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Article ; Online: Blepharoptosis and Cholesterol-Lowering Medications: A Retrospective Study.

Lam, Aimee N / Thayer, Jessica N / Rahman, Effie Z / Martinez, Andre N / Fry, Constance L

Ophthalmic plastic and reconstructive surgery

2020 Volume 36, Issue 1, Page(s) 86–88

Abstract: Purpose: To investigate the prevalence and frequency of patients with blepharoptosis who take anticholesterol therapies. To our knowledge, this is the first large single-center series to evaluate this association.: Methods: A retrospective chart ... ...

Abstract	Purpose: To investigate the prevalence and frequency of patients with blepharoptosis who take anticholesterol therapies. To our knowledge, this is the first large single-center series to evaluate this association. Methods: A retrospective chart review of adult patients presenting with ptosis on concomitant anticholesterol medications. Results: Two hundred ninety-three adult patients with ptosis taking anticholesterol therapy were identified from October 2011 to October 2016. Forty-seven patients (16.0%) reported muscle weakness. Laboratory markers including creatine kinase (CK) and myoglobin levels were obtained. Of the 47 patients, 13 patients (4.4%) were identified to have ptosis and laboratory confirmed anticholesterol therapy-induced myopathy. Two additional patients with statin-induced myositis and rhabdomyolysis were identified from the period 2008-2011. All patients had measurably elevated CK and/or myoglobin levels. All patients experienced improvement in ptosis or systemic symptoms after discontinuation or changing medications. Nine patients (60%) demonstrated statistically significant improvement in the ptosis. Conclusions: Many patients with involutional ptosis also have both cardiovascular disease and hyperlipidemia and thus take cholesterol-lowering medication. Our study demonstrates a World Health Organization-defined probable association between ptosis and anticholesterol-induced myopathy. The frequency of anticholesterol-induced myopathy in adult ptosis was 4.4%, which is substantially higher than previously predicted. Anticholesterol-induced myositis can cause a reversible ptosis, and thus, a thorough evaluation of adult patients presenting with involutional ptosis includes inquiry into the use of anticholesterol drugs and associated muscle weakness.Anticholesterol medication may induce or exacerbate myogenic ptosis in some individuals.
MeSH term(s)	Adult ; Blepharoptosis/chemically induced ; Cholesterol ; Humans ; Muscular Diseases/chemically induced ; Myositis ; Retrospective Studies
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000001476
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Article ; Online: PMMA functionalized boron nitride sheets as nanofillers.

Cui, Zhenhua / Martinez, Andre P / Adamson, Douglas H

Nanoscale

2015 Volume 7, Issue 22, Page(s) 10193–10197

Abstract: We report the functionalization of hexagonal boron nitride (hBN) with polymer chains. These chains are grown by atom transfer radical polymerization (ATRP) from hBN following thermal treatment. When used as a nanofiller, the material shows improved ... ...

Abstract	We report the functionalization of hexagonal boron nitride (hBN) with polymer chains. These chains are grown by atom transfer radical polymerization (ATRP) from hBN following thermal treatment. When used as a nanofiller, the material shows improved dispersion resulting in significantly improved toughness as compared to pristine hBN without polymer functionalization. The polymer functionalized BN is also characterized by TGA, FTIR and FESEM.
Language	English
Publishing date	2015-06-14
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c5nr00936g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrolytically Degradable PEGylated Polyelectrolyte Nanocomplexes for Protein Delivery.

Andrianov, Alexander K / Marin, Alexander / Martinez, Andre P / Weidman, Jacob L / Fuerst, Thomas R

Biomacromolecules

2018 Volume 19, Issue 8, Page(s) 3467–3478

Abstract: Novel oppositely charged polyphosphazene polyelectrolytes containing grafted poly(ethylene glycol) (PEG) chains were synthesized as modular components for the assembly of biodegradable PEGylated protein delivery vehicles. These macromolecular ... ...

