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  1. Article: Oligometastatic Prostate Cancer: Is there a Role for Surgery? A Narrative Review.

    Martorana, Eugenio / Bruschi, Morgan / Scialpi, Pietro / Grisanti, Riccardo / Scialpi, Michele

    Turkish journal of urology

    2022  Volume 48, Issue 3, Page(s) 174–179

    Abstract: Oligometastatic prostate cancer is commonly considered a transition between high metastatic and local- ized disease and includes a large spectrum of conditions with a polymorphic clinical behavior. The current management of these patients contemplates ... ...

    Abstract Oligometastatic prostate cancer is commonly considered a transition between high metastatic and local- ized disease and includes a large spectrum of conditions with a polymorphic clinical behavior. The current management of these patients contemplates systemic therapy (i.e., androgen-deprivation drugs, chemothera- peutic drugs, or both treatments administered simultaneously) which have been shown to improve survival. Radiotherapy has also been introduced, into a multimodal setting, among the therapeutic treatments forpatients who are defined as oligometastatic prostate cancer according to Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) criteria.The role of surgical debulking in patients with oligometastatic prostate cancer has always been considered impracticable, both for a marginal therapeutic role and for the greater risk of sequelae and/or complications related to the procedure itself. Several authors have demonstrated some mechanisms by which the persistence of the primary tumor can facilitate the clinical progression of the disease itself and promote carcinogenesis, differentiation, migration, and angiogenesis in prostate cancer. From these studies emerges the hypothesis of a possible therapeutic advantage in oncological terms also for cytoreductive radical prostatectomy, in a multimodal therapy setting, compared to systemic therapy alone. The present review summarizes the main knowledge regarding the safety, feasibility, and oncological outcomes of cytoreductive radical prostatectomy in oligometastatic prostate cancer patients.
    Language English
    Publishing date 2022-05-30
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2022.22064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Apparent Diffusion Coefficient and Lesion Volume to Detect Prostate Cancer.

    Scialpi, Michele / Martorana, Eugenio / Scalera, Giovanni Battista / Scialpi, Pietro / Di Blasi, Aldo

    Radiology

    2023  Volume 307, Issue 3, Page(s) e222177

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging ; Retrospective Studies
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.222177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Risk stratification system for biparametric prostate magnetic resonance imaging.

    Martorana, Eugenio / Scialpi, Pietro / Grisanti, Riccardo / Scialpi, Michele

    Translational andrology and urology

    2020  Volume 8, Issue Suppl 5, Page(s) S482–S483

    Language English
    Publishing date 2020-01-23
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2019.09.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Research of Prostate Cancer Urinary Diagnostic Biomarkers by Proteomics: The Noteworthy Influence of Inflammation.

    Bellei, Elisa / Caramaschi, Stefania / Giannico, Giovanna A / Monari, Emanuela / Martorana, Eugenio / Reggiani Bonetti, Luca / Bergamini, Stefania

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 7

    Abstract: Nowadays, in the case of suspected prostate cancer (PCa), tissue needle biopsy remains the benchmark for diagnosis despite its invasiveness and poor tolerability, as serum prostate-specific antigen (PSA) is limited by low specificity. The aim of this ... ...

    Abstract Nowadays, in the case of suspected prostate cancer (PCa), tissue needle biopsy remains the benchmark for diagnosis despite its invasiveness and poor tolerability, as serum prostate-specific antigen (PSA) is limited by low specificity. The aim of this proteomic study was to identify new diagnostic biomarkers in urine, an easily and non-invasively available sample, able to selectively discriminate cancer from benign prostatic hyperplasia (BPH), evaluating whether the presence of inflammation may be a confounding parameter. The analysis was performed by two-dimensional gel electrophoresis (2-DE), mass spectrometry (LC-MS/MS) and Enzyme-Linked Immunosorbent Assay (ELISA) on urine samples from PCa and BPH patients, divided into subgroups based on the presence or absence of inflammation. Significant quantitative and qualitative differences were found in the urinary proteomic profile of PCa and BPH groups. Of the nine differentially expressed proteins, only five can properly be considered potential biomarkers of PCa able to discriminate the two diseases, as they were not affected by the inflammatory process. Therefore, the proteomic research of novel and reliable urinary biomarkers of PCa should be conducted considering the presence of inflammation as a realistic interfering element, as it could hinder the detection of important protein targets.
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13071318
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  5. Article ; Online: The current evidence on surgical management for synchronous bilateral renal tumors: results from a scoping review.

