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Article ; Online: Insight Ventilation Perfusion Inefficiency in Patients With Heart Failure With Preserved Ejection Fraction.

De Martino, Fabiana / Agostoni, Piergiuseppe

2022 Volume 162, Issue 6, Page(s) 1233–1235

Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.07.013
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Article ; Online: Evolution of journal clubs: fostering collaborative learning in modern research.

Balamurali, Deepak / Preda, Mihai Bogdan / Ben-Aicha, Soumaya / Martino, Fabiana / Palioura, Dimitra / Kocken, Jordy M M / Emanueli, Costanza / Devaux, Yvan

European heart journal. Digital health

2024 Volume 5, Issue 2, Page(s) 195–197

Abstract: Journal clubs have been a staple in scientific communities, facilitating discussions on recent publications. However, the overwhelming volume of biomedical information poses a challenge in literature selection. This article provides an overview of ... ...

Abstract	Journal clubs have been a staple in scientific communities, facilitating discussions on recent publications. However, the overwhelming volume of biomedical information poses a challenge in literature selection. This article provides an overview of journal club types and their efficacy in training potential peer reviewers, enhancing communication skills, and critical thinking. Originating in the 19th century, journal clubs have evolved from traditional in-person meetings to virtual or hybrid formats, accelerated by the COVID-19 pandemic. Face-to-face interactions offer personal connections, while virtual events ensure wider participation and accessibility. Organizing journal clubs demands effort, but it has several benefits, including promoting new publications and providing a platform for meaningful discussions. The virtual CardioRNA J-club experience exemplifies successful multidisciplinary collaboration, fostering international connections and inspiring new research. Journal clubs remain a vital component of academic research, equipping senior researchers with the latest developments and nurturing the next generation of scientists. As millennial and Gen Z researchers join the scientific field, journal clubs continue to evolve as a fertile ground for education and collaborative learning in an ever-changing scientific landscape.
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ISSN	2634-3916
ISSN (online)	2634-3916
DOI	10.1093/ehjdh/ztae003
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Article ; Online: Exercise oscillatory ventilation: the past, present, and future.

Cunha, Gonçalo / Apostolo, Anna / De Martino, Fabiana / Salvioni, Elisabetta / Matavelli, Irene / Agostoni, Piergiuseppe

European journal of preventive cardiology

2023 Volume 30, Issue Suppl 2, Page(s) ii22–ii27

Abstract: Exercise oscillatory ventilation (EOV) is a fascinating event that can be appreciated in the cardiopulmonary exercise test and is characterized by a cyclic fluctuation of minute ventilation, tidal volume, oxygen uptake, carbon dioxide production, and end- ...

Abstract	Exercise oscillatory ventilation (EOV) is a fascinating event that can be appreciated in the cardiopulmonary exercise test and is characterized by a cyclic fluctuation of minute ventilation, tidal volume, oxygen uptake, carbon dioxide production, and end-tidal pressure for oxygen and carbon dioxide. Its mechanisms stem from a dysregulation of the normal control feedback of ventilation involving one or more of its components, namely, chemoreflex delay, chemoreflex gain, plant delay, and plant gain. In this review, we intend to breakdown therapeutic targets according to pathophysiology and revise the prognostic value of exercise oscillatory ventilation in the setting of heart failure and other diagnoses.
MeSH term(s)	Humans ; Carbon Dioxide ; Pulmonary Ventilation/physiology ; Oxygen Consumption/physiology ; Respiration ; Heart Failure ; Exercise Test ; Oxygen
Chemical Substances	Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad205
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Article ; Online: Beyond VO2: the complex cardiopulmonary exercise test.

Mattavelli, Irene / Vignati, Carlo / Farina, Stefania / Apostolo, Anna / Cattadori, Gaia / De Martino, Fabiana / Pezzuto, Beatrice / Zaffalon, Denise / Agostoni, Piergiuseppe

European journal of preventive cardiology

2023 Volume 30, Issue Suppl 2, Page(s) ii34–ii39

Abstract: Cardiopulmonary exercise test (CPET) is a valuable diagnostic tool with a specific application in heart failure (HF) thanks to the strong prognostic value of its parameters. The most important value provided by CPET is the peak oxygen uptake (peak VO2), ... ...

