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Article ; Online: A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy.

Vieira, Eduardo Guimarães / Fazzi, Rodrigo Boni / Martins, Daniel O T A / Sheveleva, Alena M / Tuna, Floriana / da Costa Ferreira, Ana Maria

RSC advances

2023 Volume 13, Issue 14, Page(s) 9715–9719

Abstract: A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron ... ...

Abstract	A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra07266a
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Article ; Online: Multisensory Stimulation Reverses Memory Impairment in Adrβ

Ravache, Thaís T / Batistuzzo, Alice / Nunes, Gabriela G / Gomez, Thiago G B / Lorena, Fernanda B / Do Nascimento, Bruna P P / Bernardi, Maria Martha / Lima, Eduarda R R / Martins, Daniel O / Campos, Ana Carolina P / Pagano, Rosana L / Ribeiro, Miriam O

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Norepinephrine plays an important role in modulating memory through its beta-adrenergic receptors (Adrβ: ... ...

Abstract	Norepinephrine plays an important role in modulating memory through its beta-adrenergic receptors (Adrβ: β
MeSH term(s)	Mice ; Animals ; Male ; Memory Disorders/genetics ; Memory Disorders/therapy ; Memory Disorders/metabolism ; Receptors, Adrenergic, beta/metabolism ; Hippocampus/metabolism ; Norepinephrine/metabolism
Chemical Substances	Receptors, Adrenergic, beta ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310522
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Article: Unparalleled selectivity and electronic structure of heterometallic [LnLn'Ln] molecules as 3-qubit quantum gates.

Maniaki, Diamantoula / Garay-Ruiz, Diego / Barrios, Leoní A / Martins, Daniel O T A / Aguilà, David / Tuna, Floriana / Reta, Daniel / Roubeau, Olivier / Bo, Carles / Aromí, Guillem

Chemical science

2022 Volume 13, Issue 19, Page(s) 5574–5581

Abstract: Heterometallic lanthanide [LnLn'] coordination complexes that are accessible thermodynamically are very scarce because the metals of this series have very similar chemical behaviour. Trinuclear systems of this category have not been reported. A ... ...

Abstract	Heterometallic lanthanide [LnLn'] coordination complexes that are accessible thermodynamically are very scarce because the metals of this series have very similar chemical behaviour. Trinuclear systems of this category have not been reported. A coordination chemistry scaffold has been shown to produce molecules of type [LnLn'Ln] of high purity,
Language	English
Publishing date	2022-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc00436d
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Article ; Online: Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases.

Leonelli, Mauro / Martins, Daniel O / Britto, Luiz R G

Cellular and molecular neurobiology

2013 Volume 33, Issue 3, Page(s) 379–392

Abstract: The activation of the transient receptor potential vanilloid type 1 channel (TRPV1) has been correlated with oxidative and nitrosative stress and cell death in the nervous system. Our previous results indicate that TRPV1 activation in the adult retina ... ...

Abstract	The activation of the transient receptor potential vanilloid type 1 channel (TRPV1) has been correlated with oxidative and nitrosative stress and cell death in the nervous system. Our previous results indicate that TRPV1 activation in the adult retina can lead to constitutive and inducible nitric oxide synthase-dependent protein nitration and apoptosis. In this report, we have investigated the potential effects of TRPV1 channel activation on nitric oxide synthase (NOS) expression and function, and the putative participation of ionotropic glutamate receptors in retinal TRPV1-induced protein nitration, lipid peroxidation, and DNA fragmentation. Intravitreal injections of the classical TRPV1 agonist capsaicin up-regulated the protein expression of the inducible and endothelial NOS isoforms. Using 4,5-diaminofluorescein diacetate for nitric oxide (NO) imaging, we found that capsaicin also increased the production of NO in retinal blood vessels. Processes and perikarya of TRPV1-expressing neurons in the inner nuclear layer of the retina were found in the vicinity of nNOS-positive neurons, but those two proteins did not colocalize. Retinal explants exposed to capsaicin presented high protein nitration, lipid peroxidation, and cell death, which were observed in the inner nuclear and plexiform layers and in ganglion cells. This effect was partially blocked by AP-5, a NMDA glutamate receptor antagonist, but not by CNQX, an AMPA/kainate receptor antagonist. These data support a potential role for TRPV1 channels in physiopathological retinal processes mediated by NO, which at least in part involve glutamate release.
MeSH term(s)	Aldehydes/pharmacology ; Animals ; Cell Death/drug effects ; DNA Fragmentation/drug effects ; Ion Channel Gating/drug effects ; Lipid Peroxidation/drug effects ; Male ; N-Methylaspartate/metabolism ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Nitrosation/drug effects ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism ; Retina/drug effects ; Retina/enzymology ; Retina/pathology ; Signal Transduction/drug effects ; TRPV Cation Channels/metabolism ; Tyrosine/analogs & derivatives ; Tyrosine/pharmacology ; Up-Regulation/drug effects
Chemical Substances	Aldehydes ; Receptors, N-Methyl-D-Aspartate ; TRPV Cation Channels ; Trpv1 protein, rat ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U) ; N-Methylaspartate (6384-92-5) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; 4-hydroxy-2-nonenal (K1CVM13F96)
Language	English
Publishing date	2013-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	283404-2
ISSN	1573-6830 ; 0272-4340
ISSN (online)	1573-6830
ISSN	0272-4340
DOI	10.1007/s10571-012-9904-5
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Zs.A 1727: Show issues