Abstract	Novel oppositely charged polyphosphazene polyelectrolytes containing grafted poly(ethylene glycol) (PEG) chains were synthesized as modular components for the assembly of biodegradable PEGylated protein delivery vehicles. These macromolecular counterparts, which contained either carboxylic acid or tertiary amino groups, were then formulated at near physiological conditions into supramolecular assemblies of nanoscale level, below 100 nm. Nanocomplexes with electroneutral surface charge, as assessed by zeta potential measurements, were stable in aqueous solutions, which suggests their compact polyelectrolyte complex "core"-hydrophilic PEG "shell" structure. Investigation of PEGylated polyphosphazene nanocomplexes as agents for noncovalent PEGylation of the therapeutic protein l-asparaginase (L-ASP) in vitro demonstrated their ability to dramatically reduce protein antigenicity, as measured by antibody binding using enzyme linked immunosorbent assay (ELISA). Encapsulation in nanocomplexes did not affect enzymatic activity of L-ASP, but improved its thermal stability and proteolytic resistance. Gel permeation chromatography (GPC) experiments revealed that all synthesized polyphosphazenes exhibited composition controlled hydrolytic degradability in aqueous solutions at neutral pH and showed greater stability at lower temperatures. Overall, novel hydrolytically degradable polyphosphazene polyelectrolytes capable of spontaneous self-assembly into PEGylated nanoparticulates in aqueous solutions can potentially enable a simple and effective approach to modifying therapeutic proteins without the need for their covalent modification.
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Asparaginase/administration & dosage ; Hydrolysis ; Nanoparticles/chemistry ; Organophosphorus Compounds/chemistry ; Polyelectrolytes/chemistry ; Polyethylene Glycols/chemistry ; Polymers/chemistry
Chemical Substances	Antineoplastic Agents ; Organophosphorus Compounds ; Polyelectrolytes ; Polymers ; poly(phosphazene) ; Polyethylene Glycols (3WJQ0SDW1A) ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2018-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.8b00785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Colonial institutions, commodity booms, and the diffusion of elementary education in Brazil, 1889 - 1930

Musacchio, Aldo / Martinez, Andre / Viarengo, Martina

(NBER working paper series ; 20029)

2014

Author's details	Aldo Musacchio; Andre Martinez; Martina Viarengo
Series title	NBER working paper series ; 20029
Keywords	Schulfinanzierung ; Finanzbeziehungen ; Allgemeinbildende Schule ; Kolonialismus ; Rohstoffpreis ; Räumliche Verteilung ; Schätzung ; Brasilien
Language	English
Size	[40] S.
Publishing place	Cambridge, Mass
Document type	Book
Database	ECONomics Information System

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Article: Biodegradable “Smart” Polyphosphazenes with Intrinsic Multifunctionality as Intracellular Protein Delivery Vehicles

Martinez, AndreP / Qamar, Bareera / Fuerst, Thomas R / Muro, Silvia / Andrianov, Alexander K

Biomacromolecules. 2017 June 12, v. 18, no. 6

2017

Abstract: A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and ... ...

Abstract	A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and pyrrolidone moieties attached to an inorganic phosphorus–nitrogen backbone, were characterized by a suite of physicochemical methods to confirm their structure, composition, and molecular sizes. All synthesized polyphosphazenes displayed composition-dependent hydrolytic degradability in aqueous solutions at neutral pH. Their formulations were stable at lower temperatures, potentially indicating adequate shelf life, but were characterized by accelerated degradation kinetics at elevated temperatures, including 37 °C. It was found that synthesized polyphosphazenes are capable of environmentally triggered self-assembly to produce nanoparticles with narrow polydispersity in the size range of 150–700 nm. Protein loading capacity of copolymers has been validated via their ability to noncovalently bind avidin without altering biological functionality. Acid-induced membrane-disruptive activity of polyphosphazenes has been established with an onset corresponding to the endosomal pH range and being dependent on polymer composition. The synthesized polyphosphazenes facilitated cell–surface interactions followed by time-dependent, vesicular-mediated, and saturable internalization of a model protein cargo into cancer cells, demonstrating the potential for intracellular delivery.
Keywords	aqueous solutions ; avidin ; biodegradability ; composite polymers ; drugs ; engineering ; molecular weight ; nanoparticles ; neoplasm cells ; neoplasms ; pH ; pyrrolidones ; shelf life ; temperature
Language	English
Dates of publication	2017-0612
Size	p. 2000-2011.
Publishing place	American Chemical Society
Document type	Article
ISSN	1526-4602
DOI	10.1021%2Facs.biomac.7b00537
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sternal Route More Effective than Tibial Route for Intraosseous Amiodarone Administration in a Swine Model of Ventricular Fibrillation.

Burgert, James M / Martinez, Andre / O'Sullivan, Mara / Blouin, Dawn / Long, Audrey / Johnson, Arthur D

Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

2017 Volume 22, Issue 2, Page(s) 266–275

Abstract: Objective: The pharmacokinetics of IO administered lipid soluble amiodarone during ventricular fibrillation (VF) with ongoing CPR are unknown. This study measured mean plasma concentration over 5 minutes, maximum plasma concentration (Cmax), and time to ...

