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Article ; Online: Skin and Soft-Tissue Infections: It's More Than Just Skin Deep.

Martinez, Nicole

2020 Volume 42, Issue 3, Page(s) 196–203

Abstract: Skin and soft-tissue infection (SSTI) are one of the most common infections in both the community and hospital settings and account for nearly 4.8 million emergency department visits annually. These infections can vary in presentation, treatment, ... ...

Abstract	Skin and soft-tissue infection (SSTI) are one of the most common infections in both the community and hospital settings and account for nearly 4.8 million emergency department visits annually. These infections can vary in presentation, treatment, management, and potential for complication. As emergency medicine providers, early recognition and diagnosis of the disease are key. Point-of-care ultrasound is an invaluable tool that has contributed to the expeditious evaluation of these diseases with ultimate guidance for clinical management for SSTIs. This article reviews 3 SSTIs-cellulitis, abscess, and necrotizing fasciitis-and presents a common case study for consideration.
MeSH term(s)	Abscess/diagnosis ; Abscess/microbiology ; Abscess/therapy ; Adult ; Cellulitis/diagnosis ; Cellulitis/microbiology ; Cellulitis/therapy ; Diagnosis, Differential ; Emergency Service, Hospital ; Fasciitis, Necrotizing/diagnosis ; Fasciitis, Necrotizing/microbiology ; Fasciitis, Necrotizing/therapy ; Humans ; Male ; Point-of-Care Systems ; Ultrasonography/methods
Language	English
Publishing date	2020-07-21
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2257871-7
ISSN	1931-4493 ; 1931-4485
ISSN (online)	1931-4493
ISSN	1931-4485
DOI	10.1097/TME.0000000000000312
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Article: Aquaporins in Fetal Development.

Martínez, Nora / Damiano, Alicia E

Advances in experimental medicine and biology

2023 Volume 1398, Page(s) 251–266

Abstract: Water homeostasis is essential for fetal growth, and it depends on the successful development of the placenta. Many aquaporins (AQPs) were identified from blastocyst stages to term placenta. In the last years, cytokines, hormones, second messengers, ... ...

Abstract	Water homeostasis is essential for fetal growth, and it depends on the successful development of the placenta. Many aquaporins (AQPs) were identified from blastocyst stages to term placenta. In the last years, cytokines, hormones, second messengers, intracellular pH, and membrane proteins were found to regulate their expression and function in the human placenta and fetal membranes. Accumulated data suggest that these proteins may be involved not only in the maintenance of the amniotic fluid volume homeostasis but also in the development of the placenta and fetal organs. In this sense, dysregulation of placental AQPs is associated with gestational disorders. Thus, current evidence shows that AQPs may collaborate in cellular events including trophoblast migration and apoptosis. In addition, aquaglyceroporins are involved in energy metabolism as well as urea elimination across the placenta. In the last year, the presence of AQP9 in trophoblast mitochondria opened new hypotheses about its role in pregnancy. However, much further work is needed to understand the importance of these proteins in human pregnancies.
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta/metabolism ; Aquaporins/genetics ; Aquaporins/metabolism ; Fetal Development ; Amniotic Fluid ; Extraembryonic Membranes
Chemical Substances	Aquaporins
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-981-19-7415-1_17
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Article ; Online: The 2018 Bo Lindell Laureate Lecture: Finding common ground between science, ethics, and experience.

Martinez, N E

Annals of the ICRP

2020 Volume 49, Issue 1_suppl, Page(s) 9–31

Abstract: The present system of radiological protection has evolved with the advancement of science; evolution of ethical and societal values; and the lessons of our individual, collective, and historical experience. In communicating with each other and members of ...

Abstract	The present system of radiological protection has evolved with the advancement of science; evolution of ethical and societal values; and the lessons of our individual, collective, and historical experience. In communicating with each other and members of the public, words are often not enough to completely relay thoughts, ideas, or experiences. Art is a shared experience, beyond the spoken language, where many can find common ground. This paper provides several examples of utilising the visual arts, cinema, and popular culture for communication in different contexts, with discussion of how each relates to the ethical values of the system of radiological protection. In this way, we find inter-relationships between science, ethics, and experience. Experience improves understanding; empathy, or the awareness and feeling of another's experience, can lead to similar understanding. Drawing on art and the broader human experience will help us improve our communication, promote transparency, and encourage empathy. Through this, we will be more likely to develop trust with stakeholders, which is an essential, yet challenging, aspect of radiological protection.
MeSH term(s)	Communication ; Humans ; Radiation Protection/instrumentation ; Radiation Protection/methods ; Radiation Protection/standards
Language	English
Publishing date	2020-10-13
Publishing country	England
Document type	Journal Article ; Lecture
ISSN	1872-969X ; 0146-6453
ISSN (online)	1872-969X
ISSN	0146-6453
DOI	10.1177/0146645320946618
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Article ; Online: Tuberculosis and diabetes: from bench to bedside and back.

