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  1. Article ; Online: Recurrent Lymphocytic Hypophysitis Presenting as Internal Carotid Artery Stenosis and Oculomotor Nerve Palsy.

    Watanabe, Yui / Maruoka, Hiroyuki / Yokote, Hiroaki / Uchihara, Toshiki / Toru, Shuta

    Internal medicine (Tokyo, Japan)

    2023  

    Abstract: A 75-year-old woman presented with nausea and vomiting. Magnetic resonance imaging (MRI) revealed that she had a pituitary mass. A biopsy revealed lymphocytic hypophysitis (LYH). Symptoms were improved by hormone replacement therapy. Although she was ... ...

    Abstract A 75-year-old woman presented with nausea and vomiting. Magnetic resonance imaging (MRI) revealed that she had a pituitary mass. A biopsy revealed lymphocytic hypophysitis (LYH). Symptoms were improved by hormone replacement therapy. Although she was asymptomatic, follow-up MRI revealed an increase in the size of the mass. Intravenous methylprednisolone (IVMP) reduced the size of the mass; however, right ophthalmalgia and oculomotor nerve palsy developed. MRI showed that the pituitary mass had enlarged to the right oculomotor nerve in the cavernous sinus and to the right internal carotid artery (ICA), causing stenosis of the ICA. After IVMP administration, the symptoms dramatically improved, but ICA stenosis persisted.
    Language English
    Publishing date 2023-10-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2674-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aberrant morphometric networks in Alzheimer's disease have hemispheric asymmetry and age dependence.

    Maruoka, Hiroyuki / Hattori, Takaaki / Hase, Takeshi / Takahashi, Kunihiko / Ohara, Masahiro / Orimo, Satoshi / Yokota, Takanori

    The European journal of neuroscience

    2023  Volume 59, Issue 6, Page(s) 1332–1347

    Abstract: Alzheimer's disease (AD) is associated with abnormal accumulations of hyperphosphorylated tau and amyloid-β proteins, resulting in unique patterns of atrophy in the brain. We aimed to elucidate some characteristics of the AD's morphometric networks ... ...

    Abstract Alzheimer's disease (AD) is associated with abnormal accumulations of hyperphosphorylated tau and amyloid-β proteins, resulting in unique patterns of atrophy in the brain. We aimed to elucidate some characteristics of the AD's morphometric networks constructed by associating different morphometric features among brain areas and evaluating their relationship to Mini-Mental State Examination total score and age. Three-dimensional T1-weighted (3DT1) image data scanned by the same 1.5T magnetic resonance imaging (MRI) were obtained from 62 AD patients and 41 healthy controls (HCs) and were analysed by using FreeSurfer. The associations of the extracted six morphometric features between regions were estimated by correlation coefficients. The global and local graph theoretical measures for this network were evaluated. Associations between graph theoretical measures and age, sex and cognition were evaluated by multiple regression analysis in each group. Global measures of integration: global efficiency and mean information centrality were significantly higher in AD patients. Local measures of integration: node global efficiency and information centrality were significantly higher in the entorhinal cortex, fusiform gyrus and posterior cingulate cortex of AD patients but only in the left hemisphere. All global measures were correlated with age in AD patients but not in HCs. The information centrality was associated with age in AD's broad brain regions. Our results showed that altered morphometric networks due to AD are left-hemisphere dominant, suggesting that AD pathogenesis has a left-right asymmetry. Ageing has a unique impact on the morphometric networks in AD patients. The information centrality is a sensitive graph theoretical measure to detect this association.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Brain Mapping ; Aging ; Magnetic Resonance Imaging/methods
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-12-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2548: Show issues Location:
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  3. Article ; Online: Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans.

    Kuroyanagi, Hidehito / Ohno, Genta / Sakane, Hiroaki / Maruoka, Hiroyuki / Hagiwara, Masatoshi

    Nature protocols

    2010  Volume 5, Issue 9, Page(s) 1495–1517

    Abstract: Transgenic multicolor fluorescence reporters enable the visualization of alternative splicing patterns at a single-cell resolution in living organisms and facilitate further genetic analyses to identify cis-elements and trans-acting factors involved in ... ...

