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  1. Article ; Online: Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder in an Unusual Location.

    Ruiz-Sánchez, Daniel / Valtueña, Jara / Cantero, Maria Garayar / Barrutia, Leire / Volo, Víctor / López, Pilar Manchado / Martínez-García, Gerardo

    Indian journal of dermatology

    2023  Volume 67, Issue 6, Page(s) 837

    Language English
    Publishing date 2023-03-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.IJD_543_20
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    Zs.B 817: Show issues Location:
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  2. Article ; Online: Ecthyma gangrenosum, beyond Pseudomonas aeruginosa.

    Ruiz-Sanchez, Daniel / Valtueña, Jara / Garabito Solovera, Esther / Martínez García, Gerardo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  

    Title translation Ectima gangrenoso, más allá de Pseudomonas aeruginosa.
    Language Spanish
    Publishing date 2021-01-10
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2020.11.016
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  3. Article ; Online: Ecthyma gangrenosum, beyond Pseudomonas aeruginosa.

    Ruiz-Sanchez, Daniel / Valtueña, Jara / Garabito Solovera, Esther / Martinez Garcia, Gerardo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  Volume 39, Issue 10, Page(s) 526–527

    MeSH term(s) Ecthyma/diagnosis ; Humans ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Sepsis
    Language English
    Publishing date 2021-09-23
    Publishing country Spain
    Document type Case Reports ; Letter
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.09.005
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  4. Article ; Online: Tracheobronchial Amyloidosis as an Incidental Finding in a Patient With Lung Cancer.

    de Vega Sánchez, Blanca / Disdier Vicente, Carlos / Martínez García, Gerardo

    Archivos de bronconeumologia

    2019  Volume 55, Issue 10, Page(s) 532

    Title translation Amiloidosis traqueobronquial como hallazgo incidental en un paciente con neoplasia pulmonar.
    MeSH term(s) Aged ; Amyloidosis/complications ; Bronchial Diseases/complications ; Humans ; Incidental Findings ; Lung Neoplasms/complications ; Male ; Tracheal Diseases/complications
    Language Spanish
    Publishing date 2019-01-23
    Document type Case Reports ; Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2018.12.006
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    Zs.B 2655: Show issues Location:
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  5. Article ; Online: Recurrent reactive infectious mucocutaneous eruption (RIME) secondary to Chlamydophila pneumoniae infection in an adult.

    Carballido-Vázquez, Ana M / Volo, Víctor / Vega-López, Teresa L / Santamarina-Albertos, Alba S / Garabito-Solovera, Esther L / Martínez-García, Gerardo / Manchado-López, Pilar

    The Australasian journal of dermatology

    2023  Volume 64, Issue 4, Page(s) 537–543

    Abstract: The terminology surrounding the clinical syndrome characterized by acute mucositis with minimal skin involvement has been a subject of debate over time. In recent years, terms such as mycoplasma-induced rash and mucositis and reactive infectious ... ...

    Abstract The terminology surrounding the clinical syndrome characterized by acute mucositis with minimal skin involvement has been a subject of debate over time. In recent years, terms such as mycoplasma-induced rash and mucositis and reactive infectious mucocutaneous eruption (RIME) have been introduced to encompass milder mucocutaneous diseases associated with respiratory infections, with implications for management and prognosis. We report the first case of recurrent RIME associated with Chlamydophila pneumoniae infection in an adult patient. RIME is likely underreported due to misclassification and a lack of testing for potential pathogens. Early recognition of recurrent RIME is of particular interest from the patient's perspective to reduce the frequency and duration of hospital admissions.
    MeSH term(s) Humans ; Adult ; Mycoplasma pneumoniae ; Chlamydophila pneumoniae ; Mucositis/complications ; Exanthema/etiology ; Syndrome ; Pneumonia, Mycoplasma/complications
    Language English
    Publishing date 2023-10-12
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14173
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  6. Article ; Online: Differentiating pagetoid Bowen disease from Paget disease on the nipple-areola complex: Two unique, challenging cases.

    Barrutia, Leire / Martínez-García, Gerardo / Santamarina-Albertos, Alba / Garabito Solovera, Esther Leticia / Volo, Víctor / Ruíz-Sánchez, Daniel / Manchado López, Pilar

    Journal of cutaneous pathology

    2021  Volume 48, Issue 11, Page(s) 1416–1422

    Abstract: Pagetoid Bowen disease is a subtype of Bowen disease that accounts for 5% of Bowen disease. It is extremely rare for Bowen disease to appear on the nipple-areola complex, with only seven cases described in the previous literature. Of those seven cases, ... ...

