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  1. Article: Editorial: New strategies to overcome platinum resistance in ovarian cancer.

    Wei, Jian-Jun / Martinelli, Fabio

    Frontiers in oncology

    2024  Volume 14, Page(s) 1390760

    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1390760
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  2. Article ; Online: Alzheimer's Disease Evaluation Through Visual Explainability by Means of Convolutional Neural Networks.

    Mercaldo, Francesco / Di Giammarco, Marcello / Ravelli, Fabrizio / Martinelli, Fabio / Santone, Antonella / Cesarelli, Mario

    International journal of neural systems

    2024  Volume 34, Issue 2, Page(s) 2450007

    Abstract: Background and ... ...

    Abstract Background and Objective
    MeSH term(s) Humans ; Male ; Female ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Neural Networks, Computer ; Magnetic Resonance Imaging/methods ; Algorithms ; Neuroimaging/methods
    Language English
    Publishing date 2024-01-12
    Publishing country Singapore
    Document type Journal Article
    ISSN 1793-6462
    ISSN (online) 1793-6462
    DOI 10.1142/S0129065724500072
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  3. Article ; Online: Endovenous laser ablation (EVLA) for vein insufficiency: two-year results of a multicenter experience with 1940-nm laser diode and a novel optical fiber.

    Palombi, Luca / Morelli, Monica / Bruzzese, Dario / Martinelli, Fabio / Quarto, Gennaro / Bianchi, Pier Giovanni

    Lasers in medical science

    2024  Volume 39, Issue 1, Page(s) 61

    Abstract: Thermoablative techniques currently represent, in accordance with international guidelines, the most used methods in the treatment of varicose veins. From some years, lasers with a wavelength greater than 1900 nm have been introduced for EndoVenous Laser ...

    Abstract Thermoablative techniques currently represent, in accordance with international guidelines, the most used methods in the treatment of varicose veins. From some years, lasers with a wavelength greater than 1900 nm have been introduced for EndoVenous Laser Ablation (EVLA) treatment. However, currently, few clinical studies regarding this new technology are reported in the medical literature. The aim of this study is to evaluate outcomes at a 2-year follow-up (mid-term) of EVLA of varicose veins of the lower limbs using a 1940-nm laser and a new cylindric monoring fiber. This clinical trial was conducted as a multicenter, retrospective, non-randomized, non-blind clinical study. Ninety-three patients were enrolled for a total of one hundred consecutive procedures performed in the period between January 2021 and May 2021 in two Italian facilities. The primary efficacy endpoint was the occlusion rate of the treated vein immediately after surgery and at the follow-up (24 months). The secondary efficacy endpoint was the evaluation of the parameters of energy delivered during the procedure (power and linear energy density or LEED). The primary safety endpoints were the incidence of pain (1 day and 7 days after surgery) and the rate of intraoperative and postoperative complications. The precepted pain was evaluated with the visual analog scale (VAS). The secondary safety endpoint was the evaluation of the improvement of the patient's symptoms related to venous disease. This evaluation was conducted by recording the changes in clinical, etiologic, anatomic, and pathophysiologic (CEAP) classification. All procedures were carried out regularly on an outpatient basis, and no intraoperative complications occurred. The occlusion rate of the target veins was 100% at 7- and 30-day controls. At follow-up controls, performed at 6 months, 1 and 2 years carried out showed an occlusion rate respectively of 99% (97 to 100), 96.9% (93.6 to 100), and 95.9% (92.1 to 99.9). The secondary efficacy endpoint was the evaluation of the parameters of energy delivered during the procedure (power watt and linear energy density): As regards the power parameters, we report an average of watts of 4.5 ± 0.8 [2.5 to 6] and linear energy density delivered (LEED) of 41.2 ± 8.6 [(21.1 to 66.7)]. The pain reported (with VAS scale) on 1 day of the procedure was 2 [1; 3] and 1 [0 to 4] at 7 days. All patients showed improved symptoms related to venous disease, with reduction of the individual CEAP class to which they belong. This study demonstrates that EndoVascular Laser Ablation (EVLA) treatment of varicose veins with a wavelength > 1900 nm is safe and effective. The overall occlusion rate was high. The reported results suggest that using lower parameters, such as output power (watts) and LEED (linear energy density), do not reduce the success rate of the treatment when used over 35 J/cm.
    MeSH term(s) Humans ; Optical Fibers ; Retrospective Studies ; Laser Therapy ; Varicose Veins/surgery ; Pain
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Clinical Trial ; Multicenter Study ; Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-024-04000-7
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  4. Article ; Online: "Pelvic neuro-visualization: an anatomical illustration of the autonomic pelvic nervous network in gynecologic surgery".