Martinez, N / Kornfeld, H

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2019 Volume 23, Issue 6, Page(s) 669–677

Abstract: People living with diabetes (DM) are at increased risk to become infected ... ...

Abstract	People living with diabetes (DM) are at increased risk to become infected with
MeSH term(s)	Animals ; Comorbidity ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/prevention & control ; Disease Models, Animal ; Mycobacterium tuberculosis ; Research Design ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/prevention & control
Language	English
Publishing date	2019-07-18
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.18.0805
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Article ; Online: Historia natural de la mucopolisacaridosis III en una serie de pacientes colombianos.

Cabarcas, L / Ramón, J L / Espinosa, E / Guerrero, G P / Martínez, N / Santamaría, N / Lince, I / Reyes, S

Revista de neurologia

2024 Volume 78, Issue 6, Page(s) 171–177

Abstract: Introduction: Mucopolysaccharidosis type III (MPS III), also known as Sanfilippo syndrome, is a lysosomal storage disease with progressive neurodegenerative features, predominantly affecting the central nervous system. Diagnosis is based on clinical ... ...

Title translation	Natural history of mucopolysaccharidosis type III in a series of Colombian patients.
Abstract	Introduction: Mucopolysaccharidosis type III (MPS III), also known as Sanfilippo syndrome, is a lysosomal storage disease with progressive neurodegenerative features, predominantly affecting the central nervous system. Diagnosis is based on clinical features, with neurodevelopmental and neuropsychiatric alterations taking precedence, including over phenotype alterations. The disease is confirmed by biochemical analysis to identify the type of glycosaminoglycans present, enzyme assay and molecular genetic studies. Case reports: A clinical description was performed for eight patients diagnosed with MPS III in Colombia. Their initial symptoms were related to developmental delay and behavioural disorders presenting between 3 and 8 years of age, associated in all cases with coarse facial features, thick eyebrows, hepatomegaly and progressive hearing loss. One of the patients presented cardiac anomalies; two presented focal epilepsy; and one presented optic atrophy. They all presented neuroimaging alterations, with evidence of parenchymal volume loss, corpus callosum atrophy and cortical thinning; the diagnosis was performed by biochemical glycosaminoglycan chromatography studies, and all patients have a confirmatory genetic study. Conclusions: MPS III is a challenge for diagnosis, particularly in its early stages and in patients in which the course of the disease is attenuated. This is due to its variable course, non-specific early neuropsychiatric symptoms, and the absence of obvious somatic features compared to other types of MPS. After a definitive diagnosis has been made, interdisciplinary care must be provided for the patient and their family, and support given for the treatment of physical symptoms, ensuring the best possible care and quality of life for the patient and their family, as the condition is neurodegenerative.
MeSH term(s)	Humans ; Colombia ; Mucopolysaccharidosis III/diagnosis ; Mucopolysaccharidosis III/genetics ; Mucopolysaccharidosis III/therapy ; Quality of Life ; Phenotype ; Neuroimaging
Language	Spanish
Publishing date	2024-03-14
Publishing country	Spain
Document type	Case Reports ; English Abstract
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
DOI	10.33588/rn.7806.2023281
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Article ; Online: Effect of carbohydrates on the adhesion of Bordetella bronchiseptica to the respiratory epithelium in rabbits.

Patiño, Pilar / Gallego, Carolina / Martínez, Nhora / Iregui, Carlos / Rey, Alba

Veterinary research communications

2024

Abstract: This study proposes an ecological approach for preventing respiratory tract infections caused by Bordetella bronchiseptica in mammals using a mixture of carbohydrates. In an in vivo study, 51-day-old New Zealand rabbits were treated with a solution ... ...

Abstract	This study proposes an ecological approach for preventing respiratory tract infections caused by Bordetella bronchiseptica in mammals using a mixture of carbohydrates. In an in vivo study, 51-day-old New Zealand rabbits were treated with a solution containing 1 × 10
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-024-10307-1
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Article ; Online: Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring.

