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  1. Article: How COVID-19 interacts with interstitial lung disease.

    Myall, Katherine J / Martinovic, Jennifer L / West, Alex

    Breathe (Sheffield, England)

    2021  Volume 18, Issue 1, Page(s) 210158

    Abstract: The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had far-reaching impacts on patients with interstitial lung disease (ILD), from diagnosis to management. In addition, after infection, persistent parenchymal ... ...

    Abstract The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had far-reaching impacts on patients with interstitial lung disease (ILD), from diagnosis to management. In addition, after infection, persistent parenchymal change is associated with ongoing symptoms and functional impairment even in patients without pre-existing lung disease. The challenge of investigating and treating these patients has often fallen to ILD physicians. This review therefore seeks to explore the relationship between COVID-19 and the interstitium, as well as the model of care for patients with pre-existing ILD and those patients with persistent disease following recovery from their initial infection.
    Educational aims: To understand the impact of the COVID-19 pandemic on patients with existing interstitial lung disease.To explore the development of interstitial lung disease after COVID-19 infection.
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0158-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nocturnal Hypoxemia Associates With Symptom Progression and Mortality in Patients With Progressive Fibrotic Interstitial Lung Disease.

    Myall, Katherine J / West, Alex G / Martinovic, Jennifer L / Lam, Jodie L / Roque, Diana / Wu, Zhe / Maher, Toby M / Molyneaux, Philip L / Suh, Eui-Sik / Kent, Brian D

    Chest

    2023  Volume 164, Issue 5, Page(s) 1232–1242

    Abstract: Background: OSA and nocturnal hypoxemia (NH) are common in patients with fibrotic interstitial lung disease (F-ILD), but their relationship with disease outcomes remains unclear.: Research question: What is the relationship between NH and OSA and ... ...

    Abstract Background: OSA and nocturnal hypoxemia (NH) are common in patients with fibrotic interstitial lung disease (F-ILD), but their relationship with disease outcomes remains unclear.
    Research question: What is the relationship between NH and OSA and clinical outcomes in patients with F-ILD?
    Study design and methods: This was a prospective observational cohort study of patients with F-ILD and without daytime hypoxemia. Patients underwent home sleep study at baseline and were followed up for at least 1 year or until death. NH was defined as ≥ 10% of sleep with oxygen saturation of < 90%. OSA was defined as an apnea-hypopnea index of ≥ 15 events/h.
    Results: Among 102 participants (male, 74.5%; age, 73.0 ± 8.7 years; FVC, 2.74 ± 0.78 L; 91.1% idiopathic pulmonary fibrosis), 20 patients (19.6%) demonstrated prolonged NH and 32 patients (31.4%) showed OSA. No significant differences were found between those with and without NH or OSA at baseline. Despite this, NH was associated with a more rapid decline in both quality of life as measured by the King's Brief Interstitial Lung Disease questionnaire (change, -11.3 ± 5.3 points in the NH group vs -6.7 ± 6.5 in those without NH; P = .005) and higher all-cause mortality at 1 year (hazard ratio, 8.21; 95% CI, 2.40-28.1; P < .001). No statistically significant difference was seen between the groups in annualized change in measures of pulmonary function testing.
    Interpretation: Prolonged NH, but not OSA, is associated with worsening disease-related quality of life and increased mortality in patients with F-ILD.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Disease Progression ; Hypoxia/complications ; Lung Diseases, Interstitial/diagnosis ; Prospective Studies ; Quality of Life ; Sleep Apnea, Obstructive/complications ; Female
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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