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Article ; Online: TRPV1 receptors modulate retinal development.

Leonelli, Mauro / Martins, Daniel O / Britto, Luiz R G

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

2011 Volume 29, Issue 4, Page(s) 405–413

Abstract: We investigated the possible participation of TRPV1 channels in retinal apoptosis and overall development. Retinas from newborn, male albino rats were treated in vitro with capsazepine, a TRPV1 antagonist. The expression of cell cycle markers was not ... ...

Abstract	We investigated the possible participation of TRPV1 channels in retinal apoptosis and overall development. Retinas from newborn, male albino rats were treated in vitro with capsazepine, a TRPV1 antagonist. The expression of cell cycle markers was not changed after TRPV1 blockade, whereas capsazepine reduced the number of apoptotic cells throughout the retina,increased ERK1/2 and p38 phosphorylation and slightly reduced JNK phosphorylation. The expression of BAD, Bcl-2, as well as integral and cleaved capsase-3 were similar in all experimental conditions. Newborn rats were kept for 2 months after receiving high doses of capsazepine. In their retinas, calbindin and parvalbumin protein levels were upregulated, but only the number of amacrine-like, parvalbumin-positive cells was increased. The numbers of calretinin, calbindin, ChAT, vimentin, PKC-alpha and GABA-positive cells were similar in both conditions. Protein expression of synapsin Ib was also increased in the retinas of capsazepine-treated rats. Calretinin, vimentin, GFAP, synapsin Ia, synaptophysin and light neurofilament protein levels were not changed when compared to control values. Our results indicate that TRPV1 channels play a role in the control of the early apoptosis that occur during retinal development, which might be dependent on MAPK signaling. Moreover, it seems that TRPV1 function might be important for neuronal and synaptic maturation in the retina.
MeSH term(s)	Animals ; Animals, Newborn ; Apoptosis/drug effects ; Biomarkers/metabolism ; Capsaicin/analogs & derivatives ; Capsaicin/pharmacology ; Caspase 3/metabolism ; Cell Proliferation ; MAP Kinase Signaling System/physiology ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Rats ; Retina/cytology ; Retina/drug effects ; Retina/growth & development ; Retina/metabolism ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/metabolism
Chemical Substances	Biomarkers ; TRPV Cation Channels ; TRPV1 receptor ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Caspase 3 (EC 3.4.22.-) ; capsazepine (LFW48MY844) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2011-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605533-3
ISSN	1873-474X ; 0736-5748
ISSN (online)	1873-474X
ISSN	0736-5748
DOI	10.1016/j.ijdevneu.2011.03.002
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Article ; Online: TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina.

Leonelli, Mauro / Martins, Daniel O / Britto, Luiz R G

Experimental eye research

2010 Volume 91, Issue 5, Page(s) 755–768

Abstract: We report here the protein expression of TRPV1 receptor in axotomized rat retinas and its possible participation in mechanisms involved in retinal ganglion cell (RGC) death. Adult rats were subjected to unilateral, intraorbital axotomy of the optic nerve, ...

