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  1. Book: Role of macronutrient distribution on weight loss

    Martínez, Alfredo

    (Nutrition, metabolism and cardiovascular diseases ; 21, Suppl. 2)

    2011  

    Author's details guest ed. Alfredo Martínez
    Series title Nutrition, metabolism and cardiovascular diseases ; 21, Suppl. 2
    Collection
    Language English
    Size B48 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017008474
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3149 -21,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Online: Precision Nutrition and Metabolic Syndrome Management

    Martínez, Alfredo J. / Zulet, Angeles M.

    2018  

    Abstract: Precision nutrition is an emerging concept encompassing an integrated action considering not only the genetic/epigenetic makeup and ethnic aspects of individuals, but other personalized phenotypical features, such as family and individual clinical issues, ...

    Abstract Precision nutrition is an emerging concept encompassing an integrated action considering not only the genetic/epigenetic makeup and ethnic aspects of individuals, but other personalized phenotypical features, such as family and individual clinical issues, previous diseases and therapeutic treatments, perinatal nutrition, food likes/dislikes, allergies/intolerances, lifestyle attitudes and patterns, social and cultural circumstances or religious beliefs, etc.In this context, chronic disease prevalence is a global public health problem itself, which is also accompanied by a number of complications, including insulin resistance, hypertension, hypercholesterolemia, fatty liver, inflammation, oxidative status and immunocompetence disturbances, and other adverse manifestations related to metabolic syndrome, which may need individualized nutritional approaches.Therefore, the current Special Issue attempts to provide specific nutritional strategies to prevent or treat the complications associated with metabolic syndrome features concerning diabetes, vascular events, liver diseases, dyslipemia, and cancer with a precision nutrition scope
    Keywords Public aspects of medicine
    Size 1 electronic resource (VIII, 214 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note englisch ; Open Access
    HBZ-ID HT020099051
    ISBN 9783038428596 ; 9783038428602 ; 3038428590 ; 3038428604
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Adrenomedullin

    Martínez, Alfredo

    1998  

    Author's details ed. by Alfredo Martínez
    Language English
    Size XIII, 391 S. : Ill., graph. Darst.
    Publisher IOS Press u.a.
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT009424955
    ISBN 90-5199-360-9 ; 4-274-90182-3 ; 978-90-5199-360-8 ; 978-4-274-90182-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 8588 order for loan Magazin

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  4. Article ; Online: Adrenomedullin: Not Just Another Gastrointestinal Peptide.

    Martínez-Herrero, Sonia / Martínez, Alfredo

    Biomolecules

    2022  Volume 12, Issue 2

    Abstract: Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others. AM and PAMP are ... ...

    Abstract Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others. AM and PAMP are widely expressed throughout the gastrointestinal (GI) tract where they behave as GI hormones, regulating numerous physiological processes such as gastric emptying, gastric acid release, insulin secretion, bowel movements, or intestinal barrier function. Furthermore, it has been recently demonstrated that AM/PAMP have an impact on gut microbiome composition, inhibiting the growth of bacteria related with disease and increasing the number of beneficial bacteria such as
    MeSH term(s) Adrenomedullin ; Gastrointestinal Tract ; Intestinal Mucosa ; Peptide Fragments ; Proteins/physiology
    Chemical Substances Peptide Fragments ; Proteins ; Adrenomedullin (148498-78-6)
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12020156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Succinate-Directed Approaches for Warburg Effect-Targeted Cancer Management, an Alternative to Current Treatments?

    Casas-Benito, Adrian / Martínez-Herrero, Sonia / Martínez, Alfredo

    Cancers

    2023  Volume 15, Issue 10

    Abstract: Approximately a century ago, Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of ... ...

    Abstract Approximately a century ago, Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of this fermentative metabolism even in the presence of oxygen, and this process is called aerobic glycolysis or the Warburg effect. This alternative metabolism is mainly characterized by higher glycolytic rates, which allow cancer cells to obtain higher amounts of total ATP, and the production of lactate, but there are also an activation of protumoral signaling pathways and the generation of molecules that favor cancer progression. One of these molecules is succinate, a Krebs cycle intermediate whose concentration is increased in cancer and which is considered an oncometabolite. Several protumoral actions have been associated to succinate and its role in several cancer types has been already described. Despite playing a major role in metabolism and cancer, so far, the potential of succinate as a target in cancer prevention and treatment has remained mostly unexplored, as most previous Warburg-directed anticancer strategies have focused on other intermediates. In this review, we aim to summarize succinate's protumoral functions and discuss the use of succinate expression regulators as a potential cancer therapy strategy.
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15102862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Non-pharmacologic Sustained Endothelial Shear Stress: An Evolving Clinical Paradigm.

    Adams, Jose A / Martínez, Alfredo

    Frontiers in physiology

    2021  Volume 12, Page(s) 790022

    Language English
    Publishing date 2021-11-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.790022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Highly sensitive serum volatolomic biomarkers for pancreatic cancer diagnosis.

