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  1. Article ; Online: Not just another kinase mutation!

    Plo, Isabelle / Marty, Caroline

    Blood

    2020  Volume 134, Issue 26, Page(s) 2335–2337

    MeSH term(s) Humans ; Hypereosinophilic Syndrome ; Janus Kinase 2 ; Leukemia ; Mutation ; Oncogenes ; Polycythemia Vera
    Chemical Substances JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019003650
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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  2. Article ; Online: Recent advances in therapies for primary myelofibrosis.

    Vainchenker, William / Yahmi, Nasrine / Havelange, Violaine / Marty, Caroline / Plo, Isabelle / Constantinescu, Stefan N

    Faculty reviews

    2023  Volume 12, Page(s) 23

    Abstract: Primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET) form the ... ...

    Abstract Primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET) form the classical
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/12-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lessons from mouse models of MPN.

    Benlabiod, Camelia / Dagher, Tracy / Marty, Caroline / Villeval, Jean-Luc

    International review of cell and molecular biology

    2021  Volume 366, Page(s) 125–185

    Abstract: Over the past decades, a variety of MPN mouse models have been developed to express in HSC the main mutations identified in patients: ... ...

    Abstract Over the past decades, a variety of MPN mouse models have been developed to express in HSC the main mutations identified in patients: JAK2
    MeSH term(s) Animals ; Disease Models, Animal ; Disease Progression ; Genetic Predisposition to Disease ; Humans ; Mice ; Mutation ; Receptors, Thrombopoietin/genetics ; Thrombocythemia, Essential/genetics
    Chemical Substances Receptors, Thrombopoietin
    Language English
    Publishing date 2021-04-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2021.02.009
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  4. Article ; Online: Rôle de l’interaction entre le récepteur de la thrombopoïétine et la calréticuline mutée dans les néoplasmes myéloprolifératifs.

    Tetu, Maude / El Hachami, Kenza / Marty, Caroline

    Medecine sciences : M/S

    2019  Volume 35, Issue 11, Page(s) 901–903

    Title translation Thrombopoietin receptor and mutant calreticulin : the pathogenic interaction leading to myeloproliferative neoplasms.
    MeSH term(s) Calreticulin/genetics ; Calreticulin/metabolism ; Cell Proliferation ; Hematopoietic Stem Cells ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Mutation ; Myeloproliferative Disorders/etiology ; Myeloproliferative Disorders/genetics ; Receptors, Thrombopoietin/metabolism ; STAT1 Transcription Factor/metabolism ; Thrombopoietin/metabolism
    Chemical Substances CALR protein, human ; Calreticulin ; Receptors, Thrombopoietin ; STAT1 Transcription Factor ; MPL protein, human (143641-95-6) ; Thrombopoietin (9014-42-0) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language French
    Publishing date 2019-12-17
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019176
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    Zs.B 2872: Show issues Location:
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  5. Article ; Online: Deregulation of the p19/CDK4/CDK6 axis in Jak2

    Duparc, Hélène / Muller, Delphine / Gilles, Laure / Chédeville, Agathe L / El Khoury, Mira / Guignard, Rose / Debili, Najet / Wittner, Monika / Kauskot, Alexandre / Pasquier, Florence / Antony-Debré, Iléana / Marty, Caroline / Vainchenker, William / Plo, Isabelle / Raslova, Hana

    Leukemia

    2024  Volume 38, Issue 4, Page(s) 898–902

    MeSH term(s) Humans ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 6/genetics ; Janus Kinase 2/genetics ; Megakaryocytes ; Myeloproliferative Disorders ; Primary Myelofibrosis/genetics
    Chemical Substances CDK4 protein, human (EC 2.7.11.22) ; CDK6 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22) ; Janus Kinase 2 (EC 2.7.10.2) ; CDKN2D protein, human
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02170-5
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    Zs.A 2295: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Cortical Bone Microarchitecture in Dialysis Patients.

    Benillouche, Eva / Ostertag, Agnes / Marty, Caroline / Ureña Torres, Pablo / Cohen-Solal, Martine

    American journal of nephrology

    2020  Volume 51, Issue 10, Page(s) 833–838

    Abstract: Background: The incidence of skeletal fractures is high in dialysis patients. Current available tools are insufficient to predict bone fragility. We analyzed the microarchitecture in patients on dialysis therapy using bone biopsies and peripheral ... ...

    Abstract Background: The incidence of skeletal fractures is high in dialysis patients. Current available tools are insufficient to predict bone fragility. We analyzed the microarchitecture in patients on dialysis therapy using bone biopsies and peripheral microcomputed tomography.
    Methods: We analyzed 12 trans-iliac bone biopsies of patients with recent fractures. Bone microarchitecture was assessed in the bone cores by histology (2D-), microcomputed tomography (3D-µCT), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia.
    Results: Trabecular bone volume/tissue volume was similar in 2D histology and 3D-µCT (p = 0.40), while lower in HR-pQCT (p < 0.01). There was no correlation in trabecular microarchitectural indices between 2-histology and 3D-µCT, or HR-pQCT. The 3D-µCT cortical thickness (Ct.Th) were positively correlated with 2D (p < 0.05), but with HR-pQCT (p = 0.33). Ct.Th was lower in patients with ≥2 vertebral fractures than with one fracture.
    Conclusions: 3D-µCT is a reliable method for the measurement of cortical bone in bone biopsies. Prospective studies are awaited to address its value in discriminating fracture risk.
    MeSH term(s) Aged ; Aged, 80 and over ; Biopsy ; Cortical Bone/diagnostic imaging ; Cortical Bone/pathology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/etiology ; Osteoporotic Fractures/pathology ; Prospective Studies ; Renal Dialysis/adverse effects ; Reproducibility of Results ; Risk Assessment/methods ; X-Ray Microtomography
    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000510064
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    Zs.A 1635: Show issues Location:
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  7. Article ; Online: Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms.