Abstract	We report here the protein expression of TRPV1 receptor in axotomized rat retinas and its possible participation in mechanisms involved in retinal ganglion cell (RGC) death. Adult rats were subjected to unilateral, intraorbital axotomy of the optic nerve, and the retinal tissue was removed for further processing. TRPV1 total protein expression decreased progressively after optic nerve transection, reaching 66.2% of control values 21 days after axotomy. The number of cells labeled for TRPV1 in the remnant GCL decreased after 21 days post-lesion (to 63%). Fluoro-Jade B staining demonstrated that the activation of TRPV1 in acutely-lesioned eyes elicited more intense neuronal degeneration in the GCL and in the inner nuclear layer than in sham-operated retinas. A single intraocular injection of capsazepine (100 μM), a TRPV1 antagonist, 5 days after optic nerve lesion, decreased the number of GFAP-expressing Müller cells (72.5% of control values) and also decreased protein nitration in the retinal vitreal margin (75.7% of control values), but did not affect lipid peroxidation. Furthermore, retinal explants were treated with capsaicin (100 μM), and remarkable protein nitration was then present, which was reduced by blockers of the constitutive and inducible nitric oxide synthases (7-NI and aminoguanidine, respectively). TRPV1 activation also increased GFAP expression, which was reverted by both TRPV1 antagonism with capsazepine and by 7-NI and aminoguanidine. Given that Müller cells do not express TRPV1, we suppose that the increased GFAP expression in these cells might be elicited by TRPV1 activation and by its indirect effect upon nitric oxide overproduction and peroxynitrite formation. We incubated Fluorogold pre-labeled retinal explants in the presence of capsazepine (1 μM) during 48 h. The numbers of surviving RGCs stained with fluorogold and the numbers of apoptotic cells in the GCL detected with TUNEL were similar in lesioned and control retinas. We conclude that TRPV1 receptor expression decreased after optic nerve injury due to death of TRPV1-containing cells. Furthermore, these data indicate that TRPV1 might be involved in intrinsic protein nitration and Müller cell reaction observed after optic nerve injury.
MeSH term(s)	Animals ; Axotomy ; Capsaicin/analogs & derivatives ; Capsaicin/pharmacology ; Cell Count ; Fluoresceins ; Fluorescent Antibody Technique, Indirect ; Fluorescent Dyes ; Glial Fibrillary Acidic Protein/metabolism ; In Situ Nick-End Labeling ; Lipid Peroxidation ; Neuroglia/metabolism ; Nitric Oxide/metabolism ; Nitrosation ; Optic Nerve/physiology ; Organic Chemicals ; Rats ; Rats, Wistar ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/metabolism ; TRPV Cation Channels/physiology
Chemical Substances	Fluoresceins ; Fluorescent Dyes ; Glial Fibrillary Acidic Protein ; Organic Chemicals ; TRPV Cation Channels ; TRPV1 receptor ; Trpv1 protein, rat ; fluoro jade ; Nitric Oxide (31C4KY9ESH) ; capsazepine (LFW48MY844) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2010-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2010.08.026
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Article ; Online: Fragmentation Study, Dual Anti-Bactericidal and Anti-Viral Effects and Molecular Docking of Cobalt(III) Complexes.

Fernandes, Laísa de P / Silva, Júlia M B / Martins, Daniel O S / Santiago, Mariana B / Martins, Carlos H G / Jardim, Ana C G / Oliveira, Guedmiller S / Pivatto, Marcos / Souza, Rafael A C / Franca, Eduardo de F / Deflon, Victor M / Machado, Antonio E H / Oliveira, Carolina G

International journal of molecular sciences

2020 Volume 21, Issue 21

Abstract: Considering our previous findings on the remarkable activity exhibited by cobalt(III) with 2-acetylpyridine- ...

Abstract	Considering our previous findings on the remarkable activity exhibited by cobalt(III) with 2-acetylpyridine-
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Antiviral Agents/pharmacology ; Bacteria/drug effects ; Chikungunya Fever/drug therapy ; Chikungunya virus/drug effects ; Chromatography, Liquid/methods ; Cobalt/chemistry ; Cobalt/pharmacology ; Coordination Complexes/pharmacology ; Ligands ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Tandem Mass Spectrometry/methods ; Thiosemicarbazones/chemistry ; Thiosemicarbazones/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antiviral Agents ; Coordination Complexes ; Ligands ; Thiosemicarbazones ; Cobalt (3G0H8C9362)
Language	English
Publishing date	2020-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21218355
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Article ; Online: Ontogenetic expression of the vanilloid receptors TRPV1 and TRPV2 in the rat retina.