Abstract	Cardiopulmonary exercise test (CPET) is a valuable diagnostic tool with a specific application in heart failure (HF) thanks to the strong prognostic value of its parameters. The most important value provided by CPET is the peak oxygen uptake (peak VO2), the maximum rate of oxygen consumption attainable during physical exertion. According to the Fick principle, VO2 equals cardiac output (Qc) times the arteriovenous content difference [C(a-v)O2], where Ca is the arterial oxygen and Cv is the mixed venous oxygen content, respectively; therefore, VO2 can be reduced both by impaired O2 delivery (reduced Qc) or extraction (reduced arteriovenous O2 content). However, standard CPET is not capable of discriminating between these different impairments, leading to the need for 'complex' CPET technologies. Among non-invasive methods for Qc measurement during CPET, inert gas rebreathing and thoracic impedance cardiography are the most used techniques, both validated in healthy subjects and patients with HF, at rest and during exercise. On the other hand, the non-invasive assessment of peripheral muscle perfusion is possible with the application of near-infrared spectroscopy, capable of measuring tissue oxygenation. Measuring Qc allows, by having haemoglobin values available, to discriminate how much any VO2 deficit depends on the muscle, anaemia or heart.
MeSH term(s)	Humans ; Exercise Test/methods ; Cardiac Output/physiology ; Oxygen Consumption/physiology ; Prognosis ; Heart Failure/diagnosis ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad154
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Article: Is red distribution width a valid tool to predict impaired iron transport in heart failure?

Campodonico, Jeness / Carulli, Ermes / Doni, Francesco / Russo, Gerardo Lo / Junod, Daniele / Gaudenzi Asinelli, Margherita / Bonomi, Alice / De Martino, Fabiana / Vignati, Carlo / Pezzuto, Beatrice / Agostoni, Piergiuseppe

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1133233

Abstract: Background: Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis ... ...

Abstract	Background: Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis irrespective of anaemia. Objectives: In this retrospective study we searched for a surrogate biomarker of IIT. Methods: We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients. Results: At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison between the true and false negative groups showed that estimated glomerular filtration rate (eGFR) was significantly higher ( Conclusion: RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1133233
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Article: Anemia and Iron Deficiency in Heart Failure: Clinical and Prognostic Role.

Magrì, Damiano / De Martino, Fabiana / Moscucci, Federica / Agostoni, Piergiuseppe / Sciomer, Susanna

Heart failure clinics

2019 Volume 15, Issue 3, Page(s) 359–369

Abstract: Anemia and iron deficiency (ID) represent 2 prevalent, often interrelated, comorbidities in heart failure (HF). Both of them are significantly related to functional capacity and are undoubted predictors of poor prognosis in patients with HF. Although ... ...

Abstract	Anemia and iron deficiency (ID) represent 2 prevalent, often interrelated, comorbidities in heart failure (HF). Both of them are significantly related to functional capacity and are undoubted predictors of poor prognosis in patients with HF. Although anemia and ID both have "global" detrimental effects, these 2 conditions are too often overlooked in cardiology daily clinical practice. The present review sought to summarize briefly the prevalence and the underlying pathophysiologic mechanisms of anemia and ID as regards HF severity (ie, exercise capacity) and prognosis.
MeSH term(s)	Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/epidemiology ; Comorbidity ; Global Health ; Heart Failure/blood ; Heart Failure/epidemiology ; Humans ; Iron/blood ; Iron/deficiency ; Prevalence ; Prognosis
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212019-1
ISSN	1551-7136
ISSN	1551-7136
DOI	10.1016/j.hfc.2019.02.005
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Article ; Online: Sacubitril/valsartan can improve exercise performance in systolic chronic heart failure patients: a case report.

Mapelli, Massimo / Vignati, Carlo / Paolillo, Stefania / De Martino, Fabiana / Righini, Francesca / Agostoni, Piergiuseppe

Current medical research and opinion

2019 Volume 35, Issue sup1, Page(s) 3–5

Abstract: Objective: The cardiopulmonary exercise test (CPET) provides functional prognostic parameters for patients with chronic heart failure (CHF), such as peak volume of oxygen (VO: Case presentation: We present a 64 year old woman with systolic HF (New ... ...

