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  1. Article ; Online: Improving Health Equity Through Health Literacy Education.

    Nepps, Peggy / Lake, Adam / Fox, Jenna / Martinez, Cindy / Matsen, Phebe / Zimmerman, Kristina

    Health literacy research and practice

    2023  Volume 7, Issue 2, Page(s) e99–e104

    Abstract: Health literacy is the ability to understand and use health information. More than one-third of adults living in the United States have limited health literacy, which is associated with adverse health outcomes. Physicians need education about how to ... ...

    Abstract Health literacy is the ability to understand and use health information. More than one-third of adults living in the United States have limited health literacy, which is associated with adverse health outcomes. Physicians need education about how to communicate effectively across the range of health literacy levels, but residency programs often fail to provide it. We aimed to develop and evaluate a curriculum to establish evidence-based recommendations for training family medicine resident physicians to communicate effectively across the range of health literacy levels. We developed and implemented a 6-month curriculum about health literacy and best practices for communication and collected three pre-/post-measures: patient surveys, videos of residents' patient encounters, and resident self-surveys of knowledge, attitudes, and use of communication techniques. Training of 39 residents included conferences, videotape reviews, written feedback, targeted supervision, and environmental cues. All knowledge/attitude questions on the resident survey improved significantly, as did the use of 4 of 6 communication techniques. Video observation also showed significant improvement in the residents' use of three techniques and a decrease in jargon use and an increase in "plain language" explanations of terms. Multimodal interventions improved residents' knowledge and attitudes about health literacy and use of health literacy precautions. [
    MeSH term(s) Adult ; Humans ; Health Literacy ; Health Equity ; Educational Status ; Health Education ; General Practitioners
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2474-8307
    ISSN (online) 2474-8307
    DOI 10.3928/24748307-20230522-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antimicrobial activity, mechanical and thermal properties of cassava starch films incorporated with beeswax and propolis.

    Betancur-D Ambrosio, María Carolina / Pérez-Cervera, Carmen Elena / Barrera-Martinez, Cindy / Andrade-Pizarro, Ricardo

    Journal of food science and technology

    2023  Volume 61, Issue 4, Page(s) 782–789

    Abstract: Edible films can be formed from different polymeric compounds. The use of starch has gained extra value; because it can be used in combination with plasticizers and lipids, helping to improve mechanical properties. Besides, with the addition of an ... ...

    Abstract Edible films can be formed from different polymeric compounds. The use of starch has gained extra value; because it can be used in combination with plasticizers and lipids, helping to improve mechanical properties. Besides, with the addition of an antimicrobial, the function of these films can be extended. The objective of this research was to evaluate the effect of native cassava starch, beeswax and ethanolic propolis extract (EPE) on the mechanical, thermal and inhibitory properties against the
    Language English
    Publishing date 2023-11-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 242498-8
    ISSN 0975-8402 ; 0022-1155
    ISSN (online) 0975-8402
    ISSN 0022-1155
    DOI 10.1007/s13197-023-05878-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development and Characterization of Rice Husk and Recycled Polypropylene Composite Filaments for 3D Printing.

    Morales, Maria A / Atencio Martinez, Cindy L / Maranon, Alejandro / Hernandez, Camilo / Michaud, Veronique / Porras, Alicia

    Polymers

    2021  Volume 13, Issue 7

    Abstract: Nowadays the use of natural fiber composites has gained significant interest due to their low density, high availability, and low cost. The present study explores the development of sustainable 3D printing filaments based on rice husk (RH), an ... ...

    Abstract Nowadays the use of natural fiber composites has gained significant interest due to their low density, high availability, and low cost. The present study explores the development of sustainable 3D printing filaments based on rice husk (RH), an agricultural residue, and recycled polypropylene (rPP) and the influence of fiber weight ratio on physical, thermal, mechanical, and morphological properties of 3D printing parts. Thermogravimetric analysis revealed that the composite's degradation process started earlier than for the neat rPP due to the lignocellulosic fiber components. Mechanical tests showed that tensile strength increased when using a raster angle of 0° than specimens printed at 90°, due to the weaker inter-layer bonding compared to in-layer. Furthermore, inter layer bonding tensile strength was similar for all tested materials. Scanning electron microscope (SEM) images revealed the limited interaction between the untreated fiber and matrix, which led to reduced tensile properties. However, during the printing process, composites presented lower warping than printed neat rPP. Thus, 3D printable ecofriendly natural fiber composite filaments with low density and low cost can be developed and used for 3D printing applications, contributing to reduce the impact of plastic and agricultural waste.
    Language English
    Publishing date 2021-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13071067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-neuroinflammatory effect of Iresine celosia on lipopolysaccharide-stimulated microglial cells and mouse.