    Giulioni, Carlo / Maggi, Martina / Pirola, Giacomo Maria / Martorana, Eugenio / Cormio, Angelo / Teoh, Jeremy Yuen-Chun / Gauhar, Vineet / Galosi, Andrea Benedetto / Castellani, Daniele

    World journal of urology

    2023  Volume 41, Issue 8, Page(s) 2107–2118

    Abstract: Purpose: Synchronous bilateral renal masses (SBRM) account for a low percentage of kidney tumors, and there is no current recommendation for their management. The objective was to review evidence regarding the best surgical approach for SBRM in terms of ...

    Abstract Purpose: Synchronous bilateral renal masses (SBRM) account for a low percentage of kidney tumors, and there is no current recommendation for their management. The objective was to review evidence regarding the best surgical approach for SBRM in terms of type and timing of surgery.
    Methods: A broad literature search was performed on 28th January 2023 using Scopus, PubMed, and EMBASE. Only English papers dealing with adults were included. Meeting abstracts were excluded.
    Results: Twenty-four papers were accepted and included. SBRM behave less aggressively than metachronous tumors, and partial nephrectomy (PN) is the preferred therapeutic option to preserve renal function. Open, laparoscopic, and robot-assisted approaches were found to be similar in oncological outcomes, though robot-assisted surgery resulted in lower comorbidities. Same-sitting PN was demonstrated to be a safe approach, particularly in the robotic-assisted one. Finally, the same-siting and staged NSS were similar in preserving renal function.
    Conclusions: PN should be the desirable treatment for SBRM whenever feasible and if patients are fit, but surgeon expertise should also be taken into the account.
    MeSH term(s) Humans ; Kidney Neoplasms/pathology ; Kidney/physiology ; Kidney/pathology ; Nephrectomy/methods ; Neoplasms, Multiple Primary/surgery ; Laparoscopy ; Treatment Outcome ; Carcinoma, Renal Cell/pathology
    Language English
    Publishing date 2023-07-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04503-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1832: Show issues Location:
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  6. Article ; Online: Prostate Cancer Index Lesion Detection and Volume Estimation: Is Dynamic Contrast-Enhanced MRI Really Reliable?

    Scialpi, Michele / Scialpi, Pietro / Martorana, Eugenio

    AJR. American journal of roentgenology

    2019  Volume 213, Issue 6, Page(s) W289

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.19.21764
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    Ue I Zs.57: Show issues Location:
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  7. Article ; Online: In defense to arguments against using an abbreviated or biparametric prostate MRI protocol.

    Scialpi, Michele / Di Blasi, Aldo / Scialpi, Pietro / Martorana, Eugenio

    Abdominal radiology (New York)

    2020  Volume 45, Issue 12, Page(s) 4271–4272

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Male ; Prostate/diagnostic imaging ; Prostate-Specific Antigen
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-020-02537-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1262: Show issues Location:
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  8. Article: MRI apparent diffusion coefficient (ADC): A biomarker for prostate cancer after radiation therapy.

    Scialpi, Michele / Martorana, Eugenio / Scialpi, Pietro / D'Andrea, Alfredo / Mancioli, Francesco Maria / Mignogna, Marcello / Blasi, Aldo Di / Trippa, Fabio

    Turkish journal of urology

    2022  Volume 47, Issue 6, Page(s) 448–451

    Abstract: Prostate specific antigen (PSA) remains the most used test to assess the response after therapies including the radiation therapy (RT). Apparent diffusion coefficient (ADC) derived from the conventional diffusionweighted imaging (DWI), as a part of ... ...