Abstract	Objective: The pharmacokinetics of IO administered lipid soluble amiodarone during ventricular fibrillation (VF) with ongoing CPR are unknown. This study measured mean plasma concentration over 5 minutes, maximum plasma concentration (Cmax), and time to maximum concentration (Tmax) of amiodarone administered by the sternal IO (SIO), tibial IO (TIO), and IV routes in a swine model of VF with ongoing CPR. Methods: Twenty-one Yorkshire-cross swine were randomly assigned to three groups: SIO, TIO, and IV. Ventricular fibrillation was induced under general anesthesia. After 4 minutes in VF, 300 mg amiodarone was administered as indicated by group assignment. Serial blood specimens collected at 30, 60, 90, 120, 150, 180, 240, and 300 seconds were analyzed using high performance liquid chromatography with tandem mass spectrometry. Results: The mean plasma concentration of IV amiodarone over 5 minutes was significantly higher than the TIO group at 60 seconds (P = 0.02) and 90 seconds (P = 0.017) post-injection. No significant differences in Cmax between the groups were found (P <0.05). The Tmax of amiodarone was significantly shorter in the SIO (99 secs) and IV (86 secs) groups compared to the TIO group (215 secs); P = 0.002 and P = 0.002, respectively. Conclusions: The SIO and IV routes of amiodarone administration were comparable. The TIO group took nearly three times longer to reach Tmax than the SIO and IV groups, likely indicating depot of lipid-soluble amiodarone in adipose-rich tibial yellow bone marrow. The SIO route was more effective than the TIO route for amiodarone delivery in a swine model of VF with ongoing CPR. Further investigations are necessary to determine if the kinetic differences found between the SIO and TIO routes in this study affect survival of VF in humans.
MeSH term(s)	Amiodarone/administration & dosage ; Amiodarone/pharmacokinetics ; Animals ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/pharmacokinetics ; Cardiopulmonary Resuscitation/methods ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Emergency Medical Services ; Infusions, Intraosseous/methods ; Prospective Studies ; Random Allocation ; Sternum ; Swine ; Tandem Mass Spectrometry ; Tibia ; Ventricular Fibrillation/drug therapy
Chemical Substances	Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
Language	English
Publishing date	2017-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2017.1358782
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4762: Show issues

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Article ; Online: Biodegradable "Smart" Polyphosphazenes with Intrinsic Multifunctionality as Intracellular Protein Delivery Vehicles.

Martinez, Andre P / Qamar, Bareera / Fuerst, Thomas R / Muro, Silvia / Andrianov, Alexander K

Biomacromolecules

2017 Volume 18, Issue 6, Page(s) 2000–2011

Abstract	A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and pyrrolidone moieties attached to an inorganic phosphorus-nitrogen backbone, were characterized by a suite of physicochemical methods to confirm their structure, composition, and molecular sizes. All synthesized polyphosphazenes displayed composition-dependent hydrolytic degradability in aqueous solutions at neutral pH. Their formulations were stable at lower temperatures, potentially indicating adequate shelf life, but were characterized by accelerated degradation kinetics at elevated temperatures, including 37 °C. It was found that synthesized polyphosphazenes are capable of environmentally triggered self-assembly to produce nanoparticles with narrow polydispersity in the size range of 150-700 nm. Protein loading capacity of copolymers has been validated via their ability to noncovalently bind avidin without altering biological functionality. Acid-induced membrane-disruptive activity of polyphosphazenes has been established with an onset corresponding to the endosomal pH range and being dependent on polymer composition. The synthesized polyphosphazenes facilitated cell-surface interactions followed by time-dependent, vesicular-mediated, and saturable internalization of a model protein cargo into cancer cells, demonstrating the potential for intracellular delivery.
MeSH term(s)	Animals ; Avidin/metabolism ; Biological Transport ; Carboxylic Acids/chemistry ; Cell Line, Tumor ; Drug Compounding ; Drug Delivery Systems/methods ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Erythrocytes/cytology ; Erythrocytes/drug effects ; Fluorescein-5-isothiocyanate/analogs & derivatives ; Fluorescein-5-isothiocyanate/metabolism ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Organophosphorus Compounds/chemical synthesis ; Organophosphorus Compounds/pharmacology ; Particle Size ; Polymers/chemical synthesis ; Polymers/pharmacology ; Pyrrolidinones/chemistry ; Swine
Chemical Substances	Carboxylic Acids ; Organophosphorus Compounds ; Polymers ; Pyrrolidinones ; fluorescein isothiocyante avidin ; poly(phosphazene) ; Avidin (1405-69-2) ; Fluorescein-5-isothiocyanate (I223NX31W9)
Language	English
Publishing date	2017-05-30
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.7b00537
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Article: Distribution of Chains in Polymer Brushes Produced by a “Grafting From” Mechanism

Martinez, AndreP / Adamson Douglas H / Carrillo Jan-Michael Y / Dobrynin Andrey V

Macromolecules. 2016 Jan. 26, v. 49, no. 2

2016

Abstract: The molecular weight and polydispersity of the chains in a polymer brush are critical parameters determining the brush properties. However, the characterization of polymer brushes is hindered by the vanishingly small mass of polymer present in brush ... ...