Abstract	Objective: The cardiopulmonary exercise test (CPET) provides functional prognostic parameters for patients with chronic heart failure (CHF), such as peak volume of oxygen (VO Case presentation: We present a 64 year old woman with systolic HF (New York Heart Association [NYHA] class III, ejection fraction 35%) due to moderate/severe aortic and tricuspid regurgitation and pulmonary hypertension. The patient had several co-morbidities and a history of CV surgery (mitral valve replacement due to bacterial endocarditis). In November 2016, a CPET was performed in stable clinical conditions, showing severe cardiogenic limitation with signs of pulmonary hypertension (peak VO Conclusions: We present a case of a systolic HF patient successfully treated with sacubitril/valsartan who showed a rapid improvement of exercise performance at CPET.
MeSH term(s)	Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Carbon Dioxide/metabolism ; Chronic Disease ; Drug Combinations ; Exercise ; Exercise Test ; Female ; Heart Failure, Systolic/drug therapy ; Heart Failure, Systolic/physiopathology ; Humans ; Middle Aged ; Tetrazoles/therapeutic use
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Drug Combinations ; Tetrazoles ; Carbon Dioxide (142M471B3J) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2019-03-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2019.1576480
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Article ; Online: Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO

Respiratory research

2024 Volume 25, Issue 1, Page(s) 82

Abstract: Background: Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients' reported symptomatology is still unclear.: Methods: Consecutive post COVID-19 patients were included. Patients underwent full ... ...

Abstract	Background: Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients' reported symptomatology is still unclear. Methods: Consecutive post COVID-19 patients were included. Patients underwent full clinical evaluation, symptoms dedicated questionnaires, blood tests, echocardiography, thoracic computer tomography (CT), spirometry including alveolar capillary membrane diffusion (DM) and capillary volume (Vcap) assessment by combined carbon dioxide and nitric oxide lung diffusion (DLCO/DLNO) and cardiopulmonary exercise test. We measured surfactant derive protein B (immature form) as blood marker of alveolar cell function. Results: We evaluated 204 consecutive post COVID-19 patients (56.5 ± 14.5 years, 89 females) 171 ± 85 days after the end of acute COVID-19 infection. We measured: forced expiratory volume (FEV Conclusions: In patients with post COVID-19, cardiorespiratory symptoms are linked to VE/VCO
MeSH term(s)	Female ; Humans ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; Lung/diagnostic imaging ; Respiratory Function Tests ; Exercise Test/methods ; Dyspnea ; Oxygen Consumption/physiology ; Heart Failure/diagnosis
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02602-3
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Article ; Online: Effects of sacubitril/valsartan on exercise capacity: a prognostic improvement that starts during uptitration.

Mapelli, Massimo / Mattavelli, Irene / Paolillo, Stefania / Salvioni, Elisabetta / Magrì, Damiano / Galotta, Arianna / De Martino, Fabiana / Mantegazza, Valentina / Vignati, Carlo / Esposito, Immacolata / Dell'Aversana, Simona / Paolillo, Roberta / Capovilla, Teresa / Tamborini, Gloria / Nepitella, Alessandro Alberto / Filardi, Pasquale Perrone / Agostoni, Piergiuseppe

European journal of clinical pharmacology

2023 Volume 79, Issue 9, Page(s) 1173–1184

Abstract: Purpose: Sacubitril/valsartan is a mainstay of the treatment of heart failure with reduced ejection fraction (HFrEF); however, its effects on exercise performance yielded conflicting results. Aim of our study was to evaluate the impact of sacubitril/ ... ...

