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Article ; Online: Shoe and Bracing Considerations for the Insensate Foot: Shoe considerations for diabetic foot.

Moon, Daniel / Cao, Ning / Martinez, Bianca

Physical medicine and rehabilitation clinics of North America

2022 Volume 33, Issue 4, Page(s) 845–856

Abstract: Diabetic individuals with peripheral neuropathy are at risk for the development of foot ulcers due to musculoskeletal abnormalities and abnormal loading in the gait cycle leading to elevated plantar pressures. To prevent diabetic foot ulcers, ... ...

Abstract	Diabetic individuals with peripheral neuropathy are at risk for the development of foot ulcers due to musculoskeletal abnormalities and abnormal loading in the gait cycle leading to elevated plantar pressures. To prevent diabetic foot ulcers, practitioners should regularly screen patients for the presence of neuropathy as well as neuroarthropathies and prescribe the appropriate shoes and orthotics based on the best available clinical evidence. Although not widely available, there is potential for data-driven customization of orthotics and shoe wear based on plantar pressure data to prevent the development of diabetic foot ulcers more effectively, and ultimately prevent lower limb amputations.
MeSH term(s)	Diabetes Mellitus ; Diabetic Foot/prevention & control ; Diabetic Neuropathies/therapy ; Foot ; Gait ; Humans ; Pressure ; Shoes
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196791-2
ISSN	1558-1381 ; 1047-9651
ISSN (online)	1558-1381
ISSN	1047-9651
DOI	10.1016/j.pmr.2022.06.012
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Article ; Online: Phytoestrogen-Based Hormonal Replacement Therapy Could Benefit Women Suffering Late-Onset Asthma.

Sommer, Bettina / González-Ávila, Georgina / Flores-Soto, Edgar / Montaño, Luis M / Solís-Chagoyán, Héctor / Romero-Martínez, Bianca S

International journal of molecular sciences

2023 Volume 24, Issue 20

Abstract: It has been observed that plasmatic concentrations of estrogens, progesterone, or both correlate with symptoms in asthmatic women. Fluctuations in female sex steroid concentrations during menstrual periods are closely related to asthma symptoms, while ... ...

Abstract	It has been observed that plasmatic concentrations of estrogens, progesterone, or both correlate with symptoms in asthmatic women. Fluctuations in female sex steroid concentrations during menstrual periods are closely related to asthma symptoms, while menopause induces severe physiological changes that might require hormonal replacement therapy (HRT), that could influence asthma symptoms in these women. Late-onset asthma (LOA) has been categorized as a specific asthmatic phenotype that includes menopausal women and novel research regarding therapeutic alternatives that might provide relief to asthmatic women suffering LOA warrants more thorough and comprehensive analysis. Therefore, the present review proposes phytoestrogens as a promising HRT that might provide these females with relief for both their menopause and asthma symptoms. Besides their well-recognized anti-inflammatory and antioxidant capacities, phytoestrogens activate estrogen receptors and promote mild hormone-like responses that benefit postmenopausal women, particularly asthmatics, constituting therefore a very attractive potential therapy largely due to their low toxicity and scarce side effects.
MeSH term(s)	Female ; Humans ; Phytoestrogens/therapeutic use ; Estrogen Replacement Therapy ; Hormone Replacement Therapy ; Menopause/physiology ; Estrogens/therapeutic use ; Asthma/drug therapy
Chemical Substances	Phytoestrogens ; Estrogens
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242015335
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Article ; Online: 17β-estradiol induces hyperresponsiveness in guinea pig airway smooth muscle by inhibiting the plasma membrane Ca

Romero-Martinez, Bianca S / Flores-Soto, Edgar / Sommer, Bettina / Reyes-García, Jorge / Arredondo-Zamarripa, David / Solis-Chagoyan, Héctor / Lemini, Cristina / Rivero-Segura, Nadia A / Santiago-de-la-Cruz, José A / Perez-Plascencia, Carlos / Montaño, Luis M

Molecular and cellular endocrinology

2024 , Page(s) 112273

Abstract: High serum estrogen concentrations are associated with asthma development and severity, suggesting a link between estradiol and airway hyperresponsiveness (AHR). 17β-estradiol (E2) has non-genomic effects via ... ...

Abstract	High serum estrogen concentrations are associated with asthma development and severity, suggesting a link between estradiol and airway hyperresponsiveness (AHR). 17β-estradiol (E2) has non-genomic effects via Ca
Language	English
Publishing date	2024-05-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2024.112273
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Article: Good syndrome, bad problem.

Martinez, Bianca / Browne, Sarah K

Frontiers in oncology

2014 Volume 4, Page(s) 307

Language	English
Publishing date	2014-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2014.00307
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Article ; Online: Estrogenic Modulation of Ionic Channels, Pumps and Exchangers in Airway Smooth Muscle.

