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  1. Article ; Online: Dendritic cell cross-dressing and tumor immunity.

    Martinez-Usatorre, Amaia / De Palma, Michele

    EMBO molecular medicine

    2022  Volume 14, Issue 10, Page(s) e16523

    Abstract: In addition to direct and cross-presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called "cross-dressing." DC cross-dressing involves the acquisition of preformed peptide-major ... ...

    Abstract In addition to direct and cross-presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called "cross-dressing." DC cross-dressing involves the acquisition of preformed peptide-major histocompatibility class I/II (p-MHC) complexes from cancer cells. This process has been documented both in cell culture and in tumor models; may occur via the uptake of tumor-derived extracellular vesicles or the horizontal transfer of plasma membrane fragments from cancer cells to DCs; and can be enhanced through DC engineering for therapeutic applications. In some experimental contexts, DC cross-dressing may be essential for productive anti-tumor immunity, possibly owing to the fact that tumor-derived p-MHC complexes encompass the full repertoire of immunologically relevant TAs against which primed cytotoxic T cells can exert their tumoricidal activity.
    MeSH term(s) Antigen Presentation ; Antigens, Neoplasm/metabolism ; Bandages ; Cross-Priming ; Dendritic Cells ; Peptides
    Chemical Substances Antigens, Neoplasm ; Peptides
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202216523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Alzheimer's drug turns macrophages against cancer.

    Martinez-Usatorre, Amaia / De Palma, Michele

    Nature cancer

    2021  Volume 2, Issue 11, Page(s) 1119–1121

    MeSH term(s) Alzheimer Disease/drug therapy ; Humans ; Macrophages ; Neoplasms/drug therapy ; Protein Structure, Secondary
    Language English
    Publishing date 2021-11-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-021-00284-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Generation of affinity ranged antigen-expressing tumor cell lines.

    Martinez-Usatorre, Amaia / Romero, Pedro

    Methods in enzymology

    2019  Volume 632, Page(s) 503–519

    Abstract: The interaction strength between ... ...

    Abstract The interaction strength between CD8
    MeSH term(s) Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Autoantigens/genetics ; Autoantigens/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor/immunology ; Cell Line, Tumor/metabolism ; Cell Proliferation ; Clone Cells/immunology ; Clone Cells/metabolism ; HEK293 Cells ; Humans ; Neoplasms/genetics ; Neoplasms/immunology ; Retroviridae/genetics ; Retroviridae/immunology ; Transduction, Genetic
    Chemical Substances Antigens, Neoplasm ; Autoantigens
    Language English
    Publishing date 2019-12-18
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/bs.mie.2019.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A LIGHTning Strike to the Metastatic Niche.

    Martinez-Usatorre, Amaia / De Palma, Michele

    Cell reports

    2020  Volume 30, Issue 3, Page(s) 599–601

    Abstract: Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung ... ...

    Abstract Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung metastasis in mice.
    MeSH term(s) Animals ; Immunotherapy ; Lightning Injuries ; Lung ; Lung Neoplasms ; Male ; Mice
    Language English
    Publishing date 2020-01-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells.

    Martínez-Usatorre, Amaia / Donda, Alena / Zehn, Dietmar / Romero, Pedro

    Journal of immunology (Baltimore, Md. : 1950)

    2018  Volume 201, Issue 2, Page(s) 792–803

    Abstract: Antitumor T cell responses involve ... ...

    Abstract Antitumor T cell responses involve CD8
    MeSH term(s) Animals ; Antibodies, Monoclonal/therapeutic use ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/immunology ; Cell Proliferation ; Immunotherapy/methods ; Lymphocyte Activation ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neoplasms, Experimental/immunology ; Ovalbumin/immunology ; Peptide Fragments/immunology ; Programmed Cell Death 1 Receptor/immunology ; Protein Binding ; Receptors, Antigen, T-Cell/metabolism ; T-Cell Antigen Receptor Specificity
    Chemical Substances Antibodies, Monoclonal ; Cancer Vaccines ; Pdcd1 protein, mouse ; Peptide Fragments ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell ; ovalbumin (256-264) ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2018-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1701644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  6. Article ; Online: An Immunomodulatory Gallotanin-Rich Fraction From

    Lasso, Paola / Gomez-Cadena, Alejandra / Urueña, Claudia / Donda, Alena / Martinez-Usatorre, Amaia / Romero, Pedro / Barreto, Alfonso / Fiorentino, Susana

    Frontiers in immunology

    2020  Volume 11, Page(s) 584959

    Abstract: PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are ... ...