Abstract	Purpose: Sacubitril/valsartan is a mainstay of the treatment of heart failure with reduced ejection fraction (HFrEF); however, its effects on exercise performance yielded conflicting results. Aim of our study was to evaluate the impact of sacubitril/valsartan on exercise parameters and echocardiographic and biomarker changes at different drug doses. Methods: We prospectively enrolled consecutive HFrEF outpatients eligible to start sacubitril/valsartan. Patients underwent clinical assessment, cardiopulmonary exercise test (CPET), blood sampling, echocardiography, and completed the Kansas City Cardiomyopathy Questionnaire (KCCQ-12). Sacubitril/valsartan was introduced at 24/26 mg b.i.d. dose and progressively uptitrated in a standard monthly-based fashion to 97/103 mg b.i.d. or maximum tolerated dose. Study procedures were repeated at each titration visit and 6 months after reaching the maximum tolerated dose. Results: Ninety-six patients completed the study, 73 (75%) reached maximum sacubitril/valsartan dose. We observed a significant improvement in functional capacity across all study steps: oxygen intake increased, at peak exercise (from 15.6 ± 4.5 to 16.5 ± 4.9 mL/min/kg; p trend = 0.001), while minute ventilation/carbon dioxide production relationship reduced in patients with an abnormal value at baseline. Sacubitril/valsartan induced positive left ventricle reverse remodeling (EF from 31 ± 5 to 37 ± 8%; p trend < 0.001), while NT-proBNP reduced from 1179 [610-2757] to 780 [372-1344] pg/ml (p trend < 0.0001). NYHA functional class and the subjective perception of limitation in daily life at KCCQ-12 significantly improved. The Metabolic Exercise Cardiac Kidney Index (MECKI) score progressively improved from 4.35 [2.42-7.71] to 2.35% [1.24-4.96], p = 0.003. Conclusions: A holistic and progressive HF improvement was observed with sacubitril/valsartan in parallel with quality of life. Likewise, a prognostic enhancement was observed.
MeSH term(s)	Humans ; Heart Failure/drug therapy ; Prognosis ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use ; Quality of Life ; Exercise Tolerance ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Stroke Volume ; Treatment Outcome ; Valsartan/therapeutic use ; Valsartan/pharmacology ; Aminobutyrates/pharmacology ; Aminobutyrates/therapeutic use ; Biphenyl Compounds/therapeutic use ; Drug Combinations
Chemical Substances	sacubitril (17ERJ0MKGI) ; Tetrazoles ; Angiotensin Receptor Antagonists ; Valsartan (80M03YXJ7I) ; Aminobutyrates ; Biphenyl Compounds ; Drug Combinations
Language	English
Publishing date	2023-06-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-023-03527-y
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Article ; Online: The science behind soft skills: Do's and Don'ts for early career researchers and beyond. A review paper from the EU-CardioRNA COST Action CA17129.

Acharya, Shubhra / Preda, Mihai Bogdan / Papatheodorou, Ioanna / Palioura, Dimitra / Giardoglou, Panagiota / Tsata, Vasiliki / Erceg, Sanja / Barbalata, Teodora / Ben-Aicha, Soumaya / Martino, Fabiana / Nicastro, Laura / Lazou, Antigone / Beis, Dimitris / Martelli, Fabio / Sopic, Miron / Emanueli, Costanza / Kardassis, Dimitris / Devaux, Yvan

Open research Europe

2023 Volume 3, Page(s) 55

Abstract: Soft skills are the elementary management, personal, and interpersonal abilities that are vital for an individual to be efficient at workplace or in their personal life. Each work place requires different set of soft skills. Thus, in addition to ... ...

Abstract	Soft skills are the elementary management, personal, and interpersonal abilities that are vital for an individual to be efficient at workplace or in their personal life. Each work place requires different set of soft skills. Thus, in addition to scientific/technical skills that are easier to access within a short time frame, several key soft skills are essential for the success of a researcher in today's international work environment. In this paper, the trainees and trainers of the EU-CardioRNA COST Action CA17129 training school on soft skills present basic and advanced soft skills for early career researchers. Here, we particularly emphasize on the importance of transferable and presentation skills, ethics, literature reading and reviewing, research protocol and grant writing, networking, and career opportunities for researchers. All these skills are vital but are often overlooked by some scholars. We also provide tips to ace in aforementioned skills that are crucial in a day-to-day life of early and late career researchers in academia and industry.
Language	English
Publishing date	2023-10-12
Publishing country	Belgium
Document type	Journal Article
ISSN	2732-5121
ISSN (online)	2732-5121
DOI	10.12688/openreseurope.15746.2
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