    Abstract Pagetoid Bowen disease is a subtype of Bowen disease that accounts for 5% of Bowen disease. It is extremely rare for Bowen disease to appear on the nipple-areola complex, with only seven cases described in the previous literature. Of those seven cases, only one was of the pagetoid subtype. We report two cases of pagetoid Bowen disease on this location, one of them being the first case of pagetoid Bowen disease affecting the nipple reported to date. On this location, it is crucial to perform a meticulous differential diagnosis to rule out Paget disease, because of its contrasting therapeutic and prognostic implications. In order to do this, clinical and histopathological aspects must be considered. From a clinical point of view, previous literature has stated that nipple involvement can be a clue that points to Paget disease. However, one of our cases shows that this is not always true. Regarding histopathological analysis, a complete excision of the tumor might be necessary to observe clear features of Bowen disease, such as full-thickness atypia of the epidermis and intercellular bridges. An immunohistochemical panel comprising carcinoembryonic antigen, gross cystic disease fluid protein, epithelial membrane antigen, p63, CK34betaE12, periodic acid-Schiff, estrogen receptor, and progesterone receptor can be decisive in complicated cases.
    MeSH term(s) Aged, 80 and over ; Biomarkers, Tumor/analysis ; Bowen's Disease/diagnosis ; Bowen's Disease/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Nipples/pathology ; Paget's Disease, Mammary/diagnosis ; Paget's Disease, Mammary/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14092
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    Zs.A 1043: Show issues Location:
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  7. Article ; Online: Vascular obliteration because of endothelial and myointimal growth in COVID-19 patients.

    Valtueña, Jara / Martínez-García, Gerardo / Ruiz-Sánchez, Daniel / Garayar-Cantero, María / Dueñas, Carlos / Hadi, Ali / Hadi, Suhail / Aguado-García, Ángel / Prieto de Paula, José M / Manchado-López, Pilar

    International journal of dermatology

    2020  Volume 60, Issue 1, Page(s) 73–80

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is a systemic multi-organ viral illness. Previous studies have found that many patients had a procoagulant state and/or severe hypoxemia with relatively well-preserved lung mechanics. Mechanisms underlying ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a systemic multi-organ viral illness. Previous studies have found that many patients had a procoagulant state and/or severe hypoxemia with relatively well-preserved lung mechanics. Mechanisms underlying the damage to vascular tissues are not well-elucidated yet. Histological data in COVID-19 patients are still limited and are mainly focused on post-mortem analysis. Given that the skin is affected by COVID-19 and the relative ease of its histological examination, we aimed to examine the histology of skin lesions in COVID-19 patients to better understand the disease's pathology.
    Methods: Five skin lesions from COVID-19 adult patients were selected for a deep histological tissue examination.
    Results: A strong vasculopathic reaction pattern based on prominent vascular endothelial and myointimal cell growth was identified. Endothelial cell distortion generated vascular lumen obliteration and striking erythrocyte and serum extravasation. Significant deposition of C4d and C3 throughout the vascular cell wall was also identified. A regenerative epidermal hyperplasia with tissue structure preservation was also observed.
    Conclusions: COVID-19 could comprise an obliterative microangiopathy consisting on endothelial and myointimal growth with complement activation. This mechanism, together with the increased vascular permeability identified, could contribute to obliteration of the vascular lumen and hemorrhage in COVID-19. Thus, anticoagulation by itself could not completely reverse vascular lumen obliteration, with consequent increased risk of hemorrhage. Findings of this study could contribute to a better understanding of physiopathological mechanisms underlying COVID-19 on living patients and could help further studies find potential targets for specific therapeutic interventions in severe cases.
    MeSH term(s) Aged ; Blood Vessels/pathology ; CD3 Complex/metabolism ; CD4 Antigens/metabolism ; COVID-19/complications ; Endothelial Cells/pathology ; Endothelium/metabolism ; Endothelium/pathology ; Humans ; Hyperplasia/pathology ; Hyperplasia/virology ; Myocytes, Smooth Muscle/pathology ; SARS-CoV-2 ; Skin/blood supply ; Skin Diseases/pathology ; Skin Diseases/virology ; Vascular Diseases/pathology ; Vascular Diseases/virology
    Chemical Substances CD3 Complex ; CD4 Antigens
    Keywords covid19
    Language English
    Publishing date 2020-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15300
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  8. Article ; Online: Neuroendocrine tumor associate with inflammatory bowel disease: two cases report.

    Trujillo-Díaz, Jeancarlos J / Blanco-Antona, Francisco / de Solórzano-Aurusa, Javier Ortiz / Martínez-García, Gerardo / Fernández-Salazar, Luis / Rentería, Juan P Beltrán-de Heredia Y

    Cirugia y cirujanos

    2019  Volume 87, Issue S1, Page(s) 17–21

    Abstract: Introduction: Patients with inflammatory bowel disease (IBD) have a higher risk of developing gastrointestinal tumors, the adenocarcinoma is the most frequently associated, and neuroendocrine tumor (NET) the most rare.: Clinical cases: We present two ...

