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  1. Book ; Online: Understanding the Cost and Quality of Military-Related Education Benefit Programs

    Martorell, Paco / Bergman, Peter

    2013  

    Keywords Personnel & human resources management ; Military veterans ; Military engineering ; Business ; History ; Technology
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030609906
    ISBN 9780833084798 ; 0833084798
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Effects of Military Service on Earnings and Education Revisited

    Martorell, Paco / Miller, Trey / Daugherty, Lindsay / Borgschulte, Mark

    Variation by Service Duration, Occupation, and Civilian Unemployment

    2014  

    Keywords Personnel & human resources management ; Education ; Military engineering ; Technology ; Management & Organizational Behavior
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030609407
    ISBN 9780833086273 ; 0833086278
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: In the literature: April 2021.

    Martín-Martorell, P / Gonzalez-Barrallo, I / Gambardella, V / Cejalvo, J M / Cervantes, A

    ESMO open

    2021  Volume 6, Issue 3, Page(s) 100116

    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type News
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1016/j.esmoop.2021.100116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison of different agents and doses of anti-vascular endothelial growth factors (aflibercept, bevacizumab, conbercept, ranibizumab) versus laser for retinopathy of prematurity: A network meta-analysis.

    Ortiz-Seller, Amparo / Martorell, Pablo / Barranco, Honorio / Pascual-Camps, Isabel / Morcillo, Esteban / Ortiz, José L

    Survey of ophthalmology

    2024  

    Abstract: Laser photocoagulation (LPC) and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections constitute the current standard treatment for retinopathy of prematurity (ROP). This network meta-analysis focus on whether a ranking of ... ...

    Abstract Laser photocoagulation (LPC) and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections constitute the current standard treatment for retinopathy of prematurity (ROP). This network meta-analysis focus on whether a ranking of interventions may be established for different dose levels of intravitreal injection of anti-VEGF agents (aflibercept, bevacizumab, conbercept, ranibizumab) as primary treatments for ROP versus laser in terms of retreatment rate as primary outcome, and time to retreatment and refractive error as secondary endpoints, since best anti-VEGF dosage remains under debate. Sixty-eight studies (15 randomized control trials and 53 nonrandomized studies) of 12,356 eyes of 6445 infants were retrieved from databases (2005 Jan. - 2023 June). Studies were evaluated for model fit, risk of bias and confidence of evidence in Network Meta-Analysis (CINeMA). Bayesian NMA showed that anti-VEGF drugs were not inferior to laser in terms of retreatment rate. For intravitreal bevacizumab (IVB), doses half of the conventional infant dose showed a low risk of retreatment rate (risk ratio (RR) of 1.43; 95% credible interval (CrI): 0.508, 4.03). On probability ranking as surface under the cumulative ranking curve (SUCRA) plot, half dose of bevacizumab had a better position than conventional and augmented (1.2-2 times the regular dose) doses. A similar probability trend was observed for half vs. conventional doses of aflibercept and ranibizumab. Conventional infant dose of conbercept showed the lowest risk for retreatment (RR 0.846; 95% CrI: 0.245, 2.91). For secondary endpoints, lower doses of anti-VEGF agents were associated with shorter times to retreatment. The largest changes were noted for the augmented doses of bevacizumab and ranibizumab (0.3 mg) with means of 14.1 weeks (95% CrI: 6.65, 21.6) and 12.8 weeks (95% CrI: 3.19, 20.9), respectively. Finally, NMA demonstrated better refractive profile for anti-VEGF than laser therapy, especially for the conventional infant doses of bevacizumab and ranibizumab which exhibited a significantly better refractive profile than LPC, with mean differences of 1.67 (spherical equivalent - diopters) (95% CrI: 0.705, 2.67) and 2.19 (95% CrI: 0.782, 3.59), respectively. In the SUCRA plots, LPC had a markedly different position with a higher probability for myopia. Further clinical trials comparing different intravitreal doses of anti-VEGF agents are needed, but our findings suggest that low doses of these drugs retain efficacy and may reduce ocular and systemic undesired events.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2024.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Evaluation of

    Rea, K / Colom, J / Simon, E A / Khokhlova, E / Mazhar, S / Barrena, M / Enrique, M / Martorell, P / Perez, B Alvarez / Tortajada, M / Phipps, C / Deaton, J

    Beneficial microbes

    2023  Volume 14, Issue 2, Page(s) 165–182

    Abstract: In the present study, the safety, tolerance and impact of 1× ... ...