    Guy, Alexandre / Garcia, Geoffrey / Gourdou-Latyszenok, Virginie / Wolff-Trombini, Laura / Josserand, Lara / Kimmerlin, Quentin / Favre, Simon / Kilani, Badr / Marty, Caroline / Boulaftali, Yacine / Labrouche-Colomer, Sylvie / Mansier, Olivier / James, Chloé

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 1, Page(s) 172–187

    Abstract: Background: Neutrophils participate in the pathogenesis of thrombosis through the formation of neutrophil extracellular traps (NETs). Thrombosis is the main cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). Recent ... ...

    Abstract Background: Neutrophils participate in the pathogenesis of thrombosis through the formation of neutrophil extracellular traps (NETs). Thrombosis is the main cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). Recent studies have shown an increase in NET formation (NETosis) both in patients with JAK2V617F neutrophils and in mouse models, and reported the participation of NETosis in the pathophysiology of thrombosis in mice.
    Objectives: This study investigated whether JAK2V617F neutrophils are sufficient to promote thrombosis or whether their cooperation with other blood cell types is necessary.
    Methods: NETosis was studied in PF4iCre;Jak2
    Results: In PF4iCre;Jak2
    Conclusion: Our study demonstrates that JAK2V617F neutrophils alone are not sufficient to promote thrombosis; rather, platelets cooperate with neutrophils to promote NETosis in vivo. A new role for aspirin in thrombosis prevention in MPNs was also identified.
    MeSH term(s) Humans ; Mice ; Animals ; Neutrophils/metabolism ; Extracellular Traps/metabolism ; Neoplasms/metabolism ; Myeloproliferative Disorders/genetics ; Janus Kinase 2/genetics ; Thrombosis ; Venous Thrombosis/metabolism ; Aspirin
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.08.028
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  8. Article ; Online: HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity.

    Tak, Tamar / Prevedello, Giulio / Simon, Gaël / Paillon, Noémie / Benlabiod, Camélia / Marty, Caroline / Plo, Isabelle / Duffy, Ken R / Perié, Leïla

    eLife

    2021  Volume 10

    Abstract: High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a ...

    Abstract High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a method that enables simultaneous determination of common ancestor, division number, and differentiation status of a large collection of single cells, our data revealed that murine cells that derived from a common ancestor had significant similarities in their division progression and differentiation outcomes. Although each family diversifies, the overall collection of cell types observed is composed of homogeneous families. Heterogeneity between families could be explained, in part, by differences in ancestral expression of cell surface markers. Our analyses demonstrate that fate decisions of cells are largely inherited from ancestor cells, indicating the importance of common ancestor effects. These results may have ramifications for bone marrow transplantation and leukemia, where substantial heterogeneity in HSPC behavior is observed.
    MeSH term(s) Animals ; Bone Marrow ; Bone Marrow Cells ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Hematopoietic Stem Cells/classification ; Hematopoietic Stem Cells/physiology ; Mice ; Mice, Inbred C57BL
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.60624
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  9. Article ; Online: The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications.

    Vainchenker, William / Plo, Isabelle / Marty, Caroline / Varghese, Leila N / Constantinescu, Stefan N

    Expert review of hematology

    2019  Volume 12, Issue 6, Page(s) 437–448

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Humans ; Myeloproliferative Disorders/genetics ; Receptors, Thrombopoietin/metabolism
    Chemical Substances Receptors, Thrombopoietin ; MPL protein, human (143641-95-6)
    Language English
    Publishing date 2019-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2019.1617129
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    Zs.A 6943: Show issues Location:
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  10. Article ; Online: Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2

    Courdy, Charly / Platteeuw, Loïc / Ducau, Charlotte / De Araujo, Isabelle / Boet, Emeline / Sahal, Ambrine / Saland, Estelle / Edmond, Valérie / Tavitian, Suzanne / Bertoli, Sarah / Cougoul, Pierre / Granat, Fanny / Poillet, Laura / Marty, Caroline / Plo, Isabelle / Sarry, Jean-Emmanuel / Manenti, Stéphane / Mansat-De Mas, Véronique / Joffre, Carine

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 106

    Abstract: The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are chronic malignancies associated with high-risk complications and suboptimal responses to JAK inhibitors such as ruxolitinib. A better understanding of cellular changes induced by ... ...

    Abstract The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are chronic malignancies associated with high-risk complications and suboptimal responses to JAK inhibitors such as ruxolitinib. A better understanding of cellular changes induced by ruxolitinib is required to develop new combinatory therapies to improve treatment efficacy. Here, we demonstrate that ruxolitinib induced autophagy in JAK2
    MeSH term(s) Mice ; Animals ; Janus Kinase 2 ; Protein Phosphatase 2/genetics ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/metabolism ; Neoplasms ; Autophagy ; Mutation
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2) ; ruxolitinib (82S8X8XX8H) ; Protein Phosphatase 2 (EC 3.1.3.16)
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00875-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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