    Kim, Namkwon / Martínez, Cindy Cruz / Jang, Dae Sik / Lee, Jong Kil / Oh, Myung Sook

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2019  Volume 111, Page(s) 1359–1366

    Abstract: Abnormal inflammatory response in the central nervous system plays a critical role in various neurological disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease. Therefore, modulation of abnormal neuroinflammation is thought ...

    Abstract Abnormal inflammatory response in the central nervous system plays a critical role in various neurological disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease. Therefore, modulation of abnormal neuroinflammation is thought to be a promising therapeutic strategy for these diseases. Based on this idea, we focused on finding a potential candidate material that would regulate excessive neuroinflammation. Iresine celosia has long been used as a traditional Mexican medicine to treat fever and oral disorders. In the present study, we evaluated the anti-neuroinflammatory effects of Iresine celosia extract (ICE) in lipopolysaccharide (LPS)-stimulated BV2 microglia cells and mice models. In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 without causing cytotoxicity. ICE also ameliorated translocation of nuclear factor-κB from cytosol to nucleus by LPS. Moreover, ICE attenuated behavioral disturbances by inhibiting activation of microglia and astrocytes in LPS-treated mice. Collectively, these data indicate that ICE is a potential therapeutic agent for treating inflammation-related diseases.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cell Line ; Celosia/chemistry ; Cytokines/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Medicine, Traditional/methods ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Nitric Oxide/metabolism ; Plant Extracts/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Lipopolysaccharides ; Plant Extracts ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2019-01-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of traditional herbal medicine as an alternative in dental treatment in Mexican dentistry: a review.

    Cruz Martínez, Cindy / Diaz Gómez, Martha / Oh, Myung Sook

    Pharmaceutical biology

    2017  Volume 55, Issue 1, Page(s) 1992–1998

    Abstract: Context: Herbal therapies are used worldwide to treat health conditions. In Mexico, generations have used them to treat gingivitis, periodontitis, mouth infections, and discoloured teeth. However, few studies have collected scientific evidence on their ... ...

    Abstract Context: Herbal therapies are used worldwide to treat health conditions. In Mexico, generations have used them to treat gingivitis, periodontitis, mouth infections, and discoloured teeth. However, few studies have collected scientific evidence on their effects.
    Objective: This study aimed at searching and compiling scientific evidence of alternative oral and dental treatments using medicinal herbs from Mexico.
    Methods: We collected various Mexican medicinal plants used in the dental treatment from the database of the Institute of Biology at the National Autonomous University of Mexico. To correlate with existing scientific evidence, we used the PubMed database with the key term '(scientific name) and (oral or dental)'.
    Results: Mexico has various medical herbs with antibacterial and antimicrobial properties, according to ancestral medicinal books and healers. Despite a paucity of experimental research demonstrating the antibacterial, antimicrobial, and antiplaque effects of these Mexican plants, they could still be useful as an alternative treatment of several periodontal diseases or as anticariogenic agents. However, the number of studies supporting their uses and effects remains insufficient.
    Discussion and conclusion: It is important for the health of consumers to scientifically demonstrate the real effects of natural medicine, as well as clarify and establish their possible therapeutic applications. Through this bibliographical revision, we found papers that testify or refute their ancestral uses, and conclude that the use of plants to treat oral conditions or to add to the dental pharmacological arsenal should be based on experimental studies verifying their suitability for dental treatments.
    MeSH term(s) Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/therapeutic use ; Dentistry/methods ; Dentistry/trends ; Herbal Medicine/methods ; Herbal Medicine/trends ; Humans ; Medicine, Traditional/methods ; Medicine, Traditional/trends ; Mexico/ethnology ; Periodontal Diseases/drug therapy ; Periodontal Diseases/ethnology ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Plants, Medicinal
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2017-07-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2017.1347188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Layer-by-layer anionic diffusion in two-dimensional halide perovskite vertical heterostructures.