    Abstract PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced to a group of patients. The research in combined therapies, which allow for a greater response, is strongly encouraging. We previously characterized a polyphenol-rich extract from
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antineoplastic Agents/immunology ; B7-H1 Antigen/immunology ; Breast Neoplasms/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Caesalpinia/immunology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Female ; Humans ; Hydrolyzable Tannins/immunology ; Immunity/immunology ; Immunologic Factors/immunology ; MCF-7 Cells ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plant Extracts/immunology ; Polyphenols/immunology
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; B7-H1 Antigen ; Cd274 protein, mouse ; Hydrolyzable Tannins ; Immunologic Factors ; Plant Extracts ; Polyphenols
    Language English
    Publishing date 2020-11-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.584959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.

    Martinez-Usatorre, Amaia / Carmona, Santiago J / Godfroid, Céline / Yacoub Maroun, Céline / Labiano, Sara / Romero, Pedro

    Frontiers in immunology

    2020  Volume 11, Page(s) 340

    Abstract: In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to ... ...

    Abstract In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate
    MeSH term(s) Adoptive Transfer/methods ; Animals ; Antigens, CD/analysis ; Apyrase/analysis ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Cell Separation/methods ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma/immunology ; Melanoma/therapy ; Mice ; Mice, Inbred C57BL ; Phenotype ; Programmed Cell Death 1 Receptor/analysis ; Receptors, CXCR5/analysis
    Chemical Substances Antigens, CD ; Programmed Cell Death 1 Receptor ; Receptors, CXCR5 ; Apyrase (EC 3.6.1.5) ; CD39 antigen (EC 3.6.1.5)
    Language English
    Publishing date 2020-02-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy.

    Ghasemi, Ali / Martinez-Usatorre, Amaia / Li, Luqing / Hicham, Mehdi / Guichard, Alan / Marcone, Rachel / Fournier, Nadine / Torchia, Bruno / Martinez Bedoya, Darel / Davanture, Suzel / Fernández-Vaquero, Mirian / Fan, Chaofan / Janzen, Jakob / Mohammadzadeh, Yahya / Genolet, Raphael / Mansouri, Nahal / Wenes, Mathias / Migliorini, Denis / Heikenwalder, Mathias /
    De Palma, Michele

    Nature cancer

    2023  Volume 5, Issue 2, Page(s) 240–261

    Abstract: Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical ... ...

    Abstract Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical results. Here, we present a cell-therapy platform based on mouse or human DC progenitors (DCPs) engineered to produce two immunostimulatory cytokines, IL-12 and FLT3L. Cytokine-armed DCPs differentiated into conventional type-I DCs (cDC1) and suppressed tumor growth, including melanoma and autochthonous liver models, without the need for antigen loading or myeloablative host conditioning. Tumor response involved synergy between IL-12 and FLT3L and was associated with natural killer and T cell infiltration and activation, M1-like macrophage programming and ischemic tumor necrosis. Antitumor immunity was dependent on endogenous cDC1 expansion and interferon-γ signaling but did not require CD8
    MeSH term(s) Humans ; Mice ; Animals ; Cytokines ; Immunotherapy ; Dendritic Cells ; Neoplasms/therapy ; Interleukin-12
    Chemical Substances Cytokines ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00668-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models.

    Martinez-Usatorre, Amaia / Kadioglu, Ece / Boivin, Gael / Cianciaruso, Chiara / Guichard, Alan / Torchia, Bruno / Zangger, Nadine / Nassiri, Sina / Keklikoglou, Ioanna / Schmittnaegel, Martina / Ries, Carola H / Meylan, Etienne / De Palma, Michele

    Science translational medicine

    2021  Volume 13, Issue 606

    Abstract: Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non-small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and ... ...

    Abstract Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non-small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic drugs may improve the efficacy of ICB in mouse tumor models and patients with cancer. Here, we used genetically engineered mouse models of
    MeSH term(s) Animals ; B7-H1 Antigen ; CD8-Positive T-Lymphocytes ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mice ; Programmed Cell Death 1 Receptor ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abd1616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  10. Article ; Online: Gain of HIF1 Activity and Loss of miRNA

    Wyss, Christof B / Duffey, Nathalie / Peyvandi, Sanam / Barras, David / Martinez Usatorre, Amaïa / Coquoz, Oriana / Romero, Pedro / Delorenzi, Mauro / Lorusso, Girieca / Rüegg, Curzio

    Cancer research

    2021  Volume 81, Issue 3, Page(s) 594–605

    Abstract: Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management of metastatic disease remains unresolved. Brain metastasis is a late complication frequently ... ...

    Abstract Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management of metastatic disease remains unresolved. Brain metastasis is a late complication frequently observed among patients with metastatic breast cancer, whose poor prognosis calls for novel and more effective therapies. Here, we report that active hypoxia inducible factor-1 (HIF1) signaling and loss of the miRNA
    MeSH term(s) Animals ; Brain ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Humans ; Hypoxia-Inducible Factor 1 ; Mice ; MicroRNAs/genetics ; Platelet-Derived Growth Factor/genetics
    Chemical Substances Hypoxia-Inducible Factor 1 ; MicroRNAs ; Platelet-Derived Growth Factor
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-19-3560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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