    Abstract Transgenic multicolor fluorescence reporters enable the visualization of alternative splicing patterns at a single-cell resolution in living organisms and facilitate further genetic analyses to identify cis-elements and trans-acting factors involved in splicing regulation. In this paper, we describe a method of generating fluorescence alternative splicing reporters for the nematode Caenorhabditis elegans. We describe strategies for designing minigene reporters and methods for constructing them; DNA fragments ('modules', such as promoter/3' cassettes, a genomic fragment of interest and a fluorescent protein cassette) that exist in separate vectors are assembled using site-directed recombination. We also describe strategies and methods for mutant screening and single-nucleotide polymorphism mapping using fluorescence reporters. This is the first detailed description of the design and construction of fluorescence alternative splicing reporters for C. elegans and their use in subsequent genetic analyses. It takes 2-4 months to construct minigenes and generate extrachromosomal lines for visualizing spatiotemporal distribution of alternative splicing events in vivo. Identification of regulators by integration of transgenes, mutant screening and mapping of the responsible genes takes a further 6-12 months. The fluorescence-reporter construction described here can also be applied to the vertebrate cell culture system.
    MeSH term(s) Alternative Splicing ; Animals ; Animals, Genetically Modified/metabolism ; Caenorhabditis elegans/genetics ; Cloning, Molecular ; Genes, Reporter ; Green Fluorescent Proteins/analysis ; Luminescent Proteins/analysis ; Microscopy, Fluorescence/methods ; Mutagenesis ; Polymorphism, Single Nucleotide ; Red Fluorescent Protein
    Chemical Substances Luminescent Proteins ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2010-08-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/nprot.2010.107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sjögren's syndrome.

    Mukaino, Akihiro / Nakane, Shunya / Higuchi, Osamu / Nakamura, Hideki / Miyagi, Tomo / Shiroma, Kanako / Tokashiki, Takashi / Fuseya, Yasuhiro / Ochi, Kazuhide / Umeda, Masataka / Nakazato, Tetsuya / Akioka, Shinji / Maruoka, Hiroyuki / Hayashi, Masatoshi / Igarashi, Shu-Ichi / Yokoi, Katsunori / Maeda, Yasuhiro / Sakai, Waka / Matsuo, Hidenori /
    Kawakami, Atsushi

    Modern rheumatology

    2016  Volume 26, Issue 5, Page(s) 708–715

    Abstract: Objective: It is not known whether autonomic neuropathy is a feature of Sjögren's syndrome (SS) or whether it is related to circulating antiganglionic acetylcholine receptor (gAChR) antibodies. The goal of the present study was to investigate the ... ...

    Abstract Objective: It is not known whether autonomic neuropathy is a feature of Sjögren's syndrome (SS) or whether it is related to circulating antiganglionic acetylcholine receptor (gAChR) antibodies. The goal of the present study was to investigate the autonomic dysfunction in patients with SS and the associations between autonomic dysfunction, anti-gAChR antibodies, and clinical features of SS.
    Methods: (1) The first observational study tested for the presence of gAChR antibodies in the serum samples from 39 patients with SS (absent information regarding autonomic symptoms) and healthy volunteers. (2) In the second study, serological and clinical data from 10 Japanese patients diagnosed with SS were reviewed. These patients showed autonomic dysfunction, and luciferase immunoprecipitation systems (LIPS) test was conducted to detect anti-α3 and anti-β4 gAChR antibodies. (3) In the final analysis, we combined the data of seropositive SS patients with autonomic symptom from the first study with all of the patients from the second study, and analyzed the clinical features.
    Results: (1) The LIPS assay revealed that anti-gAChRα3 and anti-gAChRβ4 antibodies were detected in the sera from patients with SS (23.1%, 9/39). Five of nine SS patients had autonomic symptoms. (2) Anti-α3 and anti-β4 gAChR antibodies were also detected in 80.0% (8/10) of patients with SS with autonomic symptoms. Six of the ten patients were diagnosed as having SS after neurological symptoms developed. These seropositive patients had predominant and severe autonomic symptoms and were diagnosed with autonomic neuropathy. (3) Thirteen of fifteen SS patients with autonomic symptoms (86.7%) were seropositive for anti-gAChR antibodies, and we confirmed sicca complex, orthostatic hypotension, upper and lower gastrointestinal (GI) symptoms, and bladder dysfunction at high rates.
    Conclusion: The present results suggest the possibility of anti-gAChR antibodies aiding the diagnostics of SS with autonomic dysfunction.
    MeSH term(s) Adult ; Aged ; Autoantibodies/blood ; Female ; Humans ; Male ; Middle Aged ; Receptors, Cholinergic/immunology ; Sjogren's Syndrome/blood ; Sjogren's Syndrome/immunology
    Chemical Substances Autoantibodies ; Receptors, Cholinergic
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.3109/14397595.2016.1147404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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