    Ditto, Antonino / Ferla, Stefano / Martinelli, Fabio / Bogani, Giorgio / Maggiore, Umberto Leone Roberti / Raspagliesi, Francesco

    Journal of minimally invasive gynecology

    2024  

    Abstract: Objective: During radical pelvic surgeries fibers of the autonomic pelvic nervous network can be accidentally damaged leading to significant visceral sequelae, which dramatically affect women's quality of life because of urinary, anorectal, and sexual ... ...

    Abstract Objective: During radical pelvic surgeries fibers of the autonomic pelvic nervous network can be accidentally damaged leading to significant visceral sequelae, which dramatically affect women's quality of life because of urinary, anorectal, and sexual postoperative dysfunctions.
    Design: Narrated laparoscopic video footage for identifying, dissecting, and preserving the autonomic nerve bundles during pelvic surgery.
    Setting: Tertiary level hospital - "IRCCS Istituto Nazionale dei Tumori", Milano, Italy.
    Interventions: Visceral pelvic innervation is established by the superior hypogastric plexus(SHP) located anteriorly to the aortic bifurcation and the median sacral vessels and carries mostly sympathetic fibers. SHP divides in front of the sacrum into the right and left HN. At the level of the paracervix, the HNs join the parasympathetic PSNs coming out from sacral root S2, S3, S4 to form the IHP.
    Conclusion: Nerve-sparing surgery reduces bowel-, bladder- and sexual- dysfunction without decreasing surgical efficacy.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2024.04.014
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  5. Article ; Online: Explainable Convolutional Neural Networks for Brain Cancer Detection and Localisation.

    Mercaldo, Francesco / Brunese, Luca / Martinelli, Fabio / Santone, Antonella / Cesarelli, Mario

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 17

    Abstract: Brain cancer is widely recognised as one of the most aggressive types of tumors. In fact, approximately 70% of patients diagnosed with this malignant cancer do not survive. In this paper, we propose a method aimed to detect and localise brain cancer, ... ...

    Abstract Brain cancer is widely recognised as one of the most aggressive types of tumors. In fact, approximately 70% of patients diagnosed with this malignant cancer do not survive. In this paper, we propose a method aimed to detect and localise brain cancer, starting from the analysis of magnetic resonance images. The proposed method exploits deep learning, in particular convolutional neural networks and class activation mapping, in order to provide explainability by highlighting the areas of the medical image related to brain cancer (from the model point of view). We evaluate the proposed method with 3000 magnetic resonances using a free available dataset. The results we obtained are encouraging. We reach an accuracy ranging from 97.83% to 99.67% in brain cancer detection by exploiting four different models: VGG16, ResNet50, Alex_Net, and MobileNet, thus showing the effectiveness of the proposed method.
    MeSH term(s) Humans ; Brain ; Brain Neoplasms/diagnostic imaging ; Aggression ; Neural Networks, Computer ; Records
    Language English
    Publishing date 2023-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23177614
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  6. Article ; Online: Water Meter Reading for Smart Grid Monitoring.