Leonelli, Mauro / Martins, Daniel O / Kihara, Alexandre H / Britto, Luiz R G

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

2009 Volume 27, Issue 7, Page(s) 709–718

Abstract: The present study aimed to analyze the gene and protein expression and the pattern of distribution of the vanilloid receptors TRPV1 and TRPV2 in the developing rat retina. During the early phases of development, TRPV1 was found mainly in the neuroblastic ...

Abstract	The present study aimed to analyze the gene and protein expression and the pattern of distribution of the vanilloid receptors TRPV1 and TRPV2 in the developing rat retina. During the early phases of development, TRPV1 was found mainly in the neuroblastic layer of the retina and in the pigmented epithelium. In the adult, TRPV1 was found in microglial cells, blood vessels, astrocytes and in neuronal structures, namely synaptic boutons of both retinal plexiform layers, as well as in cell bodies of the inner nuclear layer and the ganglion cell layer. The pattern of distribution of TRPV1 was mainly punctate, and there was higher TRPV1 labeling in the peripheral retina than in central regions. TRPV2 expression was quite distinct. Its expression was virtually undetectable by immunoblotting before P1, and that receptor was found by immunohistochemistry only by postnatal day 15 (P15). RNA and protein analysis showed that the adult levels are only reached by P60, which includes small processes in the retinal plexiform layers, and labeled cellular bodies in the inner nuclear layer and the ganglion cell layer. There was no overlapping between the signal observed for both receptors. In conclusion, our results showed that the patterns of distribution of TRPV1 and TRPV2 are different during the development of the rat retina, suggesting that they have specific roles in both visual processing and in providing specific cues to neural development.
MeSH term(s)	Animals ; Gene Expression Regulation, Developmental ; Rats ; Retina/cytology ; Retina/embryology ; Retina/growth & development ; Retina/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
Chemical Substances	TRPV Cation Channels ; Trpv1 protein, rat ; Trpv2 protein, rat
Language	English
Publishing date	2009-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605533-3
ISSN	1873-474X ; 0736-5748
ISSN (online)	1873-474X
ISSN	0736-5748
DOI	10.1016/j.ijdevneu.2009.07.003
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Article ; Online: First coordination compounds based on a bis(imino nitroxide) biradical and 4f metal ions: synthesis, crystal structures and magnetic properties.

Reis, Samira G / Briganti, Matteo / Martins, Daniel O T A / Akpinar, Handan / Calancea, Sergiu / Guedes, Guilherme P / Soriano, Stéphane / Andruh, Marius / Cassaro, Rafael A A / Lahti, Paul M / Totti, Federico / Vaz, Maria G F

Dalton transactions (Cambridge, England : 2003)

2016 Volume 45, Issue 7, Page(s) 2936–2944

Abstract: The synthesis, crystal structures and magnetic properties of two families of heterospin complexes containing lanthanide ions and a bis(imino nitroxide) biradical (IPhIN = 1-iodo-3,5-bis(4',4',5',5'-tetramethyl-4',5'-dihydro-1H-imidazole-1'-oxyl)benzene) ... ...

Abstract	The synthesis, crystal structures and magnetic properties of two families of heterospin complexes containing lanthanide ions and a bis(imino nitroxide) biradical (IPhIN = 1-iodo-3,5-bis(4',4',5',5'-tetramethyl-4',5'-dihydro-1H-imidazole-1'-oxyl)benzene) are reported: in [Ln2(hfac)6(IPhIN)(H2O)2] compounds, two lanthanide ions [Ln = Gd(III) (1) and Dy(III) (2)] are coordinated to the biradical, and in [Ln(hfac)3(IPhIN)(H2O)] compounds, one lanthanide ion (Ln = Tb(III) (3), Gd(III) (4) or Dy(III) (5)) is coordinated to the biradical. Ferromagnetic intramolecular magnetic interactions between Gd(III) and the biradical were found for 1 and 4, while intramolecular magnetic interactions between the radicals were ferro- and antiferromagnetic, respectively. Compound 2 shows a field induced slow relaxation of magnetization, which (under an external applied field of 2 kOe) exhibits an activation energy barrier of ΔE/kB = 27 K and a pre-exponential factor of 1.4 × 10(-8) s. To support the magnetic characterization of compound 3ab initio calculations were also performed.
Language	English
Publishing date	2016-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c5dt04469c
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Article ; Online: Early phase of allergic airway inflammation in diabetic rats: role of insulin on the signaling pathways and mediators.

