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  1. Article ; Online: Asthma in the Time of COVID-19.

    Martinez, Fernando D

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 7, Page(s) 785–786

    MeSH term(s) Asthma/epidemiology ; Biomedical Research/statistics & numerical data ; COVID-19/epidemiology ; Humans ; Pandemics/statistics & numerical data ; Periodicals as Topic/statistics & numerical data ; Research Report ; SARS-CoV-2 ; United States
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202102-0389ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Childhood Asthma Inception and Progression: Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization.

    Martinez, Fernando D

    Immunology and allergy clinics of North America

    2019  Volume 39, Issue 2, Page(s) 141–150

    Abstract: Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its ... ...

    Abstract Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in early life. Being raised on animal farms is highly protective against the development of asthma, and this protective effect is mediated by exposure to microbes. Two trials in high-risk young children, one to prevent wheezing lower respiratory tract illness using bacterial lyophilizates and another using anti-immunoglobulin E to prevent asthma progression, are already under way.
    MeSH term(s) Allergens/immunology ; Asthma/epidemiology ; Asthma/prevention & control ; Child ; Disease Progression ; Disease Susceptibility ; Environmental Exposure/adverse effects ; Host-Pathogen Interactions ; Humans ; Immunization ; Microbiota/immunology ; United States/epidemiology ; Virus Diseases/epidemiology
    Chemical Substances Allergens
    Language English
    Publishing date 2019-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2018.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The State of Asthma Research: Considerable Advances, but Still a Long Way to Go.

    Martinez, Fernando D

    American journal of respiratory and critical care medicine

    2019  Volume 199, Issue 4, Page(s) 397–399

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/etiology ; Asthma/genetics ; Biomedical Research ; Humans
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2019-02-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201901-0013ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bending the Twig Does the Tree Incline: Lung Function after Lower Respiratory Tract Illness in Infancy.

    Martinez, Fernando D

    American journal of respiratory and critical care medicine

    2017  Volume 195, Issue 2, Page(s) 154–155

    Language English
    Publishing date 2017-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201611-2325ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Role of Lung Function in Determining Which Children Develop Asthma.

    McEvoy, Cindy T / Le Souef, Peter N / Martinez, Fernando D

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 3, Page(s) 677–683

    Abstract: Longitudinal studies have demonstrated that altered indices of airway function, assessed shortly after birth, are a risk factor for the subsequent development of wheezing illnesses and asthma, and that these indices predict airway size and airway wall ... ...

    Abstract Longitudinal studies have demonstrated that altered indices of airway function, assessed shortly after birth, are a risk factor for the subsequent development of wheezing illnesses and asthma, and that these indices predict airway size and airway wall thickness in adult life. Pre- and postnatal factors that directly alter early airway function, such as extreme prematurity and cigarette smoke, may continue to affect airway function and, hence, the risks for wheeze and asthma. Early airway function and an associated asthma risk may also be indirectly influenced by immune system responses, respiratory viruses, the airway microbiome, genetics, and epigenetics, especially if they affect airway epithelial dysfunction. Few if any interventions, apart from smoking avoidance, have been proven to alter the risks of developing asthma, but vitamin C supplementation to pregnant smokers may help decrease the effects of in utero smoke on offspring lung function. We conclude that airway size and the factors influencing this play an important role in determining the risk for asthma across the lifetime. Progress in asthma prevention is long overdue and this may benefit from carefully designed interventions in well-phenotyped longitudinal birth cohorts with early airway function assessments monitored through to adulthood.
    MeSH term(s) Pregnancy ; Female ; Adult ; Child ; Humans ; Asthma/complications ; Risk Factors ; Respiratory Sounds/etiology ; Longitudinal Studies ; Lung
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stress and asthma: Physiological manifestations and clinical implications.

    Oren, Eyal / Martinez, Fernando D

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 4, Page(s) 372–373.e1

    MeSH term(s) Asthma/immunology ; Asthma/psychology ; Humans ; Stress, Psychological/immunology
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.07.022
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  7. Article ; Online: The Complex Beginnings of Chronic Obstructive Pulmonary Disease.

    Guerra, Stefano / Martinez, Fernando D

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 6, Page(s) 641–642

    MeSH term(s) Humans ; Prevalence ; Prognosis ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201912-2363ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Beyond the Paradigm of Asthma as an Inflammatory Disease. A Summary of the 2015 Aspen Lung Conference.

    Martinez, Fernando D

    Annals of the American Thoracic Society

    2016  Volume 13 Suppl 1, Page(s) S91–4

    MeSH term(s) Asthma/pathology ; Congresses as Topic ; Humans ; Inflammation/pathology ; Lung/pathology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201510-677MG
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  9. Article ; Online: Safety of Fluticasone plus Salmeterol in Asthma--Reassuring Data, but No Final Answer.

    Martinez, Fernando D

    The New England journal of medicine

    2016  Volume 374, Issue 19, Page(s) 1887–1888

    MeSH term(s) Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Female ; Fluticasone/therapeutic use ; Fluticasone-Salmeterol Drug Combination/therapeutic use ; Humans ; Male
    Chemical Substances Bronchodilator Agents ; Fluticasone-Salmeterol Drug Combination ; Fluticasone (CUT2W21N7U)
    Language English
    Publishing date 2016-05-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1601040
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  10. Article ; Online: Early-Life Origins of Chronic Obstructive Pulmonary Disease.

    Martinez, Fernando D

    The New England journal of medicine

    2016  Volume 375, Issue 9, Page(s) 871–878

    MeSH term(s) Adolescent ; Age of Onset ; Air Pollution/adverse effects ; Asthma/complications ; Bronchopulmonary Dysplasia/complications ; Child ; Female ; Forced Expiratory Volume ; Humans ; Infant, Premature ; Lung/physiology ; Pneumonia/complications ; Pregnancy ; Prenatal Exposure Delayed Effects ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Mechanics/genetics ; Smoking/adverse effects
    Language English
    Publishing date 2016-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1603287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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