    Martinelli, Fabio / Mercaldo, Francesco / Santone, Antonella

    Sensors (Basel, Switzerland)

    2022  Volume 23, Issue 1

    Abstract: Many tasks that require a large workforce are automated. In many areas of the world, the consumption of utilities, such as electricity, gas and water, is monitored by meters that need to be read by humans. The reading of such meters requires the presence ...

    Abstract Many tasks that require a large workforce are automated. In many areas of the world, the consumption of utilities, such as electricity, gas and water, is monitored by meters that need to be read by humans. The reading of such meters requires the presence of an employee or a representative of the utility provider. Automatic meter reading is crucial in the implementation of smart grids. For this reason, with the aim to boost the implementation of the smart grid paradigm, in this paper, we propose a method aimed to automatically read digits from a dial meter. In detail, the proposed method aims to localise the dial meter from an image, to detect the digits and to classify the digits. Deep learning is exploited, and, in particular, the YOLOv5s model is considered for the localisation of digits and for their recognition. An experimental real-world case study is presented to confirm the effectiveness of the proposed method for automatic digit localisation recognition from dial meters.
    MeSH term(s) Humans ; Computer Systems ; Electricity
    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23010075
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  7. Article ; Online: Change in practice in gynecologic oncology during the COVID-19 pandemic: a social media survey.

    Martinelli, Fabio / Garbi, Annalisa

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 8, Page(s) 1101–1107

    Abstract: Objective: COVID-19 has affected gynecologic cancer management. The goal of this survey was to evaluate changes that occurred in gynecologic oncology practice during the COVID-19 pandemic.: Methods: A anonymous survey consisting of 33 questions ( ... ...

    Abstract Objective: COVID-19 has affected gynecologic cancer management. The goal of this survey was to evaluate changes that occurred in gynecologic oncology practice during the COVID-19 pandemic.
    Methods: A anonymous survey consisting of 33 questions (https://sites.google.com/view/gyncacovidfmartinelli) regarding interaction between gynecologic cancers and COVID-19 was distributed online via social media from April 9 to April 30, 2020. Basic descriptive statistics were applied. Analytics of survey-diffusion and generated-interest (visualizations, engagement rates, response rate) were analyzed.
    Results: The survey received 20 836 visualizations, generating an average engagement rates by reach of 4.7%. The response rate was 30%. A total of 86% of respondents completed the survey, for a total of 187 physicians surveyed across 49 countries. The majority (143/187; 76%) were gynecologic oncologists, and most were ≤50 years old (146/187; 78%). A total of 49.7% (93/187) were facing the early phase of the COVID-19 pandemic, while 26.7% (50/187) and 23.5% (44/187) were in the peak and plateau phases, respectively. For 97.3% (182/187) of respondents COVID-19 affected or changed their respective clinical practice. Between 16% (27/165) (before surgery) and 25% (26/102) (before medical treatment) did not perform any tests to rule out COVID-19 infection among patients. The majority of respondents did not alter indications of treatment if patients were COVID-19-negative, while treatments were generally postponed in COVID-19-positive patients. Treatments were considered priority for: early stage high-risk uterine cancers (85/187; 45%), newly diagnosed epithelial ovarian cancer (76/187; 41%), and locally advanced cervical cancer (76/187; 41%). Treatment of early stage low-grade endometrioid endometrial cancer was deferred according to 49% (91/187) of respondents, with hormonal treatment as the option of therapy (31%; 56/178). A total of 77% (136/177) of respondents reported no changes in (surgical) treatment for early stage cervical cancer in COVID-19-negative patients, while treatment was postponed by 54% (96/177) of respondent, if the patient tested COVID-19-positive. Neoadjuvant chemotherapy for advanced ovarian cancers was considered by over one-third of respondents as well as hypofractionation of radiation treatment for locally advanced cervical cancers.
    Conclusion: COVID-19 affected the treatment of gynecologic cancers patients, both in terms of prioritization and identification of strategies to reduce hospital access and length of stay. Social media is a reliable tool to perform fast-tracking, worldwide surveys.
    MeSH term(s) Adult ; Attitude of Health Personnel ; Betacoronavirus ; COVID-19 ; Combined Modality Therapy ; Coronavirus Infections/prevention & control ; Female ; Genital Neoplasms, Female/diagnosis ; Genital Neoplasms, Female/therapy ; Global Health ; Gynecology/methods ; Gynecology/trends ; Health Care Rationing/trends ; Health Care Surveys ; Health Services Accessibility/trends ; Humans ; Infection Control/methods ; Infection Control/trends ; Male ; Medical Oncology/methods ; Medical Oncology/trends ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Practice Patterns, Physicians'/trends ; SARS-CoV-2 ; Social Media
    Keywords covid19
    Language English
    Publishing date 2020-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001585
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  8. Article ; Online: The evolution of endovenous laser ablation (EVLA). A single-center experience with a 1470 nm versus a 1940 nm diode laser.

