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Article ; Online: Do I Belong?

Martinez, Michael A

2022 Volume 18, Issue 5, Page(s) 378–379

Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Editorial
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.22.00115
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A wavefront adaptive sensing beamformer for ocean acoustic waveguides.

Ganti, Anil / Martinez, Michael / Hickman, Granger / Krolik, Jeffrey

The Journal of the Acoustical Society of America

2023 Volume 154, Issue 4, Page(s) 2398–2409

Abstract: This paper addresses robust adaptive beamforming for passive sonar in uncertain, shallow-water environments. Conventional beamforming is still common in passive sonar because adaptive beamformers suffer from signal mismatch in complex multipath ... ...

Abstract	This paper addresses robust adaptive beamforming for passive sonar in uncertain, shallow-water environments. Conventional beamforming is still common in passive sonar because adaptive beamformers suffer from signal mismatch in complex multipath environments. Existing approaches to robust adaptive beamforming try to model and account for the uncertainty in the beamformer's hypothesized signal subspace by using additional linear or quadratic constraints. Doing so, however, reduces the adaptivity of the beamformer and is prone to insufficiently suppressing interference. Instead, this paper uses blind source separation methods to adaptively estimate the complex spatial wavefronts of both targets and interference without requiring detailed physical modeling of the channel. By exploiting the different temporal spectra and/or frequency-selective multipath fading of targets and interference, this approach constructs a "signal-free" covariance matrix without imposing directional gain constraints. In doing so, the wavefront adaptive sensing (WAS) beamformer is able to separate targets from strong interference that is within the conventional beam width of the target. Simulation results in a realistic shallow-water channel are presented as well as results using the SWellEx96 S59 data with an injected target to show that the proposed WAS beamformer outperforms conventional and minimum variance adaptive beamformers in a shallow-water scenario.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0021310
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Article: Self-Reported Long-Term Side Effects of Isotretinoin: A Case Series.

Ghadimi, T Roxana / Martinez, Michael / Rieder, Evan

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 4, Page(s) 423–424

Abstract: Citation: Ghadimi TR, Martinez MJ, Rieder EA. Self-reported long-term side effects of isotretinoin: A case series. J Drugs Dermatol. 2023;22(4):423-424. doi:10.36849/JDD.2303. ...

Abstract	Citation: Ghadimi TR, Martinez MJ, Rieder EA. Self-reported long-term side effects of isotretinoin: A case series. J Drugs Dermatol. 2023;22(4):423-424. doi:10.36849/JDD.2303.
MeSH term(s)	Humans ; Isotretinoin/adverse effects ; Acne Vulgaris/drug therapy ; Acne Vulgaris/chemically induced ; Self Report
Chemical Substances	Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Editorial
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.2303
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Article ; Online: Perceptions of Factors Associated With Sustainability of Health Care Innovation Centers.

Krelle, Holly / Martinez, Michael / Garry, Kira / Horwitz, Leora I

JAMA network open

2023 Volume 6, Issue 10, Page(s) e2339129

Abstract: Importance: Innovation centers in US health care systems are increasingly common but variably successful and sustainable. Few studies have examined how and why some centers achieve sustainable success but others do not.: Objective: To explore whether ...

Abstract	Importance: Innovation centers in US health care systems are increasingly common but variably successful and sustainable. Few studies have examined how and why some centers achieve sustainable success but others do not. Objective: To explore whether and how innovation centers in US health care systems are able to successfully sustain themselves over multiple years. Design, setting, and participants: In this qualitative study, semistructured, qualitative interviews of leaders at 9 innovation centers across the US were conducted from January 1, 2019, to December 31, 2020. Data analysis was conducted from December 2020 to April 2021 using qualitative methods and a deductive framework based on the Consolidated Framework for Implementation Research. Centers were identified through purposeful sampling. The 9 study centers had a mean age of 6 years (range, 2-15 years); most were affiliated with an academic teaching hospital and half with a medical school. Two were wholly separate from the health care system. Two-thirds had fewer than 10 full-time staff members. Exposures: All interviewees were staff of a US-based innovation center. This study did not evaluate particular interventions or innovations. Main outcomes and measures: Perceptions of and views on factors associated with the success and sustainability of innovation centers. Results: Staff interviewed at 9 innovation centers across the US described 3 key activities that appeared to be associated with long-term sustainability: facilitating innovation projects that were valued for quality improvement and cost avoidance, not just return on investment; acting as networking nodes for their institutions; and upskilling staff. These activities were associated with improved institutional culture. Two structural characteristics underpinned successful centers: finding an effective balance between being "internal" and being "external" to the organization and providing practical support and skills otherwise lacking within the wider institution. Conclusions and relevance: This qualitative study of 9 innovation centers explored how centers sustained themselves within US health care institutions and showed that success was often associated with interpersonal relationships and cultural benefits. Independent financial sustainability was not always essential to longevity; systems also valued how centers could create cultures of innovation and upskill staff.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Adolescent ; Delivery of Health Care ; Quality Improvement ; Hospitals, Teaching ; Qualitative Research
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.39129
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Article ; Online: Motivations for Seeking Cosmetic Enhancing Procedures of the Face: A Systematic Review.