    Akriti / Shi, Enzheng / Shiring, Stephen B / Yang, Jiaqi / Atencio-Martinez, Cindy L / Yuan, Biao / Hu, Xiangchen / Gao, Yao / Finkenauer, Blake P / Pistone, Alan J / Yu, Yi / Liao, Peilin / Savoie, Brett M / Dou, Letian

    Nature nanotechnology

    2021  Volume 16, Issue 5, Page(s) 584–591

    Abstract: Anionic diffusion in a soft crystal lattice of hybrid halide perovskites affects their stability, optoelectronic properties and the resulting device performance. The use of two-dimensional (2D) halide perovskites improves the chemical stability of ... ...

    Abstract Anionic diffusion in a soft crystal lattice of hybrid halide perovskites affects their stability, optoelectronic properties and the resulting device performance. The use of two-dimensional (2D) halide perovskites improves the chemical stability of perovskites and suppresses the intrinsic anionic diffusion in solid-state devices. Based on this strategy, devices with an enhanced stability and reduced hysteresis have been achieved. However, a fundamental understanding of the role of organic cations in inhibiting anionic diffusion across the perovskite-ligand interface is missing. Here we demonstrate the first quantitative investigation of the anionic interdiffusion across atomically flat 2D vertical heterojunctions. Interestingly, the halide diffusion does not follow the classical diffusion process. Instead, a 'quantized' layer-by-layer diffusion model is proposed to describe the behaviour of the anionic migration in 2D halide perovskites. Our results provide important insights into the mechanism of anionic diffusion in 2D perovskites and provide a new materials platform with an enhanced stability for heterostructure integration.
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-021-00848-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Philadelphia-like acute lymphoblastic leukemia: Characterization in a pediatric cohort in a referral center in Colombia.

    Linares Ballesteros, Adriana / Yunis, Luz Karime / García, Johnny / Aponte, Nelson / Flechas, Jessica / Martinez, Cindy / Uribe, Gloria / Quintero, Edna / Díaz, Angela / Pardo, Carlos / Sarmiento, Isabel Cristina / Contreras, Agustin / Yunis, Juan Jose

    Cancer reports (Hoboken, N.J.)

    2021  Volume 5, Issue 5, Page(s) e1587

    Abstract: Background: Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America.: Aim: This study evaluated the frequency ... ...

    Abstract Background: Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America.
    Aim: This study evaluated the frequency and clinical and biological characteristics of Ph-like ALL in a pediatric cancer center in Colombia.
    Methods: The Ph-like genetic profile was analyzed by a low-density array (LDA). Samples from patients with Ph-like ALL were analyzed by fluorescent in situ hybridization for cytokine receptor like factor 2 (CRLF2) and ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) rearrangements. Copy number variations were assessed by multiplex ligation probe amplification.
    Results: Data from 121 patients were analyzed. Fifteen patients (12.4%) had Ph-like ALL, and these patients had significantly higher leukocyte counts at diagnosis and higher levels of minimal residual disease on days 15 and 33 of induction than patients without the Ph-like subtype. There were no significant differences in sex, age, or response to prednisone at day 8 between the two groups. CRLF2 rearrangements were identified in eight patients, and ABL1 rearrangements were identified in two patients. Other genetic alterations alone or in combination were identified in 77% of patients, including deletions in cyclin dependent kinase inhibitor 2 A/B (46.2%), IKAROS family zinc finger 1 (38.3%), and paired box 5 (30.8%).
    Conclusions: Ph-like ALL had a 12.4% prevalence in our cohort of patients with pediatric ALL. The identification of this group of patients has importance for risk stratification and future targeted therapy.
    MeSH term(s) Child ; Colombia/epidemiology ; DNA Copy Number Variations ; Humans ; Ikaros Transcription Factor/genetics ; In Situ Hybridization, Fluorescence ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Referral and Consultation
    Chemical Substances Ikaros Transcription Factor (148971-36-2)
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Adversarial Machine Learning and Cybersecurity

    Musser, Micah / Lohn, Andrew / Dempsey, James X. / Spring, Jonathan / Kumar, Ram Shankar Siva / Leong, Brenda / Liaghati, Christina / Martinez, Cindy / Grant, Crystal D. / Rohrer, Daniel / Frase, Heather / Elliott, Jonathan / Bansemer, John / Rodriguez, Mikel / Regan, Mitt / Chowdhury, Rumman / Hermanek, Stefan

    Risks, Challenges, and Legal Implications

    2023  

    Abstract: In July 2022, the Center for Security and Emerging Technology (CSET) at Georgetown University and the Program on Geopolitics, Technology, and Governance at the Stanford Cyber Policy Center convened a workshop of experts to examine the relationship ... ...