Romero-Martínez, Bianca S / Sommer, Bettina / Solís-Chagoyán, Héctor / Calixto, Eduardo / Aquino-Gálvez, Arnoldo / Jaimez, Ruth / Gomez-Verjan, Juan C / González-Avila, Georgina / Flores-Soto, Edgar / Montaño, Luis M

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: To preserve ionic homeostasis (primarily ... ...

Abstract	To preserve ionic homeostasis (primarily Ca
MeSH term(s)	Calcium/metabolism ; Myocytes, Smooth Muscle/metabolism ; Muscle Contraction/physiology ; Muscle, Smooth/metabolism ; Ion Channels/metabolism ; Estrogens/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Ion Channels ; Estrogens
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24097879
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Article ; Online: Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review).

Sánchez-Florentino, Zuly A / Romero-Martínez, Bianca S / Flores-Soto, Edgar / Serrano, Héctor / Montaño, Luis M / Valdés-Tovar, Marcela / Calixto, Eduardo / Aquino-Gálvez, Arnoldo / López-Riquelme, Germán O / Alvarado, Ramón / Argueta, Jesús / Solís-Chagoyán, Héctor / Sommer, Bettina

International journal of molecular medicine

2023 Volume 53, Issue 1

Abstract: Schizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disrupted‑in‑ ... ...

Abstract	Schizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disrupted‑in‑Schizophrenia 1 protein. In this regard, it is essential to understand the underlying molecular disturbances to determine the pathophysiological mechanisms of the disease. The signaling pathways activated by G protein‑coupled receptors (GPCRs) are key molecular signaling pathways altered in SZ. Convenient models need to be designed and validated to study these processes and mechanisms at the cellular level. Cultured olfactory stem cells are used to investigate neural molecular and cellular alterations related to the pathophysiology of SZ. Multipotent human olfactory stem cells are undifferentiated and express GPCRs involved in numerous physiological functions such as proliferation, differentiation and bioenergetics. The use of olfactory stem cells obtained from patients with SZ may identify alterations in GPCR signaling that underlie dysfunctional processes in both undifferentiated and specialized neurons or derived neuroglia. The present review aimed to analyze the role of GPCRs and their signaling in the pathophysiology of SZ. Culture of olfactory epithelial cells constitutes a suitable model to study SZ and other psychiatric disorders at the cellular level.
MeSH term(s)	Humans ; Schizophrenia/genetics ; Schizophrenia/metabolism ; Neuroepithelial Cells/metabolism ; Neurons/metabolism ; Receptors, G-Protein-Coupled ; Stem Cells/metabolism
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-12-01
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2023.5331
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Article ; Online: Efficacy of Early Inpatient Rehabilitation of Post-COVID-19 Survivors: Single-Center Retrospective Analysis.

Cao, Ning / Barcikowski, Jaclyn / Womble, Franklin / Martinez, Bianca / Sergeyenko, Yevgeniya / Koffer, Jacob H / Kwasniewski, Michael / Watanabe, Thomas / Xiao, Rui / Esquenazi, Alberto

American journal of physical medicine & rehabilitation

2022 Volume 102, Issue 6, Page(s) 498–503

Abstract: Objective: The aim of this study was to understand the demographic, clinical characteristics, and effectiveness of early inpatient rehabilitation of post-COVID survivors.: Design: A single-center retrospective chart review analysis of 100 patients ... ...

Abstract	Objective: The aim of this study was to understand the demographic, clinical characteristics, and effectiveness of early inpatient rehabilitation of post-COVID survivors. Design: A single-center retrospective chart review analysis of 100 patients admitted to a newly created acute COVID rehabilitation unit (CORE+) from April to December 2020 was conducted. Results: The demographic and clinical characteristics and complications of 100 post-COVID patients were reviewed. Functional outcomes of GG Self-care and Mobility Activities Items (Section GG0130 and GG0170) of the Centers for Medicare & Medicaid Services of the Inpatient Rehabilitation Facility Patient Assessment Instrument (Version 3.0) at admission and discharge, prevalence of oxygen requirement, the need for cognitive and neuropsychology support by discharge, and dispositions after completion of inpatient rehabilitation facility stay were analyzed. The functional outcomes of 59 primary pulmonary manifestations of COVID patients were further analyzed based on the presence of intensive care unit stay before transfer to the COVID rehabilitation unit. Most patients demonstrated significant functional gains after completion of inpatient rehabilitation facility stay; however, a considerable number of patients continued to require cognitive support by discharge. Conclusion: The data suggested the benefit of early rehabilitation for hospitalized post-COVID patients. Services need to be geared to include patients' cognitive deficits.
MeSH term(s)	Aged ; Humans ; United States ; Retrospective Studies ; Inpatients ; Medicare ; COVID-19 ; Hospitalization ; Rehabilitation Centers ; Length of Stay ; Recovery of Function
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002122
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Article ; Online: Could Lower Testosterone in Older Men Explain Higher COVID-19 Morbidity and Mortalities?