    Abstract Prostate specific antigen (PSA) remains the most used test to assess the response after therapies including the radiation therapy (RT). Apparent diffusion coefficient (ADC) derived from the conventional diffusionweighted imaging (DWI), as a part of noncontrast or biparametric MRI (bpMRI) (T2-weighted and DWI), offers diagnostic accuracy and cancer detection rate equivalent to that of multiparametric MRI. Cellular changes induced by RT can be quali-qualitatively demonstrated as early as 3months after RT as an increase in the signal intensity of the tumor on the ADC map. ADC, in association with PSA, represents a potential biomarker imaging for evaluating treatment efficacy in PCa both during and shortly after RT.
    Language English
    Publishing date 2022-02-03
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2021.21274
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  9. Article: Simplified PI-RADS (S-PI-RADS) for biparametric MRI to detect and manage prostate cancer: What urologists need to know.

    Scialpi, Michele / Scialpi, Pietro / Martorana, Eugenio / Torre, Riccardo / Improta, Antonio / Aisa, Maria Cristina / D'Andrea, Alfredo / Di Blasi, Aldo

    Turkish journal of urology

    2022  Volume 47, Issue 3, Page(s) 175–182

    Abstract: Biparametric magnetic resonance imaging (bpMRI) of the prostate has emerged as an alternative to multiparametric MRI (mpMRI) for the detection of clinically significant prostate cancer (csPCa). However, while the Prostate Imaging Reporting and Data ... ...

    Abstract Biparametric magnetic resonance imaging (bpMRI) of the prostate has emerged as an alternative to multiparametric MRI (mpMRI) for the detection of clinically significant prostate cancer (csPCa). However, while the Prostate Imaging Reporting and Data System (PI-RADS) is widely known for mpMRI, a proper PI-RADS for bpMRI has not yet been adopted. In this review, we report the current status and the future directions of bpMRI, and propose a simplified PI-RADS (S-PI-RADS) that could help radiologists and urologists in the detection and management of PCa.
    Language English
    Publishing date 2022-08-05
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2021.21004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prostate Imaging for Local Recurrence Reporting and Data System for Biparametric Magnetic Resonance Imaging: A Proposal.

    Scialpi, Michele / Martorana, Eugenio / Trippa, Fabio / Di Marzo, Alessandro / Scalera, Giovanni Battista / Aisa, Maria Cristina / D'Andrea, Alfredo / Mancioli, Francesco Maria / Nicola, Refky / Scialpi, Pietro / Di Blasi, Aldo

    Urology research & practice

    2023  Volume 49, Issue 4, Page(s) 233–240

    Abstract: We investigated a novel dedicated Prostate Imaging for Local Recurrence Reporting and Data System (PI-RRADS) in biochemical recurrence after radiotherapy (RT) and rad- ical prostatectomy (RP) evaluating biparametric magnetic resonance imaging (bpMRI) ... ...

    Abstract We investigated a novel dedicated Prostate Imaging for Local Recurrence Reporting and Data System (PI-RRADS) in biochemical recurrence after radiotherapy (RT) and rad- ical prostatectomy (RP) evaluating biparametric magnetic resonance imaging (bpMRI) exams, at 3T MRI of 55 patients. Associating bpMRI and biochemical recurrence data, we calculated bpMRI diagnostic accuracy. Four probability categories, from 1 (very low) to 4 (very high), were distinguished. In 20 patients with radiotherapy, 25% and 75% of lesions were reported as PI-RRADS 3, and 4, respectively. In 35 patients with radi- cal prostatectomy, 7.7% of lesions were included in PI-RRADS 1-2, whereas 40.4% and 51.9% in PI-RRADS 3 and 4 categories, respectively. Excellent agreement and significant correlation between bpMRI and biochemical recurrence were found. BpMRI showed sensitivity, specificity, positive predictive value, negative predictive value, false-posi- tive value, false-negative value, and total diagnostic accuracy of 96.15%, 86.7%, 97.4 %, 81.25%, 13.3%, 3.8% and 94.6%, respectively. BpMRI-based PI-RRADS allows the detection and localization local recurrence in biochemical recurrence after RT and RP contributing in clinical management and treatment.
    Language English
    Publishing date 2023-10-25
    Publishing country Turkey
    Document type Journal Article
    ISSN 2980-1478
    ISSN (online) 2980-1478
    DOI 10.5152/tud.2023.22228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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