    Abstract In the present study, the safety, tolerance and impact of 1×10
    MeSH term(s) Humans ; Bacillus clausii ; Bacillus megaterium ; Pilot Projects ; Treatment Outcome ; Probiotics ; Double-Blind Method ; Pain
    Language English
    Publishing date 2023-04-07
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2561259-1
    ISSN 1876-2891 ; 1876-2883
    ISSN (online) 1876-2891
    ISSN 1876-2883
    DOI 10.3920/BM2022.0117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7963: Show issues

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  6. Article ; Online: Composition of Nonextractable Polyphenols from Sweet Cherry Pomace Determined by DART-Orbitrap-HRMS and Their

    Domínguez-Rodríguez, Gloria / Ramón Vidal, Daniel / Martorell, Patricia / Plaza, Merichel / Marina, María Luisa

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 26, Page(s) 7993–8009

    Abstract: Sweet cherry pomace is an important source of phenolic compounds with beneficial health properties. As after the extraction of phenolic compounds, a phenolic fraction called nonextractable polyphenols (NEPs) remains usually retained in the extraction ... ...

    Abstract Sweet cherry pomace is an important source of phenolic compounds with beneficial health properties. As after the extraction of phenolic compounds, a phenolic fraction called nonextractable polyphenols (NEPs) remains usually retained in the extraction residue, alkaline and acid hydrolyses and enzymatic-assisted extraction (EAE) were carried out in this work to recover NEPs from the residue of conventional extraction from sweet cherry pomace.
    MeSH term(s) Antioxidants/chemistry ; Chromatography, High Pressure Liquid/methods ; Humans ; Phenols/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyphenols/analysis ; Polyphenols/pharmacology ; Prunus avium/chemistry
    Chemical Substances Antioxidants ; Phenols ; Plant Extracts ; Polyphenols
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c03346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Bifidobacterium animalis

    Balaguer, Ferran / Barrena, Marta / Enrique, María / Maicas, Miren / Álvarez, Beatriz / Tortajada, Marta / Chenoll, Empar / Ramón, Daniel / Martorell, Patricia

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Life expectancy has increased globally in recent decades, driving interest in maintaining a healthy life that includes preservation of physical and mental abilities, particularly in elderly people. The gut microbiome becomes increasingly perturbed with ... ...

    Abstract Life expectancy has increased globally in recent decades, driving interest in maintaining a healthy life that includes preservation of physical and mental abilities, particularly in elderly people. The gut microbiome becomes increasingly perturbed with aging so the use of probiotics can be a strategy for maintaining a balanced gut microbiome. A previous report showed that
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12122107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study.

    Cui, Hongchang / Feng, Congrui / Zhang, Tao / Martínez-Ríos, Verónica / Martorell, Patricia / Tortajada, Marta / Cheng, Sidao / Cheng, Shumin / Duan, Zhi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16879

    Abstract: There is an emergent need to develop functional cosmetic ingredients for the topical management of skin barrier function. This study aimed to investigate the efficacy of a lotion containing fermented lysates VHProbi® Mix R for enhancing the skin barrier. ...

    Abstract There is an emergent need to develop functional cosmetic ingredients for the topical management of skin barrier function. This study aimed to investigate the efficacy of a lotion containing fermented lysates VHProbi® Mix R for enhancing the skin barrier. In vitro studies demonstrated that fermented cultures of both Lacticaseibacillus rhamnosus VHProbi® E06 (E06) and L. paracasei VHProbi® E12 (E12) had antioxidant capacity, showing promising scavenging capability for 2,2-diphenyl-1-picryl-hydrazyl. The antioxidant capacity of these strains was also demonstrated in the model of Caenorhabditis elegans. In addition, the fermented lysates of both E06 and E12 enhanced the proliferation of HaCaT cells and ameliorated the toxicity induced by Staphylococcus aureus ATCC 25923, hydrogen peroxide, and ultraviolet B radiation in the HaCaT cell models, which simulated the irritants that facial sensitive skin is exposed to. Subsequently, the ingredient VHProbi® Mix R was formulated using four kinds of fermented lysates: E06, E12, Lactiplantibacillus plantarum VHProbi® E15, and Lactobacillus helveticus VHProbi® Y21. A clinical study was conducted to investigate whether a lotion containing VHProbi® Mix R would be beneficial for people to enhance skin barrier. The participants were asked to use the investigational product for 30 days. Several indicators, including transepidermal water loss (TEWL), skin moisturization, and redness were measured at day 0 and day 30 using VISIA®-CR and CK®-MPA systems. Meanwhile, the burden of sensitive skin (BoSS) and self-assessment questionnaires were performed at baseline and endpoint of this study. The study data showed that at day 30, there was a significant decrease in TEWL (P < 0.01), redness measured by CK®-MPA (P < 0.01), and redness profile measured by VISIA®-CR compared with the baseline measurements. Skin moisturization had significantly increased after treatment with the lotion for 30 days. BoSS and self-assessment questionnaires also substantiated that the participants felt a markedly positive change in their sensitive skin. Hence, we hypothesize that applying the topical functional VHProbi® Mix R could confer effective benefits for people with sensitive skin and this represents a promising intervention for enhancing skin barrier.
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Dermatologic Agents/pharmacology ; Emollients/pharmacology ; Emollients/therapeutic use ; Skin ; Probiotics/pharmacology ; Fibrinolytic Agents/therapeutic use ; Water/pharmacology
    Chemical Substances Antioxidants ; Dermatologic Agents ; Emollients ; Fibrinolytic Agents ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43336-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Anti-obesity properties of the strain Bifidobacterium animalis subsp. lactis CECT 8145 in Zücker fatty rats.