Martins, Joilson O / Wittlin, Beatriz M / Anger, Denise B C / Martins, Daniel O / Sannomiya, Paulina / Jancar, Sonia

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2010 Volume 26, Issue 4-5, Page(s) 739–748

Abstract: Background: Allergic lung inflammation is impaired in diabetic rats and is restored by insulin treatment. In the present study we investigated the effect of insulin on the signaling pathways triggered by allergic inflammation in the lung and the release ...

Abstract	Background: Allergic lung inflammation is impaired in diabetic rats and is restored by insulin treatment. In the present study we investigated the effect of insulin on the signaling pathways triggered by allergic inflammation in the lung and the release of selected mediators. Methods: Diabetic male Wistar rats (alloxan, 42 mg/kg, i.v., 10 days) and matching controls were sensitized by s.c. injections of ovalbumin (OA) in aluminium hydroxide, 14 days before OA (1 mg/0.4 ml) or saline intratracheal challenge. A group of diabetic rats were treated with neutral protamine Hagedorn insulin (NPH, 4 IU, s.c.), 2 h before the OA challenge. Six hours after the challenge, bronchoalveolar lavage (BAL) was performed for mediator release and lung tissue was homogenized for Western blotting analysis of signaling pathways. Results: Relative to non-diabetic rats, the diabetic rats exhibited a significant reduction in OA-induced phosphorylation of the extracellular signal-regulated kinase (ERK, 59%), p38 (53%), protein kinase B (Akt, 46%), protein kinase C (PKC)-α (63%) and PKC-δ (38%) in lung homogenates following the antigen challenge. Activation of the NF-κB p65 subunit and phosphorylation of IκBα were almost suppressed in diabetic rats. Reduced expression of inducible nitric oxide synthase (iNOS, 32%) and cyclooxygenase-2 (COX-2, 46%) in the lung homogenates was also observed. The BAL concentration of prostaglandin (PG)-E(2), nitric oxide (NO) and interleukin (IL)-6 was reduced in diabetic rats (74%, 44% and 65%, respectively), whereas the cytokine-induced neutrophil chemoattractant (CINC)-2 concentration was not different from the control animals. Treatment of diabetic rats with insulin completely or partially restored all of these parameters. This protocol of insulin treatment only partially reduced the blood glucose levels. Conclusion: The data presented show that insulin regulates MAPK, PI3K, PKC and NF-κB pathways, the expression of the inducible enzymes iNOS and COX-2, and the levels of NO, PGE(2) and IL-6 in the early phase of allergic lung inflammation in diabetic rats. It is suggested that insulin is required for optimal transduction of the intracellular signals that follow allergic stimulation.
MeSH term(s)	Aluminum Oxide/chemistry ; Animals ; Bronchoalveolar Lavage Fluid ; Chemokines, CXC/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Dinoprostone/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Insulin/pharmacology ; Insulin/physiology ; Interleukin-6/metabolism ; Male ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Ovalbumin/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Pneumonia/metabolism ; Protein Kinase C-alpha/metabolism ; Protein Kinase C-delta/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Signal Transduction
Chemical Substances	Chemokines, CXC ; Cxcl3 protein, rat ; Insulin ; Interleukin-6 ; NF-kappa B ; Nitric Oxide (31C4KY9ESH) ; Ovalbumin (9006-59-1) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Protein Kinase C-alpha (EC 2.7.11.13) ; Protein Kinase C-delta (EC 2.7.11.13) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dinoprostone (K7Q1JQR04M) ; Aluminum Oxide (LMI26O6933)
Language	English
Publishing date	2010-10-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000322341
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