Martinez, Michael J / Dixit, Dhaval / White, Michael W / Rieder, Evan A

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 49, Issue 3, Page(s) 278–282

Abstract: Background: Cosmetic enhancing procedures continue to grow in demand. Physicians should understand the complex factors that drive patient motivation for seeking such procedures.: Objective: In contrast to a lens of psychopathology, this review ... ...

Abstract	Background: Cosmetic enhancing procedures continue to grow in demand. Physicians should understand the complex factors that drive patient motivation for seeking such procedures. Objective: In contrast to a lens of psychopathology, this review reveals the driving power of everyday intrapersonal, social, and behavioral factors that motivate interest in elective facial cosmetic procedures. Materials and methods: The review was conducted according to PRISMA guidelines and included studies with at least 50 adult patients seeking facial cosmetic enhancements between January 1, 2000, and July 1, 2022. Results: Among 1,239 identified publications, 21 studies with 9,005 participants were selected for inclusion. The review documents everyday factors as patient motivators for pursuing cosmetic enhancements of the face, with the majority of work focusing on intrapersonal factors (17 of 21 studies), such as preventing aging or negative appearance based self-appraisals. For studies reporting social factors (15 of 21 studies), the most common motivators were the patient's social network and a desire to promote social standing. Behavioral factors revealed that social media and media consumption impact patient motivation for cosmetic enhancements (5 of 21 studies). Conclusion: In summary, this review demonstrates that patient motivations for facial cosmetic enhancements may be best understood through everyday intrapersonal, social, and behavioral factors.
MeSH term(s)	Adult ; Humans ; Motivation ; Cosmetic Techniques
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003702
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Article ; Online: State-of-the-art 2023 on gene therapy for phenylketonuria.

Martinez, Michael / Harding, Cary O / Schwank, Gerald / Thöny, Beat

Journal of inherited metabolic disease

2023 Volume 47, Issue 1, Page(s) 80–92

Abstract: Phenylketonuria (PKU) or hyperphenylalaninemia is considered a paradigm for an inherited (metabolic) liver defect and is, based on murine models that replicate all human pathology, an exemplar model for experimental studies on liver gene therapy. ... ...

Abstract	Phenylketonuria (PKU) or hyperphenylalaninemia is considered a paradigm for an inherited (metabolic) liver defect and is, based on murine models that replicate all human pathology, an exemplar model for experimental studies on liver gene therapy. Variants in the PAH gene that lead to hyperphenylalaninemia are never fatal (although devastating if untreated), newborn screening has been available for two generations, and dietary treatment has been considered for a long time as therapeutic and satisfactory. However, significant shortcomings of contemporary dietary treatment of PKU remain. A long list of various gene therapeutic experimental approaches using the classical model for human PKU, the homozygous enu2/2 mouse, witnesses the value of this model to develop treatment for a genetic liver defect. The list of experiments for proof of principle includes recombinant viral (AdV, AAV, and LV) and non-viral (naked DNA or LNP-mRNA) vector delivery methods, combined with gene addition, genome, gene or base editing, and gene insertion or replacement. In addition, a list of current and planned clinical trials for PKU gene therapy is included. This review summarizes, compares, and evaluates the various approaches for the sake of scientific understanding and efficacy testing that may eventually pave the way for safe and efficient human application.
MeSH term(s)	Humans ; Mice ; Animals ; Phenylalanine Hydroxylase/genetics ; Phenylketonurias/genetics ; Phenylketonurias/therapy ; Genetic Therapy/methods ; Liver/pathology ; DNA
Chemical Substances	Phenylalanine Hydroxylase (EC 1.14.16.1) ; DNA (9007-49-2)
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	438341-2
ISSN	1573-2665 ; 0141-8955
ISSN (online)	1573-2665
ISSN	0141-8955
DOI	10.1002/jimd.12651
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Article ; Online: CDK activity sensors: genetically encoded ratiometric biosensors for live analysis of the cell cycle.