    Carreras, N López / Martorell, P / Chenoll, E / Genovés, S / Ramón, D / Aleixandre, A

    Beneficial microbes

    2018  Volume 9, Issue 4, Page(s) 629–641

    Abstract: We evaluated the effect of oral administration of Bifidobacterium animalis subsp. lactis CECT 8145 strain in Zücker fatty rats. The Zücker fatty rats were randomly divided into two groups (n=10 each) and administered either B. animalis subsp. lactis CECT ...

    Abstract We evaluated the effect of oral administration of Bifidobacterium animalis subsp. lactis CECT 8145 strain in Zücker fatty rats. The Zücker fatty rats were randomly divided into two groups (n=10 each) and administered either B. animalis subsp. lactis CECT 8145 (10
    MeSH term(s) Animals ; Appetite Depressants/pharmacology ; Bifidobacterium animalis ; Disease Models, Animal ; Eating/drug effects ; Ghrelin/blood ; Glucose/metabolism ; Humans ; Lipid Metabolism ; Male ; Malondialdehyde/blood ; Obesity/microbiology ; Obesity/therapy ; Probiotics/administration & dosage ; Probiotics/pharmacology ; Rats ; Rats, Zucker ; Tumor Necrosis Factor-alpha/blood ; Weight Gain/drug effects
    Chemical Substances Appetite Depressants ; Ghrelin ; Tumor Necrosis Factor-alpha ; Malondialdehyde (4Y8F71G49Q) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2561259-1
    ISSN 1876-2891 ; 1876-2883
    ISSN (online) 1876-2891
    ISSN 1876-2883
    DOI 10.3920/BM2017.0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 7963: Show issues

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  10. Article ; Online: Small flexible automated system for monitoring Caenorhabditis elegans lifespan based on active vision and image processing techniques.

    Puchalt, Joan Carles / Sánchez-Salmerón, Antonio-José / Ivorra, Eugenio / Llopis, Silvia / Martínez, Roberto / Martorell, Patricia

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 12289

    Abstract: Traditionally Caenorhabditis elegans lifespan assays are performed by manually inspecting nematodes with a dissection microscope, which involves daily counting of live/dead worms cultured in Petri plates for 21-25 days. This manual inspection requires ... ...

    Abstract Traditionally Caenorhabditis elegans lifespan assays are performed by manually inspecting nematodes with a dissection microscope, which involves daily counting of live/dead worms cultured in Petri plates for 21-25 days. This manual inspection requires the screening of hundreds of worms to ensure statistical robustness, and is therefore a time-consuming approach. In recent years, various automated artificial vision systems have been reported to increase the throughput, however they usually provide less accurate results than manual assays. The main problems identified when using these vision systems are the false positives and false negatives, which occur due to culture media changes, occluded zones, dirtiness or condensation of the Petri plates. In this work, we developed and described a new C. elegans monitoring machine, SiViS, which consists of a flexible and compact platform design to analyse C. elegans cultures using the standard Petri plates seeded with E. coli. Our system uses an active vision illumination technique and different image-processing pipelines for motion detection, both previously reported, providing a fully automated image processing pipeline. In addition, this study validated both these methods and the feasibility of the SiViS machine for lifespan experiments by comparing them with manual lifespan assays. Results demonstrated that the automated system yields consistent replicates (p-value log rank test 0.699), and there are no significant differences between automated system assays and traditionally manual assays (p-value 0.637). Finally, although we have focused on the use of SiViS in longevity assays, the system configuration is flexible and can, thus, be adapted to other C. elegans studies such as toxicity, mobility and behaviour.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Escherichia coli ; Image Processing, Computer-Assisted ; Longevity/physiology
    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-91898-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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