Vélez-Godínez, Blanca Rubí / López-Sánchez, Pedro / Páez-Martínez, Nayeli

Psychopharmacology

2024

Abstract: Rationale: Preeclampsia is a condition that can affect the health in offspring at adult life. The effect on several systems has been described, but less is known about its effect on neuropsychiatric disorders at early ages.: Objective: Evaluate the ... ...

Abstract	Rationale: Preeclampsia is a condition that can affect the health in offspring at adult life. The effect on several systems has been described, but less is known about its effect on neuropsychiatric disorders at early ages. Objective: Evaluate the possible relationship of preeclampsia with development of anxiety- and depressive-like behavior, as well as memory impairments in male and female early adolescent offspring from preeclamptic mice. Methods: Thirty pregnant females were divided into control group receiving vehicle, and preeclampsia group receiving L-NAME in drinking water at a dose of 60 mg/Kg from day 10 of pregnancy until delivery. Offspring was weaned and sexed at 4 weeks after birth. Each group was evaluated using the elevated plus maze test (anxiety- like response), tail suspension test (depressive-like behavior) and the recognition of novel objects test (recognition memory), in addition to the open field test was performance to corroborate their motor activity and validate our results. Results: We found that preeclampsia produces behavioral alterations in offspring, and this effect is dependent on sex. The male offspring from preeclampsia showed an enhancement in the time that mice spend in the close arms in the elevated plus maze test, and longer immobility time in the tail suspension test, compared to the offspring from healthy pregnancies. On the other hand, female offspring from preeclampsia showed a lower percentage of recognition in the memory test compared to offspring from normal pregnancy. Conclusions: These results suggest that preeclampsia predisposes early adolescent young male offspring to develop anxiety- and depressive-like behavior as well as memory impairment in early adolescent young female offspring.
Language	English
Publishing date	2024-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-024-06568-y
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Article ; Online: Post-thaw application of ROCK-inhibitors increases cryopreserved T-cell yield.

Gonzalez-Martinez, Natalia / Gibson, Matthew I

RSC medicinal chemistry

2023 Volume 14, Issue 10, Page(s) 2058–2067

Abstract: Emerging cell-based therapies such as CAR-T (Chimeric Antigen Receptor T) cells require cryopreservation to store and deliver intact and viable cells. Conventional cryopreservation formulations use DMSO to mitigate cold-induced damage, but do not address ...

Abstract	Emerging cell-based therapies such as CAR-T (Chimeric Antigen Receptor T) cells require cryopreservation to store and deliver intact and viable cells. Conventional cryopreservation formulations use DMSO to mitigate cold-induced damage, but do not address all the biochemical damage mechanisms induced by cold stress, such as programmed cell death (apoptosis). Rho-associated protein kinases (ROCK) are a key component of apoptosis, and their activation contributes to apoptotic blebbing. Here we demonstrate that the ROCK inhibitor fasudil hydrochloride, when supplemented into the thawing medium of T-cells increases the overall yield of healthy cells. Cell yield was highest using 5 or 10% DMSO cryopreservation solutions, with lower DMSO concentrations (2.5%) leading to significant physical damage to the cells. After optimisation, the post-thaw yield of T-cells increased by approximately 20% using this inhibitor, a significant increase in the context of a therapy. Flow cytometry analysis did not show a significant reduction in the relative percentage of cell populations undergoing apoptosis, but there was a small reduction in the 8 hours following thawing. Fasudil also led to a reduction in reactive oxygen species. Addition of fasudil into the cryopreservation solution, followed by dilution (rather than washing) upon thaw also gave a 20% increase in cell yield, demonstrating how this could be deployed in a cell-therapy context, without needing to change clinical thawing routines. Overall, this shows that modulation of post-thaw biochemical pathways which lead to apoptosis (or other degradative pathways) can be effectively targeted as a strategy to increase T-cell yield and function post-thaw.
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00378g
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Article ; Online: Characterizing the information transmission of inverse stochastic resonance and noise-induced activity amplification in neuronal systems.

Martínez, Nataniel / Deza, Roberto R / Montani, Fernando

Physical review. E

2023 Volume 107, Issue 5-1, Page(s) 54402

Abstract: Purkinje cells exhibit a reduction of the mean firing rate at intermediate-noise intensities, which is somewhat reminiscent of the response enhancement known as "stochastic resonance" (SR). Although the comparison with the stochastic resonance ends here, ...