Montaño, Luis M / Sommer, Bettina / Solís-Chagoyán, Héctor / Romero-Martínez, Bianca S / Aquino-Gálvez, Arnoldo / Gomez-Verjan, Juan C / Calixto, Eduardo / González-Avila, Georgina / Flores-Soto, Edgar

International journal of molecular sciences

2022 Volume 23, Issue 2

Abstract: The health scourge imposed on humanity by the COVID-19 pandemic seems not to recede. This fact warrants refined and novel ideas analyzing different aspects of the illness. One such aspect is related to the observation that most COVID-19 casualties were ... ...

Abstract	The health scourge imposed on humanity by the COVID-19 pandemic seems not to recede. This fact warrants refined and novel ideas analyzing different aspects of the illness. One such aspect is related to the observation that most COVID-19 casualties were older males, a tendency also noticed in the epidemics of SARS-CoV in 2003 and the Middle East respiratory syndrome in 2012. This gender-related difference in the COVID-19 death toll might be directly involved with testosterone (TEST) and its plasmatic concentration in men. TEST has been demonstrated to provide men with anti-inflammatory and immunological advantages. As the plasmatic concentration of this androgen decreases with age, the health benefit it confers also diminishes. Low plasmatic levels of TEST can be determinant in the infection's outcome and might be related to a dysfunctional cell Ca
MeSH term(s)	Age Factors ; Aged ; Aging/metabolism ; Animals ; COVID-19/etiology ; COVID-19/metabolism ; COVID-19/mortality ; Calcium Signaling ; Humans ; Inflammation/metabolism ; Male ; Morbidity ; Testosterone/metabolism
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2022-01-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23020935
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Article ; Online: Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies.

Montaño, Luis M / Sommer, Bettina / Gomez-Verjan, Juan C / Morales-Paoli, Genaro S / Ramírez-Salinas, Gema Lizbeth / Solís-Chagoyán, Héctor / Sanchez-Florentino, Zuly A / Calixto, Eduardo / Pérez-Figueroa, Gloria E / Carter, Rohan / Jaimez-Melgoza, Ruth / Romero-Martínez, Bianca S / Flores-Soto, Edgar

International journal of molecular sciences

2022 Volume 23, Issue 8

Abstract: Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 pandemic urged the development of effective pharmacological treatments to ... ...

Abstract	Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 pandemic urged the development of effective pharmacological treatments to directly attack the development of new variants of the SARS-CoV-2 virus and possess a therapeutical battery of compounds that could improve the current management of the disease worldwide. In this context, theophylline, through bronchodilatory, immunomodulatory, and potentially antiviral mechanisms, is an interesting proposal as an adjuvant in the treatment of COVID-19 patients. Nevertheless, it is essential to understand how this compound could behave against such a disease, not only at a pharmacodynamic but also at a pharmacokinetic level. In this sense, the quickest approach in drug discovery is through different computational methods, either from network pharmacology or from quantitative systems pharmacology approaches. In the present review, we explore the possibility of using theophylline in the treatment of COVID-19 patients since it seems to be a relevant candidate by aiming at several immunological targets involved in the pathophysiology of the disease. Theophylline down-regulates the inflammatory processes activated by SARS-CoV-2 through various mechanisms, and herein, they are discussed by reviewing computational simulation studies and their different applications and effects.
MeSH term(s)	Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Molecular Docking Simulation ; Pandemics ; SARS-CoV-2 ; Theophylline/pharmacology ; Theophylline/therapeutic use
Chemical Substances	Antiviral Agents ; Theophylline (C137DTR5RG)
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23084167
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Article ; Online: Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases.

Castillejos-López, Manuel / Romero, Yair / Varela-Ordoñez, Angelica / Flores-Soto, Edgar / Romero-Martinez, Bianca S / Velázquez-Cruz, Rafael / Vázquez-Pérez, Joel Armando / Ruiz, Víctor / Gomez-Verjan, Juan C / Rivero-Segura, Nadia A / Camarena, Ángel / Torres-Soria, Ana Karen / Gonzalez-Avila, Georgina / Sommer, Bettina / Solís-Chagoyán, Héctor / Jaimez, Ruth / Torres-Espíndola, Luz María / Aquino-Gálvez, Arnoldo

Cells

2023 Volume 12, Issue 23

Abstract: The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present ... ...

Abstract	The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body's tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases. In the present work, we intended to review the functional repercussions of hypoxia in the presence of asthma, chronic obstructive sleep apnea, lung cancer, idiopathic pulmonary fibrosis, obstructive sleep apnea, influenza, and COVID-19 and its repercussions on the circadian cycles.
MeSH term(s)	Animals ; Humans ; Circadian Rhythm/genetics ; Hypoxia ; Biological Clocks/physiology ; Sleep Apnea, Obstructive ; Lung Diseases
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12232724
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