experimental setup in collaboration with physicists is required ...
    Schlagwörter biological dosimetry (biodosimetry) ; dose-response curves ; X-ray cabinet ; dose variation ; dicentric chromosome (DC) ; micronuclei (MN) ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: 3,10,17,24-Tetra(1-methylethyl)-[29H,31H-tetrapyrido[2,3-b:2′,3′-g:2″-3″-I:2‴,3‴ -q]porphyrazinato-(2-)N29,N30,N31,N32]-nickel- [Eu(fod)3]4- Ein lösliches Pyridoporphyrazin / 3,10,17,24-Tetra(1-methylethyl)- [29H,31H-tetrapyrido[2,3-b:2′,3′-g:2″-3″-I:2‴,3‴-q]porphyrazinato-(2-)N29,N30,N31,N32]-nickel-[Eu(fod)3]4 - A Soluble Pyridoporphyrazine

    Eichinger, Karl / Christoph Brunmair / Martin Bucher

    Zeitschrift für Naturforschung. 2014 June 2, v. 53, no. 5-6

    2014  

    Abstract: Starting from diethyl 5-(methylethyl)pyridine- 2,3-dicarboxylate the crystalline and highly soluble complex 3,10,17,24-Tetra(1-methylethyl)- [29H,31H-tetrapyrido[2,3-b:2′, 3′, -g:2″-3″-I:2‴, 3‴-q]porphyrazinato(2-)N29,N30,N31 ,N32]- nickel-[Eu(fod)₃]₄ ... ...

    Abstract Starting from diethyl 5-(methylethyl)pyridine- 2,3-dicarboxylate the crystalline and highly soluble complex 3,10,17,24-Tetra(1-methylethyl)- [29H,31H-tetrapyrido[2,3-b:2′, 3′, -g:2″-3″-I:2‴, 3‴-q]porphyrazinato(2-)N29,N30,N31 ,N32]- nickel-[Eu(fod)₃]₄ was prepared. In this compound each europium ligand is coordinated to a pyridine N-atom and neighboured N-atom of the porphyrazine ring.
    Schlagwörter europium ; ligands ; pyridines
    Sprache Englisch
    Erscheinungsverlauf 2014-0602
    Umfang p. 637.
    Erscheinungsort Verlag der Zeitschrift für Naturforschung
    Dokumenttyp Artikel
    ZDB-ID 124635-5
    ISSN 0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
    ISSN 0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
    DOI 10.1515/znb-1998-5-624
    Datenquelle NAL Katalog (AGRICOLA)

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