Martinez, Michael A Q / Matus, David Q

Biochemical Society transactions

2022 Volume 50, Issue 3, Page(s) 1081–1090

Abstract: Cyclin-dependent kinase (CDK) sensors have facilitated investigations of the cell cycle in living cells. These genetically encoded fluorescent biosensors change their subcellular location upon activation of CDKs. Activation is primarily regulated by ... ...

Abstract	Cyclin-dependent kinase (CDK) sensors have facilitated investigations of the cell cycle in living cells. These genetically encoded fluorescent biosensors change their subcellular location upon activation of CDKs. Activation is primarily regulated by their association with cyclins, which in turn trigger cell-cycle progression. In the absence of CDK activity, cells exit the cell cycle and become quiescent, a key step in stem cell maintenance and cancer cell dormancy. The evolutionary conservation of CDKs has allowed for the rapid development of CDK activity sensors for cell lines and several research organisms, including nematodes, fish, and flies. CDK activity sensors are utilized for their ability to visualize the exact moment of cell-cycle commitment. This has provided a breakthrough in understanding the proliferation-quiescence decision. Further adoption of these biosensors will usher in new discoveries focused on the cell-cycle regulation of development, ageing, and cancer.
MeSH term(s)	Animals ; Biosensing Techniques ; Cell Cycle/physiology ; Cell Division ; Cyclin-Dependent Kinases/metabolism ; Cyclins/genetics ; Cyclins/metabolism
Chemical Substances	Cyclins ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST20211131
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Article: Dermatomal Granulomatous Dermatitis and Vasculitis Following Herpes Zoster Ophthalmicus.

Martinez, Michael / Kim, Randie / Zampella, John

Journal of drugs in dermatology : JDD

2022 Volume 21, Issue 10, Page(s) 1127–1128

Abstract: Cutaneous granulomatous dermatoses are uncommon sequelae of herpes zoster (HZ) infection that have been documented in the literature, with granulomatous vasculitis described in rare cases. Here, we report a patient with HZ ophthalmicus who developed ... ...

Abstract	Cutaneous granulomatous dermatoses are uncommon sequelae of herpes zoster (HZ) infection that have been documented in the literature, with granulomatous vasculitis described in rare cases. Here, we report a patient with HZ ophthalmicus who developed edematous plaques with central scarring in a V1 dermatomal distribution with histopathological changes of a granulomatous dermatitis including features of granulomatous vasculitis. J Drugs Dermatol. 2022;21(10):1127-1128. oi:10.36849/JDD.6749.
MeSH term(s)	Autoimmune Diseases/complications ; Cicatrix/pathology ; Dermatitis/complications ; Dermatitis/etiology ; Granuloma/diagnosis ; Granuloma/etiology ; Herpes Zoster/complications ; Herpes Zoster/diagnosis ; Herpes Zoster Ophthalmicus/complications ; Herpes Zoster Ophthalmicus/diagnosis ; Herpes Zoster Ophthalmicus/drug therapy ; Humans ; Vasculitis/complications
Language	English
Publishing date	2022-05-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.6749
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Article: Ketamine as an Analgesic Adjunct for Opioid-Induced Hyperalgesia in a Patient With a Sickle Cell Pain Episode.

Martinez, Michael R / Garmon, Emily H / Starling, Garrett D / Sheth, Monish A

The Ochsner journal

2022 Volume 22, Issue 3, Page(s) 281–284

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Case Reports
ISSN	1524-5012
ISSN	1524-5012
DOI	10.31486/toj.22.0011
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Article: Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell.

Martinez, Michael A Q / Zhao, Chris Z / Moore, Frances E Q / Yee, Callista / Zhang, Wan / Shen, Kang / Martin, Benjamin L / Matus, David Q

bioRxiv : the preprint server for biology

2024

Abstract: The acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. ... ...

Abstract	The acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.16.533034
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