Abstract	Purkinje cells exhibit a reduction of the mean firing rate at intermediate-noise intensities, which is somewhat reminiscent of the response enhancement known as "stochastic resonance" (SR). Although the comparison with the stochastic resonance ends here, the current phenomenon has been given the name "inverse stochastic resonance" (ISR). Recent research has demonstrated that the ISR effect, like its close relative "nonstandard SR" [or, more correctly, noise-induced activity amplification (NIAA)], has been shown to stem from the weak-noise quenching of the initial distribution, in bistable regimes where the metastable state has a larger attraction basin than the global minimum. To understand the underlying mechanism of the ISR and NIAA phenomena, we study the probability distribution function of a one-dimensional system subjected to a bistable potential that has the property of symmetry, i.e., if we change the sign of one of its parameters, we can obtain both phenomena with the same properties in the depth of the wells and the width of their basins of attraction subjected to Gaussian white noise with variable intensity. Previous work has shown that one can theoretically determine the probability distribution function using the convex sum between the behavior at small and high noise intensities. To determine the probability distribution function more precisely, we resort to the "weighted ensemble Brownian dynamics simulation" model, which provides an accurate estimate of the probability distribution function for both low and high noise intensities and, most importantly, for the transition of both behaviors. In this way, on the one hand, we show that both phenomena emerge from a metastable system where, in the case of ISR, the global minimum of the system is in a state of lower activity, while in the case of NIAA, the global minimum is in a state of increased activity, the importance of which does not depend on the width of the basins of attraction. On the other hand, we see that quantifiers such as Fisher information, statistical complexity, and especially Shannon entropy fail to distinguish them, but they show the existence of the mentioned phenomena. Thus, noise management may well be a mechanism by which Purkinje cells find an efficient way to transmit information in the cerebral cortex.
MeSH term(s)	Stochastic Processes ; Neurons/physiology ; Likelihood Functions ; Noise ; Normal Distribution
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.107.054402
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Article ; Online: Resolving disputed subspecies distribution limits, and revealing intraspecific intergradation, in the Common Redstart Phoenicurus phoenicurus using citizen science and museum data

Martinez, Nicolas / Kirwan, Guy M. / Schweizer, Manuel

J Ornithol. 2023 Jan., v. 164, no. 1 p.1-12

2023

Abstract: Contact zones with hybridization are documented for several Palearctic bird taxa. However, their extent is still poorly understood in many cases, including the Common Redstart Phoenicurus phoenicurus. Nominate P. p. phoenicurus breeds across most of the ... ...

Abstract	Contact zones with hybridization are documented for several Palearctic bird taxa. However, their extent is still poorly understood in many cases, including the Common Redstart Phoenicurus phoenicurus. Nominate P. p. phoenicurus breeds across most of the species’ range, whereas P. p. samamisicus is restricted to the south-eastern part. Their precise distributions are disputed as is the existence and prevalence of hybridization between them within potential contact zones in the Balkans, Turkey and the Caucasus region. Adult males differ by the presence (samamisicus) or absence (phoenicurus) of a white wing patch; however, there is variation and white is lacking in most second-calendar-year males of both subspecies. Further, male samamisicus is thought to be darker on the mantle. We map the occurrence of pre-defined states in these two characters during the breeding season across the species’ range based upon photos in online citizen science databases, subsequently complemented by an examination of museum specimens to refute or verify the pattern inferred from photos. We demonstrate that the extent of white in the wing varies throughout the range, but nevertheless is geographically structured. Adult breeders with a large white wing patch and black mantle occurred only in Greece, southern Bulgaria, Turkey, Crimea, and the Caucasus to Iran, which should be considered the breeding range of samamisicus. Earlier reports of intermediates and/or phoenicurus breeding there perhaps reflect confusion with second-year male samamisicus. Broad areas in the Balkans and north of the Black Sea were revealed as zones of intraspecific intergradation. Employing citizen science data enabled us to acquire a much larger sample than by using museum material alone. Although photographs from citizen science databases are unlikely to ever completely replace museum specimens, our approach of combining both types of data could prove a model for similar future research.
Keywords	Palearctic region ; adults ; birds ; citizen science ; hybridization ; males ; models ; museums ; Black Sea ; Bulgaria ; Caucasus region ; Greece ; Iran
Language	English
Dates of publication	2023-01
Size	p. 1-12.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2134595-8
ISSN	2193-7206 ; 2193-7192
ISSN (online)	2193-7206
ISSN	2193-7192
DOI	10.1007/s10336-022-02007-x
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