    Title translation Tumor neuroendocrino relacionado con enfermedad inflamatoria intestinal: a propósito de dos casos.
    Abstract Introduction: Patients with inflammatory bowel disease (IBD) have a higher risk of developing gastrointestinal tumors, the adenocarcinoma is the most frequently associated, and neuroendocrine tumor (NET) the most rare.
    Clinical cases: We present two patients, one with Crohn's disease and the other with ulcerative colitis, who present nonspecific symptoms, and after resection of an intestinal lesion, a gastrointestinal NET (GINET) is diagnosed.
    Discussion and conclusion: The GINET have an insidious clinic and these can be confused with those of the IBD. There could be an association between both pathologies; an important role of the chronic intestinal inflammatory process is suggested. The best treatment for GINET is the resection.
    MeSH term(s) Aged ; Carcinoma, Renal Cell ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/surgery ; Colonic Polyps/complications ; Colonic Polyps/drug therapy ; Colonoscopy ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Crohn Disease/surgery ; Delayed Diagnosis ; Diagnosis, Differential ; Disease Susceptibility ; Humans ; Ileal Neoplasms/complications ; Ileal Neoplasms/diagnosis ; Ileal Neoplasms/surgery ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Incidental Findings ; Inflammation ; Kidney Neoplasms ; Male ; Middle Aged ; Neoplasms, Second Primary/complications ; Neoplasms, Second Primary/diagnosis ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/surgery ; Rectal Neoplasms/complications ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2019-06-01
    Publishing country Mexico
    Document type Case Reports ; Journal Article
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.18000519
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    Zs.B 797: Show issues Location:
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  9. Article: Vascular obliteration because of endothelial and myointimal growth in COVID-19 patients

    Valtueña, Jara / Martínez-García, Gerardo / Ruiz-Sánchez, Daniel / Garayar-Cantero, María / Dueñas, Carlos / Hadi, Ali / Hadi, Suhail / Aguado-García, Ángel / Prieto de Paula, José M / Manchado-López, Pilar

    Int. j. dermatol

    Abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a systemic multi-organ viral illness. Previous studies have found that many patients had a procoagulant state and/or severe hypoxemia with relatively well-preserved lung mechanics. Mechanisms underlying ... ...

    Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) is a systemic multi-organ viral illness. Previous studies have found that many patients had a procoagulant state and/or severe hypoxemia with relatively well-preserved lung mechanics. Mechanisms underlying the damage to vascular tissues are not well-elucidated yet. Histological data in COVID-19 patients are still limited and are mainly focused on post-mortem analysis. Given that the skin is affected by COVID-19 and the relative ease of its histological examination, we aimed to examine the histology of skin lesions in COVID-19 patients to better understand the disease's pathology. METHODS: Five skin lesions from COVID-19 adult patients were selected for a deep histological tissue examination. RESULTS: A strong vasculopathic reaction pattern based on prominent vascular endothelial and myointimal cell growth was identified. Endothelial cell distortion generated vascular lumen obliteration and striking erythrocyte and serum extravasation. Significant deposition of C4d and C3 throughout the vascular cell wall was also identified. A regenerative epidermal hyperplasia with tissue structure preservation was also observed. CONCLUSIONS: COVID-19 could comprise an obliterative microangiopathy consisting on endothelial and myointimal growth with complement activation. This mechanism, together with the increased vascular permeability identified, could contribute to obliteration of the vascular lumen and hemorrhage in COVID-19. Thus, anticoagulation by itself could not completely reverse vascular lumen obliteration, with consequent increased risk of hemorrhage. Findings of this study could contribute to a better understanding of physiopathological mechanisms underlying COVID-19 on living patients and could help further studies find potential targets for specific therapeutic interventions in severe cases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #919217
    Database COVID19

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  10. Article ; Online: Lymphomatoid photocontact dermatitis to benzydamine hydrochloride.

    Alvarez-Garrido, Helena / Sanz-Muñoz, Carolina / Martínez-García, Gerardo / Miranda-Romero, Alberto

    Contact dermatitis

    2010  Volume 62, Issue 2, Page(s) 117–119

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Aged, 80 and over ; Anti-Inflammatory Agents/adverse effects ; Benzydamine/adverse effects ; Dermatitis, Photoallergic/diagnosis ; Dermatitis, Photoallergic/etiology ; Dermatitis, Photoallergic/pathology ; Female ; Humans ; Pseudolymphoma/chemically induced ; Pseudolymphoma/diagnosis ; Pseudolymphoma/pathology
    Chemical Substances Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Benzydamine (4O21U048EF)
    Language English
    Publishing date 2010-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/j.1600-0536.2009.01676.x
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