Abstract	The molecular weight and polydispersity of the chains in a polymer brush are critical parameters determining the brush properties. However, the characterization of polymer brushes is hindered by the vanishingly small mass of polymer present in brush layers. In this study, in order to obtain sufficient quantities of polymer for analysis, polymer brushes were grown from high surface area fibrous nylon membranes by ATRP. The brushes were synthesized with varying surface initiator densities, polymerization times, and amounts of sacrificial initiator, then cleaved from the substrate, and analyzed by GPC and NMR. Characterization showed that the surface-grown polymer chains were more polydisperse and had lower average molecular weight compared to solution-grown polymers synthesized concurrently. Furthermore, the molecular weight distribution of the polymer brushes was observed to be bimodal, with a low molecular weight population of chains representing a significant mass fraction of the polymer chains at high surface initiator densities. The origin of this low MW polymer fraction is proposed to be the termination of growing chains by recombination during the early stages of polymerization, a mechanism confirmed by molecular dynamics simulations of brush polymerization.
Keywords	molecular dynamics ; molecular weight ; nuclear magnetic resonance spectroscopy ; nylon ; polymerization ; simulation models ; surface area
Language	English
Dates of publication	2016-0126
Size	p. 547-553.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1491942-4
ISSN	1520-5835 ; 0024-9297
ISSN (online)	1520-5835
ISSN	0024-9297
DOI	10.1021%2Facs.macromol.5b02261
Database	NAL-Catalogue (AGRICOLA)

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Book: Twisted pseudodifferential calculus and application to the quantum evolution of molecules

Martinez, André / Sordoni, Vania

(Memoirs of the American Mathematical Society ; 936 = Vol. 200,1)

2009

Author's details	André Martinez; Vania Sordoni
Series title	Memoirs of the American Mathematical Society ; 936 = Vol. 200,1
Keywords	Born-Oppenheimer approximation ; Evolution (Biology)/Mathematical models ; Evolution equations ; Pseudodifferential operators ; Quantum theory/Mathematics ; Wave packets
Language	English
Size	VI, 82 S.
Publisher	American Math. Soc
Publishing place	Providence, RI
Document type	Book
Note	"Volume 200, number 936 (first of 6 numbers ) ; Includes bibliographical references and index
ISBN	9780821842966 ; 082184296X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Endowments, fiscal federalism, and the cost of capital for states

Martínez, André / Musacchio, Aldo

evidence from Brazil, 1891-1930

(Working papers / Banco de México, Dirección de Investigación Económica ; 2009,12)

2009

Abstract: In this paper, we contribute to the discussion of what determines country risk by arguing that an important explanatory factor is the impact that commodities have on the capacity to pay. We use a newly created data base with state-level fiscal and risk ... ...

Author's details	André Martínez; Aldo Musacchio
Series title	Working papers / Banco de México, Dirección de Investigación Económica ; 2009,12
Abstract	In this paper, we contribute to the discussion of what determines country risk by arguing that an important explanatory factor is the impact that commodities have on the capacity to pay. We use a newly created data base with state-level fiscal and risk premium data for Brazil states between 1891 and 1930 to show that Brazilian states with natural endowments that allowed them to export commodities that were in high demand ended up having higher revenues per capita and, thus, lower cost of capital. We also explain that the variation in revenues per capita across states was both a product of the variation in natural endowments and a commodity boom that had asymmetric effects among states. We end by running instrumental variable estimates using indices of export prices for each state to instrument for revenues per capita. Our IV estimates confirm our results that states with commodities that had higher price increases had lower risk premia. -- State public debt fiscal decentralization endowments public revenue
Language	English
Size	Online-Ressource (45 S.), graph. Darst.
Publisher	Banco de México
Publishing place	México
Document type	Book ; Online
Note	IMD-Felder maschinell generiert ; Zsfassung in span. Sprache
Database	ECONomics Information System

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