    Bianchi, Pier Giovanni / Martinelli, Fabio / Quarto, Gennaro / Palombi, Luca

    Annali italiani di chirurgia

    2022  Volume 93, Page(s) 578–583

    Abstract: Aim: To evalue the short-term results obtained in endovenous laser ablation (EVLA) procedure of the varicose insufficiency of the lower limbs with Diode 1470 nm laser compared to Diode 1940 nm laser.: Materials of study: A total of 55 patients were ... ...

    Abstract Aim: To evalue the short-term results obtained in endovenous laser ablation (EVLA) procedure of the varicose insufficiency of the lower limbs with Diode 1470 nm laser compared to Diode 1940 nm laser.
    Materials of study: A total of 55 patients were enrolled in the study. The patients were divided into two groups: those subjected to 1470 nm laser treatment in group A and those with 1940 nm laser treatment in group B. The endpoints were: Closure of the target vessel, complications and post-operative pain.
    Results: There are no intra-and post-operative complications. The occlusion rate of the target veins was 100% at 7- and 60-day controls. The pain perceived in the immediate post-operative and at the controls showed no statistically significant differences between the two groups. However in group B it was necessary to apply lower values of Power (W) and Linear Energy Density (LEED) with a statistically significant difference compared to group A.
    Discussion: Short-term results demonstrate closure rates comparable to those obtained with 1470 nm lasers. There were no statistically significant differences in the two groups in terms of primary and secondary endpoints. The advantage of using 1940 nm laser technology is that it is possible to dispense a lower linear energy density (LEED) at a lower power (Watt).
    Conclusions: Endovenous laser ablation with Diode 1940 nm is particularly suitable and advantageous in the treatment of superficial and small vessels, as well as venous segment adjacent to nerve structures.
    Key words: Diode laser, Intravenous ablation, Varicose, Venous insufficiency, Veins.
    MeSH term(s) Humans ; Laser Therapy/methods ; Lasers, Semiconductor/therapeutic use ; Saphenous Vein/surgery ; Treatment Outcome ; Varicose Veins/surgery ; Venous Insufficiency/surgery
    Language English
    Publishing date 2022-10-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
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  9. Article: Editorial: Molecular influences in therapies in ovarian cancer.

    Restaino, Stefano / Wei, Jian-Jun / Vizzielli, Giuseppe / Martinelli, Fabio

    Frontiers in oncology

    2022  Volume 12, Page(s) 991769

    Language English
    Publishing date 2022-08-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.991769
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  10. Article ; Online: Low pressure laparoscopic procedure in morbidly obese patients with endometrial carcinoma using a new subcutaneous abdominal wall-retraction device: a surgical challenge.

    Ditto, Antonino / Chiarello, Giulia / Leone Roberti Maggiore, Umberto / Martinelli, Fabio / Bogani, Giorgio / Raspagliesi, Francesco

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 12, Page(s) 1974–1975

    MeSH term(s) Humans ; Female ; Abdominal Wall/surgery ; Abdominal Wall/pathology ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Laparoscopy/methods ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004577
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