    Martínez-Moral, María-Pilar / Tena, María Teresa / Martín-Carnicero, Alfonso / Martínez, Alfredo

    Clinica chimica acta; international journal of clinical chemistry

    2024  Volume 557, Page(s) 117895

    Abstract: The discovery of new diagnostic tools for the early detection of diseases with poor prognosis such as pancreatic adenocarcinoma (PAC) is of high importance. The results from a control-case study (20 PAC patients, 19 healthy controls) for the search of ... ...

    Abstract The discovery of new diagnostic tools for the early detection of diseases with poor prognosis such as pancreatic adenocarcinoma (PAC) is of high importance. The results from a control-case study (20 PAC patients, 19 healthy controls) for the search of new biomarkers of pancreatic cancer based in differences in the serum volatolome are presented in this work. Volatolomics were performed following a non-targeted HS-SPME-GC/MS approach, and a total of 433 volatile organic compounds (VOCs) was detected in the human serum samples. Of these, 125 VOC indexes showed a significant variation when controls and patients were compared (p-value < 0.05). Bonferroni corrected p-values < 0.05 were found for 40 features. PCA analysis showed the control-PAC discrimination capability of VOCs in serum, and PLS-DA was performed to select the best candidate biomarkers for the diagnosis of PAC. For the 40 selected VOCs, calculated areas under the curve (AUC) ranged from 0.98 to 0.85, and 11 of them were successfully validated using an independent set of samples (5 PAC patients, 5 healthy controls). Four of the proposed PAC biomarkers were identified as toluene, 2-ethyl-1-hexanol, pentylbenzene, and butoxymethylbenzene. Combinations of the identified PAC biomarkers were tested and showed AUC > 0.90, with the more promising candidate being butoxymethylbenzene (AUC = 0.98).
    MeSH term(s) Humans ; Adenocarcinoma/diagnosis ; Biomarkers ; Pancreatic Neoplasms/diagnosis ; Single-Case Studies as Topic ; Volatile Organic Compounds/analysis ; Case-Control Studies
    Chemical Substances Biomarkers ; Volatile Organic Compounds
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.117895
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.173: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Muscle Recovery and Nutrition

    Caballero-García, Alberto / Córdova-Martínez, Alfredo

    Nutrients. 2022 June 10, v. 14, no. 12

    2022  

    Abstract: Recovery strategies, both in the general population and in athletes, must be aimed at the main causes of fatigue [ ... ] ...

    Abstract Recovery strategies, both in the general population and in athletes, must be aimed at the main causes of fatigue [...]
    Keywords athletes ; muscles ; nutrients ; nutrition
    Language English
    Dates of publication 2022-0610
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14122416
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Muscle Recovery and Nutrition.

    Caballero-García, Alberto / Córdova-Martínez, Alfredo

    Nutrients

    2022  Volume 14, Issue 12

    Abstract: Recovery strategies, both in the general population and in athletes, must be aimed at the main causes of fatigue [ ... ]. ...

    Abstract Recovery strategies, both in the general population and in athletes, must be aimed at the main causes of fatigue [...].
    MeSH term(s) Athletes ; Fatigue ; Humans ; Muscle Fatigue/physiology ; Muscle, Skeletal/physiology ; Nutritional Status
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14122416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases

    Bobadilla, Miriam / García-Sanmartín, Josune / Martínez, Alfredo

    Antioxidants. 2021 Jan. 02, v. 10, no. 1

    2021  

    Abstract: Neurodegenerative diseases pose a major health problem for developed countries, and stress has been identified as one of the main risk factors in the development of these disorders. Here, we have examined the protective properties against oxidative ... ...

    Abstract Neurodegenerative diseases pose a major health problem for developed countries, and stress has been identified as one of the main risk factors in the development of these disorders. Here, we have examined the protective properties against oxidative stress of several bioactive natural food supplements. We found that MecobalActive®, Olews®, and red and white grape seed polyphenol extracts may have a neuroprotective effect in vitro, both in the SH-SY 5Y cell line and in hippocampal neuron cultures, mainly by reducing reactive oxygen species levels and decreasing caspase-3 activity. In vivo, we demonstrated that oral administration of the supplements reduces the expression of genes involved in inflammation and oxidation mechanisms, whereas it increments the expression of genes related to protection against oxidative stress. Furthermore, we found that preventive treatment with these natural extracts increases the activity of antioxidant enzymes and prevents lipid peroxidation in the brain of stressed mice. Thus, our results indicate that some natural bioactive supplements may have important protective properties against oxidative stress processes occurring in the brain.
    Keywords brain ; caspase-3 ; cell lines ; developed countries ; dietary supplements ; enzyme activity ; extracts ; gene expression ; grape seeds ; inflammation ; lipid peroxidation ; mice ; neurodegenerative diseases ; neurons ; neuroprotective effect ; oral administration ; oxidation ; oxidative stress ; polyphenols ; reactive oxygen species ; risk factors
    Language English
    Dates of publication 2021-0102
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10010046
    Database NAL-Catalogue (AGRICOLA)

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