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  1. Article ; Online: Correspondence to: Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.

    Maher, Eamonn / Martiniuk, Frank / Levis, William

    Allergy

    2022  Volume 77, Issue 3, Page(s) 1073–1074

    MeSH term(s) Alopecia Areata/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Dermatitis, Atopic ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2022-02-24
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15185
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  2. Article: In Vitro Clonal Priming Data Suggests Mechanism for Lower Initial Vaccine Dose Yielding Increased Immunity in Astra-Zeneca Vaccine Trial.

    Dattner, Alan M / Martiniuk, Frank / Levis, William R

    Journal of drugs in dermatology : JDD

    2021  Volume 20, Issue 4, Page(s) 483–484

    MeSH term(s) Humans ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.2021.6003
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    Zs.A 5931: Show issues Location:
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  3. Book ; Thesis: BIOCHEMICAL AND GENETIC STUDIES OF TWO HUMAN NEUTRAL ALPHA-GLUCOSIDASES (NEUTRAL ALPHA-GLUCOSIDASE AB AND C)

    MARTINIUK, FRANK

    BIOCHEMICAL CHARACTERIZATION,S DEMONSTRATION OF A GENETIC POLYMORPHISM FOR NEUTRAL ALPHA-GLUCOSIDASE C AND CHROMOSOMAL ASSIGNMENT OF THE GENES FOR NEUTRAL ALPHA-GLUCOSIDASE AB AND C

    1982  

    Title variant BIOCHEMICAL AND GENETIC STUDIES OF TWO HUMAN NEUTRAL ALPHA-GLUCOSIDASES NEUTRAL ALPHA-GLUCOSIDASE AB AND C
    Size IX, 105 P.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis NEW YORK, NEW YORK UNIV., DISS., 1982
    HBZ-ID HT002707533
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Increasing Virulence in Leprosy Indicated by Global Mycobacterium spp.

    Levis, William / Rendini, Tina / Martiniuk, Frank

    Emerging infectious diseases

    2017  Volume 24, Issue 1, Page(s) 183a–184

    MeSH term(s) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/microbiology ; Drug Resistance, Bacterial ; Global Health ; Humans ; Leprosy/drug therapy ; Leprosy/epidemiology ; Leprosy/microbiology ; Leprosy/transmission ; Mycobacterium leprae/drug effects ; Mycobacterium leprae/pathogenicity ; United States/epidemiology ; Virulence
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2017-12-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2401.171785
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  5. Article: Psoriasis and leprosy are teaching us T-cell plasticity.

    Levis, William R / Martiniuk, Frank

    Journal of drugs in dermatology : JDD

    2013  Volume 12, Issue 10, Page(s) 1082

    MeSH term(s) Humans ; Leprosy/immunology ; Leprosy/pathology ; Psoriasis/immunology ; Psoriasis/pathology ; RNA, Messenger/genetics ; RNA, Messenger/physiology ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology ; Th2 Cells
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
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  6. Article: Molecular skin research can impact systemic cancers.

    Levis, William / Martiniuk, Frank

    Journal of drugs in dermatology : JDD

    2013  Volume 12, Issue 5, Page(s) 510

    MeSH term(s) Biomedical Research/methods ; Drug Design ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy ; Neoplasms/pathology ; Neoplasms/therapy ; Periodicals as Topic ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
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  7. Article ; Online: Leprosy as a model to understand cancer immunosurveillance and T cell anergy.

    Park, Andrew J / Rendini, Tina / Martiniuk, Frank / Levis, William R

    Journal of leukocyte biology

    2016  Volume 100, Issue 1, Page(s) 47–54

    Abstract: Leprosy is a disease caused by Mycobacterium leprae that presents on a spectrum of both clinical manifestations and T cell response. On one end of this spectrum, tuberculoid leprosy is a well-controlled disease, characterized by a cell-mediated immunity ... ...

    Abstract Leprosy is a disease caused by Mycobacterium leprae that presents on a spectrum of both clinical manifestations and T cell response. On one end of this spectrum, tuberculoid leprosy is a well-controlled disease, characterized by a cell-mediated immunity and immunosurveillance. On the opposite end of the spectrum, lepromatous leprosy is characterized by M. leprae proliferation and T cell anergy. Similar to progressive tumor cells, M. leprae escapes immunosurveillance in more severe forms of leprosy. The mechanisms by which M. leprae is able to evade the host immune response involve many, including the alterations of lipid droplets, microRNA, and Schwann cells, and involve the regulation of immune regulators, such as the negative checkpoint regulators CTLA-4, programmed death 1, and V-domain Ig suppressor of T cell activation-important targets in today's cancer immunotherapies. The means by which tumor cells become able to escape immunosurveillance through negative checkpoint regulators are evidenced by the successes of treatments, such as nivolumab and ipilimumab. Many parallels can be drawn between the immune responses seen in leprosy and cancer. Therefore, the understanding of how M. leprae encourages immune escape during proliferative disease states has potential to add to our understanding of cancer immunotherapy.
    MeSH term(s) Animals ; Humans ; Immunity, Cellular/immunology ; Leprosy/immunology ; Lymphocyte Activation ; Models, Biological ; Neoplasms/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.5RU1215-537RR
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  8. Article: The role of complement in dendritic cell (DC) control of T-cell subsets.

    Levis, William R / Martiniuk, Frank

    Journal of drugs in dermatology : JDD

    2010  Volume 9, Issue 11, Page(s) 1364–1366

    Abstract: This section of the Journal of Drugs in Dermatology (JDD) is dedicated to Dendreon's Provenge (Sipuleucel-T), the first therapeutic DC vaccine proven effective and approved by the United States (U.S.) Food and Drug Administration (FDA) for advanced ... ...

    Abstract This section of the Journal of Drugs in Dermatology (JDD) is dedicated to Dendreon's Provenge (Sipuleucel-T), the first therapeutic DC vaccine proven effective and approved by the United States (U.S.) Food and Drug Administration (FDA) for advanced cancer. This editorial will discuss three articles in this issue, their relationship to Provenge and the recent TH17-Treg subsets that are regulated by CD46.
    MeSH term(s) Animals ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Complement System Proteins/immunology ; Dendritic Cells/immunology ; Humans ; Male ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/therapy ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Tissue Extracts/immunology
    Chemical Substances Cancer Vaccines ; Tissue Extracts ; sipuleucel-T (8Q622VDR18) ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
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  9. Article: Mycobacterium lepromatosis: emerging strain or species?

    Levis, William R / Zhang, Shali / Martiniuk, Frank

    Journal of drugs in dermatology : JDD

    2012  Volume 11, Issue 2, Page(s) 158

    MeSH term(s) Humans ; Leprosy, Lepromatous/diagnosis ; Leprosy, Lepromatous/genetics ; Male ; Mycobacterium leprae/genetics
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
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  10. Article ; Online: Erythema nodosum leprosum, Sweet's syndrome, and human immunodeficiency virus may be related through an overlap in immunopathogenesis.

    Elbuluk, Nada / Martiniuk, Frank / Levis, William R

    International journal of dermatology

    2010  Volume 49, Issue 11, Page(s) 1344–1345

    MeSH term(s) Diagnosis, Differential ; Erythema Nodosum/diagnosis ; Erythema Nodosum/immunology ; HIV Infections/immunology ; Humans ; Leprosy, Lepromatous/diagnosis ; Leprosy, Lepromatous/immunology ; Sweet Syndrome/diagnosis ; Sweet Syndrome/immunology
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/j.1365-4632.2009.04066.x
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