    Abstract In July 2022, the Center for Security and Emerging Technology (CSET) at Georgetown University and the Program on Geopolitics, Technology, and Governance at the Stanford Cyber Policy Center convened a workshop of experts to examine the relationship between vulnerabilities in artificial intelligence systems and more traditional types of software vulnerabilities. Topics discussed included the extent to which AI vulnerabilities can be handled under standard cybersecurity processes, the barriers currently preventing the accurate sharing of information about AI vulnerabilities, legal issues associated with adversarial attacks on AI systems, and potential areas where government support could improve AI vulnerability management and mitigation. This report is meant to accomplish two things. First, it provides a high-level discussion of AI vulnerabilities, including the ways in which they are disanalogous to other types of vulnerabilities, and the current state of affairs regarding information sharing and legal oversight of AI vulnerabilities. Second, it attempts to articulate broad recommendations as endorsed by the majority of participants at the workshop.
    Keywords Computer Science - Cryptography and Security ; Computer Science - Artificial Intelligence ; Computer Science - Computers and Society
    Subject code 303
    Publishing date 2023-05-23
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction.

    Shivshankar, Pooja / Halade, Ganesh V / Calhoun, Cheresa / Escobar, Gladys P / Mehr, Ali J / Jimenez, Fabio / Martinez, Cindy / Bhatnagar, Harshita / Mjaatvedt, Corey H / Lindsey, Merry L / Le Saux, Claude Jourdan

    Journal of molecular and cellular cardiology

    2014  Volume 76, Page(s) 84–93

    Abstract: Adverse remodeling following myocardial infarction (MI) leading to heart failure is driven by an imbalanced resolution of inflammation. The macrophage cell is an important control of post-MI inflammation, as macrophage subtypes secrete mediators to ... ...

    Abstract Adverse remodeling following myocardial infarction (MI) leading to heart failure is driven by an imbalanced resolution of inflammation. The macrophage cell is an important control of post-MI inflammation, as macrophage subtypes secrete mediators to either promote inflammation and extend injury (M1 phenotype) or suppress inflammation and promote scar formation (M2 phenotype). We have previously shown that the absence of caveolin-1 (Cav1), a membrane scaffolding protein, is associated with adverse cardiac remodeling in mice, but the mechanisms responsible remain to be elucidated. We explore here the role of Cav1 in the activation of macrophages using wild type C57BL6/J (WT) and Cav1(tm1Mls/J) (Cav1(-/-)) mice. By echocardiography, cardiac function was comparable between WT and Cav1(-/-) mice at 3days post-MI. In the absence of Cav1, there were a surprisingly higher percentage of M2 macrophages (arginase-1 positive) detected in the infarcted zone. Conversely, restoring Cav1 function after MI in WT mice by adding back the Cav1 scaffolding domain reduced the M2 activation profile. Further, adoptive transfer of Cav1 null macrophages into WT mice on d3 post-MI exacerbated adverse cardiac remodeling at d14 post-MI. In vitro studies revealed that Cav1 null macrophages had a more pronounced M2 profile activation in response to IL-4 stimulation. In conclusion, Cav1 deletion promotes an array of maladaptive repair processes after MI, including increased TGF-β signaling, increased M2 macrophage infiltration and dysregulation of the M1/M2 balance. Our data also suggest that cardiac remodeling can be improved by therapeutic intervention regulating Cav1 function during the inflammatory response phase.
    MeSH term(s) Animals ; Cardiac Volume ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Female ; Fibrosis ; Gene Knockout Techniques ; Macrophage Activation ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardial Infarction/immunology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardium/immunology ; Myocardium/metabolism ; Myocardium/pathology ; Ventricular Function, Left
    Chemical Substances Caveolin 1
    Language English
    Publishing date 2014-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2014.07.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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